Amino acid dipepetide frequency for Calditerrivibrio nitroreducens (strain DSM 19672 / NBRC 101217 / Yu37-1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.776AlaAla: 3.776 ± 0.114
0.584AlaCys: 0.584 ± 0.035
2.894AlaAsp: 2.894 ± 0.083
3.826AlaGlu: 3.826 ± 0.094
2.713AlaPhe: 2.713 ± 0.065
4.076AlaGly: 4.076 ± 0.098
0.837AlaHis: 0.837 ± 0.039
5.675AlaIle: 5.675 ± 0.105
4.598AlaLys: 4.598 ± 0.09
5.473AlaLeu: 5.473 ± 0.103
1.45AlaMet: 1.45 ± 0.057
2.358AlaAsn: 2.358 ± 0.074
1.507AlaPro: 1.507 ± 0.05
1.346AlaGln: 1.346 ± 0.05
1.999AlaArg: 1.999 ± 0.055
3.134AlaSer: 3.134 ± 0.075
2.78AlaThr: 2.78 ± 0.075
4.072AlaVal: 4.072 ± 0.082
0.298AlaTrp: 0.298 ± 0.021
2.097AlaTyr: 2.097 ± 0.058
0.0AlaXaa: 0.0 ± 0.0
Cys
0.478CysAla: 0.478 ± 0.03
0.149CysCys: 0.149 ± 0.017
0.5CysAsp: 0.5 ± 0.027
0.609CysGlu: 0.609 ± 0.035
0.388CysPhe: 0.388 ± 0.024
0.986CysGly: 0.986 ± 0.042
0.281CysHis: 0.281 ± 0.034
0.655CysIle: 0.655 ± 0.035
0.748CysLys: 0.748 ± 0.036
0.674CysLeu: 0.674 ± 0.032
0.208CysMet: 0.208 ± 0.018
0.461CysAsn: 0.461 ± 0.027
0.502CysPro: 0.502 ± 0.032
0.208CysGln: 0.208 ± 0.019
0.388CysArg: 0.388 ± 0.023
0.664CysSer: 0.664 ± 0.034
0.401CysThr: 0.401 ± 0.028
0.481CysVal: 0.481 ± 0.031
0.069CysTrp: 0.069 ± 0.011
0.424CysTyr: 0.424 ± 0.026
0.0CysXaa: 0.0 ± 0.0
Asp
3.036AspAla: 3.036 ± 0.068
0.556AspCys: 0.556 ± 0.032
3.195AspAsp: 3.195 ± 0.079
4.495AspGlu: 4.495 ± 0.084
3.44AspPhe: 3.44 ± 0.077
3.457AspGly: 3.457 ± 0.069
0.758AspHis: 0.758 ± 0.035
6.707AspIle: 6.707 ± 0.113
5.286AspLys: 5.286 ± 0.084
5.663AspLeu: 5.663 ± 0.097
1.337AspMet: 1.337 ± 0.04
3.08AspAsn: 3.08 ± 0.089
1.953AspPro: 1.953 ± 0.055
1.096AspGln: 1.096 ± 0.04
2.452AspArg: 2.452 ± 0.058
2.786AspSer: 2.786 ± 0.079
2.629AspThr: 2.629 ± 0.064
3.564AspVal: 3.564 ± 0.081
0.392AspTrp: 0.392 ± 0.023
2.672AspTyr: 2.672 ± 0.069
0.0AspXaa: 0.0 ± 0.0
Glu
3.7GluAla: 3.7 ± 0.075
0.455GluCys: 0.455 ± 0.025
3.732GluAsp: 3.732 ± 0.083
5.381GluGlu: 5.381 ± 0.111
3.122GluPhe: 3.122 ± 0.074
3.527GluGly: 3.527 ± 0.075
1.017GluHis: 1.017 ± 0.042
7.508GluIle: 7.508 ± 0.104
7.915GluLys: 7.915 ± 0.123
6.631GluLeu: 6.631 ± 0.116
1.95GluMet: 1.95 ± 0.057
4.259GluAsn: 4.259 ± 0.081
1.612GluPro: 1.612 ± 0.058
1.725GluGln: 1.725 ± 0.056
2.724GluArg: 2.724 ± 0.062
3.415GluSer: 3.415 ± 0.078
2.696GluThr: 2.696 ± 0.063
4.435GluVal: 4.435 ± 0.083
0.462GluTrp: 0.462 ± 0.03
2.878GluTyr: 2.878 ± 0.065
0.0GluXaa: 0.0 ± 0.0
Phe
2.793PheAla: 2.793 ± 0.067
0.559PheCys: 0.559 ± 0.027
3.248PheAsp: 3.248 ± 0.069
3.623PheGlu: 3.623 ± 0.079
3.195PhePhe: 3.195 ± 0.087
3.507PheGly: 3.507 ± 0.067
0.777PheHis: 0.777 ± 0.031
5.103PheIle: 5.103 ± 0.13
4.157PheLys: 4.157 ± 0.081
5.576PheLeu: 5.576 ± 0.112
1.247PheMet: 1.247 ± 0.047
2.702PheAsn: 2.702 ± 0.07
1.465PhePro: 1.465 ± 0.045
1.075PheGln: 1.075 ± 0.041
1.779PheArg: 1.779 ± 0.044
3.887PheSer: 3.887 ± 0.086
2.594PheThr: 2.594 ± 0.061
3.684PheVal: 3.684 ± 0.089
0.389PheTrp: 0.389 ± 0.026
2.519PheTyr: 2.519 ± 0.066
0.0PheXaa: 0.0 ± 0.0
Gly
3.703GlyAla: 3.703 ± 0.097
0.797GlyCys: 0.797 ± 0.038
3.486GlyAsp: 3.486 ± 0.083
4.132GlyGlu: 4.132 ± 0.077
3.783GlyPhe: 3.783 ± 0.074
4.326GlyGly: 4.326 ± 0.106
1.002GlyHis: 1.002 ± 0.044
6.342GlyIle: 6.342 ± 0.106
5.625GlyLys: 5.625 ± 0.104
5.781GlyLeu: 5.781 ± 0.107
1.659GlyMet: 1.659 ± 0.057
2.708GlyAsn: 2.708 ± 0.072
1.198GlyPro: 1.198 ± 0.051
1.252GlyGln: 1.252 ± 0.046
2.546GlyArg: 2.546 ± 0.086
3.475GlySer: 3.475 ± 0.077
3.023GlyThr: 3.023 ± 0.079
4.942GlyVal: 4.942 ± 0.096
0.547GlyTrp: 0.547 ± 0.029
3.093GlyTyr: 3.093 ± 0.074
0.0GlyXaa: 0.0 ± 0.0
His
0.752HisAla: 0.752 ± 0.036
0.205HisCys: 0.205 ± 0.017
0.695HisAsp: 0.695 ± 0.032
0.692HisGlu: 0.692 ± 0.034
0.922HisPhe: 0.922 ± 0.039
0.974HisGly: 0.974 ± 0.043
0.351HisHis: 0.351 ± 0.026
1.498HisIle: 1.498 ± 0.049
1.147HisLys: 1.147 ± 0.047
1.542HisLeu: 1.542 ± 0.052
0.272HisMet: 0.272 ± 0.019
0.796HisAsn: 0.796 ± 0.036
0.828HisPro: 0.828 ± 0.038
0.41HisGln: 0.41 ± 0.022
0.612HisArg: 0.612 ± 0.033
0.919HisSer: 0.919 ± 0.035
0.777HisThr: 0.777 ± 0.041
0.679HisVal: 0.679 ± 0.034
0.089HisTrp: 0.089 ± 0.011
0.642HisTyr: 0.642 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
5.706IleAla: 5.706 ± 0.106
0.903IleCys: 0.903 ± 0.034
6.497IleAsp: 6.497 ± 0.122
6.598IleGlu: 6.598 ± 0.121
5.51IlePhe: 5.51 ± 0.118
5.539IleGly: 5.539 ± 0.092
1.336IleHis: 1.336 ± 0.046
8.639IleIle: 8.639 ± 0.153
8.786IleLys: 8.786 ± 0.122
9.541IleLeu: 9.541 ± 0.151
1.807IleMet: 1.807 ± 0.056
5.287IleAsn: 5.287 ± 0.102
3.618IlePro: 3.618 ± 0.08
2.121IleGln: 2.121 ± 0.057
3.309IleArg: 3.309 ± 0.072
6.944IleSer: 6.944 ± 0.109
4.97IleThr: 4.97 ± 0.095
6.268IleVal: 6.268 ± 0.099
0.528IleTrp: 0.528 ± 0.03
3.92IleTyr: 3.92 ± 0.094
0.0IleXaa: 0.0 ± 0.0
Lys
4.386LysAla: 4.386 ± 0.095
0.587LysCys: 0.587 ± 0.037
5.895LysAsp: 5.895 ± 0.106
6.928LysGlu: 6.928 ± 0.106
3.703LysPhe: 3.703 ± 0.074
5.33LysGly: 5.33 ± 0.095
1.27LysHis: 1.27 ± 0.046
9.233LysIle: 9.233 ± 0.132
8.854LysLys: 8.854 ± 0.128
7.675LysLeu: 7.675 ± 0.116
2.259LysMet: 2.259 ± 0.053
6.135LysAsn: 6.135 ± 0.115
2.686LysPro: 2.686 ± 0.065
2.025LysGln: 2.025 ± 0.053
3.737LysArg: 3.737 ± 0.08
5.295LysSer: 5.295 ± 0.109
4.088LysThr: 4.088 ± 0.081
5.706LysVal: 5.706 ± 0.088
0.572LysTrp: 0.572 ± 0.031
3.969LysTyr: 3.969 ± 0.086
0.0LysXaa: 0.0 ± 0.0
Leu
5.188LeuAla: 5.188 ± 0.099
0.732LeuCys: 0.732 ± 0.039
5.04LeuAsp: 5.04 ± 0.088
6.123LeuGlu: 6.123 ± 0.109
5.099LeuPhe: 5.099 ± 0.131
5.903LeuGly: 5.903 ± 0.107
1.383LeuHis: 1.383 ± 0.051
8.262LeuIle: 8.262 ± 0.132
10.278LeuLys: 10.278 ± 0.149
8.856LeuLeu: 8.856 ± 0.149
2.269LeuMet: 2.269 ± 0.058
5.737LeuAsn: 5.737 ± 0.108
3.567LeuPro: 3.567 ± 0.08
2.158LeuGln: 2.158 ± 0.056
3.462LeuArg: 3.462 ± 0.07
7.078LeuSer: 7.078 ± 0.112
4.515LeuThr: 4.515 ± 0.083
5.554LeuVal: 5.554 ± 0.099
0.584LeuTrp: 0.584 ± 0.035
3.454LeuTyr: 3.454 ± 0.073
0.0LeuXaa: 0.0 ± 0.0
Met
1.653MetAla: 1.653 ± 0.052
0.155MetCys: 0.155 ± 0.015
1.261MetAsp: 1.261 ± 0.049
1.652MetGlu: 1.652 ± 0.046
0.939MetPhe: 0.939 ± 0.038
1.669MetGly: 1.669 ± 0.049
0.323MetHis: 0.323 ± 0.021
2.184MetIle: 2.184 ± 0.055
2.323MetLys: 2.323 ± 0.062
2.307MetLeu: 2.307 ± 0.061
0.597MetMet: 0.597 ± 0.029
1.188MetAsn: 1.188 ± 0.043
0.827MetPro: 0.827 ± 0.037
0.53MetGln: 0.53 ± 0.029
0.906MetArg: 0.906 ± 0.035
1.391MetSer: 1.391 ± 0.049
1.102MetThr: 1.102 ± 0.043
1.725MetVal: 1.725 ± 0.052
0.117MetTrp: 0.117 ± 0.013
0.619MetTyr: 0.619 ± 0.032
0.0MetXaa: 0.0 ± 0.0
Asn
2.737AsnAla: 2.737 ± 0.06
0.603AsnCys: 0.603 ± 0.032
2.71AsnAsp: 2.71 ± 0.067
3.289AsnGlu: 3.289 ± 0.074
3.143AsnPhe: 3.143 ± 0.078
3.255AsnGly: 3.255 ± 0.079
0.729AsnHis: 0.729 ± 0.031
6.082AsnIle: 6.082 ± 0.11
4.301AsnLys: 4.301 ± 0.087
5.595AsnLeu: 5.595 ± 0.091
1.241AsnMet: 1.241 ± 0.04
3.056AsnAsn: 3.056 ± 0.089
2.265AsnPro: 2.265 ± 0.059
1.236AsnGln: 1.236 ± 0.043
2.373AsnArg: 2.373 ± 0.064
3.058AsnSer: 3.058 ± 0.078
2.244AsnThr: 2.244 ± 0.055
3.17AsnVal: 3.17 ± 0.08
0.344AsnTrp: 0.344 ± 0.025
2.429AsnTyr: 2.429 ± 0.068
0.0AsnXaa: 0.0 ± 0.0
Pro
1.707ProAla: 1.707 ± 0.071
0.278ProCys: 0.278 ± 0.019
2.234ProAsp: 2.234 ± 0.066
2.879ProGlu: 2.879 ± 0.063
1.902ProPhe: 1.902 ± 0.061
1.887ProGly: 1.887 ± 0.063
0.59ProHis: 0.59 ± 0.036
2.851ProIle: 2.851 ± 0.058
2.451ProLys: 2.451 ± 0.071
2.837ProLeu: 2.837 ± 0.057
0.623ProMet: 0.623 ± 0.037
1.46ProAsn: 1.46 ± 0.05
0.922ProPro: 0.922 ± 0.043
0.865ProGln: 0.865 ± 0.037
0.888ProArg: 0.888 ± 0.041
1.952ProSer: 1.952 ± 0.054
1.614ProThr: 1.614 ± 0.05
2.508ProVal: 2.508 ± 0.062
0.231ProTrp: 0.231 ± 0.017
1.5ProTyr: 1.5 ± 0.054
0.0ProXaa: 0.0 ± 0.0
Gln
1.242GlnAla: 1.242 ± 0.049
0.178GlnCys: 0.178 ± 0.016
1.115GlnAsp: 1.115 ± 0.04
1.403GlnGlu: 1.403 ± 0.051
1.184GlnPhe: 1.184 ± 0.042
1.159GlnGly: 1.159 ± 0.049
0.351GlnHis: 0.351 ± 0.022
2.252GlnIle: 2.252 ± 0.054
2.396GlnLys: 2.396 ± 0.073
2.256GlnLeu: 2.256 ± 0.065
0.699GlnMet: 0.699 ± 0.028
1.355GlnAsn: 1.355 ± 0.041
0.579GlnPro: 0.579 ± 0.03
0.653GlnGln: 0.653 ± 0.028
0.913GlnArg: 0.913 ± 0.036
1.2GlnSer: 1.2 ± 0.041
1.053GlnThr: 1.053 ± 0.044
1.369GlnVal: 1.369 ± 0.052
0.14GlnTrp: 0.14 ± 0.015
0.871GlnTyr: 0.871 ± 0.041
0.0GlnXaa: 0.0 ± 0.0
Arg
1.756ArgAla: 1.756 ± 0.051
0.401ArgCys: 0.401 ± 0.025
2.294ArgAsp: 2.294 ± 0.063
2.702ArgGlu: 2.702 ± 0.077
2.394ArgPhe: 2.394 ± 0.067
2.361ArgGly: 2.361 ± 0.057
0.521ArgHis: 0.521 ± 0.029
3.621ArgIle: 3.621 ± 0.078
3.112ArgLys: 3.112 ± 0.07
3.677ArgLeu: 3.677 ± 0.078
1.039ArgMet: 1.039 ± 0.039
1.887ArgAsn: 1.887 ± 0.051
1.081ArgPro: 1.081 ± 0.038
0.844ArgGln: 0.844 ± 0.035
1.601ArgArg: 1.601 ± 0.057
2.057ArgSer: 2.057 ± 0.061
1.328ArgThr: 1.328 ± 0.046
2.56ArgVal: 2.56 ± 0.065
0.337ArgTrp: 0.337 ± 0.02
2.089ArgTyr: 2.089 ± 0.055
0.0ArgXaa: 0.0 ± 0.0
Ser
3.176SerAla: 3.176 ± 0.063
0.597SerCys: 0.597 ± 0.032
3.541SerAsp: 3.541 ± 0.079
3.92SerGlu: 3.92 ± 0.074
3.756SerPhe: 3.756 ± 0.086
4.347SerGly: 4.347 ± 0.085
0.913SerHis: 0.913 ± 0.043
6.294SerIle: 6.294 ± 0.125
5.106SerLys: 5.106 ± 0.087
5.89SerLeu: 5.89 ± 0.111
1.416SerMet: 1.416 ± 0.046
3.147SerAsn: 3.147 ± 0.092
1.868SerPro: 1.868 ± 0.052
1.374SerGln: 1.374 ± 0.041
2.244SerArg: 2.244 ± 0.057
4.203SerSer: 4.203 ± 0.089
2.639SerThr: 2.639 ± 0.065
3.917SerVal: 3.917 ± 0.079
0.426SerTrp: 0.426 ± 0.025
2.778SerTyr: 2.778 ± 0.065
0.0SerXaa: 0.0 ± 0.0
Thr
2.878ThrAla: 2.878 ± 0.068
0.344ThrCys: 0.344 ± 0.024
2.796ThrAsp: 2.796 ± 0.073
2.695ThrGlu: 2.695 ± 0.068
2.48ThrPhe: 2.48 ± 0.069
3.823ThrGly: 3.823 ± 0.09
0.713ThrHis: 0.713 ± 0.029
4.628ThrIle: 4.628 ± 0.096
3.462ThrLys: 3.462 ± 0.073
4.363ThrLeu: 4.363 ± 0.085
0.898ThrMet: 0.898 ± 0.035
2.203ThrAsn: 2.203 ± 0.062
1.966ThrPro: 1.966 ± 0.057
0.929ThrGln: 0.929 ± 0.037
1.462ThrArg: 1.462 ± 0.051
2.68ThrSer: 2.68 ± 0.066
2.487ThrThr: 2.487 ± 0.072
3.263ThrVal: 3.263 ± 0.071
0.218ThrTrp: 0.218 ± 0.019
1.713ThrTyr: 1.713 ± 0.047
0.0ThrXaa: 0.0 ± 0.0
Val
4.237ValAla: 4.237 ± 0.093
0.689ValCys: 0.689 ± 0.035
4.405ValAsp: 4.405 ± 0.09
4.84ValGlu: 4.84 ± 0.103
3.295ValPhe: 3.295 ± 0.078
4.155ValGly: 4.155 ± 0.085
0.812ValHis: 0.812 ± 0.033
5.914ValIle: 5.914 ± 0.117
5.811ValLys: 5.811 ± 0.104
5.753ValLeu: 5.753 ± 0.098
1.576ValMet: 1.576 ± 0.052
3.241ValAsn: 3.241 ± 0.059
1.968ValPro: 1.968 ± 0.053
1.245ValGln: 1.245 ± 0.042
2.366ValArg: 2.366 ± 0.057
4.451ValSer: 4.451 ± 0.084
2.869ValThr: 2.869 ± 0.067
5.282ValVal: 5.282 ± 0.107
0.375ValTrp: 0.375 ± 0.024
2.563ValTyr: 2.563 ± 0.067
0.0ValXaa: 0.0 ± 0.0
Trp
0.366TrpAla: 0.366 ± 0.022
0.064TrpCys: 0.064 ± 0.011
0.435TrpAsp: 0.435 ± 0.037
0.475TrpGlu: 0.475 ± 0.028
0.395TrpPhe: 0.395 ± 0.028
0.443TrpGly: 0.443 ± 0.023
0.146TrpHis: 0.146 ± 0.015
0.559TrpIle: 0.559 ± 0.025
0.483TrpLys: 0.483 ± 0.024
0.595TrpLeu: 0.595 ± 0.031
0.18TrpMet: 0.18 ± 0.018
0.331TrpAsn: 0.331 ± 0.023
0.177TrpPro: 0.177 ± 0.017
0.198TrpGln: 0.198 ± 0.016
0.246TrpArg: 0.246 ± 0.021
0.326TrpSer: 0.326 ± 0.023
0.279TrpThr: 0.279 ± 0.019
0.459TrpVal: 0.459 ± 0.028
0.098TrpTrp: 0.098 ± 0.013
0.332TrpTyr: 0.332 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.221TyrAla: 2.221 ± 0.063
0.439TyrCys: 0.439 ± 0.025
2.579TyrAsp: 2.579 ± 0.063
2.885TyrGlu: 2.885 ± 0.064
2.518TyrPhe: 2.518 ± 0.07
2.695TyrGly: 2.695 ± 0.069
0.693TyrHis: 0.693 ± 0.03
3.819TyrIle: 3.819 ± 0.09
3.494TyrLys: 3.494 ± 0.076
4.556TyrLeu: 4.556 ± 0.094
0.74TyrMet: 0.74 ± 0.032
2.468TyrAsn: 2.468 ± 0.073
1.589TyrPro: 1.589 ± 0.051
1.08TyrGln: 1.08 ± 0.043
1.658TyrArg: 1.658 ± 0.047
2.638TyrSer: 2.638 ± 0.062
1.911TyrThr: 1.911 ± 0.055
2.208TyrVal: 2.208 ± 0.061
0.372TyrTrp: 0.372 ± 0.025
1.949TyrTyr: 1.949 ± 0.064
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2089 proteins (683502 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski