Amino acid dipepetide frequency for Mycoplasma caviae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.527AlaAla: 2.527 ± 0.125
0.267AlaCys: 0.267 ± 0.027
2.295AlaAsp: 2.295 ± 0.088
2.768AlaGlu: 2.768 ± 0.099
2.553AlaPhe: 2.553 ± 0.114
2.556AlaGly: 2.556 ± 0.111
0.764AlaHis: 0.764 ± 0.049
4.758AlaIle: 4.758 ± 0.135
6.018AlaLys: 6.018 ± 0.174
5.208AlaLeu: 5.208 ± 0.133
1.034AlaMet: 1.034 ± 0.057
3.607AlaAsn: 3.607 ± 0.111
1.089AlaPro: 1.089 ± 0.06
1.815AlaGln: 1.815 ± 0.082
2.054AlaArg: 2.054 ± 0.081
3.329AlaSer: 3.329 ± 0.104
2.931AlaThr: 2.931 ± 0.105
2.498AlaVal: 2.498 ± 0.099
0.407AlaTrp: 0.407 ± 0.036
1.969AlaTyr: 1.969 ± 0.083
0.0AlaXaa: 0.0 ± 0.0
Cys
0.412CysAla: 0.412 ± 0.038
0.073CysCys: 0.073 ± 0.015
0.404CysAsp: 0.404 ± 0.038
0.5CysGlu: 0.5 ± 0.039
0.488CysPhe: 0.488 ± 0.037
0.468CysGly: 0.468 ± 0.036
0.148CysHis: 0.148 ± 0.017
0.508CysIle: 0.508 ± 0.037
0.517CysLys: 0.517 ± 0.037
0.688CysLeu: 0.688 ± 0.047
0.078CysMet: 0.078 ± 0.014
0.398CysAsn: 0.398 ± 0.034
0.224CysPro: 0.224 ± 0.028
0.224CysGln: 0.224 ± 0.025
0.2CysArg: 0.2 ± 0.023
0.5CysSer: 0.5 ± 0.039
0.308CysThr: 0.308 ± 0.03
0.343CysVal: 0.343 ± 0.031
0.073CysTrp: 0.073 ± 0.014
0.305CysTyr: 0.305 ± 0.031
0.0CysXaa: 0.0 ± 0.0
Asp
3.079AspAla: 3.079 ± 0.091
0.314AspCys: 0.314 ± 0.032
2.942AspAsp: 2.942 ± 0.108
4.906AspGlu: 4.906 ± 0.141
3.523AspPhe: 3.523 ± 0.098
2.547AspGly: 2.547 ± 0.101
0.694AspHis: 0.694 ± 0.043
4.717AspIle: 4.717 ± 0.118
5.914AspLys: 5.914 ± 0.14
5.202AspLeu: 5.202 ± 0.134
0.703AspMet: 0.703 ± 0.053
3.863AspAsn: 3.863 ± 0.115
1.47AspPro: 1.47 ± 0.079
1.624AspGln: 1.624 ± 0.075
1.609AspArg: 1.609 ± 0.085
3.3AspSer: 3.3 ± 0.101
2.434AspThr: 2.434 ± 0.09
3.111AspVal: 3.111 ± 0.103
0.537AspTrp: 0.537 ± 0.046
2.754AspTyr: 2.754 ± 0.093
0.0AspXaa: 0.0 ± 0.0
Glu
3.698GluAla: 3.698 ± 0.127
0.36GluCys: 0.36 ± 0.031
3.244GluAsp: 3.244 ± 0.106
4.88GluGlu: 4.88 ± 0.143
3.915GluPhe: 3.915 ± 0.115
2.298GluGly: 2.298 ± 0.09
1.043GluHis: 1.043 ± 0.053
6.744GluIle: 6.744 ± 0.156
7.898GluLys: 7.898 ± 0.205
7.511GluLeu: 7.511 ± 0.16
1.29GluMet: 1.29 ± 0.065
5.464GluAsn: 5.464 ± 0.126
1.313GluPro: 1.313 ± 0.069
2.492GluGln: 2.492 ± 0.086
2.193GluArg: 2.193 ± 0.09
3.814GluSer: 3.814 ± 0.12
3.343GluThr: 3.343 ± 0.11
3.599GluVal: 3.599 ± 0.116
0.648GluTrp: 0.648 ± 0.046
3.41GluTyr: 3.41 ± 0.11
0.0GluXaa: 0.0 ± 0.0
Phe
2.69PheAla: 2.69 ± 0.099
0.41PheCys: 0.41 ± 0.033
3.671PheAsp: 3.671 ± 0.098
3.796PheGlu: 3.796 ± 0.113
2.536PhePhe: 2.536 ± 0.111
2.858PheGly: 2.858 ± 0.09
0.677PheHis: 0.677 ± 0.049
4.848PheIle: 4.848 ± 0.148
5.629PheLys: 5.629 ± 0.133
4.842PheLeu: 4.842 ± 0.16
0.877PheMet: 0.877 ± 0.052
4.395PheAsn: 4.395 ± 0.129
1.075PhePro: 1.075 ± 0.063
1.179PheGln: 1.179 ± 0.055
1.493PheArg: 1.493 ± 0.069
3.991PheSer: 3.991 ± 0.114
2.478PheThr: 2.478 ± 0.087
3.3PheVal: 3.3 ± 0.099
0.607PheTrp: 0.607 ± 0.044
2.451PheTyr: 2.451 ± 0.089
0.0PheXaa: 0.0 ± 0.0
Gly
2.501GlyAla: 2.501 ± 0.111
0.366GlyCys: 0.366 ± 0.033
2.109GlyAsp: 2.109 ± 0.079
2.434GlyGlu: 2.434 ± 0.097
2.905GlyPhe: 2.905 ± 0.103
2.501GlyGly: 2.501 ± 0.101
0.886GlyHis: 0.886 ± 0.051
4.383GlyIle: 4.383 ± 0.135
4.557GlyLys: 4.557 ± 0.139
4.29GlyLeu: 4.29 ± 0.123
0.961GlyMet: 0.961 ± 0.059
2.762GlyAsn: 2.762 ± 0.096
0.976GlyPro: 0.976 ± 0.073
1.461GlyGln: 1.461 ± 0.076
1.478GlyArg: 1.478 ± 0.084
3.061GlySer: 3.061 ± 0.101
2.573GlyThr: 2.573 ± 0.101
2.803GlyVal: 2.803 ± 0.097
0.453GlyTrp: 0.453 ± 0.036
2.181GlyTyr: 2.181 ± 0.073
0.0GlyXaa: 0.0 ± 0.0
His
0.604HisAla: 0.604 ± 0.042
0.093HisCys: 0.093 ± 0.013
0.671HisAsp: 0.671 ± 0.055
0.845HisGlu: 0.845 ± 0.045
0.932HisPhe: 0.932 ± 0.05
0.709HisGly: 0.709 ± 0.048
0.351HisHis: 0.351 ± 0.038
1.438HisIle: 1.438 ± 0.063
1.612HisLys: 1.612 ± 0.067
1.348HisLeu: 1.348 ± 0.062
0.311HisMet: 0.311 ± 0.035
1.121HisAsn: 1.121 ± 0.054
0.546HisPro: 0.546 ± 0.039
0.485HisGln: 0.485 ± 0.037
0.424HisArg: 0.424 ± 0.041
1.008HisSer: 1.008 ± 0.055
0.764HisThr: 0.764 ± 0.043
0.61HisVal: 0.61 ± 0.046
0.139HisTrp: 0.139 ± 0.019
0.72HisTyr: 0.72 ± 0.045
0.0HisXaa: 0.0 ± 0.0
Ile
4.79IleAla: 4.79 ± 0.135
0.793IleCys: 0.793 ± 0.061
6.164IleAsp: 6.164 ± 0.118
6.805IleGlu: 6.805 ± 0.171
4.624IlePhe: 4.624 ± 0.151
4.029IleGly: 4.029 ± 0.144
1.214IleHis: 1.214 ± 0.062
7.88IleIle: 7.88 ± 0.192
10.088IleLys: 10.088 ± 0.138
7.857IleLeu: 7.857 ± 0.201
1.525IleMet: 1.525 ± 0.066
7.747IleAsn: 7.747 ± 0.16
2.449IlePro: 2.449 ± 0.09
2.196IleGln: 2.196 ± 0.076
2.64IleArg: 2.64 ± 0.103
7.16IleSer: 7.16 ± 0.146
4.366IleThr: 4.366 ± 0.122
5.272IleVal: 5.272 ± 0.126
0.796IleTrp: 0.796 ± 0.05
3.494IleTyr: 3.494 ± 0.111
0.0IleXaa: 0.0 ± 0.0
Lys
4.868LysAla: 4.868 ± 0.146
0.546LysCys: 0.546 ± 0.035
6.213LysAsp: 6.213 ± 0.139
8.133LysGlu: 8.133 ± 0.19
5.124LysPhe: 5.124 ± 0.123
4.008LysGly: 4.008 ± 0.103
1.598LysHis: 1.598 ± 0.068
10.692LysIle: 10.692 ± 0.197
11.27LysLys: 11.27 ± 0.215
9.687LysLeu: 9.687 ± 0.182
2.637LysMet: 2.637 ± 0.087
9.289LysAsn: 9.289 ± 0.187
2.614LysPro: 2.614 ± 0.09
3.541LysGln: 3.541 ± 0.098
3.361LysArg: 3.361 ± 0.099
6.872LysSer: 6.872 ± 0.158
5.527LysThr: 5.527 ± 0.154
5.94LysVal: 5.94 ± 0.141
1.205LysTrp: 1.205 ± 0.058
5.647LysTyr: 5.647 ± 0.142
0.0LysXaa: 0.0 ± 0.0
Leu
5.17LeuAla: 5.17 ± 0.143
0.674LeuCys: 0.674 ± 0.049
5.443LeuAsp: 5.443 ± 0.126
6.503LeuGlu: 6.503 ± 0.141
4.761LeuPhe: 4.761 ± 0.149
4.557LeuGly: 4.557 ± 0.117
1.214LeuHis: 1.214 ± 0.06
9.019LeuIle: 9.019 ± 0.243
9.687LeuLys: 9.687 ± 0.195
8.522LeuLeu: 8.522 ± 0.184
1.842LeuMet: 1.842 ± 0.078
7.401LeuAsn: 7.401 ± 0.167
2.454LeuPro: 2.454 ± 0.077
2.254LeuGln: 2.254 ± 0.086
3.125LeuArg: 3.125 ± 0.095
6.942LeuSer: 6.942 ± 0.166
4.822LeuThr: 4.822 ± 0.131
5.312LeuVal: 5.312 ± 0.156
0.871LeuTrp: 0.871 ± 0.055
2.986LeuTyr: 2.986 ± 0.084
0.0LeuXaa: 0.0 ± 0.0
Met
1.075MetAla: 1.075 ± 0.055
0.148MetCys: 0.148 ± 0.02
0.95MetAsp: 0.95 ± 0.05
1.051MetGlu: 1.051 ± 0.06
1.046MetPhe: 1.046 ± 0.057
0.784MetGly: 0.784 ± 0.047
0.369MetHis: 0.369 ± 0.036
1.516MetIle: 1.516 ± 0.076
2.013MetLys: 2.013 ± 0.07
1.786MetLeu: 1.786 ± 0.064
0.36MetMet: 0.36 ± 0.03
1.568MetAsn: 1.568 ± 0.062
0.741MetPro: 0.741 ± 0.047
0.604MetGln: 0.604 ± 0.047
0.601MetArg: 0.601 ± 0.046
1.513MetSer: 1.513 ± 0.065
0.97MetThr: 0.97 ± 0.056
0.889MetVal: 0.889 ± 0.053
0.166MetTrp: 0.166 ± 0.021
0.514MetTyr: 0.514 ± 0.039
0.0MetXaa: 0.0 ± 0.0
Asn
3.303AsnAla: 3.303 ± 0.101
0.52AsnCys: 0.52 ± 0.04
4.098AsnAsp: 4.098 ± 0.126
5.899AsnGlu: 5.899 ± 0.18
4.095AsnPhe: 4.095 ± 0.125
3.25AsnGly: 3.25 ± 0.105
1.054AsnHis: 1.054 ± 0.061
7.093AsnIle: 7.093 ± 0.166
9.3AsnLys: 9.3 ± 0.195
7.322AsnLeu: 7.322 ± 0.168
1.351AsnMet: 1.351 ± 0.067
6.965AsnAsn: 6.965 ± 0.195
2.106AsnPro: 2.106 ± 0.087
2.356AsnGln: 2.356 ± 0.093
1.966AsnArg: 1.966 ± 0.074
5.6AsnSer: 5.6 ± 0.184
3.076AsnThr: 3.076 ± 0.12
4.075AsnVal: 4.075 ± 0.107
0.79AsnTrp: 0.79 ± 0.051
3.744AsnTyr: 3.744 ± 0.12
0.0AsnXaa: 0.0 ± 0.0
Pro
1.141ProAla: 1.141 ± 0.061
0.218ProCys: 0.218 ± 0.026
1.153ProAsp: 1.153 ± 0.057
1.621ProGlu: 1.621 ± 0.064
1.484ProPhe: 1.484 ± 0.066
1.261ProGly: 1.261 ± 0.066
0.386ProHis: 0.386 ± 0.037
2.184ProIle: 2.184 ± 0.08
2.617ProLys: 2.617 ± 0.093
2.3ProLeu: 2.3 ± 0.093
0.465ProMet: 0.465 ± 0.036
2.074ProAsn: 2.074 ± 0.093
0.418ProPro: 0.418 ± 0.041
0.941ProGln: 0.941 ± 0.085
0.654ProArg: 0.654 ± 0.051
1.627ProSer: 1.627 ± 0.068
1.441ProThr: 1.441 ± 0.059
1.354ProVal: 1.354 ± 0.075
0.264ProTrp: 0.264 ± 0.028
1.237ProTyr: 1.237 ± 0.072
0.0ProXaa: 0.0 ± 0.0
Gln
1.656GlnAla: 1.656 ± 0.075
0.166GlnCys: 0.166 ± 0.02
1.452GlnAsp: 1.452 ± 0.06
2.109GlnGlu: 2.109 ± 0.08
1.449GlnPhe: 1.449 ± 0.067
1.185GlnGly: 1.185 ± 0.066
0.45GlnHis: 0.45 ± 0.031
2.919GlnIle: 2.919 ± 0.101
3.526GlnLys: 3.526 ± 0.099
2.719GlnLeu: 2.719 ± 0.094
0.7GlnMet: 0.7 ± 0.069
2.553GlnAsn: 2.553 ± 0.099
0.802GlnPro: 0.802 ± 0.099
1.046GlnGln: 1.046 ± 0.06
1.066GlnArg: 1.066 ± 0.056
1.807GlnSer: 1.807 ± 0.07
1.368GlnThr: 1.368 ± 0.067
1.661GlnVal: 1.661 ± 0.065
0.267GlnTrp: 0.267 ± 0.033
1.316GlnTyr: 1.316 ± 0.059
0.0GlnXaa: 0.0 ± 0.0
Arg
1.525ArgAla: 1.525 ± 0.074
0.221ArgCys: 0.221 ± 0.025
1.737ArgAsp: 1.737 ± 0.08
2.158ArgGlu: 2.158 ± 0.081
1.542ArgPhe: 1.542 ± 0.066
1.397ArgGly: 1.397 ± 0.064
0.468ArgHis: 0.468 ± 0.043
2.78ArgIle: 2.78 ± 0.098
3.384ArgLys: 3.384 ± 0.109
2.794ArgLeu: 2.794 ± 0.1
0.729ArgMet: 0.729 ± 0.045
2.315ArgAsn: 2.315 ± 0.089
0.863ArgPro: 0.863 ± 0.052
0.97ArgGln: 0.97 ± 0.06
1.319ArgArg: 1.319 ± 0.077
1.833ArgSer: 1.833 ± 0.074
1.603ArgThr: 1.603 ± 0.079
1.812ArgVal: 1.812 ± 0.07
0.415ArgTrp: 0.415 ± 0.032
1.478ArgTyr: 1.478 ± 0.074
0.0ArgXaa: 0.0 ± 0.0
Ser
3.34SerAla: 3.34 ± 0.128
0.523SerCys: 0.523 ± 0.04
3.671SerAsp: 3.671 ± 0.109
4.357SerGlu: 4.357 ± 0.116
3.988SerPhe: 3.988 ± 0.123
3.567SerGly: 3.567 ± 0.11
1.15SerHis: 1.15 ± 0.058
6.434SerIle: 6.434 ± 0.141
7.877SerLys: 7.877 ± 0.175
6.797SerLeu: 6.797 ± 0.152
1.162SerMet: 1.162 ± 0.057
5.115SerAsn: 5.115 ± 0.169
1.281SerPro: 1.281 ± 0.07
2.268SerGln: 2.268 ± 0.085
2.042SerArg: 2.042 ± 0.071
4.941SerSer: 4.941 ± 0.162
3.43SerThr: 3.43 ± 0.115
3.41SerVal: 3.41 ± 0.1
0.587SerTrp: 0.587 ± 0.042
3.07SerTyr: 3.07 ± 0.08
0.0SerXaa: 0.0 ± 0.0
Thr
1.92ThrAla: 1.92 ± 0.083
0.302ThrCys: 0.302 ± 0.031
2.231ThrAsp: 2.231 ± 0.083
2.385ThrGlu: 2.385 ± 0.107
3.204ThrPhe: 3.204 ± 0.102
2.173ThrGly: 2.173 ± 0.098
0.755ThrHis: 0.755 ± 0.054
5.025ThrIle: 5.025 ± 0.13
5.603ThrLys: 5.603 ± 0.165
4.787ThrLeu: 4.787 ± 0.123
0.866ThrMet: 0.866 ± 0.054
3.764ThrAsn: 3.764 ± 0.13
1.571ThrPro: 1.571 ± 0.07
1.374ThrGln: 1.374 ± 0.075
1.641ThrArg: 1.641 ± 0.078
3.68ThrSer: 3.68 ± 0.097
3.041ThrThr: 3.041 ± 0.093
2.422ThrVal: 2.422 ± 0.082
0.465ThrTrp: 0.465 ± 0.034
2.344ThrTyr: 2.344 ± 0.073
0.0ThrXaa: 0.0 ± 0.0
Val
3.459ValAla: 3.459 ± 0.111
0.418ValCys: 0.418 ± 0.037
3.471ValAsp: 3.471 ± 0.104
4.043ValGlu: 4.043 ± 0.135
2.512ValPhe: 2.512 ± 0.102
2.783ValGly: 2.783 ± 0.102
0.778ValHis: 0.778 ± 0.056
4.615ValIle: 4.615 ± 0.129
5.763ValLys: 5.763 ± 0.13
4.755ValLeu: 4.755 ± 0.131
0.877ValMet: 0.877 ± 0.054
3.622ValAsn: 3.622 ± 0.101
1.58ValPro: 1.58 ± 0.067
1.638ValGln: 1.638 ± 0.067
1.627ValArg: 1.627 ± 0.073
4.139ValSer: 4.139 ± 0.112
2.55ValThr: 2.55 ± 0.083
3.201ValVal: 3.201 ± 0.121
0.436ValTrp: 0.436 ± 0.037
2.062ValTyr: 2.062 ± 0.082
0.0ValXaa: 0.0 ± 0.0
Trp
0.459TrpAla: 0.459 ± 0.031
0.058TrpCys: 0.058 ± 0.011
0.587TrpAsp: 0.587 ± 0.046
0.654TrpGlu: 0.654 ± 0.047
0.537TrpPhe: 0.537 ± 0.039
0.424TrpGly: 0.424 ± 0.038
0.125TrpHis: 0.125 ± 0.019
0.993TrpIle: 0.993 ± 0.057
0.86TrpLys: 0.86 ± 0.044
0.921TrpLeu: 0.921 ± 0.05
0.218TrpMet: 0.218 ± 0.024
0.831TrpAsn: 0.831 ± 0.053
0.218TrpPro: 0.218 ± 0.024
0.25TrpGln: 0.25 ± 0.028
0.392TrpArg: 0.392 ± 0.034
0.604TrpSer: 0.604 ± 0.041
0.563TrpThr: 0.563 ± 0.041
0.534TrpVal: 0.534 ± 0.046
0.134TrpTrp: 0.134 ± 0.021
0.453TrpTyr: 0.453 ± 0.04
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.231TyrAla: 2.231 ± 0.096
0.389TyrCys: 0.389 ± 0.032
2.736TyrAsp: 2.736 ± 0.093
3.308TyrGlu: 3.308 ± 0.092
2.582TyrPhe: 2.582 ± 0.084
2.289TyrGly: 2.289 ± 0.081
0.607TyrHis: 0.607 ± 0.041
3.34TyrIle: 3.34 ± 0.096
4.642TyrLys: 4.642 ± 0.122
4.223TyrLeu: 4.223 ± 0.113
0.677TyrMet: 0.677 ± 0.043
3.111TyrAsn: 3.111 ± 0.095
1.051TyrPro: 1.051 ± 0.059
1.499TyrGln: 1.499 ± 0.071
1.458TyrArg: 1.458 ± 0.069
3.291TyrSer: 3.291 ± 0.106
1.963TyrThr: 1.963 ± 0.083
2.184TyrVal: 2.184 ± 0.073
0.555TyrTrp: 0.555 ± 0.045
2.033TyrTyr: 2.033 ± 0.091
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1008 proteins (344285 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski