Amino acid dipepetide frequency for Porcine deltacoronavirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.903AlaAla: 4.903 ± 0.801
2.272AlaCys: 2.272 ± 0.512
3.946AlaAsp: 3.946 ± 1.037
2.511AlaGlu: 2.511 ± 0.522
4.066AlaPhe: 4.066 ± 0.675
3.468AlaGly: 3.468 ± 1.224
2.392AlaHis: 2.392 ± 0.797
5.979AlaIle: 5.979 ± 0.808
4.664AlaLys: 4.664 ± 1.488
8.491AlaLeu: 8.491 ± 0.691
1.913AlaMet: 1.913 ± 0.487
4.784AlaAsn: 4.784 ± 0.906
2.392AlaPro: 2.392 ± 0.838
3.348AlaGln: 3.348 ± 1.319
3.348AlaArg: 3.348 ± 0.526
4.425AlaSer: 4.425 ± 1.351
5.979AlaThr: 5.979 ± 1.256
5.262AlaVal: 5.262 ± 1.422
0.239AlaTrp: 0.239 ± 0.474
2.751AlaTyr: 2.751 ± 0.95
0.0AlaXaa: 0.0 ± 0.0
Cys
1.435CysAla: 1.435 ± 0.748
0.957CysCys: 0.957 ± 0.34
1.196CysAsp: 1.196 ± 0.447
0.957CysGlu: 0.957 ± 0.34
1.794CysPhe: 1.794 ± 0.514
1.435CysGly: 1.435 ± 0.664
0.239CysHis: 0.239 ± 0.582
1.794CysIle: 1.794 ± 0.773
0.957CysLys: 0.957 ± 0.498
1.555CysLeu: 1.555 ± 0.708
0.598CysMet: 0.598 ± 0.312
1.674CysAsn: 1.674 ± 0.966
1.435CysPro: 1.435 ± 0.565
0.837CysGln: 0.837 ± 0.282
0.837CysArg: 0.837 ± 0.436
1.794CysSer: 1.794 ± 1.263
1.674CysThr: 1.674 ± 0.84
2.153CysVal: 2.153 ± 0.537
0.359CysTrp: 0.359 ± 0.187
1.196CysTyr: 1.196 ± 0.727
0.0CysXaa: 0.0 ± 0.0
Asp
4.664AspAla: 4.664 ± 1.134
1.435AspCys: 1.435 ± 0.469
2.99AspAsp: 2.99 ± 0.676
2.033AspGlu: 2.033 ± 0.976
2.392AspPhe: 2.392 ± 0.557
3.348AspGly: 3.348 ± 0.978
0.598AspHis: 0.598 ± 0.422
3.348AspIle: 3.348 ± 1.227
2.153AspLys: 2.153 ± 0.83
4.425AspLeu: 4.425 ± 1.384
0.837AspMet: 0.837 ± 0.361
3.229AspAsn: 3.229 ± 1.171
2.392AspPro: 2.392 ± 1.18
1.794AspGln: 1.794 ± 0.505
1.435AspArg: 1.435 ± 0.776
3.946AspSer: 3.946 ± 0.927
3.348AspThr: 3.348 ± 0.687
4.425AspVal: 4.425 ± 1.238
0.718AspTrp: 0.718 ± 0.698
3.109AspTyr: 3.109 ± 0.868
0.0AspXaa: 0.0 ± 0.0
Glu
2.511GluAla: 2.511 ± 0.706
1.196GluCys: 1.196 ± 0.447
2.511GluAsp: 2.511 ± 1.423
2.153GluGlu: 2.153 ± 0.789
2.033GluPhe: 2.033 ± 0.916
1.913GluGly: 1.913 ± 0.599
1.196GluHis: 1.196 ± 0.623
2.033GluIle: 2.033 ± 0.522
1.674GluLys: 1.674 ± 0.489
4.544GluLeu: 4.544 ± 1.107
1.076GluMet: 1.076 ± 0.38
1.794GluAsn: 1.794 ± 0.439
2.033GluPro: 2.033 ± 0.523
1.794GluGln: 1.794 ± 0.616
1.794GluArg: 1.794 ± 0.566
2.153GluSer: 2.153 ± 0.909
2.272GluThr: 2.272 ± 0.749
3.109GluVal: 3.109 ± 0.785
0.718GluTrp: 0.718 ± 0.716
2.033GluTyr: 2.033 ± 0.645
0.0GluXaa: 0.0 ± 0.0
Phe
3.348PheAla: 3.348 ± 0.759
1.196PheCys: 1.196 ± 0.39
2.751PheAsp: 2.751 ± 1.071
1.794PheGlu: 1.794 ± 0.746
1.076PhePhe: 1.076 ± 0.498
2.272PheGly: 2.272 ± 0.586
0.598PheHis: 0.598 ± 0.414
2.87PheIle: 2.87 ± 1.884
2.033PheLys: 2.033 ± 0.537
3.946PheLeu: 3.946 ± 1.319
0.598PheMet: 0.598 ± 0.345
3.229PheAsn: 3.229 ± 0.83
1.555PhePro: 1.555 ± 0.536
1.435PheGln: 1.435 ± 0.518
1.555PheArg: 1.555 ± 0.602
3.109PheSer: 3.109 ± 0.987
3.468PheThr: 3.468 ± 0.777
2.87PheVal: 2.87 ± 0.815
0.239PheTrp: 0.239 ± 0.125
3.468PheTyr: 3.468 ± 0.585
0.0PheXaa: 0.0 ± 0.0
Gly
3.468GlyAla: 3.468 ± 0.976
1.555GlyCys: 1.555 ± 0.845
2.87GlyAsp: 2.87 ± 0.816
2.033GlyGlu: 2.033 ± 0.862
1.913GlyPhe: 1.913 ± 0.46
2.631GlyGly: 2.631 ± 0.592
0.837GlyHis: 0.837 ± 0.253
3.946GlyIle: 3.946 ± 0.927
2.99GlyLys: 2.99 ± 0.717
2.99GlyLeu: 2.99 ± 0.99
0.478GlyMet: 0.478 ± 0.325
2.99GlyAsn: 2.99 ± 1.059
1.674GlyPro: 1.674 ± 0.8
1.555GlyGln: 1.555 ± 0.76
1.794GlyArg: 1.794 ± 0.417
3.348GlySer: 3.348 ± 1.146
4.903GlyThr: 4.903 ± 0.764
5.023GlyVal: 5.023 ± 0.929
0.478GlyTrp: 0.478 ± 0.249
1.913GlyTyr: 1.913 ± 0.393
0.0GlyXaa: 0.0 ± 0.0
His
2.033HisAla: 2.033 ± 0.724
0.359HisCys: 0.359 ± 0.187
0.837HisAsp: 0.837 ± 0.282
0.957HisGlu: 0.957 ± 0.335
1.315HisPhe: 1.315 ± 0.506
0.837HisGly: 0.837 ± 1.05
0.478HisHis: 0.478 ± 0.249
2.033HisIle: 2.033 ± 0.517
1.196HisLys: 1.196 ± 0.447
2.751HisLeu: 2.751 ± 0.568
0.718HisMet: 0.718 ± 0.388
0.957HisAsn: 0.957 ± 0.34
1.076HisPro: 1.076 ± 0.463
1.196HisGln: 1.196 ± 1.071
0.718HisArg: 0.718 ± 0.332
0.837HisSer: 0.837 ± 0.282
1.794HisThr: 1.794 ± 0.372
2.511HisVal: 2.511 ± 0.998
0.0HisTrp: 0.0 ± 0.0
0.837HisTyr: 0.837 ± 0.822
0.0HisXaa: 0.0 ± 0.0
Ile
4.425IleAla: 4.425 ± 0.861
1.315IleCys: 1.315 ± 0.487
3.588IleAsp: 3.588 ± 0.711
2.033IleGlu: 2.033 ± 0.724
2.272IlePhe: 2.272 ± 0.454
2.392IleGly: 2.392 ± 0.796
0.957IleHis: 0.957 ± 0.498
4.066IleIle: 4.066 ± 2.334
3.229IleLys: 3.229 ± 0.775
6.338IleLeu: 6.338 ± 2.868
1.315IleMet: 1.315 ± 0.455
2.99IleAsn: 2.99 ± 0.98
3.588IlePro: 3.588 ± 0.523
2.511IleGln: 2.511 ± 0.868
2.631IleArg: 2.631 ± 1.083
4.186IleSer: 4.186 ± 0.818
3.707IleThr: 3.707 ± 1.558
4.903IleVal: 4.903 ± 0.989
0.598IleTrp: 0.598 ± 0.957
2.751IleTyr: 2.751 ± 0.835
0.12IleXaa: 0.12 ± 0.219
Lys
4.664LysAla: 4.664 ± 1.89
1.435LysCys: 1.435 ± 0.654
2.153LysAsp: 2.153 ± 0.907
1.674LysGlu: 1.674 ± 0.489
2.272LysPhe: 2.272 ± 0.749
1.794LysGly: 1.794 ± 0.566
1.196LysHis: 1.196 ± 0.495
2.99LysIle: 2.99 ± 0.735
2.99LysLys: 2.99 ± 1.314
4.305LysLeu: 4.305 ± 1.475
0.598LysMet: 0.598 ± 0.195
1.913LysAsn: 1.913 ± 0.621
4.664LysPro: 4.664 ± 2.08
1.555LysGln: 1.555 ± 1.165
1.794LysArg: 1.794 ± 0.969
2.511LysSer: 2.511 ± 0.455
4.664LysThr: 4.664 ± 1.14
2.87LysVal: 2.87 ± 0.769
0.359LysTrp: 0.359 ± 0.166
2.631LysTyr: 2.631 ± 0.775
0.0LysXaa: 0.0 ± 0.0
Leu
9.926LeuAla: 9.926 ± 1.186
1.674LeuCys: 1.674 ± 0.458
3.946LeuAsp: 3.946 ± 1.393
3.707LeuGlu: 3.707 ± 0.826
4.186LeuPhe: 4.186 ± 1.04
3.707LeuGly: 3.707 ± 0.649
2.272LeuHis: 2.272 ± 1.315
3.827LeuIle: 3.827 ± 1.55
4.784LeuLys: 4.784 ± 1.289
8.73LeuLeu: 8.73 ± 2.807
2.153LeuMet: 2.153 ± 1.122
5.74LeuAsn: 5.74 ± 1.179
5.979LeuPro: 5.979 ± 1.833
5.979LeuGln: 5.979 ± 1.282
3.468LeuArg: 3.468 ± 1.905
5.381LeuSer: 5.381 ± 1.201
8.252LeuThr: 8.252 ± 1.534
6.338LeuVal: 6.338 ± 2.011
0.478LeuTrp: 0.478 ± 0.426
5.262LeuTyr: 5.262 ± 0.746
0.0LeuXaa: 0.0 ± 0.0
Met
2.392MetAla: 2.392 ± 1.206
0.718MetCys: 0.718 ± 0.51
0.478MetAsp: 0.478 ± 0.463
0.598MetGlu: 0.598 ± 0.37
0.837MetPhe: 0.837 ± 0.282
0.957MetGly: 0.957 ± 0.435
0.718MetHis: 0.718 ± 0.234
0.478MetIle: 0.478 ± 0.363
0.598MetLys: 0.598 ± 0.422
2.272MetLeu: 2.272 ± 0.606
0.359MetMet: 0.359 ± 0.348
0.837MetAsn: 0.837 ± 0.282
0.598MetPro: 0.598 ± 0.37
0.598MetGln: 0.598 ± 0.195
0.598MetArg: 0.598 ± 0.312
1.196MetSer: 1.196 ± 0.566
0.957MetThr: 0.957 ± 0.335
2.153MetVal: 2.153 ± 0.761
0.12MetTrp: 0.12 ± 0.062
0.837MetTyr: 0.837 ± 0.528
0.12MetXaa: 0.12 ± 0.062
Asn
4.305AsnAla: 4.305 ± 0.728
1.435AsnCys: 1.435 ± 0.458
1.435AsnAsp: 1.435 ± 0.411
2.153AsnGlu: 2.153 ± 0.929
2.153AsnPhe: 2.153 ± 0.745
4.305AsnGly: 4.305 ± 1.117
1.196AsnHis: 1.196 ± 0.304
2.631AsnIle: 2.631 ± 0.864
2.87AsnLys: 2.87 ± 0.611
5.86AsnLeu: 5.86 ± 1.141
1.315AsnMet: 1.315 ± 0.457
3.588AsnAsn: 3.588 ± 1.523
2.272AsnPro: 2.272 ± 1.533
2.99AsnGln: 2.99 ± 0.885
2.751AsnArg: 2.751 ± 0.379
3.109AsnSer: 3.109 ± 1.24
4.066AsnThr: 4.066 ± 1.585
4.425AsnVal: 4.425 ± 1.674
0.12AsnTrp: 0.12 ± 0.062
2.392AsnTyr: 2.392 ± 0.988
0.0AsnXaa: 0.0 ± 0.0
Pro
2.392ProAla: 2.392 ± 1.181
0.718ProCys: 0.718 ± 0.234
2.511ProAsp: 2.511 ± 0.524
3.348ProGlu: 3.348 ± 1.938
1.794ProPhe: 1.794 ± 1.277
3.468ProGly: 3.468 ± 0.587
1.315ProHis: 1.315 ± 0.525
3.946ProIle: 3.946 ± 1.061
2.87ProLys: 2.87 ± 1.32
3.588ProLeu: 3.588 ± 1.2
0.837ProMet: 0.837 ± 0.979
2.99ProAsn: 2.99 ± 0.619
3.348ProPro: 3.348 ± 0.772
2.392ProGln: 2.392 ± 0.635
2.153ProArg: 2.153 ± 1.929
3.588ProSer: 3.588 ± 1.735
4.425ProThr: 4.425 ± 0.973
2.99ProVal: 2.99 ± 1.111
0.359ProTrp: 0.359 ± 0.166
1.435ProTyr: 1.435 ± 0.565
0.0ProXaa: 0.0 ± 0.0
Gln
3.588GlnAla: 3.588 ± 0.602
0.478GlnCys: 0.478 ± 0.249
1.913GlnAsp: 1.913 ± 0.74
2.033GlnGlu: 2.033 ± 0.875
1.435GlnPhe: 1.435 ± 0.879
1.435GlnGly: 1.435 ± 0.861
1.435GlnHis: 1.435 ± 0.387
2.153GlnIle: 2.153 ± 0.43
1.435GlnLys: 1.435 ± 0.529
5.979GlnLeu: 5.979 ± 0.923
0.837GlnMet: 0.837 ± 0.282
2.153GlnAsn: 2.153 ± 0.557
2.631GlnPro: 2.631 ± 0.673
2.631GlnGln: 2.631 ± 0.458
1.555GlnArg: 1.555 ± 0.659
3.707GlnSer: 3.707 ± 0.947
3.348GlnThr: 3.348 ± 1.339
2.392GlnVal: 2.392 ± 1.134
0.598GlnTrp: 0.598 ± 0.195
2.033GlnTyr: 2.033 ± 0.488
0.12GlnXaa: 0.12 ± 0.062
Arg
2.87ArgAla: 2.87 ± 0.606
1.555ArgCys: 1.555 ± 0.634
1.794ArgAsp: 1.794 ± 0.487
1.674ArgGlu: 1.674 ± 0.567
2.272ArgPhe: 2.272 ± 0.61
1.794ArgGly: 1.794 ± 1.492
1.315ArgHis: 1.315 ± 0.579
1.794ArgIle: 1.794 ± 0.417
1.435ArgLys: 1.435 ± 0.766
4.425ArgLeu: 4.425 ± 2.137
0.239ArgMet: 0.239 ± 0.125
2.272ArgAsn: 2.272 ± 1.04
1.555ArgPro: 1.555 ± 1.192
2.153ArgGln: 2.153 ± 0.578
1.315ArgArg: 1.315 ± 1.06
2.272ArgSer: 2.272 ± 1.245
2.751ArgThr: 2.751 ± 0.638
2.751ArgVal: 2.751 ± 1.231
0.239ArgTrp: 0.239 ± 0.125
1.794ArgTyr: 1.794 ± 0.637
0.0ArgXaa: 0.0 ± 0.0
Ser
5.621SerAla: 5.621 ± 1.499
0.718SerCys: 0.718 ± 0.44
4.066SerAsp: 4.066 ± 0.736
1.555SerGlu: 1.555 ± 0.619
2.751SerPhe: 2.751 ± 0.894
3.468SerGly: 3.468 ± 0.658
0.718SerHis: 0.718 ± 0.332
2.99SerIle: 2.99 ± 1.842
2.033SerLys: 2.033 ± 0.979
6.458SerLeu: 6.458 ± 1.274
1.076SerMet: 1.076 ± 0.331
2.511SerAsn: 2.511 ± 0.812
2.99SerPro: 2.99 ± 0.731
2.87SerGln: 2.87 ± 1.224
2.153SerArg: 2.153 ± 1.165
3.946SerSer: 3.946 ± 1.284
5.262SerThr: 5.262 ± 1.197
5.501SerVal: 5.501 ± 0.958
1.076SerTrp: 1.076 ± 0.705
3.468SerTyr: 3.468 ± 0.881
0.0SerXaa: 0.0 ± 0.0
Thr
5.74ThrAla: 5.74 ± 1.487
1.794ThrCys: 1.794 ± 0.58
5.262ThrAsp: 5.262 ± 1.504
2.631ThrGlu: 2.631 ± 0.664
3.348ThrPhe: 3.348 ± 1.08
3.946ThrGly: 3.946 ± 2.452
2.631ThrHis: 2.631 ± 0.456
5.621ThrIle: 5.621 ± 0.607
3.468ThrLys: 3.468 ± 0.793
6.697ThrLeu: 6.697 ± 0.974
1.555ThrMet: 1.555 ± 0.478
3.946ThrAsn: 3.946 ± 1.181
5.023ThrPro: 5.023 ± 1.558
2.392ThrGln: 2.392 ± 0.575
3.109ThrArg: 3.109 ± 1.182
4.664ThrSer: 4.664 ± 1.521
6.936ThrThr: 6.936 ± 1.382
6.817ThrVal: 6.817 ± 1.814
0.718ThrTrp: 0.718 ± 0.547
3.468ThrTyr: 3.468 ± 0.897
0.0ThrXaa: 0.0 ± 0.0
Val
5.621ValAla: 5.621 ± 1.713
2.272ValCys: 2.272 ± 0.837
4.903ValAsp: 4.903 ± 0.595
4.425ValGlu: 4.425 ± 0.638
2.511ValPhe: 2.511 ± 0.66
4.305ValGly: 4.305 ± 1.162
1.794ValHis: 1.794 ± 0.58
4.784ValIle: 4.784 ± 1.76
5.023ValLys: 5.023 ± 1.532
6.577ValLeu: 6.577 ± 0.921
0.718ValMet: 0.718 ± 0.545
4.066ValAsn: 4.066 ± 0.835
2.99ValPro: 2.99 ± 1.552
2.99ValGln: 2.99 ± 0.751
2.87ValArg: 2.87 ± 1.057
4.186ValSer: 4.186 ± 0.912
6.697ValThr: 6.697 ± 0.674
10.165ValVal: 10.165 ± 1.509
0.598ValTrp: 0.598 ± 0.339
3.229ValTyr: 3.229 ± 1.174
0.0ValXaa: 0.0 ± 0.0
Trp
0.837TrpAla: 0.837 ± 1.787
0.0TrpCys: 0.0 ± 0.0
0.837TrpAsp: 0.837 ± 0.253
0.478TrpGlu: 0.478 ± 0.288
0.837TrpPhe: 0.837 ± 0.345
0.12TrpGly: 0.12 ± 0.062
0.239TrpHis: 0.239 ± 0.125
0.478TrpIle: 0.478 ± 0.249
0.0TrpLys: 0.0 ± 0.0
1.315TrpLeu: 1.315 ± 1.059
0.12TrpMet: 0.12 ± 0.173
0.359TrpAsn: 0.359 ± 0.166
0.239TrpPro: 0.239 ± 0.184
0.12TrpGln: 0.12 ± 0.507
0.359TrpArg: 0.359 ± 0.507
0.239TrpSer: 0.239 ± 0.125
0.837TrpThr: 0.837 ± 0.419
0.478TrpVal: 0.478 ± 0.288
0.12TrpTrp: 0.12 ± 0.062
0.359TrpTyr: 0.359 ± 0.507
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.392TyrAla: 2.392 ± 0.382
1.794TyrCys: 1.794 ± 0.585
2.631TyrAsp: 2.631 ± 0.872
1.794TyrGlu: 1.794 ± 0.566
2.153TyrPhe: 2.153 ± 0.929
1.794TyrGly: 1.794 ± 1.114
1.315TyrHis: 1.315 ± 0.685
2.153TyrIle: 2.153 ± 0.547
2.631TyrLys: 2.631 ± 0.752
4.544TyrLeu: 4.544 ± 1.048
0.957TyrMet: 0.957 ± 0.434
3.348TyrAsn: 3.348 ± 1.087
2.033TyrPro: 2.033 ± 0.687
2.631TyrGln: 2.631 ± 0.563
2.033TyrArg: 2.033 ± 0.517
2.631TyrSer: 2.631 ± 0.988
4.305TyrThr: 4.305 ± 0.642
3.588TyrVal: 3.588 ± 0.865
0.359TyrTrp: 0.359 ± 0.648
1.913TyrTyr: 1.913 ± 0.552
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.12XaaGln: 0.12 ± 0.062
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.12XaaThr: 0.12 ± 0.219
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.12XaaTyr: 0.12 ± 0.062
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (8363 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski