Amino acid dipepetide frequency for Xylaria grammica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.098AlaAla: 9.098 ± 0.059	1.032AlaCys: 1.032 ± 0.015	4.456AlaAsp: 4.456 ± 0.03	5.11AlaGlu: 5.11 ± 0.042	3.191AlaPhe: 3.191 ± 0.023	5.814AlaGly: 5.814 ± 0.04	1.83AlaHis: 1.83 ± 0.017	4.457AlaIle: 4.457 ± 0.032	3.997AlaLys: 3.997 ± 0.031	7.917AlaLeu: 7.917 ± 0.044	1.848AlaMet: 1.848 ± 0.021	3.07AlaAsn: 3.07 ± 0.024	4.694AlaPro: 4.694 ± 0.039	3.351AlaGln: 3.351 ± 0.026	5.046AlaArg: 5.046 ± 0.027	7.274AlaSer: 7.274 ± 0.037	5.572AlaThr: 5.572 ± 0.033	5.563AlaVal: 5.563 ± 0.032	1.185AlaTrp: 1.185 ± 0.015	2.252AlaTyr: 2.252 ± 0.019	0.002AlaXaa: 0.002 ± 0.001
Cys	0.903CysAla: 0.903 ± 0.014	0.208CysCys: 0.208 ± 0.007	0.649CysAsp: 0.649 ± 0.012	0.597CysGlu: 0.597 ± 0.01	0.494CysPhe: 0.494 ± 0.009	0.891CysGly: 0.891 ± 0.013	0.315CysHis: 0.315 ± 0.008	0.673CysIle: 0.673 ± 0.013	0.449CysLys: 0.449 ± 0.01	1.17CysLeu: 1.17 ± 0.017	0.23CysMet: 0.23 ± 0.006	0.406CysAsn: 0.406 ± 0.008	0.623CysPro: 0.623 ± 0.011	0.413CysGln: 0.413 ± 0.008	0.727CysArg: 0.727 ± 0.012	0.826CysSer: 0.826 ± 0.012	0.655CysThr: 0.655 ± 0.012	0.764CysVal: 0.764 ± 0.012	0.192CysTrp: 0.192 ± 0.006	0.352CysTyr: 0.352 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	4.94AspAla: 4.94 ± 0.035	0.621AspCys: 0.621 ± 0.011	4.497AspAsp: 4.497 ± 0.043	4.559AspGlu: 4.559 ± 0.036	2.281AspPhe: 2.281 ± 0.02	4.34AspGly: 4.34 ± 0.033	1.255AspHis: 1.255 ± 0.016	3.213AspIle: 3.213 ± 0.022	2.338AspLys: 2.338 ± 0.024	5.124AspLeu: 5.124 ± 0.03	1.234AspMet: 1.234 ± 0.014	2.022AspAsn: 2.022 ± 0.017	3.398AspPro: 3.398 ± 0.026	1.848AspGln: 1.848 ± 0.017	3.068AspArg: 3.068 ± 0.028	4.188AspSer: 4.188 ± 0.033	3.121AspThr: 3.121 ± 0.025	3.846AspVal: 3.846 ± 0.027	0.927AspTrp: 0.927 ± 0.013	1.7AspTyr: 1.7 ± 0.018	0.001AspXaa: 0.001 ± 0.0
Glu	5.478GluAla: 5.478 ± 0.039	0.621GluCys: 0.621 ± 0.012	4.143GluAsp: 4.143 ± 0.033	5.005GluGlu: 5.005 ± 0.039	2.001GluPhe: 2.001 ± 0.018	3.762GluGly: 3.762 ± 0.028	1.396GluHis: 1.396 ± 0.016	3.173GluIle: 3.173 ± 0.025	3.495GluLys: 3.495 ± 0.033	5.342GluLeu: 5.342 ± 0.032	1.351GluMet: 1.351 ± 0.015	2.372GluAsn: 2.372 ± 0.02	2.867GluPro: 2.867 ± 0.034	2.338GluGln: 2.338 ± 0.023	3.898GluArg: 3.898 ± 0.031	4.278GluSer: 4.278 ± 0.026	3.542GluThr: 3.542 ± 0.032	3.492GluVal: 3.492 ± 0.026	0.917GluTrp: 0.917 ± 0.014	1.734GluTyr: 1.734 ± 0.019	0.001GluXaa: 0.001 ± 0.0
Phe	3.051PheAla: 3.051 ± 0.025	0.5PheCys: 0.5 ± 0.009	2.349PheAsp: 2.349 ± 0.023	2.177PheGlu: 2.177 ± 0.02	1.576PhePhe: 1.576 ± 0.017	2.865PheGly: 2.865 ± 0.024	0.893PheHis: 0.893 ± 0.012	1.84PheIle: 1.84 ± 0.019	1.486PheLys: 1.486 ± 0.016	3.422PheLeu: 3.422 ± 0.028	0.723PheMet: 0.723 ± 0.011	1.447PheAsn: 1.447 ± 0.015	1.968PhePro: 1.968 ± 0.019	1.379PheGln: 1.379 ± 0.017	2.018PheArg: 2.018 ± 0.02	2.942PheSer: 2.942 ± 0.025	2.201PheThr: 2.201 ± 0.022	2.414PheVal: 2.414 ± 0.021	0.646PheTrp: 0.646 ± 0.011	1.122PheTyr: 1.122 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	5.624GlyAla: 5.624 ± 0.036	0.819GlyCys: 0.819 ± 0.013	3.924GlyAsp: 3.924 ± 0.024	3.701GlyGlu: 3.701 ± 0.026	2.81GlyPhe: 2.81 ± 0.023	5.836GlyGly: 5.836 ± 0.061	1.766GlyHis: 1.766 ± 0.017	3.634GlyIle: 3.634 ± 0.027	3.295GlyLys: 3.295 ± 0.027	6.203GlyLeu: 6.203 ± 0.037	1.428GlyMet: 1.428 ± 0.016	2.706GlyAsn: 2.706 ± 0.024	3.465GlyPro: 3.465 ± 0.032	2.5GlyGln: 2.5 ± 0.022	4.197GlyArg: 4.197 ± 0.033	5.787GlySer: 5.787 ± 0.042	4.13GlyThr: 4.13 ± 0.03	4.51GlyVal: 4.51 ± 0.031	1.166GlyTrp: 1.166 ± 0.014	2.186GlyTyr: 2.186 ± 0.021	0.002GlyXaa: 0.002 ± 0.001
His	1.818HisAla: 1.818 ± 0.019	0.32HisCys: 0.32 ± 0.007	1.384HisAsp: 1.384 ± 0.018	1.389HisGlu: 1.389 ± 0.016	0.916HisPhe: 0.916 ± 0.013	1.776HisGly: 1.776 ± 0.02	0.84HisHis: 0.84 ± 0.016	1.253HisIle: 1.253 ± 0.015	0.897HisLys: 0.897 ± 0.014	2.2HisLeu: 2.2 ± 0.021	0.477HisMet: 0.477 ± 0.009	0.86HisAsn: 0.86 ± 0.012	1.615HisPro: 1.615 ± 0.016	0.972HisGln: 0.972 ± 0.014	1.532HisArg: 1.532 ± 0.019	1.806HisSer: 1.806 ± 0.018	1.286HisThr: 1.286 ± 0.015	1.45HisVal: 1.45 ± 0.017	0.35HisTrp: 0.35 ± 0.008	0.721HisTyr: 0.721 ± 0.012	0.001HisXaa: 0.001 ± 0.0
Ile	4.324IleAla: 4.324 ± 0.033	0.708IleCys: 0.708 ± 0.012	3.063IleAsp: 3.063 ± 0.023	3.005IleGlu: 3.005 ± 0.022	1.985IlePhe: 1.985 ± 0.021	3.338IleGly: 3.338 ± 0.026	1.219IleHis: 1.219 ± 0.015	2.643IleIle: 2.643 ± 0.028	2.172IleLys: 2.172 ± 0.021	4.591IleLeu: 4.591 ± 0.037	0.989IleMet: 0.989 ± 0.014	1.873IleAsn: 1.873 ± 0.019	3.157IlePro: 3.157 ± 0.022	1.94IleGln: 1.94 ± 0.021	2.935IleArg: 2.935 ± 0.022	3.915IleSer: 3.915 ± 0.028	3.009IleThr: 3.009 ± 0.021	3.28IleVal: 3.28 ± 0.028	0.759IleTrp: 0.759 ± 0.012	1.428IleTyr: 1.428 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	4.178LysAla: 4.178 ± 0.029	0.441LysCys: 0.441 ± 0.008	2.64LysAsp: 2.64 ± 0.023	3.076LysGlu: 3.076 ± 0.026	1.45LysPhe: 1.45 ± 0.016	2.904LysGly: 2.904 ± 0.028	1.067LysHis: 1.067 ± 0.015	2.255LysIle: 2.255 ± 0.02	3.019LysLys: 3.019 ± 0.039	4.036LysLeu: 4.036 ± 0.032	0.938LysMet: 0.938 ± 0.01	1.659LysAsn: 1.659 ± 0.017	2.683LysPro: 2.683 ± 0.024	1.73LysGln: 1.73 ± 0.02	3.278LysArg: 3.278 ± 0.028	3.363LysSer: 3.363 ± 0.025	2.777LysThr: 2.777 ± 0.023	2.642LysVal: 2.642 ± 0.022	0.674LysTrp: 0.674 ± 0.011	1.36LysTyr: 1.36 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	8.01LeuAla: 8.01 ± 0.044	1.154LeuCys: 1.154 ± 0.015	5.355LeuAsp: 5.355 ± 0.036	5.583LeuGlu: 5.583 ± 0.037	3.3LeuPhe: 3.3 ± 0.032	6.199LeuGly: 6.199 ± 0.034	2.175LeuHis: 2.175 ± 0.021	3.966LeuIle: 3.966 ± 0.029	4.061LeuLys: 4.061 ± 0.031	8.379LeuLeu: 8.379 ± 0.056	1.664LeuMet: 1.664 ± 0.016	3.158LeuAsn: 3.158 ± 0.025	5.441LeuPro: 5.441 ± 0.032	3.696LeuGln: 3.696 ± 0.03	5.87LeuArg: 5.87 ± 0.032	7.225LeuSer: 7.225 ± 0.034	4.83LeuThr: 4.83 ± 0.031	5.581LeuVal: 5.581 ± 0.04	1.265LeuTrp: 1.265 ± 0.015	2.38LeuTyr: 2.38 ± 0.021	0.001LeuXaa: 0.001 ± 0.0
Met	2.138MetAla: 2.138 ± 0.02	0.207MetCys: 0.207 ± 0.006	1.166MetAsp: 1.166 ± 0.014	1.179MetGlu: 1.179 ± 0.016	0.667MetPhe: 0.667 ± 0.011	1.36MetGly: 1.36 ± 0.014	0.446MetHis: 0.446 ± 0.009	0.947MetIle: 0.947 ± 0.012	0.944MetLys: 0.944 ± 0.012	1.733MetLeu: 1.733 ± 0.017	0.536MetMet: 0.536 ± 0.008	0.756MetAsn: 0.756 ± 0.012	1.207MetPro: 1.207 ± 0.015	0.769MetGln: 0.769 ± 0.012	1.263MetArg: 1.263 ± 0.013	1.717MetSer: 1.717 ± 0.014	1.228MetThr: 1.228 ± 0.015	1.22MetVal: 1.22 ± 0.015	0.242MetTrp: 0.242 ± 0.007	0.485MetTyr: 0.485 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.189AsnAla: 3.189 ± 0.023	0.434AsnCys: 0.434 ± 0.009	2.074AsnAsp: 2.074 ± 0.017	2.104AsnGlu: 2.104 ± 0.021	1.396AsnPhe: 1.396 ± 0.018	3.046AsnGly: 3.046 ± 0.026	0.861AsnHis: 0.861 ± 0.013	2.117AsnIle: 2.117 ± 0.02	1.527AsnLys: 1.527 ± 0.018	3.255AsnLeu: 3.255 ± 0.024	0.817AsnMet: 0.817 ± 0.012	1.569AsnAsn: 1.569 ± 0.02	2.524AsnPro: 2.524 ± 0.027	1.354AsnGln: 1.354 ± 0.015	2.005AsnArg: 2.005 ± 0.019	2.85AsnSer: 2.85 ± 0.026	2.354AsnThr: 2.354 ± 0.02	2.343AsnVal: 2.343 ± 0.021	0.578AsnTrp: 0.578 ± 0.01	1.098AsnTyr: 1.098 ± 0.013	0.001AsnXaa: 0.001 ± 0.0
Pro	5.008ProAla: 5.008 ± 0.04	0.499ProCys: 0.499 ± 0.009	3.336ProAsp: 3.336 ± 0.029	3.848ProGlu: 3.848 ± 0.035	2.062ProPhe: 2.062 ± 0.022	4.047ProGly: 4.047 ± 0.036	1.339ProHis: 1.339 ± 0.017	2.729ProIle: 2.729 ± 0.022	2.568ProLys: 2.568 ± 0.026	4.757ProLeu: 4.757 ± 0.034	1.016ProMet: 1.016 ± 0.015	2.378ProAsn: 2.378 ± 0.024	5.055ProPro: 5.055 ± 0.06	2.418ProGln: 2.418 ± 0.03	3.514ProArg: 3.514 ± 0.031	5.917ProSer: 5.917 ± 0.042	4.184ProThr: 4.184 ± 0.037	3.5ProVal: 3.5 ± 0.028	0.796ProTrp: 0.796 ± 0.012	1.56ProTyr: 1.56 ± 0.017	0.001ProXaa: 0.001 ± 0.0
Gln	3.37GlnAla: 3.37 ± 0.028	0.431GlnCys: 0.431 ± 0.011	2.068GlnAsp: 2.068 ± 0.018	2.24GlnGlu: 2.24 ± 0.02	1.264GlnPhe: 1.264 ± 0.014	2.445GlnGly: 2.445 ± 0.02	1.051GlnHis: 1.051 ± 0.015	1.878GlnIle: 1.878 ± 0.018	1.849GlnLys: 1.849 ± 0.021	3.441GlnLeu: 3.441 ± 0.027	0.784GlnMet: 0.784 ± 0.012	1.523GlnAsn: 1.523 ± 0.017	2.544GlnPro: 2.544 ± 0.03	2.202GlnGln: 2.202 ± 0.042	2.54GlnArg: 2.54 ± 0.022	3.002GlnSer: 3.002 ± 0.025	2.262GlnThr: 2.262 ± 0.021	2.155GlnVal: 2.155 ± 0.019	0.596GlnTrp: 0.596 ± 0.012	1.183GlnTyr: 1.183 ± 0.013	0.0GlnXaa: 0.0 ± 0.0
Arg	4.847ArgAla: 4.847 ± 0.032	0.688ArgCys: 0.688 ± 0.012	3.643ArgAsp: 3.643 ± 0.028	3.89ArgGlu: 3.89 ± 0.032	2.181ArgPhe: 2.181 ± 0.021	3.903ArgGly: 3.903 ± 0.032	1.616ArgHis: 1.616 ± 0.019	2.999ArgIle: 2.999 ± 0.025	3.265ArgLys: 3.265 ± 0.026	5.579ArgLeu: 5.579 ± 0.041	1.248ArgMet: 1.248 ± 0.017	2.343ArgAsn: 2.343 ± 0.023	3.59ArgPro: 3.59 ± 0.032	2.559ArgGln: 2.559 ± 0.021	5.117ArgArg: 5.117 ± 0.04	4.609ArgSer: 4.609 ± 0.034	3.266ArgThr: 3.266 ± 0.023	3.499ArgVal: 3.499 ± 0.024	0.939ArgTrp: 0.939 ± 0.012	1.703ArgTyr: 1.703 ± 0.016	0.001ArgXaa: 0.001 ± 0.0
Ser	6.528SerAla: 6.528 ± 0.034	0.796SerCys: 0.796 ± 0.01	4.256SerAsp: 4.256 ± 0.03	4.145SerGlu: 4.145 ± 0.031	2.988SerPhe: 2.988 ± 0.024	5.604SerGly: 5.604 ± 0.038	1.977SerHis: 1.977 ± 0.02	4.097SerIle: 4.097 ± 0.029	3.525SerLys: 3.525 ± 0.028	7.148SerLeu: 7.148 ± 0.043	1.592SerMet: 1.592 ± 0.016	3.029SerAsn: 3.029 ± 0.023	5.415SerPro: 5.415 ± 0.041	3.269SerGln: 3.269 ± 0.028	5.047SerArg: 5.047 ± 0.033	8.46SerSer: 8.46 ± 0.056	5.606SerThr: 5.606 ± 0.036	4.555SerVal: 4.555 ± 0.027	1.167SerTrp: 1.167 ± 0.014	2.132SerTyr: 2.132 ± 0.024	0.002SerXaa: 0.002 ± 0.001
Thr	5.368ThrAla: 5.368 ± 0.034	0.711ThrCys: 0.711 ± 0.011	2.918ThrAsp: 2.918 ± 0.025	3.207ThrGlu: 3.207 ± 0.028	2.227ThrPhe: 2.227 ± 0.021	4.236ThrGly: 4.236 ± 0.03	1.314ThrHis: 1.314 ± 0.018	3.238ThrIle: 3.238 ± 0.024	2.628ThrLys: 2.628 ± 0.024	5.288ThrLeu: 5.288 ± 0.033	1.185ThrMet: 1.185 ± 0.014	2.242ThrAsn: 2.242 ± 0.021	4.447ThrPro: 4.447 ± 0.04	2.152ThrGln: 2.152 ± 0.019	3.294ThrArg: 3.294 ± 0.026	5.412ThrSer: 5.412 ± 0.035	4.525ThrThr: 4.525 ± 0.046	3.792ThrVal: 3.792 ± 0.025	0.89ThrTrp: 0.89 ± 0.013	1.719ThrTyr: 1.719 ± 0.015	0.001ThrXaa: 0.001 ± 0.0
Val	5.433ValAla: 5.433 ± 0.032	0.755ValCys: 0.755 ± 0.012	3.869ValAsp: 3.869 ± 0.025	3.879ValGlu: 3.879 ± 0.026	2.48ValPhe: 2.48 ± 0.021	4.135ValGly: 4.135 ± 0.03	1.368ValHis: 1.368 ± 0.014	3.037ValIle: 3.037 ± 0.026	2.787ValLys: 2.787 ± 0.023	5.664ValLeu: 5.664 ± 0.034	1.223ValMet: 1.223 ± 0.015	2.319ValAsn: 2.319 ± 0.02	3.597ValPro: 3.597 ± 0.026	2.253ValGln: 2.253 ± 0.019	3.47ValArg: 3.47 ± 0.026	4.655ValSer: 4.655 ± 0.032	3.679ValThr: 3.679 ± 0.029	4.449ValVal: 4.449 ± 0.034	0.874ValTrp: 0.874 ± 0.011	1.755ValTyr: 1.755 ± 0.018	0.001ValXaa: 0.001 ± 0.0
Trp	1.222TrpAla: 1.222 ± 0.017	0.194TrpCys: 0.194 ± 0.006	0.961TrpAsp: 0.961 ± 0.012	0.889TrpGlu: 0.889 ± 0.012	0.553TrpPhe: 0.553 ± 0.01	0.981TrpGly: 0.981 ± 0.014	0.362TrpHis: 0.362 ± 0.008	0.768TrpIle: 0.768 ± 0.013	0.775TrpLys: 0.775 ± 0.012	1.381TrpLeu: 1.381 ± 0.014	0.334TrpMet: 0.334 ± 0.007	0.661TrpAsn: 0.661 ± 0.01	0.651TrpPro: 0.651 ± 0.011	0.574TrpGln: 0.574 ± 0.012	0.989TrpArg: 0.989 ± 0.013	1.039TrpSer: 1.039 ± 0.016	0.902TrpThr: 0.902 ± 0.013	0.932TrpVal: 0.932 ± 0.014	0.272TrpTrp: 0.272 ± 0.007	0.46TrpTyr: 0.46 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.229TyrAla: 2.229 ± 0.019	0.398TyrCys: 0.398 ± 0.009	1.77TyrAsp: 1.77 ± 0.018	1.623TyrGlu: 1.623 ± 0.017	1.198TyrPhe: 1.198 ± 0.014	2.203TyrGly: 2.203 ± 0.02	0.771TyrHis: 0.771 ± 0.012	1.416TyrIle: 1.416 ± 0.014	1.093TyrLys: 1.093 ± 0.015	2.664TyrLeu: 2.664 ± 0.024	0.593TyrMet: 0.593 ± 0.01	1.102TyrAsn: 1.102 ± 0.016	1.587TyrPro: 1.587 ± 0.021	1.112TyrGln: 1.112 ± 0.014	1.673TyrArg: 1.673 ± 0.018	2.076TyrSer: 2.076 ± 0.021	1.661TyrThr: 1.661 ± 0.016	1.695TyrVal: 1.695 ± 0.017	0.465TyrTrp: 0.465 ± 0.008	0.999TyrTyr: 0.999 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.001XaaGlu: 0.001 ± 0.0	0.001XaaPhe: 0.001 ± 0.0	0.001XaaGly: 0.001 ± 0.0	0.001XaaHis: 0.001 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.001XaaMet: 0.001 ± 0.0	0.001XaaAsn: 0.001 ± 0.001	0.001XaaPro: 0.001 ± 0.0	0.001XaaGln: 0.001 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.001XaaSer: 0.001 ± 0.0	0.001XaaThr: 0.001 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.0	0.004XaaXaa: 0.004 ± 0.002

Statistics based on 12125 proteins (5972924 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---