Amino acid dipepetide frequency for Porphyromonas sp. HMSC065F10

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.942AlaAla: 5.942 ± 0.13
0.719AlaCys: 0.719 ± 0.039
4.807AlaAsp: 4.807 ± 0.085
5.327AlaGlu: 5.327 ± 0.108
2.67AlaPhe: 2.67 ± 0.064
5.204AlaGly: 5.204 ± 0.101
1.591AlaHis: 1.591 ± 0.058
4.597AlaIle: 4.597 ± 0.095
3.984AlaLys: 3.984 ± 0.092
8.408AlaLeu: 8.408 ± 0.131
1.94AlaMet: 1.94 ± 0.066
2.305AlaAsn: 2.305 ± 0.074
2.913AlaPro: 2.913 ± 0.074
2.63AlaGln: 2.63 ± 0.088
3.992AlaArg: 3.992 ± 0.086
4.214AlaSer: 4.214 ± 0.083
4.285AlaThr: 4.285 ± 0.092
4.869AlaVal: 4.869 ± 0.108
0.732AlaTrp: 0.732 ± 0.036
2.79AlaTyr: 2.79 ± 0.074
0.0AlaXaa: 0.0 ± 0.0
Cys
0.729CysAla: 0.729 ± 0.036
0.143CysCys: 0.143 ± 0.016
0.653CysAsp: 0.653 ± 0.035
0.641CysGlu: 0.641 ± 0.032
0.418CysPhe: 0.418 ± 0.026
0.941CysGly: 0.941 ± 0.043
0.354CysHis: 0.354 ± 0.024
0.611CysIle: 0.611 ± 0.036
0.384CysLys: 0.384 ± 0.028
0.945CysLeu: 0.945 ± 0.041
0.195CysMet: 0.195 ± 0.018
0.367CysAsn: 0.367 ± 0.025
0.515CysPro: 0.515 ± 0.032
0.209CysGln: 0.209 ± 0.018
0.722CysArg: 0.722 ± 0.044
0.615CysSer: 0.615 ± 0.036
0.569CysThr: 0.569 ± 0.035
0.564CysVal: 0.564 ± 0.036
0.086CysTrp: 0.086 ± 0.012
0.409CysTyr: 0.409 ± 0.026
0.0CysXaa: 0.0 ± 0.0
Asp
4.218AspAla: 4.218 ± 0.085
0.551AspCys: 0.551 ± 0.028
3.214AspAsp: 3.214 ± 0.088
4.585AspGlu: 4.585 ± 0.088
3.28AspPhe: 3.28 ± 0.063
4.275AspGly: 4.275 ± 0.098
1.589AspHis: 1.589 ± 0.056
3.452AspIle: 3.452 ± 0.078
3.539AspLys: 3.539 ± 0.095
6.807AspLeu: 6.807 ± 0.111
1.47AspMet: 1.47 ± 0.045
2.004AspAsn: 2.004 ± 0.068
3.384AspPro: 3.384 ± 0.086
1.891AspGln: 1.891 ± 0.057
4.28AspArg: 4.28 ± 0.089
3.317AspSer: 3.317 ± 0.088
3.029AspThr: 3.029 ± 0.085
3.426AspVal: 3.426 ± 0.083
0.795AspTrp: 0.795 ± 0.044
3.061AspTyr: 3.061 ± 0.091
0.0AspXaa: 0.0 ± 0.0
Glu
5.566GluAla: 5.566 ± 0.118
0.628GluCys: 0.628 ± 0.033
4.036GluAsp: 4.036 ± 0.096
6.718GluGlu: 6.718 ± 0.127
1.298GluPhe: 1.298 ± 0.049
5.427GluGly: 5.427 ± 0.102
1.303GluHis: 1.303 ± 0.047
4.421GluIle: 4.421 ± 0.098
3.366GluLys: 3.366 ± 0.096
6.459GluLeu: 6.459 ± 0.122
2.234GluMet: 2.234 ± 0.059
1.722GluAsn: 1.722 ± 0.066
2.431GluPro: 2.431 ± 0.064
2.926GluGln: 2.926 ± 0.079
5.004GluArg: 5.004 ± 0.102
3.854GluSer: 3.854 ± 0.097
3.98GluThr: 3.98 ± 0.082
5.268GluVal: 5.268 ± 0.088
0.785GluTrp: 0.785 ± 0.034
2.465GluTyr: 2.465 ± 0.06
0.0GluXaa: 0.0 ± 0.0
Phe
2.982PheAla: 2.982 ± 0.075
0.451PheCys: 0.451 ± 0.029
2.615PheAsp: 2.615 ± 0.071
1.869PheGlu: 1.869 ± 0.054
1.823PhePhe: 1.823 ± 0.067
2.866PheGly: 2.866 ± 0.07
0.837PheHis: 0.837 ± 0.042
2.276PheIle: 2.276 ± 0.063
1.322PheLys: 1.322 ± 0.053
3.455PheLeu: 3.455 ± 0.086
0.859PheMet: 0.859 ± 0.039
1.296PheAsn: 1.296 ± 0.051
1.621PhePro: 1.621 ± 0.057
0.793PheGln: 0.793 ± 0.035
2.228PheArg: 2.228 ± 0.058
2.756PheSer: 2.756 ± 0.068
2.298PheThr: 2.298 ± 0.074
2.803PheVal: 2.803 ± 0.072
0.375PheTrp: 0.375 ± 0.025
1.441PheTyr: 1.441 ± 0.049
0.0PheXaa: 0.0 ± 0.0
Gly
5.184GlyAla: 5.184 ± 0.115
0.865GlyCys: 0.865 ± 0.037
4.337GlyAsp: 4.337 ± 0.085
5.122GlyGlu: 5.122 ± 0.086
2.692GlyPhe: 2.692 ± 0.07
5.512GlyGly: 5.512 ± 0.116
1.65GlyHis: 1.65 ± 0.053
4.59GlyIle: 4.59 ± 0.088
4.394GlyLys: 4.394 ± 0.094
7.215GlyLeu: 7.215 ± 0.138
2.01GlyMet: 2.01 ± 0.06
2.387GlyAsn: 2.387 ± 0.067
1.77GlyPro: 1.77 ± 0.053
2.313GlyGln: 2.313 ± 0.064
4.43GlyArg: 4.43 ± 0.113
4.65GlySer: 4.65 ± 0.107
4.341GlyThr: 4.341 ± 0.096
5.354GlyVal: 5.354 ± 0.101
0.887GlyTrp: 0.887 ± 0.039
3.349GlyTyr: 3.349 ± 0.082
0.0GlyXaa: 0.0 ± 0.0
His
1.376HisAla: 1.376 ± 0.049
0.263HisCys: 0.263 ± 0.021
1.167HisAsp: 1.167 ± 0.05
1.15HisGlu: 1.15 ± 0.046
1.302HisPhe: 1.302 ± 0.052
1.477HisGly: 1.477 ± 0.053
0.717HisHis: 0.717 ± 0.041
1.339HisIle: 1.339 ± 0.053
0.971HisLys: 0.971 ± 0.042
2.438HisLeu: 2.438 ± 0.069
0.428HisMet: 0.428 ± 0.026
0.766HisAsn: 0.766 ± 0.038
1.411HisPro: 1.411 ± 0.047
0.641HisGln: 0.641 ± 0.032
1.579HisArg: 1.579 ± 0.054
1.32HisSer: 1.32 ± 0.042
1.28HisThr: 1.28 ± 0.046
1.116HisVal: 1.116 ± 0.045
0.242HisTrp: 0.242 ± 0.02
1.019HisTyr: 1.019 ± 0.045
0.0HisXaa: 0.0 ± 0.0
Ile
4.943IleAla: 4.943 ± 0.098
0.668IleCys: 0.668 ± 0.037
4.499IleAsp: 4.499 ± 0.088
3.864IleGlu: 3.864 ± 0.094
2.0IlePhe: 2.0 ± 0.057
4.455IleGly: 4.455 ± 0.09
1.367IleHis: 1.367 ± 0.05
3.441IleIle: 3.441 ± 0.086
2.714IleLys: 2.714 ± 0.082
5.723IleLeu: 5.723 ± 0.105
1.113IleMet: 1.113 ± 0.046
2.152IleAsn: 2.152 ± 0.064
3.199IlePro: 3.199 ± 0.067
1.465IleGln: 1.465 ± 0.05
4.031IleArg: 4.031 ± 0.082
4.418IleSer: 4.418 ± 0.082
3.906IleThr: 3.906 ± 0.094
4.027IleVal: 4.027 ± 0.098
0.487IleTrp: 0.487 ± 0.032
2.281IleTyr: 2.281 ± 0.057
0.0IleXaa: 0.0 ± 0.0
Lys
3.529LysAla: 3.529 ± 0.087
0.347LysCys: 0.347 ± 0.024
3.186LysAsp: 3.186 ± 0.085
4.312LysGlu: 4.312 ± 0.103
1.206LysPhe: 1.206 ± 0.042
3.94LysGly: 3.94 ± 0.096
0.97LysHis: 0.97 ± 0.036
2.623LysIle: 2.623 ± 0.08
3.076LysLys: 3.076 ± 0.094
4.112LysLeu: 4.112 ± 0.096
1.534LysMet: 1.534 ± 0.052
1.536LysAsn: 1.536 ± 0.061
2.022LysPro: 2.022 ± 0.064
1.727LysGln: 1.727 ± 0.056
3.019LysArg: 3.019 ± 0.069
3.344LysSer: 3.344 ± 0.083
2.468LysThr: 2.468 ± 0.067
3.411LysVal: 3.411 ± 0.086
0.606LysTrp: 0.606 ± 0.033
2.113LysTyr: 2.113 ± 0.067
0.0LysXaa: 0.0 ± 0.0
Leu
7.063LeuAla: 7.063 ± 0.124
1.189LeuCys: 1.189 ± 0.045
5.657LeuAsp: 5.657 ± 0.107
5.76LeuGlu: 5.76 ± 0.117
4.029LeuPhe: 4.029 ± 0.086
6.693LeuGly: 6.693 ± 0.115
2.185LeuHis: 2.185 ± 0.065
5.826LeuIle: 5.826 ± 0.107
4.243LeuLys: 4.243 ± 0.091
11.306LeuLeu: 11.306 ± 0.211
2.699LeuMet: 2.699 ± 0.075
2.943LeuAsn: 2.943 ± 0.084
5.184LeuPro: 5.184 ± 0.116
2.977LeuGln: 2.977 ± 0.075
7.346LeuArg: 7.346 ± 0.148
8.74LeuSer: 8.74 ± 0.167
6.824LeuThr: 6.824 ± 0.115
5.942LeuVal: 5.942 ± 0.125
0.958LeuTrp: 0.958 ± 0.041
3.933LeuTyr: 3.933 ± 0.084
0.0LeuXaa: 0.0 ± 0.0
Met
2.057MetAla: 2.057 ± 0.066
0.189MetCys: 0.189 ± 0.016
1.583MetAsp: 1.583 ± 0.05
1.829MetGlu: 1.829 ± 0.056
0.49MetPhe: 0.49 ± 0.028
1.997MetGly: 1.997 ± 0.06
0.441MetHis: 0.441 ± 0.027
1.679MetIle: 1.679 ± 0.052
1.552MetLys: 1.552 ± 0.053
2.261MetLeu: 2.261 ± 0.069
0.78MetMet: 0.78 ± 0.039
0.931MetAsn: 0.931 ± 0.042
1.291MetPro: 1.291 ± 0.048
0.889MetGln: 0.889 ± 0.04
1.746MetArg: 1.746 ± 0.054
1.852MetSer: 1.852 ± 0.058
1.874MetThr: 1.874 ± 0.057
1.611MetVal: 1.611 ± 0.053
0.18MetTrp: 0.18 ± 0.017
0.711MetTyr: 0.711 ± 0.034
0.0MetXaa: 0.0 ± 0.0
Asn
2.482AsnAla: 2.482 ± 0.059
0.298AsnCys: 0.298 ± 0.026
1.746AsnAsp: 1.746 ± 0.062
1.645AsnGlu: 1.645 ± 0.051
1.34AsnPhe: 1.34 ± 0.049
2.522AsnGly: 2.522 ± 0.079
0.748AsnHis: 0.748 ± 0.035
2.081AsnIle: 2.081 ± 0.063
1.694AsnLys: 1.694 ± 0.061
2.965AsnLeu: 2.965 ± 0.08
0.736AsnMet: 0.736 ± 0.038
1.31AsnAsn: 1.31 ± 0.052
1.781AsnPro: 1.781 ± 0.057
1.042AsnGln: 1.042 ± 0.041
1.866AsnArg: 1.866 ± 0.062
1.761AsnSer: 1.761 ± 0.061
1.852AsnThr: 1.852 ± 0.061
2.204AsnVal: 2.204 ± 0.078
0.387AsnTrp: 0.387 ± 0.03
1.406AsnTyr: 1.406 ± 0.051
0.0AsnXaa: 0.0 ± 0.0
Pro
3.1ProAla: 3.1 ± 0.074
0.301ProCys: 0.301 ± 0.024
3.295ProAsp: 3.295 ± 0.092
4.255ProGlu: 4.255 ± 0.071
1.889ProPhe: 1.889 ± 0.054
3.037ProGly: 3.037 ± 0.08
0.983ProHis: 0.983 ± 0.045
2.724ProIle: 2.724 ± 0.077
2.078ProLys: 2.078 ± 0.058
4.206ProLeu: 4.206 ± 0.091
1.239ProMet: 1.239 ± 0.047
1.374ProAsn: 1.374 ± 0.046
1.148ProPro: 1.148 ± 0.051
1.391ProGln: 1.391 ± 0.055
2.123ProArg: 2.123 ± 0.062
3.059ProSer: 3.059 ± 0.08
2.819ProThr: 2.819 ± 0.079
2.909ProVal: 2.909 ± 0.07
0.455ProTrp: 0.455 ± 0.032
1.994ProTyr: 1.994 ± 0.063
0.0ProXaa: 0.0 ± 0.0
Gln
2.372GlnAla: 2.372 ± 0.072
0.242GlnCys: 0.242 ± 0.02
1.704GlnAsp: 1.704 ± 0.046
2.315GlnGlu: 2.315 ± 0.066
0.81GlnPhe: 0.81 ± 0.039
2.132GlnGly: 2.132 ± 0.054
0.583GlnHis: 0.583 ± 0.034
2.115GlnIle: 2.115 ± 0.054
1.515GlnLys: 1.515 ± 0.059
3.32GlnLeu: 3.32 ± 0.066
1.042GlnMet: 1.042 ± 0.037
0.948GlnAsn: 0.948 ± 0.042
1.332GlnPro: 1.332 ± 0.048
1.29GlnGln: 1.29 ± 0.053
2.095GlnArg: 2.095 ± 0.056
2.103GlnSer: 2.103 ± 0.059
1.862GlnThr: 1.862 ± 0.05
2.409GlnVal: 2.409 ± 0.067
0.379GlnTrp: 0.379 ± 0.023
1.187GlnTyr: 1.187 ± 0.044
0.0GlnXaa: 0.0 ± 0.0
Arg
4.347ArgAla: 4.347 ± 0.091
0.643ArgCys: 0.643 ± 0.036
3.78ArgAsp: 3.78 ± 0.085
5.144ArgGlu: 5.144 ± 0.117
2.313ArgPhe: 2.313 ± 0.069
4.036ArgGly: 4.036 ± 0.086
1.536ArgHis: 1.536 ± 0.064
3.834ArgIle: 3.834 ± 0.079
2.925ArgLys: 2.925 ± 0.085
6.671ArgLeu: 6.671 ± 0.116
1.837ArgMet: 1.837 ± 0.051
1.919ArgAsn: 1.919 ± 0.057
2.728ArgPro: 2.728 ± 0.07
2.561ArgGln: 2.561 ± 0.067
4.383ArgArg: 4.383 ± 0.115
3.952ArgSer: 3.952 ± 0.089
3.135ArgThr: 3.135 ± 0.075
4.211ArgVal: 4.211 ± 0.084
0.781ArgTrp: 0.781 ± 0.041
2.812ArgTyr: 2.812 ± 0.087
0.0ArgXaa: 0.0 ± 0.0
Ser
4.714SerAla: 4.714 ± 0.102
0.722SerCys: 0.722 ± 0.037
4.31SerAsp: 4.31 ± 0.088
4.213SerGlu: 4.213 ± 0.101
2.719SerPhe: 2.719 ± 0.074
5.235SerGly: 5.235 ± 0.106
1.509SerHis: 1.509 ± 0.054
3.967SerIle: 3.967 ± 0.091
3.125SerLys: 3.125 ± 0.082
7.061SerLeu: 7.061 ± 0.138
1.546SerMet: 1.546 ± 0.054
1.945SerAsn: 1.945 ± 0.062
2.928SerPro: 2.928 ± 0.073
2.022SerGln: 2.022 ± 0.061
3.965SerArg: 3.965 ± 0.091
4.3SerSer: 4.3 ± 0.085
3.6SerThr: 3.6 ± 0.09
4.411SerVal: 4.411 ± 0.088
0.736SerTrp: 0.736 ± 0.031
2.921SerTyr: 2.921 ± 0.079
0.0SerXaa: 0.0 ± 0.0
Thr
4.551ThrAla: 4.551 ± 0.096
0.539ThrCys: 0.539 ± 0.03
3.795ThrAsp: 3.795 ± 0.09
3.78ThrGlu: 3.78 ± 0.086
2.48ThrPhe: 2.48 ± 0.068
4.457ThrGly: 4.457 ± 0.097
1.155ThrHis: 1.155 ± 0.047
4.103ThrIle: 4.103 ± 0.098
2.749ThrLys: 2.749 ± 0.083
6.843ThrLeu: 6.843 ± 0.129
1.376ThrMet: 1.376 ± 0.046
1.83ThrAsn: 1.83 ± 0.066
3.569ThrPro: 3.569 ± 0.087
1.557ThrGln: 1.557 ± 0.048
2.717ThrArg: 2.717 ± 0.061
3.357ThrSer: 3.357 ± 0.081
3.603ThrThr: 3.603 ± 0.082
3.632ThrVal: 3.632 ± 0.095
0.561ThrTrp: 0.561 ± 0.03
2.531ThrTyr: 2.531 ± 0.075
0.0ThrXaa: 0.0 ± 0.0
Val
5.305ValAla: 5.305 ± 0.111
0.737ValCys: 0.737 ± 0.032
4.064ValAsp: 4.064 ± 0.075
4.347ValGlu: 4.347 ± 0.085
2.064ValPhe: 2.064 ± 0.058
4.709ValGly: 4.709 ± 0.084
1.165ValHis: 1.165 ± 0.051
4.25ValIle: 4.25 ± 0.098
3.083ValLys: 3.083 ± 0.081
6.169ValLeu: 6.169 ± 0.122
1.704ValMet: 1.704 ± 0.064
2.121ValAsn: 2.121 ± 0.066
3.027ValPro: 3.027 ± 0.06
1.748ValGln: 1.748 ± 0.053
4.324ValArg: 4.324 ± 0.103
4.834ValSer: 4.834 ± 0.095
4.546ValThr: 4.546 ± 0.082
5.007ValVal: 5.007 ± 0.103
0.667ValTrp: 0.667 ± 0.029
2.366ValTyr: 2.366 ± 0.06
0.0ValXaa: 0.0 ± 0.0
Trp
0.621TrpAla: 0.621 ± 0.031
0.138TrpCys: 0.138 ± 0.016
0.719TrpAsp: 0.719 ± 0.036
0.657TrpGlu: 0.657 ± 0.029
0.365TrpPhe: 0.365 ± 0.025
0.84TrpGly: 0.84 ± 0.041
0.278TrpHis: 0.278 ± 0.024
0.66TrpIle: 0.66 ± 0.036
0.468TrpLys: 0.468 ± 0.029
1.101TrpLeu: 1.101 ± 0.043
0.337TrpMet: 0.337 ± 0.03
0.37TrpAsn: 0.37 ± 0.025
0.271TrpPro: 0.271 ± 0.022
0.51TrpGln: 0.51 ± 0.028
0.786TrpArg: 0.786 ± 0.037
0.805TrpSer: 0.805 ± 0.036
0.569TrpThr: 0.569 ± 0.035
0.682TrpVal: 0.682 ± 0.038
0.136TrpTrp: 0.136 ± 0.014
0.386TrpTyr: 0.386 ± 0.03
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.837TyrAla: 2.837 ± 0.07
0.436TyrCys: 0.436 ± 0.03
2.999TyrAsp: 2.999 ± 0.07
2.361TyrGlu: 2.361 ± 0.063
1.778TyrPhe: 1.778 ± 0.059
3.3TyrGly: 3.3 ± 0.082
1.041TyrHis: 1.041 ± 0.047
2.167TyrIle: 2.167 ± 0.061
1.899TyrLys: 1.899 ± 0.067
4.032TyrLeu: 4.032 ± 0.089
0.864TyrMet: 0.864 ± 0.036
1.638TyrAsn: 1.638 ± 0.061
1.852TyrPro: 1.852 ± 0.059
1.172TyrGln: 1.172 ± 0.047
2.911TyrArg: 2.911 ± 0.081
2.697TyrSer: 2.697 ± 0.076
2.345TyrThr: 2.345 ± 0.068
2.379TyrVal: 2.379 ± 0.061
0.465TyrTrp: 0.465 ± 0.032
1.864TyrTyr: 1.864 ± 0.062
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1615 proteins (593930 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski