Amino acid dipepetide frequency for Ancylostoma duodenale

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.837AlaAla: 6.837 ± 0.049	1.411AlaCys: 1.411 ± 0.02	3.725AlaAsp: 3.725 ± 0.029	4.872AlaGlu: 4.872 ± 0.038	2.841AlaPhe: 2.841 ± 0.024	4.203AlaGly: 4.203 ± 0.032	1.703AlaHis: 1.703 ± 0.018	3.903AlaIle: 3.903 ± 0.027	4.186AlaLys: 4.186 ± 0.031	6.613AlaLeu: 6.613 ± 0.04	1.959AlaMet: 1.959 ± 0.02	2.878AlaAsn: 2.878 ± 0.023	3.935AlaPro: 3.935 ± 0.043	2.834AlaGln: 2.834 ± 0.024	4.244AlaArg: 4.244 ± 0.029	5.165AlaSer: 5.165 ± 0.031	4.127AlaThr: 4.127 ± 0.032	5.34AlaVal: 5.34 ± 0.031	0.708AlaTrp: 0.708 ± 0.011	1.954AlaTyr: 1.954 ± 0.021	0.0AlaXaa: 0.0 ± 0.0
Cys	1.507CysAla: 1.507 ± 0.018	0.582CysCys: 0.582 ± 0.014	1.238CysAsp: 1.238 ± 0.018	1.344CysGlu: 1.344 ± 0.017	0.865CysPhe: 0.865 ± 0.013	1.505CysGly: 1.505 ± 0.018	0.517CysHis: 0.517 ± 0.01	1.11CysIle: 1.11 ± 0.015	1.073CysLys: 1.073 ± 0.018	1.799CysLeu: 1.799 ± 0.019	0.543CysMet: 0.543 ± 0.011	0.857CysAsn: 0.857 ± 0.014	1.298CysPro: 1.298 ± 0.019	0.847CysGln: 0.847 ± 0.017	1.35CysArg: 1.35 ± 0.018	1.795CysSer: 1.795 ± 0.022	1.158CysThr: 1.158 ± 0.016	1.439CysVal: 1.439 ± 0.023	0.26CysTrp: 0.26 ± 0.007	0.609CysTyr: 0.609 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	3.884AspAla: 3.884 ± 0.025	1.134AspCys: 1.134 ± 0.018	3.665AspAsp: 3.665 ± 0.034	4.367AspGlu: 4.367 ± 0.034	2.337AspPhe: 2.337 ± 0.023	3.654AspGly: 3.654 ± 0.032	1.247AspHis: 1.247 ± 0.016	2.889AspIle: 2.889 ± 0.023	2.757AspLys: 2.757 ± 0.023	4.63AspLeu: 4.63 ± 0.031	1.38AspMet: 1.38 ± 0.017	1.99AspAsn: 1.99 ± 0.021	2.634AspPro: 2.634 ± 0.025	1.888AspGln: 1.888 ± 0.018	3.138AspArg: 3.138 ± 0.027	3.794AspSer: 3.794 ± 0.031	2.541AspThr: 2.541 ± 0.023	3.931AspVal: 3.931 ± 0.027	0.723AspTrp: 0.723 ± 0.012	1.799AspTyr: 1.799 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	4.748GluAla: 4.748 ± 0.042	1.273GluCys: 1.273 ± 0.019	3.821GluAsp: 3.821 ± 0.029	5.998GluGlu: 5.998 ± 0.054	2.334GluPhe: 2.334 ± 0.023	3.317GluGly: 3.317 ± 0.028	1.53GluHis: 1.53 ± 0.017	3.443GluIle: 3.443 ± 0.027	4.968GluLys: 4.968 ± 0.04	5.761GluLeu: 5.761 ± 0.044	1.951GluMet: 1.951 ± 0.023	2.994GluAsn: 2.994 ± 0.028	2.509GluPro: 2.509 ± 0.03	2.97GluGln: 2.97 ± 0.025	4.404GluArg: 4.404 ± 0.037	4.025GluSer: 4.025 ± 0.031	3.267GluThr: 3.267 ± 0.028	4.058GluVal: 4.058 ± 0.027	0.863GluTrp: 0.863 ± 0.012	1.878GluTyr: 1.878 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	2.932PheAla: 2.932 ± 0.026	1.011PheCys: 1.011 ± 0.013	2.393PheAsp: 2.393 ± 0.023	2.426PheGlu: 2.426 ± 0.023	1.965PhePhe: 1.965 ± 0.021	2.665PheGly: 2.665 ± 0.025	1.032PheHis: 1.032 ± 0.013	2.146PheIle: 2.146 ± 0.022	1.877PheLys: 1.877 ± 0.018	3.773PheLeu: 3.773 ± 0.029	0.984PheMet: 0.984 ± 0.013	1.638PheAsn: 1.638 ± 0.017	1.866PhePro: 1.866 ± 0.021	1.401PheGln: 1.401 ± 0.015	2.276PheArg: 2.276 ± 0.023	3.08PheSer: 3.08 ± 0.025	2.293PheThr: 2.293 ± 0.023	2.958PheVal: 2.958 ± 0.023	0.525PheTrp: 0.525 ± 0.01	1.438PheTyr: 1.438 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	4.1GlyAla: 4.1 ± 0.038	1.294GlyCys: 1.294 ± 0.016	3.149GlyAsp: 3.149 ± 0.025	3.672GlyGlu: 3.672 ± 0.033	2.481GlyPhe: 2.481 ± 0.022	4.502GlyGly: 4.502 ± 0.049	1.431GlyHis: 1.431 ± 0.016	3.08GlyIle: 3.08 ± 0.028	3.564GlyLys: 3.564 ± 0.028	4.536GlyLeu: 4.536 ± 0.035	1.606GlyMet: 1.606 ± 0.019	2.468GlyAsn: 2.468 ± 0.024	2.967GlyPro: 2.967 ± 0.053	2.335GlyGln: 2.335 ± 0.028	3.691GlyArg: 3.691 ± 0.032	4.333GlySer: 4.333 ± 0.032	3.279GlyThr: 3.279 ± 0.026	4.0GlyVal: 4.0 ± 0.03	0.741GlyTrp: 0.741 ± 0.013	2.033GlyTyr: 2.033 ± 0.023	0.0GlyXaa: 0.0 ± 0.0
His	1.558HisAla: 1.558 ± 0.017	0.59HisCys: 0.59 ± 0.012	1.175HisAsp: 1.175 ± 0.013	1.408HisGlu: 1.408 ± 0.016	1.102HisPhe: 1.102 ± 0.013	1.425HisGly: 1.425 ± 0.016	0.774HisHis: 0.774 ± 0.014	1.301HisIle: 1.301 ± 0.014	1.134HisLys: 1.134 ± 0.016	2.317HisLeu: 2.317 ± 0.021	0.664HisMet: 0.664 ± 0.01	0.939HisAsn: 0.939 ± 0.015	1.364HisPro: 1.364 ± 0.017	0.924HisGln: 0.924 ± 0.013	1.601HisArg: 1.601 ± 0.019	1.785HisSer: 1.785 ± 0.02	1.213HisThr: 1.213 ± 0.016	1.649HisVal: 1.649 ± 0.018	0.339HisTrp: 0.339 ± 0.008	0.872HisTyr: 0.872 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	4.086IleAla: 4.086 ± 0.029	1.235IleCys: 1.235 ± 0.016	3.113IleAsp: 3.113 ± 0.026	3.345IleGlu: 3.345 ± 0.026	2.184IlePhe: 2.184 ± 0.023	3.084IleGly: 3.084 ± 0.025	1.334IleHis: 1.334 ± 0.016	2.688IleIle: 2.688 ± 0.024	2.563IleLys: 2.563 ± 0.022	4.56IleLeu: 4.56 ± 0.031	1.266IleMet: 1.266 ± 0.015	2.085IleAsn: 2.085 ± 0.02	2.781IlePro: 2.781 ± 0.023	1.918IleGln: 1.918 ± 0.016	3.346IleArg: 3.346 ± 0.022	3.948IleSer: 3.948 ± 0.027	3.075IleThr: 3.075 ± 0.028	3.672IleVal: 3.672 ± 0.025	0.608IleTrp: 0.608 ± 0.011	1.649IleTyr: 1.649 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	3.943LysAla: 3.943 ± 0.028	1.238LysCys: 1.238 ± 0.016	3.061LysAsp: 3.061 ± 0.027	4.448LysGlu: 4.448 ± 0.04	2.048LysPhe: 2.048 ± 0.019	2.917LysGly: 2.917 ± 0.027	1.294LysHis: 1.294 ± 0.014	3.071LysIle: 3.071 ± 0.026	4.649LysLys: 4.649 ± 0.045	4.933LysLeu: 4.933 ± 0.032	1.737LysMet: 1.737 ± 0.016	2.405LysAsn: 2.405 ± 0.021	2.616LysPro: 2.616 ± 0.028	2.331LysGln: 2.331 ± 0.023	3.812LysArg: 3.812 ± 0.031	3.635LysSer: 3.635 ± 0.029	3.125LysThr: 3.125 ± 0.026	3.501LysVal: 3.501 ± 0.029	0.747LysTrp: 0.747 ± 0.011	1.824LysTyr: 1.824 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	6.592LeuAla: 6.592 ± 0.033	1.946LeuCys: 1.946 ± 0.02	4.68LeuAsp: 4.68 ± 0.031	5.532LeuGlu: 5.532 ± 0.041	3.748LeuPhe: 3.748 ± 0.028	4.535LeuGly: 4.535 ± 0.033	2.251LeuHis: 2.251 ± 0.024	4.446LeuIle: 4.446 ± 0.031	5.036LeuLys: 5.036 ± 0.032	8.745LeuLeu: 8.745 ± 0.056	2.288LeuMet: 2.288 ± 0.022	3.746LeuAsn: 3.746 ± 0.028	4.749LeuPro: 4.749 ± 0.037	3.667LeuGln: 3.667 ± 0.027	5.957LeuArg: 5.957 ± 0.033	6.793LeuSer: 6.793 ± 0.04	4.868LeuThr: 4.868 ± 0.033	5.531LeuVal: 5.531 ± 0.038	1.002LeuTrp: 1.002 ± 0.014	2.526LeuTyr: 2.526 ± 0.024	0.0LeuXaa: 0.0 ± 0.0
Met	2.006MetAla: 2.006 ± 0.019	0.551MetCys: 0.551 ± 0.011	1.527MetAsp: 1.527 ± 0.017	1.842MetGlu: 1.842 ± 0.02	1.06MetPhe: 1.06 ± 0.015	1.465MetGly: 1.465 ± 0.018	0.614MetHis: 0.614 ± 0.009	1.323MetIle: 1.323 ± 0.015	1.664MetLys: 1.664 ± 0.017	2.385MetLeu: 2.385 ± 0.023	0.835MetMet: 0.835 ± 0.014	1.189MetAsn: 1.189 ± 0.015	1.323MetPro: 1.323 ± 0.018	1.056MetGln: 1.056 ± 0.015	1.74MetArg: 1.74 ± 0.017	1.946MetSer: 1.946 ± 0.02	1.521MetThr: 1.521 ± 0.018	1.677MetVal: 1.677 ± 0.015	0.331MetTrp: 0.331 ± 0.007	0.78MetTyr: 0.78 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.984AsnAla: 2.984 ± 0.026	0.869AsnCys: 0.869 ± 0.014	2.205AsnAsp: 2.205 ± 0.021	2.692AsnGlu: 2.692 ± 0.025	1.691AsnPhe: 1.691 ± 0.018	2.899AsnGly: 2.899 ± 0.028	0.911AsnHis: 0.911 ± 0.015	2.385AsnIle: 2.385 ± 0.023	2.077AsnLys: 2.077 ± 0.021	3.4AsnLeu: 3.4 ± 0.022	1.094AsnMet: 1.094 ± 0.013	1.752AsnAsn: 1.752 ± 0.02	2.209AsnPro: 2.209 ± 0.025	1.489AsnGln: 1.489 ± 0.018	2.341AsnArg: 2.341 ± 0.021	2.888AsnSer: 2.888 ± 0.025	2.177AsnThr: 2.177 ± 0.022	2.88AsnVal: 2.88 ± 0.023	0.463AsnTrp: 0.463 ± 0.008	1.413AsnTyr: 1.413 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	3.886ProAla: 3.886 ± 0.039	0.905ProCys: 0.905 ± 0.018	2.553ProAsp: 2.553 ± 0.022	3.241ProGlu: 3.241 ± 0.027	1.926ProPhe: 1.926 ± 0.019	3.842ProGly: 3.842 ± 0.093	1.208ProHis: 1.208 ± 0.016	2.487ProIle: 2.487 ± 0.021	2.668ProLys: 2.668 ± 0.025	4.19ProLeu: 4.19 ± 0.026	1.199ProMet: 1.199 ± 0.017	2.011ProAsn: 2.011 ± 0.022	4.622ProPro: 4.622 ± 0.066	2.181ProGln: 2.181 ± 0.028	2.861ProArg: 2.861 ± 0.026	4.408ProSer: 4.408 ± 0.037	3.175ProThr: 3.175 ± 0.03	3.356ProVal: 3.356 ± 0.032	0.52ProTrp: 0.52 ± 0.01	1.472ProTyr: 1.472 ± 0.019	0.0ProXaa: 0.0 ± 0.0
Gln	2.669GlnAla: 2.669 ± 0.024	0.929GlnCys: 0.929 ± 0.018	1.595GlnAsp: 1.595 ± 0.019	2.349GlnGlu: 2.349 ± 0.024	1.595GlnPhe: 1.595 ± 0.016	1.94GlnGly: 1.94 ± 0.024	1.025GlnHis: 1.025 ± 0.013	2.08GlnIle: 2.08 ± 0.02	2.43GlnLys: 2.43 ± 0.021	4.094GlnLeu: 4.094 ± 0.032	1.292GlnMet: 1.292 ± 0.016	1.649GlnAsn: 1.649 ± 0.018	2.226GlnPro: 2.226 ± 0.032	2.333GlnGln: 2.333 ± 0.035	2.648GlnArg: 2.648 ± 0.024	2.568GlnSer: 2.568 ± 0.023	1.966GlnThr: 1.966 ± 0.021	2.361GlnVal: 2.361 ± 0.021	0.539GlnTrp: 0.539 ± 0.009	1.24GlnTyr: 1.24 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	4.137ArgAla: 4.137 ± 0.03	1.352ArgCys: 1.352 ± 0.018	3.183ArgAsp: 3.183 ± 0.028	4.015ArgGlu: 4.015 ± 0.035	2.521ArgPhe: 2.521 ± 0.021	3.225ArgGly: 3.225 ± 0.029	1.578ArgHis: 1.578 ± 0.015	3.368ArgIle: 3.368 ± 0.028	4.027ArgLys: 4.027 ± 0.028	5.811ArgLeu: 5.811 ± 0.034	1.822ArgMet: 1.822 ± 0.019	2.679ArgAsn: 2.679 ± 0.023	3.025ArgPro: 3.025 ± 0.025	2.573ArgGln: 2.573 ± 0.025	5.115ArgArg: 5.115 ± 0.045	4.503ArgSer: 4.503 ± 0.031	3.317ArgThr: 3.317 ± 0.026	3.725ArgVal: 3.725 ± 0.028	0.796ArgTrp: 0.796 ± 0.013	1.839ArgTyr: 1.839 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	5.419SerAla: 5.419 ± 0.034	1.557SerCys: 1.557 ± 0.017	4.059SerAsp: 4.059 ± 0.028	4.417SerGlu: 4.417 ± 0.033	3.055SerPhe: 3.055 ± 0.025	4.488SerGly: 4.488 ± 0.033	1.693SerHis: 1.693 ± 0.017	3.843SerIle: 3.843 ± 0.029	3.788SerLys: 3.788 ± 0.031	6.487SerLeu: 6.487 ± 0.036	1.901SerMet: 1.901 ± 0.02	2.826SerAsn: 2.826 ± 0.023	3.896SerPro: 3.896 ± 0.036	2.72SerGln: 2.72 ± 0.026	4.437SerArg: 4.437 ± 0.031	7.091SerSer: 7.091 ± 0.062	4.789SerThr: 4.789 ± 0.046	4.801SerVal: 4.801 ± 0.032	0.803SerTrp: 0.803 ± 0.014	2.042SerTyr: 2.042 ± 0.02	0.0SerXaa: 0.0 ± 0.0
Thr	4.304ThrAla: 4.304 ± 0.029	1.25ThrCys: 1.25 ± 0.018	2.769ThrAsp: 2.769 ± 0.021	3.229ThrGlu: 3.229 ± 0.025	2.286ThrPhe: 2.286 ± 0.021	3.244ThrGly: 3.244 ± 0.029	1.245ThrHis: 1.245 ± 0.016	3.131ThrIle: 3.131 ± 0.03	2.901ThrLys: 2.901 ± 0.026	4.898ThrLeu: 4.898 ± 0.028	1.416ThrMet: 1.416 ± 0.016	2.15ThrAsn: 2.15 ± 0.02	3.304ThrPro: 3.304 ± 0.035	1.902ThrGln: 1.902 ± 0.021	3.02ThrArg: 3.02 ± 0.026	4.6ThrSer: 4.6 ± 0.044	4.089ThrThr: 4.089 ± 0.052	4.107ThrVal: 4.107 ± 0.028	0.616ThrTrp: 0.616 ± 0.011	1.575ThrTyr: 1.575 ± 0.017	0.0ThrXaa: 0.0 ± 0.0
Val	4.998ValAla: 4.998 ± 0.034	1.55ValCys: 1.55 ± 0.017	3.963ValAsp: 3.963 ± 0.029	4.374ValGlu: 4.374 ± 0.028	2.837ValPhe: 2.837 ± 0.025	3.643ValGly: 3.643 ± 0.029	1.671ValHis: 1.671 ± 0.016	3.584ValIle: 3.584 ± 0.026	3.609ValLys: 3.609 ± 0.03	5.989ValLeu: 5.989 ± 0.035	1.695ValMet: 1.695 ± 0.018	2.687ValAsn: 2.687 ± 0.022	3.44ValPro: 3.44 ± 0.031	2.533ValGln: 2.533 ± 0.023	3.915ValArg: 3.915 ± 0.027	4.708ValSer: 4.708 ± 0.026	3.727ValThr: 3.727 ± 0.025	5.098ValVal: 5.098 ± 0.04	0.759ValTrp: 0.759 ± 0.012	1.948ValTyr: 1.948 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	0.784TrpAla: 0.784 ± 0.011	0.244TrpCys: 0.244 ± 0.007	0.649TrpAsp: 0.649 ± 0.012	0.681TrpGlu: 0.681 ± 0.009	0.482TrpPhe: 0.482 ± 0.011	0.582TrpGly: 0.582 ± 0.013	0.274TrpHis: 0.274 ± 0.007	0.726TrpIle: 0.726 ± 0.01	0.787TrpLys: 0.787 ± 0.011	1.081TrpLeu: 1.081 ± 0.014	0.423TrpMet: 0.423 ± 0.009	0.592TrpAsn: 0.592 ± 0.011	0.514TrpPro: 0.514 ± 0.011	0.477TrpGln: 0.477 ± 0.009	0.799TrpArg: 0.799 ± 0.012	0.897TrpSer: 0.897 ± 0.013	0.763TrpThr: 0.763 ± 0.012	0.64TrpVal: 0.64 ± 0.012	0.208TrpTrp: 0.208 ± 0.006	0.369TrpTyr: 0.369 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.063TyrAla: 2.063 ± 0.021	0.778TyrCys: 0.778 ± 0.013	1.858TyrAsp: 1.858 ± 0.017	1.862TyrGlu: 1.862 ± 0.02	1.322TyrPhe: 1.322 ± 0.014	2.127TyrGly: 2.127 ± 0.023	0.8TyrHis: 0.8 ± 0.013	1.533TyrIle: 1.533 ± 0.019	1.58TyrLys: 1.58 ± 0.019	2.635TyrLeu: 2.635 ± 0.024	0.78TyrMet: 0.78 ± 0.011	1.283TyrAsn: 1.283 ± 0.016	1.433TyrPro: 1.433 ± 0.016	1.149TyrGln: 1.149 ± 0.017	1.916TyrArg: 1.916 ± 0.019	2.149TyrSer: 2.149 ± 0.022	1.564TyrThr: 1.564 ± 0.017	2.005TyrVal: 2.005 ± 0.02	0.421TyrTrp: 0.421 ± 0.008	1.163TyrTyr: 1.163 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 27403 proteins (5822372 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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