Amino acid dipepetide frequency for Arcanobacterium bovis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.031AlaAla: 12.031 ± 0.208
0.865AlaCys: 0.865 ± 0.042
6.294AlaAsp: 6.294 ± 0.129
6.169AlaGlu: 6.169 ± 0.119
3.441AlaPhe: 3.441 ± 0.084
9.261AlaGly: 9.261 ± 0.131
2.441AlaHis: 2.441 ± 0.075
6.206AlaIle: 6.206 ± 0.121
4.693AlaLys: 4.693 ± 0.098
10.646AlaLeu: 10.646 ± 0.172
2.609AlaMet: 2.609 ± 0.071
3.345AlaAsn: 3.345 ± 0.094
4.339AlaPro: 4.339 ± 0.105
5.624AlaGln: 5.624 ± 0.116
6.321AlaArg: 6.321 ± 0.141
6.348AlaSer: 6.348 ± 0.11
5.947AlaThr: 5.947 ± 0.114
8.57AlaVal: 8.57 ± 0.143
1.373AlaTrp: 1.373 ± 0.054
2.354AlaTyr: 2.354 ± 0.055
0.0AlaXaa: 0.0 ± 0.0
Cys
1.055CysAla: 1.055 ± 0.05
0.091CysCys: 0.091 ± 0.014
0.498CysAsp: 0.498 ± 0.03
0.532CysGlu: 0.532 ± 0.036
0.314CysPhe: 0.314 ± 0.023
0.864CysGly: 0.864 ± 0.035
0.179CysHis: 0.179 ± 0.017
0.347CysIle: 0.347 ± 0.026
0.2CysLys: 0.2 ± 0.02
0.599CysLeu: 0.599 ± 0.031
0.139CysMet: 0.139 ± 0.017
0.226CysAsn: 0.226 ± 0.019
0.404CysPro: 0.404 ± 0.028
0.236CysGln: 0.236 ± 0.021
0.36CysArg: 0.36 ± 0.025
0.563CysSer: 0.563 ± 0.035
0.483CysThr: 0.483 ± 0.031
0.659CysVal: 0.659 ± 0.034
0.072CysTrp: 0.072 ± 0.014
0.176CysTyr: 0.176 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
6.766AspAla: 6.766 ± 0.112
0.454AspCys: 0.454 ± 0.028
3.87AspAsp: 3.87 ± 0.118
3.81AspGlu: 3.81 ± 0.102
2.324AspPhe: 2.324 ± 0.064
4.888AspGly: 4.888 ± 0.106
1.095AspHis: 1.095 ± 0.048
3.263AspIle: 3.263 ± 0.074
1.771AspLys: 1.771 ± 0.064
5.688AspLeu: 5.688 ± 0.098
1.097AspMet: 1.097 ± 0.043
1.363AspAsn: 1.363 ± 0.054
3.288AspPro: 3.288 ± 0.086
1.73AspGln: 1.73 ± 0.053
3.072AspArg: 3.072 ± 0.071
3.794AspSer: 3.794 ± 0.097
2.929AspThr: 2.929 ± 0.07
5.411AspVal: 5.411 ± 0.113
0.679AspTrp: 0.679 ± 0.032
1.465AspTyr: 1.465 ± 0.053
0.0AspXaa: 0.0 ± 0.0
Glu
6.026GluAla: 6.026 ± 0.131
0.456GluCys: 0.456 ± 0.028
2.906GluAsp: 2.906 ± 0.094
3.761GluGlu: 3.761 ± 0.115
2.067GluPhe: 2.067 ± 0.06
3.576GluGly: 3.576 ± 0.108
1.522GluHis: 1.522 ± 0.058
3.964GluIle: 3.964 ± 0.091
2.757GluLys: 2.757 ± 0.069
6.97GluLeu: 6.97 ± 0.113
1.355GluMet: 1.355 ± 0.049
2.326GluAsn: 2.326 ± 0.07
2.363GluPro: 2.363 ± 0.068
2.607GluGln: 2.607 ± 0.078
4.069GluArg: 4.069 ± 0.103
3.583GluSer: 3.583 ± 0.086
3.204GluThr: 3.204 ± 0.073
4.386GluVal: 4.386 ± 0.093
0.741GluTrp: 0.741 ± 0.033
1.558GluTyr: 1.558 ± 0.06
0.0GluXaa: 0.0 ± 0.0
Phe
4.046PheAla: 4.046 ± 0.084
0.277PheCys: 0.277 ± 0.023
2.52PheAsp: 2.52 ± 0.072
1.967PheGlu: 1.967 ± 0.066
1.353PhePhe: 1.353 ± 0.055
3.327PheGly: 3.327 ± 0.096
0.706PheHis: 0.706 ± 0.037
1.819PheIle: 1.819 ± 0.063
1.07PheLys: 1.07 ± 0.046
3.011PheLeu: 3.011 ± 0.096
0.644PheMet: 0.644 ± 0.034
1.105PheAsn: 1.105 ± 0.039
1.593PhePro: 1.593 ± 0.047
0.85PheGln: 0.85 ± 0.036
1.642PheArg: 1.642 ± 0.056
2.53PheSer: 2.53 ± 0.074
2.334PheThr: 2.334 ± 0.067
3.01PheVal: 3.01 ± 0.08
0.451PheTrp: 0.451 ± 0.034
0.867PheTyr: 0.867 ± 0.048
0.0PheXaa: 0.0 ± 0.0
Gly
7.986GlyAla: 7.986 ± 0.149
0.617GlyCys: 0.617 ± 0.034
4.188GlyAsp: 4.188 ± 0.088
4.765GlyGlu: 4.765 ± 0.096
3.087GlyPhe: 3.087 ± 0.074
5.939GlyGly: 5.939 ± 0.117
1.569GlyHis: 1.569 ± 0.058
5.356GlyIle: 5.356 ± 0.094
4.041GlyLys: 4.041 ± 0.096
6.707GlyLeu: 6.707 ± 0.135
2.014GlyMet: 2.014 ± 0.057
2.646GlyAsn: 2.646 ± 0.07
2.282GlyPro: 2.282 ± 0.066
2.534GlyGln: 2.534 ± 0.062
4.051GlyArg: 4.051 ± 0.091
5.176GlySer: 5.176 ± 0.119
5.268GlyThr: 5.268 ± 0.138
6.851GlyVal: 6.851 ± 0.117
1.132GlyTrp: 1.132 ± 0.048
2.319GlyTyr: 2.319 ± 0.071
0.0GlyXaa: 0.0 ± 0.0
His
2.072HisAla: 2.072 ± 0.075
0.198HisCys: 0.198 ± 0.021
1.363HisAsp: 1.363 ± 0.055
1.415HisGlu: 1.415 ± 0.054
0.696HisPhe: 0.696 ± 0.04
1.908HisGly: 1.908 ± 0.064
0.594HisHis: 0.594 ± 0.035
1.305HisIle: 1.305 ± 0.046
0.716HisLys: 0.716 ± 0.039
1.808HisLeu: 1.808 ± 0.052
0.381HisMet: 0.381 ± 0.024
0.743HisAsn: 0.743 ± 0.037
1.199HisPro: 1.199 ± 0.047
0.656HisGln: 0.656 ± 0.032
1.264HisArg: 1.264 ± 0.052
1.229HisSer: 1.229 ± 0.047
1.271HisThr: 1.271 ± 0.047
1.615HisVal: 1.615 ± 0.056
0.257HisTrp: 0.257 ± 0.022
0.535HisTyr: 0.535 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
7.004IleAla: 7.004 ± 0.114
0.535IleCys: 0.535 ± 0.032
4.21IleAsp: 4.21 ± 0.079
3.597IleGlu: 3.597 ± 0.077
2.047IlePhe: 2.047 ± 0.067
4.842IleGly: 4.842 ± 0.108
1.098IleHis: 1.098 ± 0.041
3.104IleIle: 3.104 ± 0.097
1.972IleLys: 1.972 ± 0.061
4.978IleLeu: 4.978 ± 0.108
1.058IleMet: 1.058 ± 0.052
1.94IleAsn: 1.94 ± 0.052
2.993IlePro: 2.993 ± 0.077
1.506IleGln: 1.506 ± 0.054
2.897IleArg: 2.897 ± 0.073
4.368IleSer: 4.368 ± 0.1
3.419IleThr: 3.419 ± 0.076
5.091IleVal: 5.091 ± 0.112
0.59IleTrp: 0.59 ± 0.038
1.251IleTyr: 1.251 ± 0.05
0.0IleXaa: 0.0 ± 0.0
Lys
4.074LysAla: 4.074 ± 0.1
0.196LysCys: 0.196 ± 0.02
2.185LysAsp: 2.185 ± 0.064
2.393LysGlu: 2.393 ± 0.08
1.113LysPhe: 1.113 ± 0.044
2.29LysGly: 2.29 ± 0.075
0.801LysHis: 0.801 ± 0.038
2.743LysIle: 2.743 ± 0.07
2.066LysLys: 2.066 ± 0.079
3.781LysLeu: 3.781 ± 0.073
1.068LysMet: 1.068 ± 0.046
1.688LysAsn: 1.688 ± 0.061
1.91LysPro: 1.91 ± 0.059
1.39LysGln: 1.39 ± 0.05
2.383LysArg: 2.383 ± 0.075
2.354LysSer: 2.354 ± 0.072
2.406LysThr: 2.406 ± 0.071
2.971LysVal: 2.971 ± 0.09
0.424LysTrp: 0.424 ± 0.027
1.147LysTyr: 1.147 ± 0.042
0.0LysXaa: 0.0 ± 0.0
Leu
11.271LeuAla: 11.271 ± 0.143
0.82LeuCys: 0.82 ± 0.039
5.778LeuAsp: 5.778 ± 0.109
5.265LeuGlu: 5.265 ± 0.114
2.966LeuPhe: 2.966 ± 0.089
7.864LeuGly: 7.864 ± 0.132
1.989LeuHis: 1.989 ± 0.063
5.19LeuIle: 5.19 ± 0.118
3.345LeuLys: 3.345 ± 0.081
8.701LeuLeu: 8.701 ± 0.158
1.943LeuMet: 1.943 ± 0.065
3.186LeuAsn: 3.186 ± 0.073
4.985LeuPro: 4.985 ± 0.093
2.594LeuGln: 2.594 ± 0.08
5.859LeuArg: 5.859 ± 0.117
6.167LeuSer: 6.167 ± 0.125
5.454LeuThr: 5.454 ± 0.096
7.502LeuVal: 7.502 ± 0.125
0.989LeuTrp: 0.989 ± 0.045
1.868LeuTyr: 1.868 ± 0.058
0.0LeuXaa: 0.0 ± 0.0
Met
2.357MetAla: 2.357 ± 0.067
0.225MetCys: 0.225 ± 0.017
1.128MetAsp: 1.128 ± 0.046
1.008MetGlu: 1.008 ± 0.047
0.724MetPhe: 0.724 ± 0.036
1.471MetGly: 1.471 ± 0.055
0.446MetHis: 0.446 ± 0.027
1.231MetIle: 1.231 ± 0.046
0.983MetLys: 0.983 ± 0.042
2.213MetLeu: 2.213 ± 0.068
0.516MetMet: 0.516 ± 0.03
0.899MetAsn: 0.899 ± 0.037
1.18MetPro: 1.18 ± 0.048
0.711MetGln: 0.711 ± 0.038
1.447MetArg: 1.447 ± 0.048
1.628MetSer: 1.628 ± 0.045
1.469MetThr: 1.469 ± 0.051
1.553MetVal: 1.553 ± 0.057
0.236MetTrp: 0.236 ± 0.021
0.402MetTyr: 0.402 ± 0.029
0.0MetXaa: 0.0 ± 0.0
Asn
3.384AsnAla: 3.384 ± 0.093
0.248AsnCys: 0.248 ± 0.021
1.958AsnAsp: 1.958 ± 0.06
1.945AsnGlu: 1.945 ± 0.05
1.207AsnPhe: 1.207 ± 0.051
2.671AsnGly: 2.671 ± 0.087
0.625AsnHis: 0.625 ± 0.03
1.95AsnIle: 1.95 ± 0.061
1.286AsnLys: 1.286 ± 0.05
3.047AsnLeu: 3.047 ± 0.07
0.781AsnMet: 0.781 ± 0.038
1.308AsnAsn: 1.308 ± 0.053
2.195AsnPro: 2.195 ± 0.073
1.066AsnGln: 1.066 ± 0.046
1.801AsnArg: 1.801 ± 0.059
2.205AsnSer: 2.205 ± 0.062
2.111AsnThr: 2.111 ± 0.067
2.565AsnVal: 2.565 ± 0.08
0.466AsnTrp: 0.466 ± 0.028
0.87AsnTyr: 0.87 ± 0.037
0.0AsnXaa: 0.0 ± 0.0
Pro
4.97ProAla: 4.97 ± 0.116
0.265ProCys: 0.265 ± 0.021
2.855ProAsp: 2.855 ± 0.069
3.172ProGlu: 3.172 ± 0.083
1.583ProPhe: 1.583 ± 0.05
3.575ProGly: 3.575 ± 0.103
1.216ProHis: 1.216 ± 0.052
2.544ProIle: 2.544 ± 0.062
1.625ProLys: 1.625 ± 0.061
3.843ProLeu: 3.843 ± 0.072
0.872ProMet: 0.872 ± 0.041
1.68ProAsn: 1.68 ± 0.06
1.554ProPro: 1.554 ± 0.062
2.186ProGln: 2.186 ± 0.061
2.347ProArg: 2.347 ± 0.064
3.132ProSer: 3.132 ± 0.088
2.668ProThr: 2.668 ± 0.077
3.914ProVal: 3.914 ± 0.09
0.666ProTrp: 0.666 ± 0.032
1.194ProTyr: 1.194 ± 0.044
0.0ProXaa: 0.0 ± 0.0
Gln
4.152GlnAla: 4.152 ± 0.083
0.24GlnCys: 0.24 ± 0.021
1.568GlnAsp: 1.568 ± 0.048
2.119GlnGlu: 2.119 ± 0.058
1.05GlnPhe: 1.05 ± 0.04
2.45GlnGly: 2.45 ± 0.069
0.763GlnHis: 0.763 ± 0.039
2.297GlnIle: 2.297 ± 0.063
1.417GlnLys: 1.417 ± 0.05
3.83GlnLeu: 3.83 ± 0.09
0.905GlnMet: 0.905 ± 0.041
1.219GlnAsn: 1.219 ± 0.045
1.598GlnPro: 1.598 ± 0.062
1.533GlnGln: 1.533 ± 0.053
2.523GlnArg: 2.523 ± 0.075
2.037GlnSer: 2.037 ± 0.059
1.963GlnThr: 1.963 ± 0.065
2.691GlnVal: 2.691 ± 0.069
0.619GlnTrp: 0.619 ± 0.034
0.882GlnTyr: 0.882 ± 0.051
0.0GlnXaa: 0.0 ± 0.0
Arg
5.983ArgAla: 5.983 ± 0.132
0.446ArgCys: 0.446 ± 0.031
3.283ArgAsp: 3.283 ± 0.082
4.095ArgGlu: 4.095 ± 0.108
2.051ArgPhe: 2.051 ± 0.072
4.091ArgGly: 4.091 ± 0.081
1.196ArgHis: 1.196 ± 0.048
3.592ArgIle: 3.592 ± 0.087
2.527ArgLys: 2.527 ± 0.075
5.025ArgLeu: 5.025 ± 0.106
1.4ArgMet: 1.4 ± 0.056
2.081ArgAsn: 2.081 ± 0.062
2.212ArgPro: 2.212 ± 0.057
1.987ArgGln: 1.987 ± 0.064
4.195ArgArg: 4.195 ± 0.103
3.642ArgSer: 3.642 ± 0.083
3.39ArgThr: 3.39 ± 0.074
4.165ArgVal: 4.165 ± 0.099
0.805ArgTrp: 0.805 ± 0.038
1.524ArgTyr: 1.524 ± 0.059
0.0ArgXaa: 0.0 ± 0.0
Ser
7.119SerAla: 7.119 ± 0.124
0.464SerCys: 0.464 ± 0.032
3.669SerAsp: 3.669 ± 0.082
3.816SerGlu: 3.816 ± 0.096
2.443SerPhe: 2.443 ± 0.075
5.654SerGly: 5.654 ± 0.119
1.392SerHis: 1.392 ± 0.046
3.506SerIle: 3.506 ± 0.079
2.344SerLys: 2.344 ± 0.058
5.869SerLeu: 5.869 ± 0.105
1.435SerMet: 1.435 ± 0.052
2.046SerAsn: 2.046 ± 0.071
2.78SerPro: 2.78 ± 0.064
2.54SerGln: 2.54 ± 0.065
3.412SerArg: 3.412 ± 0.076
4.455SerSer: 4.455 ± 0.104
3.89SerThr: 3.89 ± 0.086
5.253SerVal: 5.253 ± 0.096
0.917SerTrp: 0.917 ± 0.04
1.722SerTyr: 1.722 ± 0.052
0.0SerXaa: 0.0 ± 0.0
Thr
6.13ThrAla: 6.13 ± 0.107
0.526ThrCys: 0.526 ± 0.041
3.132ThrAsp: 3.132 ± 0.077
3.109ThrGlu: 3.109 ± 0.077
2.091ThrPhe: 2.091 ± 0.069
4.993ThrGly: 4.993 ± 0.104
1.256ThrHis: 1.256 ± 0.051
3.377ThrIle: 3.377 ± 0.091
2.25ThrLys: 2.25 ± 0.061
5.513ThrLeu: 5.513 ± 0.107
1.172ThrMet: 1.172 ± 0.043
1.965ThrAsn: 1.965 ± 0.08
3.328ThrPro: 3.328 ± 0.095
2.145ThrGln: 2.145 ± 0.064
2.857ThrArg: 2.857 ± 0.08
3.987ThrSer: 3.987 ± 0.096
3.655ThrThr: 3.655 ± 0.103
5.122ThrVal: 5.122 ± 0.135
0.853ThrTrp: 0.853 ± 0.041
1.549ThrTyr: 1.549 ± 0.065
0.0ThrXaa: 0.0 ± 0.0
Val
8.756ValAla: 8.756 ± 0.162
0.743ValCys: 0.743 ± 0.035
5.195ValAsp: 5.195 ± 0.108
5.008ValGlu: 5.008 ± 0.116
3.068ValPhe: 3.068 ± 0.073
5.932ValGly: 5.932 ± 0.123
1.625ValHis: 1.625 ± 0.051
4.64ValIle: 4.64 ± 0.101
3.077ValLys: 3.077 ± 0.088
7.817ValLeu: 7.817 ± 0.125
1.61ValMet: 1.61 ± 0.057
2.614ValAsn: 2.614 ± 0.068
4.034ValPro: 4.034 ± 0.085
2.527ValGln: 2.527 ± 0.056
4.76ValArg: 4.76 ± 0.099
5.184ValSer: 5.184 ± 0.095
5.03ValThr: 5.03 ± 0.133
7.678ValVal: 7.678 ± 0.143
0.981ValTrp: 0.981 ± 0.042
1.658ValTyr: 1.658 ± 0.051
0.0ValXaa: 0.0 ± 0.0
Trp
1.212TrpAla: 1.212 ± 0.051
0.132TrpCys: 0.132 ± 0.016
0.738TrpAsp: 0.738 ± 0.043
0.758TrpGlu: 0.758 ± 0.038
0.496TrpPhe: 0.496 ± 0.033
0.884TrpGly: 0.884 ± 0.043
0.287TrpHis: 0.287 ± 0.023
0.877TrpIle: 0.877 ± 0.044
0.483TrpLys: 0.483 ± 0.032
1.291TrpLeu: 1.291 ± 0.05
0.324TrpMet: 0.324 ± 0.024
0.57TrpAsn: 0.57 ± 0.033
0.485TrpPro: 0.485 ± 0.03
0.537TrpGln: 0.537 ± 0.031
0.879TrpArg: 0.879 ± 0.042
0.733TrpSer: 0.733 ± 0.039
0.718TrpThr: 0.718 ± 0.031
0.904TrpVal: 0.904 ± 0.039
0.252TrpTrp: 0.252 ± 0.021
0.303TrpTyr: 0.303 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.483TyrAla: 2.483 ± 0.071
0.198TyrCys: 0.198 ± 0.018
1.417TyrAsp: 1.417 ± 0.063
1.496TyrGlu: 1.496 ± 0.048
0.999TyrPhe: 0.999 ± 0.045
2.049TyrGly: 2.049 ± 0.058
0.423TyrHis: 0.423 ± 0.027
1.192TyrIle: 1.192 ± 0.047
0.765TyrLys: 0.765 ± 0.038
2.399TyrLeu: 2.399 ± 0.066
0.503TyrMet: 0.503 ± 0.034
0.741TyrAsn: 0.741 ± 0.042
1.139TyrPro: 1.139 ± 0.049
0.899TyrGln: 0.899 ± 0.042
1.548TyrArg: 1.548 ± 0.056
1.61TyrSer: 1.61 ± 0.057
1.402TyrThr: 1.402 ± 0.061
2.027TyrVal: 2.027 ± 0.066
0.357TyrTrp: 0.357 ± 0.029
0.573TyrTyr: 0.573 ± 0.037
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1664 proteins (596396 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski