Amino acid dipepetide frequency for Mucilaginibacter sp. dk17

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.572AlaAla: 7.572 ± 0.099
0.729AlaCys: 0.729 ± 0.025
5.22AlaAsp: 5.22 ± 0.064
4.591AlaGlu: 4.591 ± 0.076
3.729AlaPhe: 3.729 ± 0.055
6.305AlaGly: 6.305 ± 0.078
1.324AlaHis: 1.324 ± 0.032
5.864AlaIle: 5.864 ± 0.062
5.264AlaLys: 5.264 ± 0.087
7.493AlaLeu: 7.493 ± 0.086
2.001AlaMet: 2.001 ± 0.039
4.324AlaAsn: 4.324 ± 0.066
2.638AlaPro: 2.638 ± 0.052
3.245AlaGln: 3.245 ± 0.051
2.813AlaArg: 2.813 ± 0.05
4.612AlaSer: 4.612 ± 0.063
4.595AlaThr: 4.595 ± 0.078
5.46AlaVal: 5.46 ± 0.065
0.819AlaTrp: 0.819 ± 0.025
3.1AlaTyr: 3.1 ± 0.057
0.0AlaXaa: 0.0 ± 0.0
Cys
0.585CysAla: 0.585 ± 0.022
0.13CysCys: 0.13 ± 0.011
0.381CysAsp: 0.381 ± 0.017
0.351CysGlu: 0.351 ± 0.017
0.436CysPhe: 0.436 ± 0.021
0.636CysGly: 0.636 ± 0.023
0.186CysHis: 0.186 ± 0.014
0.601CysIle: 0.601 ± 0.021
0.456CysLys: 0.456 ± 0.02
0.753CysLeu: 0.753 ± 0.026
0.173CysMet: 0.173 ± 0.012
0.389CysAsn: 0.389 ± 0.019
0.303CysPro: 0.303 ± 0.015
0.209CysGln: 0.209 ± 0.013
0.334CysArg: 0.334 ± 0.018
0.505CysSer: 0.505 ± 0.021
0.433CysThr: 0.433 ± 0.021
0.482CysVal: 0.482 ± 0.022
0.088CysTrp: 0.088 ± 0.007
0.299CysTyr: 0.299 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
4.539AspAla: 4.539 ± 0.062
0.376AspCys: 0.376 ± 0.019
2.967AspAsp: 2.967 ± 0.058
3.551AspGlu: 3.551 ± 0.064
3.002AspPhe: 3.002 ± 0.048
3.84AspGly: 3.84 ± 0.066
0.988AspHis: 0.988 ± 0.032
4.121AspIle: 4.121 ± 0.06
3.945AspLys: 3.945 ± 0.057
4.749AspLeu: 4.749 ± 0.064
1.307AspMet: 1.307 ± 0.038
2.886AspAsn: 2.886 ± 0.049
1.937AspPro: 1.937 ± 0.039
1.648AspGln: 1.648 ± 0.04
2.109AspArg: 2.109 ± 0.048
2.891AspSer: 2.891 ± 0.055
2.885AspThr: 2.885 ± 0.046
3.803AspVal: 3.803 ± 0.062
0.746AspTrp: 0.746 ± 0.027
2.496AspTyr: 2.496 ± 0.049
0.0AspXaa: 0.0 ± 0.0
Glu
4.361GluAla: 4.361 ± 0.066
0.301GluCys: 0.301 ± 0.016
2.588GluAsp: 2.588 ± 0.054
3.145GluGlu: 3.145 ± 0.068
2.266GluPhe: 2.266 ± 0.048
3.179GluGly: 3.179 ± 0.06
1.081GluHis: 1.081 ± 0.034
3.905GluIle: 3.905 ± 0.058
4.074GluLys: 4.074 ± 0.061
5.544GluLeu: 5.544 ± 0.079
1.422GluMet: 1.422 ± 0.04
2.836GluAsn: 2.836 ± 0.051
1.723GluPro: 1.723 ± 0.043
2.484GluGln: 2.484 ± 0.057
2.51GluArg: 2.51 ± 0.055
2.587GluSer: 2.587 ± 0.049
2.7GluThr: 2.7 ± 0.046
3.581GluVal: 3.581 ± 0.047
0.57GluTrp: 0.57 ± 0.021
1.942GluTyr: 1.942 ± 0.038
0.0GluXaa: 0.0 ± 0.0
Phe
3.78PheAla: 3.78 ± 0.053
0.456PheCys: 0.456 ± 0.018
3.055PheAsp: 3.055 ± 0.047
2.637PheGlu: 2.637 ± 0.054
2.299PhePhe: 2.299 ± 0.051
3.503PheGly: 3.503 ± 0.052
0.757PheHis: 0.757 ± 0.029
3.423PheIle: 3.423 ± 0.061
3.383PheLys: 3.383 ± 0.051
4.066PheLeu: 4.066 ± 0.066
1.103PheMet: 1.103 ± 0.029
3.037PheAsn: 3.037 ± 0.065
1.67PhePro: 1.67 ± 0.037
1.208PheGln: 1.208 ± 0.03
1.701PheArg: 1.701 ± 0.036
3.252PheSer: 3.252 ± 0.065
3.229PheThr: 3.229 ± 0.062
2.943PheVal: 2.943 ± 0.058
0.547PheTrp: 0.547 ± 0.019
2.098PheTyr: 2.098 ± 0.046
0.0PheXaa: 0.0 ± 0.0
Gly
5.012GlyAla: 5.012 ± 0.072
0.593GlyCys: 0.593 ± 0.023
3.426GlyAsp: 3.426 ± 0.064
3.177GlyGlu: 3.177 ± 0.048
3.635GlyPhe: 3.635 ± 0.051
5.092GlyGly: 5.092 ± 0.087
1.326GlyHis: 1.326 ± 0.04
5.306GlyIle: 5.306 ± 0.062
5.157GlyLys: 5.157 ± 0.072
6.19GlyLeu: 6.19 ± 0.078
1.675GlyMet: 1.675 ± 0.038
3.835GlyAsn: 3.835 ± 0.073
1.734GlyPro: 1.734 ± 0.036
2.489GlyGln: 2.489 ± 0.052
2.866GlyArg: 2.866 ± 0.049
4.418GlySer: 4.418 ± 0.063
4.112GlyThr: 4.112 ± 0.081
4.658GlyVal: 4.658 ± 0.068
0.984GlyTrp: 0.984 ± 0.031
3.222GlyTyr: 3.222 ± 0.052
0.0GlyXaa: 0.0 ± 0.0
His
1.178HisAla: 1.178 ± 0.033
0.163HisCys: 0.163 ± 0.011
1.027HisAsp: 1.027 ± 0.03
0.994HisGlu: 0.994 ± 0.029
1.089HisPhe: 1.089 ± 0.032
1.202HisGly: 1.202 ± 0.034
0.508HisHis: 0.508 ± 0.023
1.383HisIle: 1.383 ± 0.038
1.047HisLys: 1.047 ± 0.032
1.845HisLeu: 1.845 ± 0.042
0.416HisMet: 0.416 ± 0.015
0.98HisAsn: 0.98 ± 0.027
0.956HisPro: 0.956 ± 0.031
0.749HisGln: 0.749 ± 0.027
0.748HisArg: 0.748 ± 0.025
1.038HisSer: 1.038 ± 0.029
0.97HisThr: 0.97 ± 0.028
1.007HisVal: 1.007 ± 0.027
0.246HisTrp: 0.246 ± 0.013
0.857HisTyr: 0.857 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
6.381IleAla: 6.381 ± 0.085
0.702IleCys: 0.702 ± 0.024
4.299IleAsp: 4.299 ± 0.065
3.906IleGlu: 3.906 ± 0.067
3.03IlePhe: 3.03 ± 0.063
4.851IleGly: 4.851 ± 0.066
1.184IleHis: 1.184 ± 0.029
5.11IleIle: 5.11 ± 0.074
5.073IleLys: 5.073 ± 0.062
5.954IleLeu: 5.954 ± 0.079
1.343IleMet: 1.343 ± 0.035
4.42IleAsn: 4.42 ± 0.078
2.869IlePro: 2.869 ± 0.052
2.068IleGln: 2.068 ± 0.045
2.795IleArg: 2.795 ± 0.05
4.873IleSer: 4.873 ± 0.057
4.649IleThr: 4.649 ± 0.072
4.397IleVal: 4.397 ± 0.062
0.686IleTrp: 0.686 ± 0.026
2.673IleTyr: 2.673 ± 0.048
0.0IleXaa: 0.0 ± 0.0
Lys
5.716LysAla: 5.716 ± 0.077
0.329LysCys: 0.329 ± 0.017
3.841LysAsp: 3.841 ± 0.064
3.827LysGlu: 3.827 ± 0.073
2.709LysPhe: 2.709 ± 0.049
4.333LysGly: 4.333 ± 0.05
1.36LysHis: 1.36 ± 0.038
4.58LysIle: 4.58 ± 0.066
4.918LysLys: 4.918 ± 0.075
6.456LysLeu: 6.456 ± 0.077
1.789LysMet: 1.789 ± 0.039
3.909LysAsn: 3.909 ± 0.059
2.994LysPro: 2.994 ± 0.055
3.09LysGln: 3.09 ± 0.052
2.882LysArg: 2.882 ± 0.054
3.733LysSer: 3.733 ± 0.056
3.964LysThr: 3.964 ± 0.054
4.456LysVal: 4.456 ± 0.06
0.769LysTrp: 0.769 ± 0.027
2.866LysTyr: 2.866 ± 0.056
0.0LysXaa: 0.0 ± 0.0
Leu
7.475LeuAla: 7.475 ± 0.074
0.8LeuCys: 0.8 ± 0.029
4.623LeuAsp: 4.623 ± 0.062
4.32LeuGlu: 4.32 ± 0.07
4.559LeuPhe: 4.559 ± 0.068
5.868LeuGly: 5.868 ± 0.077
1.702LeuHis: 1.702 ± 0.043
6.525LeuIle: 6.525 ± 0.081
6.967LeuLys: 6.967 ± 0.083
9.45LeuLeu: 9.45 ± 0.129
2.293LeuMet: 2.293 ± 0.036
5.584LeuAsn: 5.584 ± 0.076
4.14LeuPro: 4.14 ± 0.06
3.866LeuGln: 3.866 ± 0.065
3.672LeuArg: 3.672 ± 0.056
6.545LeuSer: 6.545 ± 0.075
5.586LeuThr: 5.586 ± 0.071
5.619LeuVal: 5.619 ± 0.07
0.885LeuTrp: 0.885 ± 0.026
3.328LeuTyr: 3.328 ± 0.051
0.0LeuXaa: 0.0 ± 0.0
Met
2.084MetAla: 2.084 ± 0.042
0.145MetCys: 0.145 ± 0.012
1.187MetAsp: 1.187 ± 0.036
1.25MetGlu: 1.25 ± 0.036
0.908MetPhe: 0.908 ± 0.03
1.588MetGly: 1.588 ± 0.036
0.464MetHis: 0.464 ± 0.02
1.524MetIle: 1.524 ± 0.042
1.772MetLys: 1.772 ± 0.035
2.436MetLeu: 2.436 ± 0.047
0.618MetMet: 0.618 ± 0.024
1.156MetAsn: 1.156 ± 0.028
1.192MetPro: 1.192 ± 0.028
1.14MetGln: 1.14 ± 0.032
1.04MetArg: 1.04 ± 0.027
1.323MetSer: 1.323 ± 0.034
1.041MetThr: 1.041 ± 0.029
1.563MetVal: 1.563 ± 0.035
0.158MetTrp: 0.158 ± 0.011
0.663MetTyr: 0.663 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
4.382AsnAla: 4.382 ± 0.067
0.401AsnCys: 0.401 ± 0.02
3.01AsnAsp: 3.01 ± 0.05
2.836AsnGlu: 2.836 ± 0.045
2.728AsnPhe: 2.728 ± 0.061
4.013AsnGly: 4.013 ± 0.065
0.973AsnHis: 0.973 ± 0.031
4.141AsnIle: 4.141 ± 0.063
3.706AsnLys: 3.706 ± 0.066
4.952AsnLeu: 4.952 ± 0.066
1.251AsnMet: 1.251 ± 0.028
3.514AsnAsn: 3.514 ± 0.058
2.607AsnPro: 2.607 ± 0.045
2.076AsnGln: 2.076 ± 0.045
2.435AsnArg: 2.435 ± 0.048
3.178AsnSer: 3.178 ± 0.054
3.315AsnThr: 3.315 ± 0.064
3.473AsnVal: 3.473 ± 0.059
0.784AsnTrp: 0.784 ± 0.025
2.751AsnTyr: 2.751 ± 0.058
0.0AsnXaa: 0.0 ± 0.0
Pro
3.684ProAla: 3.684 ± 0.077
0.223ProCys: 0.223 ± 0.012
2.538ProAsp: 2.538 ± 0.052
2.63ProGlu: 2.63 ± 0.05
1.881ProPhe: 1.881 ± 0.04
2.932ProGly: 2.932 ± 0.046
0.702ProHis: 0.702 ± 0.024
2.273ProIle: 2.273 ± 0.042
2.21ProLys: 2.21 ± 0.045
3.293ProLeu: 3.293 ± 0.054
0.782ProMet: 0.782 ± 0.025
2.061ProAsn: 2.061 ± 0.038
1.153ProPro: 1.153 ± 0.043
1.547ProGln: 1.547 ± 0.038
1.119ProArg: 1.119 ± 0.029
2.183ProSer: 2.183 ± 0.042
2.018ProThr: 2.018 ± 0.044
3.433ProVal: 3.433 ± 0.063
0.43ProTrp: 0.43 ± 0.02
1.604ProTyr: 1.604 ± 0.043
0.0ProXaa: 0.0 ± 0.0
Gln
2.963GlnAla: 2.963 ± 0.061
0.185GlnCys: 0.185 ± 0.012
1.648GlnAsp: 1.648 ± 0.037
1.841GlnGlu: 1.841 ± 0.042
1.657GlnPhe: 1.657 ± 0.035
2.128GlnGly: 2.128 ± 0.047
0.832GlnHis: 0.832 ± 0.028
2.513GlnIle: 2.513 ± 0.047
2.604GlnLys: 2.604 ± 0.048
3.95GlnLeu: 3.95 ± 0.06
0.967GlnMet: 0.967 ± 0.033
2.083GlnAsn: 2.083 ± 0.049
1.697GlnPro: 1.697 ± 0.041
2.314GlnGln: 2.314 ± 0.104
1.702GlnArg: 1.702 ± 0.06
2.351GlnSer: 2.351 ± 0.046
2.278GlnThr: 2.278 ± 0.048
2.488GlnVal: 2.488 ± 0.05
0.413GlnTrp: 0.413 ± 0.018
1.557GlnTyr: 1.557 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
2.662ArgAla: 2.662 ± 0.037
0.244ArgCys: 0.244 ± 0.015
2.124ArgAsp: 2.124 ± 0.044
2.251ArgGlu: 2.251 ± 0.043
2.149ArgPhe: 2.149 ± 0.042
2.308ArgGly: 2.308 ± 0.047
0.738ArgHis: 0.738 ± 0.027
2.955ArgIle: 2.955 ± 0.05
2.856ArgLys: 2.856 ± 0.056
3.929ArgLeu: 3.929 ± 0.059
1.101ArgMet: 1.101 ± 0.035
2.286ArgAsn: 2.286 ± 0.049
1.426ArgPro: 1.426 ± 0.037
1.609ArgGln: 1.609 ± 0.051
1.803ArgArg: 1.803 ± 0.04
2.361ArgSer: 2.361 ± 0.044
2.074ArgThr: 2.074 ± 0.045
2.598ArgVal: 2.598 ± 0.046
0.519ArgTrp: 0.519 ± 0.024
1.911ArgTyr: 1.911 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
5.09SerAla: 5.09 ± 0.06
0.513SerCys: 0.513 ± 0.018
2.832SerAsp: 2.832 ± 0.048
2.732SerGlu: 2.732 ± 0.047
3.334SerPhe: 3.334 ± 0.047
4.663SerGly: 4.663 ± 0.066
1.07SerHis: 1.07 ± 0.03
4.44SerIle: 4.44 ± 0.06
3.908SerLys: 3.908 ± 0.077
5.826SerLeu: 5.826 ± 0.081
1.243SerMet: 1.243 ± 0.036
3.1SerAsn: 3.1 ± 0.05
2.363SerPro: 2.363 ± 0.045
2.099SerGln: 2.099 ± 0.042
2.46SerArg: 2.46 ± 0.046
3.726SerSer: 3.726 ± 0.066
3.495SerThr: 3.495 ± 0.06
4.316SerVal: 4.316 ± 0.066
0.664SerTrp: 0.664 ± 0.023
2.599SerTyr: 2.599 ± 0.054
0.0SerXaa: 0.0 ± 0.0
Thr
5.082ThrAla: 5.082 ± 0.072
0.381ThrCys: 0.381 ± 0.018
3.537ThrAsp: 3.537 ± 0.056
3.049ThrGlu: 3.049 ± 0.05
2.78ThrPhe: 2.78 ± 0.049
4.956ThrGly: 4.956 ± 0.075
1.023ThrHis: 1.023 ± 0.028
4.242ThrIle: 4.242 ± 0.051
3.034ThrLys: 3.034 ± 0.049
5.462ThrLeu: 5.462 ± 0.075
1.019ThrMet: 1.019 ± 0.028
2.963ThrAsn: 2.963 ± 0.058
2.721ThrPro: 2.721 ± 0.066
1.908ThrGln: 1.908 ± 0.043
2.049ThrArg: 2.049 ± 0.041
3.448ThrSer: 3.448 ± 0.058
3.508ThrThr: 3.508 ± 0.083
4.128ThrVal: 4.128 ± 0.067
0.627ThrTrp: 0.627 ± 0.023
2.401ThrTyr: 2.401 ± 0.055
0.0ThrXaa: 0.0 ± 0.0
Val
5.382ValAla: 5.382 ± 0.07
0.603ValCys: 0.603 ± 0.024
3.623ValAsp: 3.623 ± 0.054
3.324ValGlu: 3.324 ± 0.054
3.148ValPhe: 3.148 ± 0.054
3.954ValGly: 3.954 ± 0.061
1.068ValHis: 1.068 ± 0.032
4.955ValIle: 4.955 ± 0.066
4.724ValLys: 4.724 ± 0.062
6.225ValLeu: 6.225 ± 0.076
1.614ValMet: 1.614 ± 0.036
3.889ValAsn: 3.889 ± 0.06
2.514ValPro: 2.514 ± 0.045
2.088ValGln: 2.088 ± 0.039
2.368ValArg: 2.368 ± 0.043
4.378ValSer: 4.378 ± 0.07
4.27ValThr: 4.27 ± 0.074
4.629ValVal: 4.629 ± 0.07
0.692ValTrp: 0.692 ± 0.024
2.582ValTyr: 2.582 ± 0.046
0.0ValXaa: 0.0 ± 0.0
Trp
0.801TrpAla: 0.801 ± 0.025
0.11TrpCys: 0.11 ± 0.01
0.642TrpAsp: 0.642 ± 0.022
0.552TrpGlu: 0.552 ± 0.024
0.615TrpPhe: 0.615 ± 0.023
0.797TrpGly: 0.797 ± 0.027
0.262TrpHis: 0.262 ± 0.014
0.719TrpIle: 0.719 ± 0.022
0.699TrpLys: 0.699 ± 0.024
1.237TrpLeu: 1.237 ± 0.038
0.336TrpMet: 0.336 ± 0.017
0.608TrpAsn: 0.608 ± 0.022
0.351TrpPro: 0.351 ± 0.02
0.6TrpGln: 0.6 ± 0.021
0.53TrpArg: 0.53 ± 0.022
0.556TrpSer: 0.556 ± 0.023
0.568TrpThr: 0.568 ± 0.022
0.704TrpVal: 0.704 ± 0.027
0.175TrpTrp: 0.175 ± 0.013
0.432TrpTyr: 0.432 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.971TyrAla: 2.971 ± 0.043
0.346TyrCys: 0.346 ± 0.015
2.219TyrAsp: 2.219 ± 0.045
1.836TyrGlu: 1.836 ± 0.041
2.191TyrPhe: 2.191 ± 0.045
2.759TyrGly: 2.759 ± 0.052
0.855TyrHis: 0.855 ± 0.026
2.681TyrIle: 2.681 ± 0.05
2.72TyrLys: 2.72 ± 0.051
3.998TyrLeu: 3.998 ± 0.061
0.797TyrMet: 0.797 ± 0.026
2.667TyrAsn: 2.667 ± 0.05
1.708TyrPro: 1.708 ± 0.04
1.732TyrGln: 1.732 ± 0.039
1.966TyrArg: 1.966 ± 0.042
2.516TyrSer: 2.516 ± 0.048
2.63TyrThr: 2.63 ± 0.048
2.294TyrVal: 2.294 ± 0.046
0.493TyrTrp: 0.493 ± 0.023
1.898TyrTyr: 1.898 ± 0.052
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3746 proteins (1255666 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski