Amino acid dipepetide frequency for Oryzias latipes (Japanese rice fish) (Japanese killifish)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.518AlaAla: 6.518 ± 0.04	1.286AlaCys: 1.286 ± 0.011	3.25AlaAsp: 3.25 ± 0.016	4.702AlaGlu: 4.702 ± 0.026	2.45AlaPhe: 2.45 ± 0.011	4.361AlaGly: 4.361 ± 0.025	1.484AlaHis: 1.484 ± 0.009	2.534AlaIle: 2.534 ± 0.013	3.322AlaLys: 3.322 ± 0.017	6.418AlaLeu: 6.418 ± 0.025	1.479AlaMet: 1.479 ± 0.008	2.121AlaAsn: 2.121 ± 0.012	3.68AlaPro: 3.68 ± 0.026	2.876AlaGln: 2.876 ± 0.016	3.089AlaArg: 3.089 ± 0.017	5.585AlaSer: 5.585 ± 0.023	3.318AlaThr: 3.318 ± 0.017	4.903AlaVal: 4.903 ± 0.02	0.637AlaTrp: 0.637 ± 0.006	1.42AlaTyr: 1.42 ± 0.01	0.0AlaXaa: 0.0 ± 0.0
Cys	1.181CysAla: 1.181 ± 0.009	0.652CysCys: 0.652 ± 0.008	1.122CysAsp: 1.122 ± 0.012	1.258CysGlu: 1.258 ± 0.013	0.949CysPhe: 0.949 ± 0.008	1.539CysGly: 1.539 ± 0.017	0.648CysHis: 0.648 ± 0.006	0.985CysIle: 0.985 ± 0.009	1.223CysLys: 1.223 ± 0.012	2.174CysLeu: 2.174 ± 0.016	0.469CysMet: 0.469 ± 0.006	0.826CysAsn: 0.826 ± 0.008	1.275CysPro: 1.275 ± 0.012	1.042CysGln: 1.042 ± 0.009	1.342CysArg: 1.342 ± 0.013	2.259CysSer: 2.259 ± 0.015	1.127CysThr: 1.127 ± 0.008	1.54CysVal: 1.54 ± 0.023	0.297CysTrp: 0.297 ± 0.004	0.582CysTyr: 0.582 ± 0.006	0.0CysXaa: 0.0 ± 0.0
Asp	3.009AspAla: 3.009 ± 0.012	1.149AspCys: 1.149 ± 0.01	2.929AspAsp: 2.929 ± 0.021	3.64AspGlu: 3.64 ± 0.016	2.2AspPhe: 2.2 ± 0.012	3.629AspGly: 3.629 ± 0.017	1.2AspHis: 1.2 ± 0.009	2.542AspIle: 2.542 ± 0.015	2.64AspLys: 2.64 ± 0.014	4.99AspLeu: 4.99 ± 0.017	1.237AspMet: 1.237 ± 0.008	1.82AspAsn: 1.82 ± 0.012	2.904AspPro: 2.904 ± 0.018	1.955AspGln: 1.955 ± 0.011	2.769AspArg: 2.769 ± 0.016	4.489AspSer: 4.489 ± 0.021	2.421AspThr: 2.421 ± 0.013	3.298AspVal: 3.298 ± 0.019	0.662AspTrp: 0.662 ± 0.006	1.471AspTyr: 1.471 ± 0.009	0.0AspXaa: 0.0 ± 0.0
Glu	4.706GluAla: 4.706 ± 0.023	1.231GluCys: 1.231 ± 0.014	4.382GluAsp: 4.382 ± 0.021	7.816GluGlu: 7.816 ± 0.057	1.951GluPhe: 1.951 ± 0.011	3.97GluGly: 3.97 ± 0.017	1.451GluHis: 1.451 ± 0.009	2.765GluIle: 2.765 ± 0.015	4.826GluLys: 4.826 ± 0.028	6.063GluLeu: 6.063 ± 0.025	1.708GluMet: 1.708 ± 0.009	2.745GluAsn: 2.745 ± 0.012	2.869GluPro: 2.869 ± 0.023	3.094GluGln: 3.094 ± 0.019	4.303GluArg: 4.303 ± 0.037	4.39GluSer: 4.39 ± 0.02	3.434GluThr: 3.434 ± 0.02	4.252GluVal: 4.252 ± 0.016	0.69GluTrp: 0.69 ± 0.007	1.51GluTyr: 1.51 ± 0.009	0.0GluXaa: 0.0 ± 0.0
Phe	1.939PheAla: 1.939 ± 0.011	1.015PheCys: 1.015 ± 0.008	1.764PheAsp: 1.764 ± 0.01	1.87PheGlu: 1.87 ± 0.011	1.719PhePhe: 1.719 ± 0.011	2.228PheGly: 2.228 ± 0.013	1.052PheHis: 1.052 ± 0.008	1.975PheIle: 1.975 ± 0.015	1.885PheLys: 1.885 ± 0.012	4.002PheLeu: 4.002 ± 0.018	0.829PheMet: 0.829 ± 0.006	1.514PheAsn: 1.514 ± 0.009	1.899PhePro: 1.899 ± 0.014	1.688PheGln: 1.688 ± 0.013	1.936PheArg: 1.936 ± 0.01	3.645PheSer: 3.645 ± 0.017	2.247PheThr: 2.247 ± 0.013	2.261PheVal: 2.261 ± 0.013	0.508PheTrp: 0.508 ± 0.005	1.228PheTyr: 1.228 ± 0.009	0.0PheXaa: 0.0 ± 0.0
Gly	4.03GlyAla: 4.03 ± 0.02	1.253GlyCys: 1.253 ± 0.011	3.066GlyAsp: 3.066 ± 0.015	3.991GlyGlu: 3.991 ± 0.022	2.479GlyPhe: 2.479 ± 0.015	5.304GlyGly: 5.304 ± 0.036	1.624GlyHis: 1.624 ± 0.011	2.515GlyIle: 2.515 ± 0.013	3.53GlyLys: 3.53 ± 0.014	5.423GlyLeu: 5.423 ± 0.021	1.387GlyMet: 1.387 ± 0.01	2.377GlyAsn: 2.377 ± 0.013	3.296GlyPro: 3.296 ± 0.04	2.692GlyGln: 2.692 ± 0.017	3.669GlyArg: 3.669 ± 0.021	5.891GlySer: 5.891 ± 0.03	3.246GlyThr: 3.246 ± 0.018	3.978GlyVal: 3.978 ± 0.018	0.766GlyTrp: 0.766 ± 0.008	1.737GlyTyr: 1.737 ± 0.013	0.0GlyXaa: 0.0 ± 0.0
His	1.401HisAla: 1.401 ± 0.011	0.753HisCys: 0.753 ± 0.008	0.954HisAsp: 0.954 ± 0.007	1.198HisGlu: 1.198 ± 0.011	1.117HisPhe: 1.117 ± 0.006	1.578HisGly: 1.578 ± 0.012	1.074HisHis: 1.074 ± 0.013	1.304HisIle: 1.304 ± 0.012	1.311HisLys: 1.311 ± 0.008	2.802HisLeu: 2.802 ± 0.018	0.694HisMet: 0.694 ± 0.009	0.99HisAsn: 0.99 ± 0.008	2.24HisPro: 2.24 ± 0.067	1.297HisGln: 1.297 ± 0.011	1.676HisArg: 1.676 ± 0.011	2.512HisSer: 2.512 ± 0.02	1.602HisThr: 1.602 ± 0.025	1.463HisVal: 1.463 ± 0.01	0.332HisTrp: 0.332 ± 0.005	0.799HisTyr: 0.799 ± 0.007	0.0HisXaa: 0.0 ± 0.0
Ile	2.356IleAla: 2.356 ± 0.012	1.078IleCys: 1.078 ± 0.009	2.007IleAsp: 2.007 ± 0.012	2.26IleGlu: 2.26 ± 0.013	1.83IlePhe: 1.83 ± 0.011	2.218IleGly: 2.218 ± 0.014	1.811IleHis: 1.811 ± 0.061	2.388IleIle: 2.388 ± 0.014	2.583IleLys: 2.583 ± 0.013	4.279IleLeu: 4.279 ± 0.017	1.003IleMet: 1.003 ± 0.008	1.98IleAsn: 1.98 ± 0.013	2.475IlePro: 2.475 ± 0.014	2.198IleGln: 2.198 ± 0.012	2.473IleArg: 2.473 ± 0.012	3.838IleSer: 3.838 ± 0.015	2.688IleThr: 2.688 ± 0.014	2.455IleVal: 2.455 ± 0.014	0.46IleTrp: 0.46 ± 0.005	1.377IleTyr: 1.377 ± 0.011	0.0IleXaa: 0.0 ± 0.0
Lys	3.819LysAla: 3.819 ± 0.017	1.027LysCys: 1.027 ± 0.008	3.271LysAsp: 3.271 ± 0.016	4.839LysGlu: 4.839 ± 0.029	1.599LysPhe: 1.599 ± 0.01	3.159LysGly: 3.159 ± 0.019	1.415LysHis: 1.415 ± 0.01	2.516LysIle: 2.516 ± 0.015	4.524LysLys: 4.524 ± 0.026	4.995LysLeu: 4.995 ± 0.021	1.49LysMet: 1.49 ± 0.012	2.34LysAsn: 2.34 ± 0.012	3.029LysPro: 3.029 ± 0.018	2.561LysGln: 2.561 ± 0.018	3.487LysArg: 3.487 ± 0.017	3.999LysSer: 3.999 ± 0.017	3.317LysThr: 3.317 ± 0.016	3.591LysVal: 3.591 ± 0.017	0.581LysTrp: 0.581 ± 0.005	1.452LysTyr: 1.452 ± 0.01	0.0LysXaa: 0.0 ± 0.0
Leu	5.786LeuAla: 5.786 ± 0.019	2.277LeuCys: 2.277 ± 0.015	4.844LeuAsp: 4.844 ± 0.02	6.448LeuGlu: 6.448 ± 0.031	3.514LeuPhe: 3.514 ± 0.02	5.047LeuGly: 5.047 ± 0.018	2.786LeuHis: 2.786 ± 0.015	3.732LeuIle: 3.732 ± 0.016	5.807LeuLys: 5.807 ± 0.025	10.135LeuLeu: 10.135 ± 0.04	2.111LeuMet: 2.111 ± 0.012	3.667LeuAsn: 3.667 ± 0.014	5.419LeuPro: 5.419 ± 0.028	5.633LeuGln: 5.633 ± 0.026	5.595LeuArg: 5.595 ± 0.022	8.467LeuSer: 8.467 ± 0.029	5.307LeuThr: 5.307 ± 0.021	5.308LeuVal: 5.308 ± 0.021	1.067LeuTrp: 1.067 ± 0.008	2.512LeuTyr: 2.512 ± 0.012	0.0LeuXaa: 0.0 ± 0.0
Met	1.779MetAla: 1.779 ± 0.01	0.473MetCys: 0.473 ± 0.006	1.387MetAsp: 1.387 ± 0.009	1.987MetGlu: 1.987 ± 0.01	0.845MetPhe: 0.845 ± 0.008	1.376MetGly: 1.376 ± 0.013	0.502MetHis: 0.502 ± 0.008	0.861MetIle: 0.861 ± 0.006	1.502MetLys: 1.502 ± 0.011	2.057MetLeu: 2.057 ± 0.012	0.695MetMet: 0.695 ± 0.006	0.885MetAsn: 0.885 ± 0.007	1.063MetPro: 1.063 ± 0.011	0.989MetGln: 0.989 ± 0.007	1.194MetArg: 1.194 ± 0.009	1.892MetSer: 1.892 ± 0.011	1.274MetThr: 1.274 ± 0.009	1.494MetVal: 1.494 ± 0.01	0.258MetTrp: 0.258 ± 0.005	0.593MetTyr: 0.593 ± 0.005	0.0MetXaa: 0.0 ± 0.0
Asn	2.161AsnAla: 2.161 ± 0.011	0.867AsnCys: 0.867 ± 0.007	1.673AsnAsp: 1.673 ± 0.012	2.05AsnGlu: 2.05 ± 0.012	1.451AsnPhe: 1.451 ± 0.01	2.674AsnGly: 2.674 ± 0.016	1.019AsnHis: 1.019 ± 0.008	2.139AsnIle: 2.139 ± 0.013	2.228AsnLys: 2.228 ± 0.012	3.701AsnLeu: 3.701 ± 0.014	1.003AsnMet: 1.003 ± 0.008	1.798AsnAsn: 1.798 ± 0.012	2.296AsnPro: 2.296 ± 0.012	1.784AsnGln: 1.784 ± 0.011	2.017AsnArg: 2.017 ± 0.011	3.354AsnSer: 3.354 ± 0.016	2.171AsnThr: 2.171 ± 0.013	2.26AsnVal: 2.26 ± 0.011	0.445AsnTrp: 0.445 ± 0.006	1.116AsnTyr: 1.116 ± 0.009	0.0AsnXaa: 0.0 ± 0.0
Pro	4.293ProAla: 4.293 ± 0.025	1.099ProCys: 1.099 ± 0.01	2.906ProAsp: 2.906 ± 0.018	3.808ProGlu: 3.808 ± 0.022	1.94ProPhe: 1.94 ± 0.015	3.951ProGly: 3.951 ± 0.041	1.606ProHis: 1.606 ± 0.016	1.959ProIle: 1.959 ± 0.014	2.646ProLys: 2.646 ± 0.022	4.96ProLeu: 4.96 ± 0.021	0.996ProMet: 0.996 ± 0.008	2.015ProAsn: 2.015 ± 0.013	5.846ProPro: 5.846 ± 0.048	2.72ProGln: 2.72 ± 0.017	2.771ProArg: 2.771 ± 0.016	6.366ProSer: 6.366 ± 0.071	3.178ProThr: 3.178 ± 0.023	3.783ProVal: 3.783 ± 0.022	0.541ProTrp: 0.541 ± 0.007	1.357ProTyr: 1.357 ± 0.01	0.0ProXaa: 0.0 ± 0.0
Gln	3.115GlnAla: 3.115 ± 0.016	0.908GlnCys: 0.908 ± 0.009	2.281GlnAsp: 2.281 ± 0.012	3.594GlnGlu: 3.594 ± 0.019	1.369GlnPhe: 1.369 ± 0.008	2.648GlnGly: 2.648 ± 0.017	1.372GlnHis: 1.372 ± 0.011	1.954GlnIle: 1.954 ± 0.012	2.728GlnLys: 2.728 ± 0.016	4.482GlnLeu: 4.482 ± 0.022	1.182GlnMet: 1.182 ± 0.012	1.872GlnAsn: 1.872 ± 0.012	2.592GlnPro: 2.592 ± 0.018	3.285GlnGln: 3.285 ± 0.03	3.181GlnArg: 3.181 ± 0.016	3.585GlnSer: 3.585 ± 0.019	2.717GlnThr: 2.717 ± 0.017	2.713GlnVal: 2.713 ± 0.015	0.529GlnTrp: 0.529 ± 0.006	1.155GlnTyr: 1.155 ± 0.009	0.0GlnXaa: 0.0 ± 0.0
Arg	3.402ArgAla: 3.402 ± 0.017	1.248ArgCys: 1.248 ± 0.011	2.867ArgAsp: 2.867 ± 0.014	3.882ArgGlu: 3.882 ± 0.022	2.033ArgPhe: 2.033 ± 0.012	3.533ArgGly: 3.533 ± 0.021	1.576ArgHis: 1.576 ± 0.016	2.395ArgIle: 2.395 ± 0.011	3.635ArgLys: 3.635 ± 0.019	5.441ArgLeu: 5.441 ± 0.022	1.322ArgMet: 1.322 ± 0.009	2.135ArgAsn: 2.135 ± 0.01	3.02ArgPro: 3.02 ± 0.019	2.717ArgGln: 2.717 ± 0.016	4.591ArgArg: 4.591 ± 0.023	4.861ArgSer: 4.861 ± 0.022	3.025ArgThr: 3.025 ± 0.015	3.308ArgVal: 3.308 ± 0.016	0.711ArgTrp: 0.711 ± 0.008	1.443ArgTyr: 1.443 ± 0.009	0.0ArgXaa: 0.0 ± 0.0
Ser	5.894SerAla: 5.894 ± 0.033	2.15SerCys: 2.15 ± 0.019	4.334SerAsp: 4.334 ± 0.018	4.942SerGlu: 4.942 ± 0.022	3.311SerPhe: 3.311 ± 0.015	5.745SerGly: 5.745 ± 0.024	2.331SerHis: 2.331 ± 0.014	3.944SerIle: 3.944 ± 0.056	4.16SerLys: 4.16 ± 0.016	8.464SerLeu: 8.464 ± 0.035	1.87SerMet: 1.87 ± 0.011	3.102SerAsn: 3.102 ± 0.014	6.113SerPro: 6.113 ± 0.036	3.938SerGln: 3.938 ± 0.02	4.759SerArg: 4.759 ± 0.022	11.005SerSer: 11.005 ± 0.058	5.015SerThr: 5.015 ± 0.03	5.505SerVal: 5.505 ± 0.021	1.029SerTrp: 1.029 ± 0.008	2.128SerTyr: 2.128 ± 0.013	0.0SerXaa: 0.0 ± 0.0
Thr	4.013ThrAla: 4.013 ± 0.018	1.349ThrCys: 1.349 ± 0.013	2.821ThrAsp: 2.821 ± 0.015	3.643ThrGlu: 3.643 ± 0.016	2.141ThrPhe: 2.141 ± 0.011	3.627ThrGly: 3.627 ± 0.022	1.511ThrHis: 1.511 ± 0.027	2.363ThrIle: 2.363 ± 0.013	2.704ThrLys: 2.704 ± 0.013	5.286ThrLeu: 5.286 ± 0.022	1.164ThrMet: 1.164 ± 0.009	1.961ThrAsn: 1.961 ± 0.014	3.735ThrPro: 3.735 ± 0.029	2.339ThrGln: 2.339 ± 0.012	2.525ThrArg: 2.525 ± 0.018	4.896ThrSer: 4.896 ± 0.024	3.413ThrThr: 3.413 ± 0.088	4.015ThrVal: 4.015 ± 0.022	0.662ThrTrp: 0.662 ± 0.007	1.396ThrTyr: 1.396 ± 0.009	0.0ThrXaa: 0.0 ± 0.0
Val	4.007ValAla: 4.007 ± 0.02	1.732ValCys: 1.732 ± 0.02	3.15ValAsp: 3.15 ± 0.017	3.986ValGlu: 3.986 ± 0.016	2.667ValPhe: 2.667 ± 0.015	3.475ValGly: 3.475 ± 0.017	1.598ValHis: 1.598 ± 0.015	2.903ValIle: 2.903 ± 0.016	3.551ValLys: 3.551 ± 0.017	6.16ValLeu: 6.16 ± 0.024	1.47ValMet: 1.47 ± 0.011	2.402ValAsn: 2.402 ± 0.013	3.289ValPro: 3.289 ± 0.018	2.787ValGln: 2.787 ± 0.012	3.34ValArg: 3.34 ± 0.018	5.411ValSer: 5.411 ± 0.03	3.842ValThr: 3.842 ± 0.02	4.366ValVal: 4.366 ± 0.028	0.786ValTrp: 0.786 ± 0.009	1.724ValTyr: 1.724 ± 0.011	0.0ValXaa: 0.0 ± 0.0
Trp	0.632TrpAla: 0.632 ± 0.005	0.238TrpCys: 0.238 ± 0.004	0.621TrpAsp: 0.621 ± 0.007	0.751TrpGlu: 0.751 ± 0.006	0.482TrpPhe: 0.482 ± 0.006	0.612TrpGly: 0.612 ± 0.006	0.257TrpHis: 0.257 ± 0.004	0.572TrpIle: 0.572 ± 0.006	0.768TrpLys: 0.768 ± 0.007	1.136TrpLeu: 1.136 ± 0.008	0.346TrpMet: 0.346 ± 0.005	0.519TrpAsn: 0.519 ± 0.005	0.436TrpPro: 0.436 ± 0.005	0.473TrpGln: 0.473 ± 0.005	0.781TrpArg: 0.781 ± 0.009	0.975TrpSer: 0.975 ± 0.008	0.718TrpThr: 0.718 ± 0.008	0.665TrpVal: 0.665 ± 0.008	0.206TrpTrp: 0.206 ± 0.003	0.334TrpTyr: 0.334 ± 0.005	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.392TyrAla: 1.392 ± 0.01	0.707TyrCys: 0.707 ± 0.008	1.325TyrAsp: 1.325 ± 0.01	1.489TyrGlu: 1.489 ± 0.01	1.159TyrPhe: 1.159 ± 0.008	1.581TyrGly: 1.581 ± 0.011	0.779TyrHis: 0.779 ± 0.006	1.41TyrIle: 1.41 ± 0.01	1.439TyrLys: 1.439 ± 0.01	2.493TyrLeu: 2.493 ± 0.014	0.65TyrMet: 0.65 ± 0.006	1.139TyrAsn: 1.139 ± 0.009	1.264TyrPro: 1.264 ± 0.012	1.19TyrGln: 1.19 ± 0.01	1.65TyrArg: 1.65 ± 0.011	2.319TyrSer: 2.319 ± 0.013	1.505TyrThr: 1.505 ± 0.012	1.488TyrVal: 1.488 ± 0.009	0.356TyrTrp: 0.356 ± 0.005	0.916TyrTyr: 0.916 ± 0.007	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 36138 proteins (21724183 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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