Amino acid dipepetide frequency for Actinokineospora bangkokensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	25.193AlaAla: 25.193 ± 0.236	1.105AlaCys: 1.105 ± 0.027	9.333AlaAsp: 9.333 ± 0.093	9.571AlaGlu: 9.571 ± 0.098	3.704AlaPhe: 3.704 ± 0.056	14.496AlaGly: 14.496 ± 0.119	3.25AlaHis: 3.25 ± 0.049	3.477AlaIle: 3.477 ± 0.046	2.554AlaLys: 2.554 ± 0.042	16.446AlaLeu: 16.446 ± 0.146	2.213AlaMet: 2.213 ± 0.031	2.038AlaAsn: 2.038 ± 0.035	7.467AlaPro: 7.467 ± 0.098	3.914AlaGln: 3.914 ± 0.048	10.731AlaArg: 10.731 ± 0.094	5.102AlaSer: 5.102 ± 0.063	8.206AlaThr: 8.206 ± 0.104	14.524AlaVal: 14.524 ± 0.111	1.932AlaTrp: 1.932 ± 0.029	2.208AlaTyr: 2.208 ± 0.036	0.0AlaXaa: 0.0 ± 0.0
Cys	1.182CysAla: 1.182 ± 0.028	0.087CysCys: 0.087 ± 0.007	0.459CysAsp: 0.459 ± 0.016	0.349CysGlu: 0.349 ± 0.01	0.197CysPhe: 0.197 ± 0.01	0.858CysGly: 0.858 ± 0.019	0.149CysHis: 0.149 ± 0.008	0.118CysIle: 0.118 ± 0.007	0.125CysLys: 0.125 ± 0.009	0.694CysLeu: 0.694 ± 0.021	0.086CysMet: 0.086 ± 0.006	0.105CysAsn: 0.105 ± 0.007	0.45CysPro: 0.45 ± 0.016	0.15CysGln: 0.15 ± 0.009	0.509CysArg: 0.509 ± 0.015	0.449CysSer: 0.449 ± 0.016	0.469CysThr: 0.469 ± 0.02	0.6CysVal: 0.6 ± 0.016	0.118CysTrp: 0.118 ± 0.007	0.138CysTyr: 0.138 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	8.103AspAla: 8.103 ± 0.084	0.372AspCys: 0.372 ± 0.014	3.925AspAsp: 3.925 ± 0.054	3.812AspGlu: 3.812 ± 0.048	1.529AspPhe: 1.529 ± 0.025	6.177AspGly: 6.177 ± 0.059	1.553AspHis: 1.553 ± 0.025	1.483AspIle: 1.483 ± 0.029	1.014AspLys: 1.014 ± 0.024	7.412AspLeu: 7.412 ± 0.073	0.616AspMet: 0.616 ± 0.017	0.925AspAsn: 0.925 ± 0.027	5.344AspPro: 5.344 ± 0.053	1.632AspGln: 1.632 ± 0.031	5.266AspArg: 5.266 ± 0.057	2.321AspSer: 2.321 ± 0.032	3.162AspThr: 3.162 ± 0.044	5.168AspVal: 5.168 ± 0.053	1.021AspTrp: 1.021 ± 0.024	1.152AspTyr: 1.152 ± 0.024	0.0AspXaa: 0.0 ± 0.0
Glu	6.538GluAla: 6.538 ± 0.069	0.354GluCys: 0.354 ± 0.014	2.637GluAsp: 2.637 ± 0.038	2.414GluGlu: 2.414 ± 0.042	1.592GluPhe: 1.592 ± 0.025	3.792GluGly: 3.792 ± 0.043	1.815GluHis: 1.815 ± 0.032	1.439GluIle: 1.439 ± 0.032	0.905GluLys: 0.905 ± 0.024	6.841GluLeu: 6.841 ± 0.072	0.665GluMet: 0.665 ± 0.017	0.737GluAsn: 0.737 ± 0.02	3.299GluPro: 3.299 ± 0.054	2.37GluGln: 2.37 ± 0.032	5.364GluArg: 5.364 ± 0.07	2.059GluSer: 2.059 ± 0.034	2.145GluThr: 2.145 ± 0.029	5.939GluVal: 5.939 ± 0.056	0.715GluTrp: 0.715 ± 0.021	0.84GluTyr: 0.84 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	4.149PheAla: 4.149 ± 0.048	0.232PheCys: 0.232 ± 0.01	2.232PheAsp: 2.232 ± 0.035	1.27PheGlu: 1.27 ± 0.026	0.776PhePhe: 0.776 ± 0.023	3.077PheGly: 3.077 ± 0.043	0.649PheHis: 0.649 ± 0.017	0.617PheIle: 0.617 ± 0.017	0.36PheLys: 0.36 ± 0.014	2.62PheLeu: 2.62 ± 0.048	0.268PheMet: 0.268 ± 0.012	0.445PheAsn: 0.445 ± 0.017	1.432PhePro: 1.432 ± 0.029	0.595PheGln: 0.595 ± 0.018	1.71PheArg: 1.71 ± 0.029	1.417PheSer: 1.417 ± 0.03	2.197PheThr: 2.197 ± 0.039	2.08PheVal: 2.08 ± 0.029	0.388PheTrp: 0.388 ± 0.014	0.519PheTyr: 0.519 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	12.541GlyAla: 12.541 ± 0.102	0.789GlyCys: 0.789 ± 0.018	5.156GlyAsp: 5.156 ± 0.054	5.009GlyGlu: 5.009 ± 0.054	3.005GlyPhe: 3.005 ± 0.038	9.511GlyGly: 9.511 ± 0.106	2.255GlyHis: 2.255 ± 0.041	2.963GlyIle: 2.963 ± 0.04	2.068GlyLys: 2.068 ± 0.037	9.687GlyLeu: 9.687 ± 0.091	1.915GlyMet: 1.915 ± 0.033	1.552GlyAsn: 1.552 ± 0.033	5.143GlyPro: 5.143 ± 0.054	2.719GlyGln: 2.719 ± 0.047	7.11GlyArg: 7.11 ± 0.068	5.185GlySer: 5.185 ± 0.059	6.603GlyThr: 6.603 ± 0.092	9.405GlyVal: 9.405 ± 0.071	1.743GlyTrp: 1.743 ± 0.035	2.121GlyTyr: 2.121 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	2.835HisAla: 2.835 ± 0.045	0.194HisCys: 0.194 ± 0.011	1.386HisAsp: 1.386 ± 0.03	1.108HisGlu: 1.108 ± 0.024	0.603HisPhe: 0.603 ± 0.018	2.284HisGly: 2.284 ± 0.037	0.707HisHis: 0.707 ± 0.024	0.451HisIle: 0.451 ± 0.014	0.263HisLys: 0.263 ± 0.011	2.65HisLeu: 2.65 ± 0.044	0.245HisMet: 0.245 ± 0.01	0.332HisAsn: 0.332 ± 0.012	1.966HisPro: 1.966 ± 0.035	0.617HisGln: 0.617 ± 0.018	2.165HisArg: 2.165 ± 0.037	0.951HisSer: 0.951 ± 0.025	1.211HisThr: 1.211 ± 0.027	1.916HisVal: 1.916 ± 0.033	0.36HisTrp: 0.36 ± 0.013	0.461HisTyr: 0.461 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	4.425IleAla: 4.425 ± 0.049	0.201IleCys: 0.201 ± 0.01	1.757IleAsp: 1.757 ± 0.033	1.402IleGlu: 1.402 ± 0.029	0.487IlePhe: 0.487 ± 0.018	3.085IleGly: 3.085 ± 0.047	0.421IleHis: 0.421 ± 0.014	0.629IleIle: 0.629 ± 0.021	0.514IleLys: 0.514 ± 0.015	1.567IleLeu: 1.567 ± 0.036	0.299IleMet: 0.299 ± 0.013	0.544IleAsn: 0.544 ± 0.017	1.541IlePro: 1.541 ± 0.03	0.531IleGln: 0.531 ± 0.016	1.626IleArg: 1.626 ± 0.031	1.513IleSer: 1.513 ± 0.03	2.309IleThr: 2.309 ± 0.044	1.87IleVal: 1.87 ± 0.035	0.252IleTrp: 0.252 ± 0.012	0.376IleTyr: 0.376 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	2.367LysAla: 2.367 ± 0.04	0.083LysCys: 0.083 ± 0.007	0.834LysAsp: 0.834 ± 0.024	0.695LysGlu: 0.695 ± 0.022	0.395LysPhe: 0.395 ± 0.015	1.256LysGly: 1.256 ± 0.032	0.391LysHis: 0.391 ± 0.015	0.533LysIle: 0.533 ± 0.017	0.428LysLys: 0.428 ± 0.017	1.738LysLeu: 1.738 ± 0.031	0.257LysMet: 0.257 ± 0.012	0.304LysAsn: 0.304 ± 0.013	1.235LysPro: 1.235 ± 0.031	0.639LysGln: 0.639 ± 0.019	1.328LysArg: 1.328 ± 0.025	0.902LysSer: 0.902 ± 0.022	0.951LysThr: 0.951 ± 0.025	1.775LysVal: 1.775 ± 0.032	0.184LysTrp: 0.184 ± 0.009	0.302LysTyr: 0.302 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	16.936LeuAla: 16.936 ± 0.137	0.734LeuCys: 0.734 ± 0.019	7.471LeuAsp: 7.471 ± 0.066	4.111LeuGlu: 4.111 ± 0.048	2.653LeuPhe: 2.653 ± 0.035	9.959LeuGly: 9.959 ± 0.096	2.389LeuHis: 2.389 ± 0.04	2.451LeuIle: 2.451 ± 0.043	1.332LeuLys: 1.332 ± 0.032	11.577LeuLeu: 11.577 ± 0.115	1.229LeuMet: 1.229 ± 0.026	1.435LeuAsn: 1.435 ± 0.031	6.897LeuPro: 6.897 ± 0.068	1.749LeuGln: 1.749 ± 0.037	9.57LeuArg: 9.57 ± 0.086	5.314LeuSer: 5.314 ± 0.05	6.643LeuThr: 6.643 ± 0.06	11.125LeuVal: 11.125 ± 0.104	1.317LeuTrp: 1.317 ± 0.027	1.401LeuTyr: 1.401 ± 0.028	0.0LeuXaa: 0.0 ± 0.0
Met	2.036MetAla: 2.036 ± 0.032	0.086MetCys: 0.086 ± 0.007	0.711MetAsp: 0.711 ± 0.019	0.474MetGlu: 0.474 ± 0.016	0.362MetPhe: 0.362 ± 0.014	1.199MetGly: 1.199 ± 0.024	0.261MetHis: 0.261 ± 0.011	0.448MetIle: 0.448 ± 0.016	0.252MetLys: 0.252 ± 0.011	1.346MetLeu: 1.346 ± 0.029	0.194MetMet: 0.194 ± 0.011	0.273MetAsn: 0.273 ± 0.012	0.918MetPro: 0.918 ± 0.026	0.343MetGln: 0.343 ± 0.013	1.226MetArg: 1.226 ± 0.025	1.072MetSer: 1.072 ± 0.023	1.311MetThr: 1.311 ± 0.028	1.26MetVal: 1.26 ± 0.024	0.154MetTrp: 0.154 ± 0.008	0.193MetTyr: 0.193 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	2.081AsnAla: 2.081 ± 0.036	0.13AsnCys: 0.13 ± 0.008	0.8AsnAsp: 0.8 ± 0.026	0.572AsnGlu: 0.572 ± 0.018	0.393AsnPhe: 0.393 ± 0.013	1.59AsnGly: 1.59 ± 0.032	0.342AsnHis: 0.342 ± 0.013	0.463AsnIle: 0.463 ± 0.016	0.303AsnLys: 0.303 ± 0.012	1.604AsnLeu: 1.604 ± 0.032	0.208AsnMet: 0.208 ± 0.01	0.363AsnAsn: 0.363 ± 0.018	1.44AsnPro: 1.44 ± 0.029	0.51AsnGln: 0.51 ± 0.016	1.199AsnArg: 1.199 ± 0.023	0.777AsnSer: 0.777 ± 0.024	1.015AsnThr: 1.015 ± 0.034	1.104AsnVal: 1.104 ± 0.027	0.223AsnTrp: 0.223 ± 0.011	0.362AsnTyr: 0.362 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	9.464ProAla: 9.464 ± 0.096	0.301ProCys: 0.301 ± 0.013	4.72ProAsp: 4.72 ± 0.062	3.986ProGlu: 3.986 ± 0.054	1.532ProPhe: 1.532 ± 0.027	7.163ProGly: 7.163 ± 0.073	1.348ProHis: 1.348 ± 0.028	1.278ProIle: 1.278 ± 0.025	0.904ProLys: 0.904 ± 0.022	5.448ProLeu: 5.448 ± 0.064	0.875ProMet: 0.875 ± 0.024	0.918ProAsn: 0.918 ± 0.023	3.775ProPro: 3.775 ± 0.069	1.658ProGln: 1.658 ± 0.036	4.171ProArg: 4.171 ± 0.043	2.719ProSer: 2.719 ± 0.043	3.872ProThr: 3.872 ± 0.054	6.27ProVal: 6.27 ± 0.076	0.954ProTrp: 0.954 ± 0.024	0.93ProTyr: 0.93 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	3.805GlnAla: 3.805 ± 0.048	0.156GlnCys: 0.156 ± 0.008	1.38GlnAsp: 1.38 ± 0.03	1.174GlnGlu: 1.174 ± 0.033	0.71GlnPhe: 0.71 ± 0.023	2.103GlnGly: 2.103 ± 0.041	0.595GlnHis: 0.595 ± 0.017	0.639GlnIle: 0.639 ± 0.02	0.422GlnLys: 0.422 ± 0.017	2.865GlnLeu: 2.865 ± 0.043	0.324GlnMet: 0.324 ± 0.014	0.419GlnAsn: 0.419 ± 0.016	1.613GlnPro: 1.613 ± 0.036	1.151GlnGln: 1.151 ± 0.036	2.578GlnArg: 2.578 ± 0.038	1.048GlnSer: 1.048 ± 0.026	1.153GlnThr: 1.153 ± 0.022	3.043GlnVal: 3.043 ± 0.043	0.445GlnTrp: 0.445 ± 0.016	0.467GlnTyr: 0.467 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	11.532ArgAla: 11.532 ± 0.1	0.598ArgCys: 0.598 ± 0.021	4.309ArgAsp: 4.309 ± 0.051	4.475ArgGlu: 4.475 ± 0.046	2.636ArgPhe: 2.636 ± 0.04	6.609ArgGly: 6.609 ± 0.06	1.799ArgHis: 1.799 ± 0.03	2.216ArgIle: 2.216 ± 0.039	1.426ArgLys: 1.426 ± 0.029	8.503ArgLeu: 8.503 ± 0.073	1.579ArgMet: 1.579 ± 0.027	1.134ArgAsn: 1.134 ± 0.025	4.63ArgPro: 4.63 ± 0.058	1.974ArgGln: 1.974 ± 0.036	7.053ArgArg: 7.053 ± 0.083	3.783ArgSer: 3.783 ± 0.043	4.908ArgThr: 4.908 ± 0.051	7.82ArgVal: 7.82 ± 0.069	1.5ArgTrp: 1.5 ± 0.029	1.625ArgTyr: 1.625 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	6.807SerAla: 6.807 ± 0.068	0.392SerCys: 0.392 ± 0.015	2.386SerAsp: 2.386 ± 0.037	1.854SerGlu: 1.854 ± 0.029	1.384SerPhe: 1.384 ± 0.03	5.602SerGly: 5.602 ± 0.059	0.776SerHis: 0.776 ± 0.017	1.312SerIle: 1.312 ± 0.024	0.749SerLys: 0.749 ± 0.021	4.429SerLeu: 4.429 ± 0.05	0.842SerMet: 0.842 ± 0.024	0.784SerAsn: 0.784 ± 0.021	2.919SerPro: 2.919 ± 0.033	1.067SerGln: 1.067 ± 0.024	3.22SerArg: 3.22 ± 0.04	2.496SerSer: 2.496 ± 0.042	3.442SerThr: 3.442 ± 0.06	4.092SerVal: 4.092 ± 0.046	0.906SerTrp: 0.906 ± 0.02	0.983SerTyr: 0.983 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	9.921ThrAla: 9.921 ± 0.122	0.454ThrCys: 0.454 ± 0.02	3.53ThrAsp: 3.53 ± 0.045	3.002ThrGlu: 3.002 ± 0.036	1.462ThrPhe: 1.462 ± 0.028	7.158ThrGly: 7.158 ± 0.074	1.133ThrHis: 1.133 ± 0.025	1.646ThrIle: 1.646 ± 0.037	0.972ThrLys: 0.972 ± 0.029	5.36ThrLeu: 5.36 ± 0.063	0.755ThrMet: 0.755 ± 0.02	0.969ThrAsn: 0.969 ± 0.025	4.626ThrPro: 4.626 ± 0.068	1.234ThrGln: 1.234 ± 0.027	4.334ThrArg: 4.334 ± 0.045	3.1ThrSer: 3.1 ± 0.053	5.093ThrThr: 5.093 ± 0.107	5.281ThrVal: 5.281 ± 0.082	0.935ThrTrp: 0.935 ± 0.02	1.18ThrTyr: 1.18 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	13.355ValAla: 13.355 ± 0.1	0.724ValCys: 0.724 ± 0.019	6.977ValAsp: 6.977 ± 0.06	5.734ValGlu: 5.734 ± 0.055	2.594ValPhe: 2.594 ± 0.038	7.719ValGly: 7.719 ± 0.075	2.158ValHis: 2.158 ± 0.032	2.503ValIle: 2.503 ± 0.041	1.494ValLys: 1.494 ± 0.029	11.729ValLeu: 11.729 ± 0.092	1.162ValMet: 1.162 ± 0.025	1.613ValAsn: 1.613 ± 0.029	5.744ValPro: 5.744 ± 0.064	2.108ValGln: 2.108 ± 0.036	7.968ValArg: 7.968 ± 0.064	4.429ValSer: 4.429 ± 0.056	5.446ValThr: 5.446 ± 0.087	11.626ValVal: 11.626 ± 0.096	1.095ValTrp: 1.095 ± 0.025	1.355ValTyr: 1.355 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	1.869TrpAla: 1.869 ± 0.031	0.145TrpCys: 0.145 ± 0.008	0.831TrpAsp: 0.831 ± 0.023	0.663TrpGlu: 0.663 ± 0.02	0.492TrpPhe: 0.492 ± 0.019	1.113TrpGly: 1.113 ± 0.029	0.332TrpHis: 0.332 ± 0.013	0.358TrpIle: 0.358 ± 0.012	0.245TrpLys: 0.245 ± 0.012	1.791TrpLeu: 1.791 ± 0.031	0.229TrpMet: 0.229 ± 0.012	0.274TrpAsn: 0.274 ± 0.011	0.814TrpPro: 0.814 ± 0.02	0.562TrpGln: 0.562 ± 0.017	1.365TrpArg: 1.365 ± 0.031	0.924TrpSer: 0.924 ± 0.022	0.918TrpThr: 0.918 ± 0.021	1.355TrpVal: 1.355 ± 0.028	0.318TrpTrp: 0.318 ± 0.013	0.271TrpTyr: 0.271 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.327TyrAla: 2.327 ± 0.036	0.155TyrCys: 0.155 ± 0.009	1.156TyrAsp: 1.156 ± 0.029	0.785TyrGlu: 0.785 ± 0.02	0.529TyrPhe: 0.529 ± 0.017	1.729TyrGly: 1.729 ± 0.034	0.383TyrHis: 0.383 ± 0.013	0.324TyrIle: 0.324 ± 0.014	0.264TyrLys: 0.264 ± 0.012	1.986TyrLeu: 1.986 ± 0.038	0.159TyrMet: 0.159 ± 0.009	0.316TyrAsn: 0.316 ± 0.013	1.034TyrPro: 1.034 ± 0.021	0.566TyrGln: 0.566 ± 0.017	1.614TyrArg: 1.614 ± 0.03	0.878TyrSer: 0.878 ± 0.021	1.09TyrThr: 1.09 ± 0.028	1.283TyrVal: 1.283 ± 0.026	0.307TyrTrp: 0.307 ± 0.011	0.385TyrTyr: 0.385 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6172 proteins (2152045 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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