Amino acid dipepetide frequency for Brevibacillus fluminis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.553AlaAla: 8.553 ± 0.098	0.828AlaCys: 0.828 ± 0.022	4.478AlaAsp: 4.478 ± 0.063	5.669AlaGlu: 5.669 ± 0.068	3.586AlaPhe: 3.586 ± 0.048	6.66AlaGly: 6.66 ± 0.079	1.685AlaHis: 1.685 ± 0.032	6.29AlaIle: 6.29 ± 0.07	5.036AlaLys: 5.036 ± 0.055	8.605AlaLeu: 8.605 ± 0.067	2.512AlaMet: 2.512 ± 0.039	2.982AlaAsn: 2.982 ± 0.036	2.761AlaPro: 2.761 ± 0.043	3.289AlaGln: 3.289 ± 0.046	3.785AlaArg: 3.785 ± 0.047	5.093AlaSer: 5.093 ± 0.061	4.561AlaThr: 4.561 ± 0.065	6.59AlaVal: 6.59 ± 0.069	0.839AlaTrp: 0.839 ± 0.024	2.697AlaTyr: 2.697 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.575CysAla: 0.575 ± 0.017	0.111CysCys: 0.111 ± 0.008	0.463CysAsp: 0.463 ± 0.016	0.506CysGlu: 0.506 ± 0.019	0.398CysPhe: 0.398 ± 0.015	0.793CysGly: 0.793 ± 0.023	0.19CysHis: 0.19 ± 0.01	0.535CysIle: 0.535 ± 0.017	0.375CysLys: 0.375 ± 0.015	0.774CysLeu: 0.774 ± 0.022	0.219CysMet: 0.219 ± 0.011	0.295CysAsn: 0.295 ± 0.013	0.358CysPro: 0.358 ± 0.015	0.265CysGln: 0.265 ± 0.011	0.415CysArg: 0.415 ± 0.014	0.56CysSer: 0.56 ± 0.021	0.444CysThr: 0.444 ± 0.016	0.497CysVal: 0.497 ± 0.017	0.102CysTrp: 0.102 ± 0.008	0.269CysTyr: 0.269 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	3.933AspAla: 3.933 ± 0.048	0.362AspCys: 0.362 ± 0.016	2.339AspAsp: 2.339 ± 0.037	3.978AspGlu: 3.978 ± 0.053	2.03AspPhe: 2.03 ± 0.035	3.682AspGly: 3.682 ± 0.051	1.069AspHis: 1.069 ± 0.027	3.211AspIle: 3.211 ± 0.044	2.606AspLys: 2.606 ± 0.038	4.749AspLeu: 4.749 ± 0.049	1.367AspMet: 1.367 ± 0.025	1.489AspAsn: 1.489 ± 0.029	2.309AspPro: 2.309 ± 0.039	2.014AspGln: 2.014 ± 0.033	2.557AspArg: 2.557 ± 0.036	2.496AspSer: 2.496 ± 0.037	2.407AspThr: 2.407 ± 0.039	3.956AspVal: 3.956 ± 0.051	0.685AspTrp: 0.685 ± 0.018	1.733AspTyr: 1.733 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	5.904GluAla: 5.904 ± 0.062	0.403GluCys: 0.403 ± 0.016	2.656GluAsp: 2.656 ± 0.038	5.433GluGlu: 5.433 ± 0.066	2.016GluPhe: 2.016 ± 0.035	4.078GluGly: 4.078 ± 0.048	1.441GluHis: 1.441 ± 0.028	4.502GluIle: 4.502 ± 0.054	4.627GluLys: 4.627 ± 0.063	7.092GluLeu: 7.092 ± 0.079	2.172GluMet: 2.172 ± 0.036	2.49GluAsn: 2.49 ± 0.039	2.308GluPro: 2.308 ± 0.031	3.845GluGln: 3.845 ± 0.049	4.203GluArg: 4.203 ± 0.05	3.373GluSer: 3.373 ± 0.048	3.544GluThr: 3.544 ± 0.039	4.422GluVal: 4.422 ± 0.057	0.903GluTrp: 0.903 ± 0.022	1.692GluTyr: 1.692 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	3.773PheAla: 3.773 ± 0.051	0.417PheCys: 0.417 ± 0.015	2.223PheAsp: 2.223 ± 0.038	2.282PheGlu: 2.282 ± 0.036	2.019PhePhe: 2.019 ± 0.044	3.265PheGly: 3.265 ± 0.047	1.055PheHis: 1.055 ± 0.029	2.706PheIle: 2.706 ± 0.044	1.461PheLys: 1.461 ± 0.031	4.417PheLeu: 4.417 ± 0.06	1.005PheMet: 1.005 ± 0.022	1.302PheAsn: 1.302 ± 0.027	1.815PhePro: 1.815 ± 0.031	1.532PheGln: 1.532 ± 0.03	1.889PheArg: 1.889 ± 0.029	2.955PheSer: 2.955 ± 0.044	2.676PheThr: 2.676 ± 0.044	3.085PheVal: 3.085 ± 0.043	0.516PheTrp: 0.516 ± 0.016	1.416PheTyr: 1.416 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	5.764GlyAla: 5.764 ± 0.074	0.768GlyCys: 0.768 ± 0.021	3.246GlyAsp: 3.246 ± 0.049	4.608GlyGlu: 4.608 ± 0.053	3.312GlyPhe: 3.312 ± 0.047	5.426GlyGly: 5.426 ± 0.074	1.459GlyHis: 1.459 ± 0.034	5.75GlyIle: 5.75 ± 0.06	4.893GlyLys: 4.893 ± 0.053	7.066GlyLeu: 7.066 ± 0.068	2.378GlyMet: 2.378 ± 0.032	2.551GlyAsn: 2.551 ± 0.043	1.986GlyPro: 1.986 ± 0.048	2.737GlyGln: 2.737 ± 0.047	3.241GlyArg: 3.241 ± 0.041	4.305GlySer: 4.305 ± 0.053	4.625GlyThr: 4.625 ± 0.064	5.582GlyVal: 5.582 ± 0.061	1.007GlyTrp: 1.007 ± 0.026	2.771GlyTyr: 2.771 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	1.833HisAla: 1.833 ± 0.034	0.206HisCys: 0.206 ± 0.011	1.147HisAsp: 1.147 ± 0.027	1.372HisGlu: 1.372 ± 0.027	1.032HisPhe: 1.032 ± 0.025	1.564HisGly: 1.564 ± 0.032	0.601HisHis: 0.601 ± 0.022	1.341HisIle: 1.341 ± 0.026	0.862HisLys: 0.862 ± 0.022	2.235HisLeu: 2.235 ± 0.041	0.551HisMet: 0.551 ± 0.016	0.655HisAsn: 0.655 ± 0.021	1.26HisPro: 1.26 ± 0.026	0.886HisGln: 0.886 ± 0.023	1.075HisArg: 1.075 ± 0.027	1.223HisSer: 1.223 ± 0.028	1.091HisThr: 1.091 ± 0.022	1.713HisVal: 1.713 ± 0.033	0.256HisTrp: 0.256 ± 0.011	0.803HisTyr: 0.803 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	6.641IleAla: 6.641 ± 0.07	0.66IleCys: 0.66 ± 0.018	3.644IleAsp: 3.644 ± 0.044	4.41IleGlu: 4.41 ± 0.055	2.44IlePhe: 2.44 ± 0.04	5.818IleGly: 5.818 ± 0.073	1.533IleHis: 1.533 ± 0.026	3.977IleIle: 3.977 ± 0.057	3.034IleLys: 3.034 ± 0.048	6.026IleLeu: 6.026 ± 0.067	1.62IleMet: 1.62 ± 0.029	2.35IleAsn: 2.35 ± 0.035	3.234IlePro: 3.234 ± 0.045	2.471IleGln: 2.471 ± 0.032	3.513IleArg: 3.513 ± 0.052	4.294IleSer: 4.294 ± 0.049	4.048IleThr: 4.048 ± 0.051	5.485IleVal: 5.485 ± 0.058	0.636IleTrp: 0.636 ± 0.018	1.83IleTyr: 1.83 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	4.657LysAla: 4.657 ± 0.058	0.238LysCys: 0.238 ± 0.011	2.583LysAsp: 2.583 ± 0.045	4.663LysGlu: 4.663 ± 0.05	1.33LysPhe: 1.33 ± 0.028	3.814LysGly: 3.814 ± 0.051	1.045LysHis: 1.045 ± 0.022	3.176LysIle: 3.176 ± 0.049	3.724LysLys: 3.724 ± 0.049	5.261LysLeu: 5.261 ± 0.058	1.743LysMet: 1.743 ± 0.031	2.15LysAsn: 2.15 ± 0.035	2.307LysPro: 2.307 ± 0.036	2.891LysGln: 2.891 ± 0.042	3.192LysArg: 3.192 ± 0.041	2.814LysSer: 2.814 ± 0.036	3.202LysThr: 3.202 ± 0.045	3.837LysVal: 3.837 ± 0.052	0.726LysTrp: 0.726 ± 0.019	1.435LysTyr: 1.435 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	9.547LeuAla: 9.547 ± 0.087	0.871LeuCys: 0.871 ± 0.024	5.147LeuAsp: 5.147 ± 0.057	6.025LeuGlu: 6.025 ± 0.069	4.883LeuPhe: 4.883 ± 0.07	7.21LeuGly: 7.21 ± 0.065	2.308LeuHis: 2.308 ± 0.037	6.551LeuIle: 6.551 ± 0.075	4.838LeuLys: 4.838 ± 0.051	11.283LeuLeu: 11.283 ± 0.111	2.433LeuMet: 2.433 ± 0.039	3.217LeuAsn: 3.217 ± 0.051	4.608LeuPro: 4.608 ± 0.051	4.328LeuGln: 4.328 ± 0.055	4.805LeuArg: 4.805 ± 0.059	6.597LeuSer: 6.597 ± 0.071	5.967LeuThr: 5.967 ± 0.057	7.046LeuVal: 7.046 ± 0.072	0.887LeuTrp: 0.887 ± 0.022	3.122LeuTyr: 3.122 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	2.377MetAla: 2.377 ± 0.035	0.19MetCys: 0.19 ± 0.01	1.32MetAsp: 1.32 ± 0.025	1.926MetGlu: 1.926 ± 0.036	0.975MetPhe: 0.975 ± 0.026	1.942MetGly: 1.942 ± 0.038	0.521MetHis: 0.521 ± 0.017	1.963MetIle: 1.963 ± 0.036	1.981MetLys: 1.981 ± 0.034	2.883MetLeu: 2.883 ± 0.036	0.894MetMet: 0.894 ± 0.02	1.307MetAsn: 1.307 ± 0.025	1.188MetPro: 1.188 ± 0.027	1.187MetGln: 1.187 ± 0.028	1.407MetArg: 1.407 ± 0.028	1.721MetSer: 1.721 ± 0.031	1.615MetThr: 1.615 ± 0.032	2.0MetVal: 2.0 ± 0.034	0.229MetTrp: 0.229 ± 0.012	0.771MetTyr: 0.771 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.761AsnAla: 2.761 ± 0.042	0.284AsnCys: 0.284 ± 0.013	1.684AsnAsp: 1.684 ± 0.032	2.3AsnGlu: 2.3 ± 0.035	1.202AsnPhe: 1.202 ± 0.028	3.103AsnGly: 3.103 ± 0.049	0.821AsnHis: 0.821 ± 0.023	2.128AsnIle: 2.128 ± 0.034	1.866AsnLys: 1.866 ± 0.033	3.257AsnLeu: 3.257 ± 0.044	0.934AsnMet: 0.934 ± 0.021	1.235AsnAsn: 1.235 ± 0.032	2.063AsnPro: 2.063 ± 0.041	1.688AsnGln: 1.688 ± 0.034	2.023AsnArg: 2.023 ± 0.032	1.768AsnSer: 1.768 ± 0.035	1.739AsnThr: 1.739 ± 0.032	2.705AsnVal: 2.705 ± 0.041	0.463AsnTrp: 0.463 ± 0.015	1.11AsnTyr: 1.11 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	3.423ProAla: 3.423 ± 0.047	0.223ProCys: 0.223 ± 0.01	2.511ProAsp: 2.511 ± 0.044	2.968ProGlu: 2.968 ± 0.04	2.068ProPhe: 2.068 ± 0.037	2.868ProGly: 2.868 ± 0.038	1.033ProHis: 1.033 ± 0.023	2.789ProIle: 2.789 ± 0.034	1.905ProLys: 1.905 ± 0.037	4.15ProLeu: 4.15 ± 0.047	0.96ProMet: 0.96 ± 0.023	1.438ProAsn: 1.438 ± 0.03	1.367ProPro: 1.367 ± 0.032	1.579ProGln: 1.579 ± 0.03	1.543ProArg: 1.543 ± 0.029	2.447ProSer: 2.447 ± 0.037	2.378ProThr: 2.378 ± 0.051	3.332ProVal: 3.332 ± 0.049	0.446ProTrp: 0.446 ± 0.017	1.526ProTyr: 1.526 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.981GlnAla: 3.981 ± 0.055	0.221GlnCys: 0.221 ± 0.01	1.661GlnAsp: 1.661 ± 0.036	2.957GlnGlu: 2.957 ± 0.047	1.594GlnPhe: 1.594 ± 0.028	2.472GlnGly: 2.472 ± 0.04	0.872GlnHis: 0.872 ± 0.023	2.755GlnIle: 2.755 ± 0.044	2.566GlnLys: 2.566 ± 0.034	4.558GlnLeu: 4.558 ± 0.05	1.344GlnMet: 1.344 ± 0.028	1.49GlnAsn: 1.49 ± 0.031	1.694GlnPro: 1.694 ± 0.033	2.124GlnGln: 2.124 ± 0.039	2.028GlnArg: 2.028 ± 0.037	2.388GlnSer: 2.388 ± 0.038	2.34GlnThr: 2.34 ± 0.038	2.974GlnVal: 2.974 ± 0.041	0.486GlnTrp: 0.486 ± 0.017	1.15GlnTyr: 1.15 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	3.542ArgAla: 3.542 ± 0.045	0.405ArgCys: 0.405 ± 0.016	2.391ArgAsp: 2.391 ± 0.034	3.868ArgGlu: 3.868 ± 0.058	2.384ArgPhe: 2.384 ± 0.039	2.831ArgGly: 2.831 ± 0.043	1.095ArgHis: 1.095 ± 0.024	3.618ArgIle: 3.618 ± 0.052	3.048ArgLys: 3.048 ± 0.036	5.303ArgLeu: 5.303 ± 0.068	1.652ArgMet: 1.652 ± 0.031	1.837ArgAsn: 1.837 ± 0.031	1.63ArgPro: 1.63 ± 0.034	2.08ArgGln: 2.08 ± 0.039	2.421ArgArg: 2.421 ± 0.042	2.645ArgSer: 2.645 ± 0.036	2.52ArgThr: 2.52 ± 0.04	3.394ArgVal: 3.394 ± 0.047	0.581ArgTrp: 0.581 ± 0.017	1.826ArgTyr: 1.826 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	4.614SerAla: 4.614 ± 0.056	0.446SerCys: 0.446 ± 0.021	2.625SerAsp: 2.625 ± 0.044	3.342SerGlu: 3.342 ± 0.045	3.124SerPhe: 3.124 ± 0.043	4.786SerGly: 4.786 ± 0.055	1.3SerHis: 1.3 ± 0.027	4.257SerIle: 4.257 ± 0.048	2.883SerLys: 2.883 ± 0.035	6.414SerLeu: 6.414 ± 0.059	1.807SerMet: 1.807 ± 0.03	1.933SerAsn: 1.933 ± 0.039	2.427SerPro: 2.427 ± 0.038	2.233SerGln: 2.233 ± 0.035	2.726SerArg: 2.726 ± 0.036	3.595SerSer: 3.595 ± 0.064	3.166SerThr: 3.166 ± 0.044	4.375SerVal: 4.375 ± 0.05	0.709SerTrp: 0.709 ± 0.02	2.027SerTyr: 2.027 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	4.913ThrAla: 4.913 ± 0.07	0.424ThrCys: 0.424 ± 0.015	2.775ThrAsp: 2.775 ± 0.047	3.278ThrGlu: 3.278 ± 0.049	2.499ThrPhe: 2.499 ± 0.033	4.733ThrGly: 4.733 ± 0.084	1.175ThrHis: 1.175 ± 0.026	4.303ThrIle: 4.303 ± 0.047	2.767ThrLys: 2.767 ± 0.043	5.684ThrLeu: 5.684 ± 0.059	1.545ThrMet: 1.545 ± 0.028	2.046ThrAsn: 2.046 ± 0.033	2.691ThrPro: 2.691 ± 0.042	1.852ThrGln: 1.852 ± 0.036	2.365ThrArg: 2.365 ± 0.033	3.257ThrSer: 3.257 ± 0.043	3.148ThrThr: 3.148 ± 0.052	4.677ThrVal: 4.677 ± 0.067	0.586ThrTrp: 0.586 ± 0.019	1.872ThrTyr: 1.872 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	6.404ValAla: 6.404 ± 0.07	0.694ValCys: 0.694 ± 0.022	3.757ValAsp: 3.757 ± 0.049	4.872ValGlu: 4.872 ± 0.054	2.988ValPhe: 2.988 ± 0.043	5.228ValGly: 5.228 ± 0.056	1.474ValHis: 1.474 ± 0.033	5.317ValIle: 5.317 ± 0.066	4.188ValLys: 4.188 ± 0.057	7.236ValLeu: 7.236 ± 0.066	2.075ValMet: 2.075 ± 0.036	2.807ValAsn: 2.807 ± 0.038	3.173ValPro: 3.173 ± 0.048	2.669ValGln: 2.669 ± 0.037	3.47ValArg: 3.47 ± 0.044	4.726ValSer: 4.726 ± 0.049	4.796ValThr: 4.796 ± 0.073	5.592ValVal: 5.592 ± 0.061	0.782ValTrp: 0.782 ± 0.023	2.17ValTyr: 2.17 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	0.794TrpAla: 0.794 ± 0.024	0.098TrpCys: 0.098 ± 0.007	0.594TrpAsp: 0.594 ± 0.019	0.682TrpGlu: 0.682 ± 0.018	0.5TrpPhe: 0.5 ± 0.019	0.77TrpGly: 0.77 ± 0.021	0.237TrpHis: 0.237 ± 0.01	0.809TrpIle: 0.809 ± 0.018	0.706TrpLys: 0.706 ± 0.023	1.351TrpLeu: 1.351 ± 0.031	0.384TrpMet: 0.384 ± 0.015	0.506TrpAsn: 0.506 ± 0.014	0.337TrpPro: 0.337 ± 0.015	0.523TrpGln: 0.523 ± 0.016	0.546TrpArg: 0.546 ± 0.016	0.682TrpSer: 0.682 ± 0.019	0.563TrpThr: 0.563 ± 0.02	0.806TrpVal: 0.806 ± 0.021	0.16TrpTrp: 0.16 ± 0.01	0.363TrpTyr: 0.363 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.51TyrAla: 2.51 ± 0.037	0.295TyrCys: 0.295 ± 0.013	1.727TyrAsp: 1.727 ± 0.032	1.964TyrGlu: 1.964 ± 0.031	1.429TyrPhe: 1.429 ± 0.031	2.432TyrGly: 2.432 ± 0.039	0.794TyrHis: 0.794 ± 0.021	1.686TyrIle: 1.686 ± 0.031	1.425TyrLys: 1.425 ± 0.032	3.329TyrLeu: 3.329 ± 0.044	0.804TyrMet: 0.804 ± 0.023	1.055TyrAsn: 1.055 ± 0.022	1.44TyrPro: 1.44 ± 0.03	1.463TyrGln: 1.463 ± 0.029	1.864TyrArg: 1.864 ± 0.031	1.848TyrSer: 1.848 ± 0.034	1.762TyrThr: 1.762 ± 0.029	2.348TyrVal: 2.348 ± 0.036	0.411TyrTrp: 0.411 ± 0.015	1.164TyrTyr: 1.164 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5987 proteins (1876288 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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