Amino acid dipepetide frequency for Clostridium fallax

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.537AlaAla: 3.537 ± 0.1
0.598AlaCys: 0.598 ± 0.03
2.164AlaAsp: 2.164 ± 0.063
3.046AlaGlu: 3.046 ± 0.079
2.465AlaPhe: 2.465 ± 0.069
3.498AlaGly: 3.498 ± 0.092
0.698AlaHis: 0.698 ± 0.027
5.664AlaIle: 5.664 ± 0.11
4.804AlaLys: 4.804 ± 0.092
5.774AlaLeu: 5.774 ± 0.101
1.498AlaMet: 1.498 ± 0.052
2.443AlaAsn: 2.443 ± 0.069
1.337AlaPro: 1.337 ± 0.046
1.138AlaGln: 1.138 ± 0.041
1.691AlaArg: 1.691 ± 0.051
2.89AlaSer: 2.89 ± 0.065
2.534AlaThr: 2.534 ± 0.066
3.655AlaVal: 3.655 ± 0.083
0.294AlaTrp: 0.294 ± 0.02
1.934AlaTyr: 1.934 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
0.566CysAla: 0.566 ± 0.028
0.228CysCys: 0.228 ± 0.025
0.773CysAsp: 0.773 ± 0.035
0.712CysGlu: 0.712 ± 0.033
0.486CysPhe: 0.486 ± 0.023
1.106CysGly: 1.106 ± 0.051
0.203CysHis: 0.203 ± 0.016
1.054CysIle: 1.054 ± 0.039
1.113CysLys: 1.113 ± 0.038
0.807CysLeu: 0.807 ± 0.031
0.237CysMet: 0.237 ± 0.017
0.827CysAsn: 0.827 ± 0.033
0.483CysPro: 0.483 ± 0.026
0.172CysGln: 0.172 ± 0.014
0.4CysArg: 0.4 ± 0.023
0.726CysSer: 0.726 ± 0.03
0.537CysThr: 0.537 ± 0.024
0.55CysVal: 0.55 ± 0.03
0.073CysTrp: 0.073 ± 0.011
0.472CysTyr: 0.472 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
2.318AspAla: 2.318 ± 0.064
0.617AspCys: 0.617 ± 0.023
2.821AspAsp: 2.821 ± 0.078
4.595AspGlu: 4.595 ± 0.079
3.062AspPhe: 3.062 ± 0.067
3.472AspGly: 3.472 ± 0.089
0.553AspHis: 0.553 ± 0.025
6.45AspIle: 6.45 ± 0.113
6.166AspLys: 6.166 ± 0.108
5.369AspLeu: 5.369 ± 0.075
1.414AspMet: 1.414 ± 0.046
3.746AspAsn: 3.746 ± 0.075
1.301AspPro: 1.301 ± 0.041
0.815AspGln: 0.815 ± 0.033
1.746AspArg: 1.746 ± 0.053
3.148AspSer: 3.148 ± 0.072
2.264AspThr: 2.264 ± 0.058
3.3AspVal: 3.3 ± 0.067
0.352AspTrp: 0.352 ± 0.024
2.777AspTyr: 2.777 ± 0.069
0.0AspXaa: 0.0 ± 0.0
Glu
3.87GluAla: 3.87 ± 0.082
0.634GluCys: 0.634 ± 0.029
4.784GluAsp: 4.784 ± 0.085
7.557GluGlu: 7.557 ± 0.125
3.134GluPhe: 3.134 ± 0.062
4.573GluGly: 4.573 ± 0.077
0.753GluHis: 0.753 ± 0.035
7.386GluIle: 7.386 ± 0.098
8.506GluLys: 8.506 ± 0.139
6.282GluLeu: 6.282 ± 0.103
1.779GluMet: 1.779 ± 0.047
5.999GluAsn: 5.999 ± 0.105
1.433GluPro: 1.433 ± 0.05
1.49GluGln: 1.49 ± 0.046
2.668GluArg: 2.668 ± 0.061
3.483GluSer: 3.483 ± 0.07
2.782GluThr: 2.782 ± 0.059
4.888GluVal: 4.888 ± 0.09
0.337GluTrp: 0.337 ± 0.02
2.692GluTyr: 2.692 ± 0.067
0.0GluXaa: 0.0 ± 0.0
Phe
2.052PheAla: 2.052 ± 0.064
0.53PheCys: 0.53 ± 0.026
2.408PheAsp: 2.408 ± 0.061
2.576PheGlu: 2.576 ± 0.068
2.24PhePhe: 2.24 ± 0.069
2.92PheGly: 2.92 ± 0.063
0.55PheHis: 0.55 ± 0.027
5.451PheIle: 5.451 ± 0.112
4.691PheLys: 4.691 ± 0.092
4.421PheLeu: 4.421 ± 0.089
1.148PheMet: 1.148 ± 0.041
3.445PheAsn: 3.445 ± 0.076
1.13PhePro: 1.13 ± 0.041
0.944PheGln: 0.944 ± 0.034
1.193PheArg: 1.193 ± 0.038
3.136PheSer: 3.136 ± 0.071
2.272PheThr: 2.272 ± 0.056
2.47PheVal: 2.47 ± 0.058
0.301PheTrp: 0.301 ± 0.021
1.899PheTyr: 1.899 ± 0.061
0.0PheXaa: 0.0 ± 0.0
Gly
4.133GlyAla: 4.133 ± 0.102
0.861GlyCys: 0.861 ± 0.036
3.434GlyAsp: 3.434 ± 0.061
4.677GlyGlu: 4.677 ± 0.09
3.169GlyPhe: 3.169 ± 0.069
4.169GlyGly: 4.169 ± 0.095
0.877GlyHis: 0.877 ± 0.034
6.877GlyIle: 6.877 ± 0.107
5.901GlyLys: 5.901 ± 0.088
5.491GlyLeu: 5.491 ± 0.103
1.638GlyMet: 1.638 ± 0.049
3.341GlyAsn: 3.341 ± 0.087
1.261GlyPro: 1.261 ± 0.04
1.334GlyGln: 1.334 ± 0.042
2.224GlyArg: 2.224 ± 0.057
3.384GlySer: 3.384 ± 0.075
3.334GlyThr: 3.334 ± 0.07
4.65GlyVal: 4.65 ± 0.095
0.573GlyTrp: 0.573 ± 0.052
2.898GlyTyr: 2.898 ± 0.063
0.0GlyXaa: 0.0 ± 0.0
His
0.507HisAla: 0.507 ± 0.027
0.219HisCys: 0.219 ± 0.016
0.579HisAsp: 0.579 ± 0.026
0.663HisGlu: 0.663 ± 0.029
0.548HisPhe: 0.548 ± 0.028
0.964HisGly: 0.964 ± 0.042
0.238HisHis: 0.238 ± 0.022
1.288HisIle: 1.288 ± 0.044
1.095HisLys: 1.095 ± 0.038
1.071HisLeu: 1.071 ± 0.036
0.294HisMet: 0.294 ± 0.023
0.693HisAsn: 0.693 ± 0.029
0.545HisPro: 0.545 ± 0.027
0.264HisGln: 0.264 ± 0.02
0.474HisArg: 0.474 ± 0.025
0.771HisSer: 0.771 ± 0.03
0.581HisThr: 0.581 ± 0.03
0.597HisVal: 0.597 ± 0.025
0.108HisTrp: 0.108 ± 0.013
0.526HisTyr: 0.526 ± 0.027
0.0HisXaa: 0.0 ± 0.0
Ile
5.533IleAla: 5.533 ± 0.104
1.292IleCys: 1.292 ± 0.041
6.114IleAsp: 6.114 ± 0.096
7.355IleGlu: 7.355 ± 0.109
4.948IlePhe: 4.948 ± 0.116
6.405IleGly: 6.405 ± 0.092
1.194IleHis: 1.194 ± 0.041
10.916IleIle: 10.916 ± 0.167
10.606IleLys: 10.606 ± 0.16
10.036IleLeu: 10.036 ± 0.153
2.256IleMet: 2.256 ± 0.053
7.359IleAsn: 7.359 ± 0.117
3.417IlePro: 3.417 ± 0.061
1.859IleGln: 1.859 ± 0.049
2.936IleArg: 2.936 ± 0.065
6.947IleSer: 6.947 ± 0.104
5.022IleThr: 5.022 ± 0.083
6.113IleVal: 6.113 ± 0.103
0.518IleTrp: 0.518 ± 0.03
3.831IleTyr: 3.831 ± 0.083
0.0IleXaa: 0.0 ± 0.0
Lys
4.965LysAla: 4.965 ± 0.09
0.874LysCys: 0.874 ± 0.039
7.511LysAsp: 7.511 ± 0.119
10.858LysGlu: 10.858 ± 0.165
3.605LysPhe: 3.605 ± 0.065
5.848LysGly: 5.848 ± 0.088
0.973LysHis: 0.973 ± 0.035
9.388LysIle: 9.388 ± 0.135
9.681LysLys: 9.681 ± 0.134
7.993LysLeu: 7.993 ± 0.115
2.336LysMet: 2.336 ± 0.054
7.894LysAsn: 7.894 ± 0.133
2.173LysPro: 2.173 ± 0.065
1.751LysGln: 1.751 ± 0.049
3.349LysArg: 3.349 ± 0.07
5.533LysSer: 5.533 ± 0.092
4.165LysThr: 4.165 ± 0.083
6.499LysVal: 6.499 ± 0.108
0.598LysTrp: 0.598 ± 0.031
4.411LysTyr: 4.411 ± 0.091
0.0LysXaa: 0.0 ± 0.0
Leu
5.002LeuAla: 5.002 ± 0.097
1.097LeuCys: 1.097 ± 0.04
5.432LeuAsp: 5.432 ± 0.09
6.654LeuGlu: 6.654 ± 0.102
3.764LeuPhe: 3.764 ± 0.099
6.428LeuGly: 6.428 ± 0.108
0.94LeuHis: 0.94 ± 0.039
9.012LeuIle: 9.012 ± 0.136
10.1LeuLys: 10.1 ± 0.16
7.871LeuLeu: 7.871 ± 0.132
2.241LeuMet: 2.241 ± 0.055
6.532LeuAsn: 6.532 ± 0.119
2.652LeuPro: 2.652 ± 0.056
1.895LeuGln: 1.895 ± 0.057
2.944LeuArg: 2.944 ± 0.062
6.549LeuSer: 6.549 ± 0.103
4.339LeuThr: 4.339 ± 0.092
5.256LeuVal: 5.256 ± 0.085
0.606LeuTrp: 0.606 ± 0.031
3.332LeuTyr: 3.332 ± 0.07
0.0LeuXaa: 0.0 ± 0.0
Met
1.757MetAla: 1.757 ± 0.057
0.221MetCys: 0.221 ± 0.018
1.442MetAsp: 1.442 ± 0.042
1.809MetGlu: 1.809 ± 0.051
0.959MetPhe: 0.959 ± 0.032
1.673MetGly: 1.673 ± 0.048
0.293MetHis: 0.293 ± 0.02
2.264MetIle: 2.264 ± 0.06
2.423MetLys: 2.423 ± 0.055
2.021MetLeu: 2.021 ± 0.057
0.652MetMet: 0.652 ± 0.025
1.599MetAsn: 1.599 ± 0.044
0.842MetPro: 0.842 ± 0.038
0.541MetGln: 0.541 ± 0.029
0.823MetArg: 0.823 ± 0.034
1.468MetSer: 1.468 ± 0.041
1.081MetThr: 1.081 ± 0.045
1.583MetVal: 1.583 ± 0.04
0.157MetTrp: 0.157 ± 0.015
0.779MetTyr: 0.779 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
2.463AsnAla: 2.463 ± 0.068
0.823AsnCys: 0.823 ± 0.04
3.283AsnAsp: 3.283 ± 0.081
4.496AsnGlu: 4.496 ± 0.093
3.083AsnPhe: 3.083 ± 0.066
3.926AsnGly: 3.926 ± 0.093
0.876AsnHis: 0.876 ± 0.033
8.254AsnIle: 8.254 ± 0.119
7.604AsnLys: 7.604 ± 0.136
6.674AsnLeu: 6.674 ± 0.114
1.64AsnMet: 1.64 ± 0.041
5.771AsnAsn: 5.771 ± 0.133
2.219AsnPro: 2.219 ± 0.06
1.355AsnGln: 1.355 ± 0.038
1.928AsnArg: 1.928 ± 0.054
4.176AsnSer: 4.176 ± 0.096
2.755AsnThr: 2.755 ± 0.06
3.278AsnVal: 3.278 ± 0.067
0.495AsnTrp: 0.495 ± 0.03
2.953AsnTyr: 2.953 ± 0.078
0.0AsnXaa: 0.0 ± 0.0
Pro
1.244ProAla: 1.244 ± 0.05
0.33ProCys: 0.33 ± 0.025
1.283ProAsp: 1.283 ± 0.042
1.975ProGlu: 1.975 ± 0.048
1.433ProPhe: 1.433 ± 0.042
1.631ProGly: 1.631 ± 0.048
0.442ProHis: 0.442 ± 0.021
2.857ProIle: 2.857 ± 0.075
2.588ProLys: 2.588 ± 0.065
2.621ProLeu: 2.621 ± 0.063
0.676ProMet: 0.676 ± 0.025
1.673ProAsn: 1.673 ± 0.053
0.59ProPro: 0.59 ± 0.029
0.701ProGln: 0.701 ± 0.027
0.771ProArg: 0.771 ± 0.035
1.782ProSer: 1.782 ± 0.052
1.395ProThr: 1.395 ± 0.045
1.89ProVal: 1.89 ± 0.056
0.242ProTrp: 0.242 ± 0.019
1.268ProTyr: 1.268 ± 0.04
0.0ProXaa: 0.0 ± 0.0
Gln
1.031GlnAla: 1.031 ± 0.048
0.319GlnCys: 0.319 ± 0.022
1.01GlnAsp: 1.01 ± 0.039
1.329GlnGlu: 1.329 ± 0.047
0.909GlnPhe: 0.909 ± 0.038
1.334GlnGly: 1.334 ± 0.045
0.229GlnHis: 0.229 ± 0.018
1.912GlnIle: 1.912 ± 0.054
1.833GlnLys: 1.833 ± 0.057
1.832GlnLeu: 1.832 ± 0.051
0.53GlnMet: 0.53 ± 0.026
1.295GlnAsn: 1.295 ± 0.041
0.458GlnPro: 0.458 ± 0.027
0.483GlnGln: 0.483 ± 0.027
0.834GlnArg: 0.834 ± 0.036
1.171GlnSer: 1.171 ± 0.035
0.876GlnThr: 0.876 ± 0.031
1.224GlnVal: 1.224 ± 0.044
0.235GlnTrp: 0.235 ± 0.018
0.876GlnTyr: 0.876 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
1.756ArgAla: 1.756 ± 0.045
0.39ArgCys: 0.39 ± 0.025
1.86ArgAsp: 1.86 ± 0.046
2.962ArgGlu: 2.962 ± 0.06
1.386ArgPhe: 1.386 ± 0.04
2.021ArgGly: 2.021 ± 0.054
0.4ArgHis: 0.4 ± 0.021
3.004ArgIle: 3.004 ± 0.061
2.99ArgLys: 2.99 ± 0.062
2.769ArgLeu: 2.769 ± 0.071
0.867ArgMet: 0.867 ± 0.034
1.832ArgAsn: 1.832 ± 0.055
0.824ArgPro: 0.824 ± 0.037
0.732ArgGln: 0.732 ± 0.033
1.397ArgArg: 1.397 ± 0.047
1.419ArgSer: 1.419 ± 0.044
1.49ArgThr: 1.49 ± 0.048
2.126ArgVal: 2.126 ± 0.052
0.217ArgTrp: 0.217 ± 0.018
1.325ArgTyr: 1.325 ± 0.046
0.0ArgXaa: 0.0 ± 0.0
Ser
2.773SerAla: 2.773 ± 0.064
0.609SerCys: 0.609 ± 0.028
2.908SerAsp: 2.908 ± 0.059
3.624SerGlu: 3.624 ± 0.076
3.214SerPhe: 3.214 ± 0.068
3.823SerGly: 3.823 ± 0.068
0.828SerHis: 0.828 ± 0.033
6.734SerIle: 6.734 ± 0.122
6.296SerLys: 6.296 ± 0.099
6.409SerLeu: 6.409 ± 0.093
1.517SerMet: 1.517 ± 0.05
3.892SerAsn: 3.892 ± 0.089
1.625SerPro: 1.625 ± 0.045
1.374SerGln: 1.374 ± 0.04
1.768SerArg: 1.768 ± 0.051
4.074SerSer: 4.074 ± 0.094
2.84SerThr: 2.84 ± 0.056
3.26SerVal: 3.26 ± 0.07
0.388SerTrp: 0.388 ± 0.026
2.449SerTyr: 2.449 ± 0.061
0.0SerXaa: 0.0 ± 0.0
Thr
2.561ThrAla: 2.561 ± 0.069
0.473ThrCys: 0.473 ± 0.026
2.093ThrAsp: 2.093 ± 0.047
2.805ThrGlu: 2.805 ± 0.057
2.223ThrPhe: 2.223 ± 0.057
3.341ThrGly: 3.341 ± 0.08
0.671ThrHis: 0.671 ± 0.031
4.973ThrIle: 4.973 ± 0.09
3.739ThrLys: 3.739 ± 0.068
4.944ThrLeu: 4.944 ± 0.08
1.017ThrMet: 1.017 ± 0.042
2.652ThrAsn: 2.652 ± 0.073
1.711ThrPro: 1.711 ± 0.047
0.792ThrGln: 0.792 ± 0.03
1.284ThrArg: 1.284 ± 0.044
2.862ThrSer: 2.862 ± 0.059
2.341ThrThr: 2.341 ± 0.068
3.123ThrVal: 3.123 ± 0.072
0.294ThrTrp: 0.294 ± 0.022
1.728ThrTyr: 1.728 ± 0.053
0.0ThrXaa: 0.0 ± 0.0
Val
3.589ValAla: 3.589 ± 0.085
0.786ValCys: 0.786 ± 0.035
3.681ValAsp: 3.681 ± 0.067
4.196ValGlu: 4.196 ± 0.081
2.755ValPhe: 2.755 ± 0.059
4.012ValGly: 4.012 ± 0.093
0.715ValHis: 0.715 ± 0.032
6.189ValIle: 6.189 ± 0.084
5.556ValLys: 5.556 ± 0.103
5.738ValLeu: 5.738 ± 0.089
1.511ValMet: 1.511 ± 0.056
3.62ValAsn: 3.62 ± 0.066
2.044ValPro: 2.044 ± 0.057
1.257ValGln: 1.257 ± 0.037
1.765ValArg: 1.765 ± 0.049
3.881ValSer: 3.881 ± 0.064
3.101ValThr: 3.101 ± 0.077
4.205ValVal: 4.205 ± 0.086
0.328ValTrp: 0.328 ± 0.021
2.292ValTyr: 2.292 ± 0.061
0.0ValXaa: 0.0 ± 0.0
Trp
0.374TrpAla: 0.374 ± 0.021
0.094TrpCys: 0.094 ± 0.011
0.363TrpAsp: 0.363 ± 0.024
0.378TrpGlu: 0.378 ± 0.02
0.312TrpPhe: 0.312 ± 0.022
0.437TrpGly: 0.437 ± 0.024
0.111TrpHis: 0.111 ± 0.013
0.712TrpIle: 0.712 ± 0.037
0.446TrpLys: 0.446 ± 0.025
0.517TrpLeu: 0.517 ± 0.028
0.163TrpMet: 0.163 ± 0.018
0.455TrpAsn: 0.455 ± 0.024
0.153TrpPro: 0.153 ± 0.015
0.226TrpGln: 0.226 ± 0.016
0.23TrpArg: 0.23 ± 0.016
0.374TrpSer: 0.374 ± 0.025
0.284TrpThr: 0.284 ± 0.021
0.393TrpVal: 0.393 ± 0.025
0.063TrpTrp: 0.063 ± 0.01
0.37TrpTyr: 0.37 ± 0.041
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.628TyrAla: 1.628 ± 0.043
0.532TyrCys: 0.532 ± 0.025
2.345TyrAsp: 2.345 ± 0.051
2.76TyrGlu: 2.76 ± 0.073
2.08TyrPhe: 2.08 ± 0.05
2.643TyrGly: 2.643 ± 0.065
0.481TyrHis: 0.481 ± 0.024
4.275TyrIle: 4.275 ± 0.092
4.264TyrLys: 4.264 ± 0.087
4.009TyrLeu: 4.009 ± 0.085
0.973TyrMet: 0.973 ± 0.036
2.985TyrAsn: 2.985 ± 0.082
1.193TyrPro: 1.193 ± 0.035
0.597TyrGln: 0.597 ± 0.026
1.342TyrArg: 1.342 ± 0.045
2.63TyrSer: 2.63 ± 0.06
1.635TyrThr: 1.635 ± 0.047
2.162TyrVal: 2.162 ± 0.053
0.276TyrTrp: 0.276 ± 0.02
1.914TyrTyr: 1.914 ± 0.071
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2521 proteins (777836 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski