Amino acid dipepetide frequency for Xanthomonas phage Xoo-sp2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.22AlaAla: 14.22 ± 1.253
0.973AlaCys: 0.973 ± 0.23
6.488AlaAsp: 6.488 ± 0.554
8.381AlaGlu: 8.381 ± 0.927
4.38AlaPhe: 4.38 ± 0.55
6.921AlaGly: 6.921 ± 0.559
2.379AlaHis: 2.379 ± 0.477
4.434AlaIle: 4.434 ± 0.476
7.407AlaLys: 7.407 ± 1.171
9.516AlaLeu: 9.516 ± 0.925
2.758AlaMet: 2.758 ± 0.476
3.46AlaAsn: 3.46 ± 0.489
3.731AlaPro: 3.731 ± 0.35
3.244AlaGln: 3.244 ± 0.473
6.759AlaArg: 6.759 ± 0.78
6.596AlaSer: 6.596 ± 0.702
6.002AlaThr: 6.002 ± 0.496
7.191AlaVal: 7.191 ± 0.558
2.109AlaTrp: 2.109 ± 0.409
3.514AlaTyr: 3.514 ± 0.38
0.0AlaXaa: 0.0 ± 0.0
Cys
0.649CysAla: 0.649 ± 0.255
0.324CysCys: 0.324 ± 0.129
0.595CysAsp: 0.595 ± 0.231
0.324CysGlu: 0.324 ± 0.172
0.27CysPhe: 0.27 ± 0.122
1.19CysGly: 1.19 ± 0.336
0.216CysHis: 0.216 ± 0.101
0.378CysIle: 0.378 ± 0.127
0.378CysLys: 0.378 ± 0.166
1.406CysLeu: 1.406 ± 0.283
0.162CysMet: 0.162 ± 0.089
0.324CysAsn: 0.324 ± 0.145
0.649CysPro: 0.649 ± 0.205
0.162CysGln: 0.162 ± 0.082
1.027CysArg: 1.027 ± 0.172
0.378CysSer: 0.378 ± 0.172
0.703CysThr: 0.703 ± 0.198
0.541CysVal: 0.541 ± 0.162
0.054CysTrp: 0.054 ± 0.056
0.216CysTyr: 0.216 ± 0.101
0.0CysXaa: 0.0 ± 0.0
Asp
7.191AspAla: 7.191 ± 0.652
0.433AspCys: 0.433 ± 0.175
4.217AspAsp: 4.217 ± 0.486
4.812AspGlu: 4.812 ± 0.477
2.92AspPhe: 2.92 ± 0.4
6.921AspGly: 6.921 ± 0.592
1.081AspHis: 1.081 ± 0.226
1.352AspIle: 1.352 ± 0.276
3.46AspLys: 3.46 ± 0.367
5.785AspLeu: 5.785 ± 0.476
1.784AspMet: 1.784 ± 0.243
1.406AspAsn: 1.406 ± 0.355
3.893AspPro: 3.893 ± 0.419
2.487AspGln: 2.487 ± 0.349
4.055AspArg: 4.055 ± 0.47
2.92AspSer: 2.92 ± 0.496
2.325AspThr: 2.325 ± 0.342
5.461AspVal: 5.461 ± 0.515
1.46AspTrp: 1.46 ± 0.307
1.568AspTyr: 1.568 ± 0.279
0.0AspXaa: 0.0 ± 0.0
Glu
9.246GluAla: 9.246 ± 0.864
0.865GluCys: 0.865 ± 0.278
4.542GluAsp: 4.542 ± 0.495
5.245GluGlu: 5.245 ± 0.678
2.325GluPhe: 2.325 ± 0.383
5.785GluGly: 5.785 ± 0.65
1.244GluHis: 1.244 ± 0.334
1.514GluIle: 1.514 ± 0.306
2.866GluLys: 2.866 ± 0.433
7.678GluLeu: 7.678 ± 0.77
2.001GluMet: 2.001 ± 0.319
2.217GluAsn: 2.217 ± 0.333
2.595GluPro: 2.595 ± 0.38
3.136GluGln: 3.136 ± 0.43
4.434GluArg: 4.434 ± 0.602
3.406GluSer: 3.406 ± 0.489
2.325GluThr: 2.325 ± 0.335
5.461GluVal: 5.461 ± 0.597
1.406GluTrp: 1.406 ± 0.236
1.622GluTyr: 1.622 ± 0.355
0.0GluXaa: 0.0 ± 0.0
Phe
2.866PheAla: 2.866 ± 0.386
0.378PheCys: 0.378 ± 0.122
2.812PheAsp: 2.812 ± 0.429
2.595PheGlu: 2.595 ± 0.391
1.19PhePhe: 1.19 ± 0.281
2.271PheGly: 2.271 ± 0.341
0.378PheHis: 0.378 ± 0.157
1.081PheIle: 1.081 ± 0.27
1.46PheLys: 1.46 ± 0.245
2.541PheLeu: 2.541 ± 0.42
0.703PheMet: 0.703 ± 0.222
1.135PheAsn: 1.135 ± 0.241
1.676PhePro: 1.676 ± 0.346
1.622PheGln: 1.622 ± 0.273
2.433PheArg: 2.433 ± 0.362
1.73PheSer: 1.73 ± 0.292
2.001PheThr: 2.001 ± 0.408
1.622PheVal: 1.622 ± 0.316
0.703PheTrp: 0.703 ± 0.173
0.757PheTyr: 0.757 ± 0.214
0.0PheXaa: 0.0 ± 0.0
Gly
6.218GlyAla: 6.218 ± 0.641
1.027GlyCys: 1.027 ± 0.292
4.65GlyAsp: 4.65 ± 0.494
5.461GlyGlu: 5.461 ± 0.593
2.379GlyPhe: 2.379 ± 0.387
6.921GlyGly: 6.921 ± 0.716
2.001GlyHis: 2.001 ± 0.337
3.46GlyIle: 3.46 ± 0.543
4.488GlyLys: 4.488 ± 0.621
7.083GlyLeu: 7.083 ± 0.505
2.487GlyMet: 2.487 ± 0.34
2.703GlyAsn: 2.703 ± 0.5
3.028GlyPro: 3.028 ± 0.416
2.649GlyGln: 2.649 ± 0.392
6.002GlyArg: 6.002 ± 0.832
4.434GlySer: 4.434 ± 0.52
4.542GlyThr: 4.542 ± 0.593
6.056GlyVal: 6.056 ± 0.499
2.217GlyTrp: 2.217 ± 0.301
2.271GlyTyr: 2.271 ± 0.419
0.0GlyXaa: 0.0 ± 0.0
His
2.001HisAla: 2.001 ± 0.422
0.108HisCys: 0.108 ± 0.078
1.298HisAsp: 1.298 ± 0.252
1.46HisGlu: 1.46 ± 0.276
0.541HisPhe: 0.541 ± 0.19
1.784HisGly: 1.784 ± 0.293
0.433HisHis: 0.433 ± 0.166
1.027HisIle: 1.027 ± 0.215
0.973HisLys: 0.973 ± 0.248
2.001HisLeu: 2.001 ± 0.335
0.703HisMet: 0.703 ± 0.202
0.595HisAsn: 0.595 ± 0.217
0.919HisPro: 0.919 ± 0.211
0.811HisGln: 0.811 ± 0.2
1.244HisArg: 1.244 ± 0.313
1.352HisSer: 1.352 ± 0.278
0.973HisThr: 0.973 ± 0.217
1.081HisVal: 1.081 ± 0.255
0.649HisTrp: 0.649 ± 0.2
0.487HisTyr: 0.487 ± 0.188
0.0HisXaa: 0.0 ± 0.0
Ile
4.055IleAla: 4.055 ± 0.55
0.378IleCys: 0.378 ± 0.169
3.244IleAsp: 3.244 ± 0.326
3.352IleGlu: 3.352 ± 0.462
0.973IlePhe: 0.973 ± 0.207
2.595IleGly: 2.595 ± 0.419
0.487IleHis: 0.487 ± 0.166
1.298IleIle: 1.298 ± 0.293
2.812IleLys: 2.812 ± 0.378
2.217IleLeu: 2.217 ± 0.371
0.649IleMet: 0.649 ± 0.195
1.514IleAsn: 1.514 ± 0.292
1.622IlePro: 1.622 ± 0.301
1.081IleGln: 1.081 ± 0.24
1.946IleArg: 1.946 ± 0.333
1.568IleSer: 1.568 ± 0.263
2.271IleThr: 2.271 ± 0.362
2.595IleVal: 2.595 ± 0.378
0.433IleTrp: 0.433 ± 0.148
0.433IleTyr: 0.433 ± 0.144
0.0IleXaa: 0.0 ± 0.0
Lys
7.191LysAla: 7.191 ± 1.128
0.487LysCys: 0.487 ± 0.181
2.812LysAsp: 2.812 ± 0.321
2.974LysGlu: 2.974 ± 0.556
1.676LysPhe: 1.676 ± 0.273
4.001LysGly: 4.001 ± 0.626
0.757LysHis: 0.757 ± 0.175
1.19LysIle: 1.19 ± 0.246
2.974LysLys: 2.974 ± 0.565
4.271LysLeu: 4.271 ± 0.48
1.135LysMet: 1.135 ± 0.271
1.027LysAsn: 1.027 ± 0.238
3.569LysPro: 3.569 ± 0.465
2.541LysGln: 2.541 ± 0.564
3.298LysArg: 3.298 ± 0.651
3.136LysSer: 3.136 ± 0.354
2.379LysThr: 2.379 ± 0.367
3.569LysVal: 3.569 ± 0.447
0.378LysTrp: 0.378 ± 0.136
1.514LysTyr: 1.514 ± 0.319
0.0LysXaa: 0.0 ± 0.0
Leu
9.029LeuAla: 9.029 ± 0.864
0.487LeuCys: 0.487 ± 0.138
6.056LeuAsp: 6.056 ± 0.475
6.218LeuGlu: 6.218 ± 0.574
2.649LeuPhe: 2.649 ± 0.419
7.299LeuGly: 7.299 ± 0.682
1.244LeuHis: 1.244 ± 0.257
2.758LeuIle: 2.758 ± 0.443
4.38LeuLys: 4.38 ± 0.61
6.813LeuLeu: 6.813 ± 0.614
2.487LeuMet: 2.487 ± 0.344
2.92LeuAsn: 2.92 ± 0.405
4.542LeuPro: 4.542 ± 0.606
3.785LeuGln: 3.785 ± 0.482
6.759LeuArg: 6.759 ± 0.677
4.271LeuSer: 4.271 ± 0.567
4.866LeuThr: 4.866 ± 0.573
6.488LeuVal: 6.488 ± 0.696
1.406LeuTrp: 1.406 ± 0.271
1.892LeuTyr: 1.892 ± 0.272
0.0LeuXaa: 0.0 ± 0.0
Met
4.001MetAla: 4.001 ± 0.437
0.216MetCys: 0.216 ± 0.105
1.676MetAsp: 1.676 ± 0.274
1.676MetGlu: 1.676 ± 0.319
0.433MetPhe: 0.433 ± 0.138
2.001MetGly: 2.001 ± 0.359
0.541MetHis: 0.541 ± 0.2
0.865MetIle: 0.865 ± 0.209
1.027MetLys: 1.027 ± 0.21
2.163MetLeu: 2.163 ± 0.339
0.541MetMet: 0.541 ± 0.204
0.811MetAsn: 0.811 ± 0.238
0.973MetPro: 0.973 ± 0.229
1.19MetGln: 1.19 ± 0.226
2.217MetArg: 2.217 ± 0.333
1.676MetSer: 1.676 ± 0.311
1.568MetThr: 1.568 ± 0.322
1.46MetVal: 1.46 ± 0.297
0.27MetTrp: 0.27 ± 0.128
0.324MetTyr: 0.324 ± 0.11
0.0MetXaa: 0.0 ± 0.0
Asn
3.893AsnAla: 3.893 ± 0.564
0.541AsnCys: 0.541 ± 0.162
1.514AsnAsp: 1.514 ± 0.334
2.055AsnGlu: 2.055 ± 0.278
0.757AsnPhe: 0.757 ± 0.166
3.082AsnGly: 3.082 ± 0.673
0.595AsnHis: 0.595 ± 0.17
0.811AsnIle: 0.811 ± 0.248
1.622AsnLys: 1.622 ± 0.345
2.541AsnLeu: 2.541 ± 0.334
0.973AsnMet: 0.973 ± 0.246
1.135AsnAsn: 1.135 ± 0.345
1.838AsnPro: 1.838 ± 0.356
1.352AsnGln: 1.352 ± 0.236
1.298AsnArg: 1.298 ± 0.272
1.46AsnSer: 1.46 ± 0.329
1.352AsnThr: 1.352 ± 0.304
1.784AsnVal: 1.784 ± 0.335
0.703AsnTrp: 0.703 ± 0.215
0.811AsnTyr: 0.811 ± 0.265
0.0AsnXaa: 0.0 ± 0.0
Pro
5.407ProAla: 5.407 ± 0.509
0.595ProCys: 0.595 ± 0.22
4.001ProAsp: 4.001 ± 0.553
3.352ProGlu: 3.352 ± 0.381
1.46ProPhe: 1.46 ± 0.254
4.163ProGly: 4.163 ± 0.5
1.46ProHis: 1.46 ± 0.268
2.055ProIle: 2.055 ± 0.309
2.163ProLys: 2.163 ± 0.423
2.866ProLeu: 2.866 ± 0.388
0.757ProMet: 0.757 ± 0.157
1.946ProAsn: 1.946 ± 0.326
2.758ProPro: 2.758 ± 0.551
1.406ProGln: 1.406 ± 0.255
2.703ProArg: 2.703 ± 0.506
2.649ProSer: 2.649 ± 0.39
3.677ProThr: 3.677 ± 0.519
3.028ProVal: 3.028 ± 0.551
0.649ProTrp: 0.649 ± 0.173
1.622ProTyr: 1.622 ± 0.387
0.0ProXaa: 0.0 ± 0.0
Gln
5.515GlnAla: 5.515 ± 0.581
0.0GlnCys: 0.0 ± 0.0
2.271GlnAsp: 2.271 ± 0.255
2.001GlnGlu: 2.001 ± 0.484
1.514GlnPhe: 1.514 ± 0.358
2.866GlnGly: 2.866 ± 0.377
0.865GlnHis: 0.865 ± 0.189
1.244GlnIle: 1.244 ± 0.332
1.514GlnLys: 1.514 ± 0.355
3.569GlnLeu: 3.569 ± 0.472
1.352GlnMet: 1.352 ± 0.204
0.595GlnAsn: 0.595 ± 0.202
2.379GlnPro: 2.379 ± 0.342
2.055GlnGln: 2.055 ± 0.42
2.866GlnArg: 2.866 ± 0.431
2.325GlnSer: 2.325 ± 0.527
2.325GlnThr: 2.325 ± 0.376
2.866GlnVal: 2.866 ± 0.416
0.865GlnTrp: 0.865 ± 0.263
1.081GlnTyr: 1.081 ± 0.235
0.0GlnXaa: 0.0 ± 0.0
Arg
6.434ArgAla: 6.434 ± 0.672
0.541ArgCys: 0.541 ± 0.197
4.542ArgAsp: 4.542 ± 0.473
5.028ArgGlu: 5.028 ± 0.662
2.001ArgPhe: 2.001 ± 0.306
4.758ArgGly: 4.758 ± 0.608
1.838ArgHis: 1.838 ± 0.408
2.812ArgIle: 2.812 ± 0.46
2.866ArgLys: 2.866 ± 0.326
5.893ArgLeu: 5.893 ± 0.56
1.73ArgMet: 1.73 ± 0.359
1.73ArgAsn: 1.73 ± 0.274
2.866ArgPro: 2.866 ± 0.464
3.406ArgGln: 3.406 ± 0.416
4.92ArgArg: 4.92 ± 0.53
3.893ArgSer: 3.893 ± 0.532
3.136ArgThr: 3.136 ± 0.441
4.65ArgVal: 4.65 ± 0.629
1.622ArgTrp: 1.622 ± 0.299
1.784ArgTyr: 1.784 ± 0.327
0.0ArgXaa: 0.0 ± 0.0
Ser
5.191SerAla: 5.191 ± 0.532
0.811SerCys: 0.811 ± 0.222
2.812SerAsp: 2.812 ± 0.394
3.298SerGlu: 3.298 ± 0.414
1.352SerPhe: 1.352 ± 0.253
5.137SerGly: 5.137 ± 0.658
1.352SerHis: 1.352 ± 0.365
2.217SerIle: 2.217 ± 0.415
3.028SerLys: 3.028 ± 0.33
5.461SerLeu: 5.461 ± 0.498
1.19SerMet: 1.19 ± 0.277
1.514SerAsn: 1.514 ± 0.346
3.19SerPro: 3.19 ± 0.428
2.055SerGln: 2.055 ± 0.342
2.541SerArg: 2.541 ± 0.346
3.46SerSer: 3.46 ± 0.402
3.893SerThr: 3.893 ± 0.639
4.271SerVal: 4.271 ± 0.576
1.135SerTrp: 1.135 ± 0.267
1.46SerTyr: 1.46 ± 0.332
0.0SerXaa: 0.0 ± 0.0
Thr
5.785ThrAla: 5.785 ± 0.578
0.324ThrCys: 0.324 ± 0.131
3.028ThrAsp: 3.028 ± 0.435
3.19ThrGlu: 3.19 ± 0.385
1.784ThrPhe: 1.784 ± 0.406
4.542ThrGly: 4.542 ± 0.667
0.757ThrHis: 0.757 ± 0.252
3.244ThrIle: 3.244 ± 0.429
1.838ThrLys: 1.838 ± 0.338
5.245ThrLeu: 5.245 ± 0.602
1.19ThrMet: 1.19 ± 0.26
1.892ThrAsn: 1.892 ± 0.333
2.92ThrPro: 2.92 ± 0.427
1.946ThrGln: 1.946 ± 0.386
3.028ThrArg: 3.028 ± 0.419
3.406ThrSer: 3.406 ± 0.474
3.136ThrThr: 3.136 ± 0.492
4.434ThrVal: 4.434 ± 0.602
1.027ThrTrp: 1.027 ± 0.241
1.892ThrTyr: 1.892 ± 0.289
0.0ThrXaa: 0.0 ± 0.0
Val
7.245ValAla: 7.245 ± 0.568
0.595ValCys: 0.595 ± 0.195
5.731ValAsp: 5.731 ± 0.506
4.92ValGlu: 4.92 ± 0.594
2.217ValPhe: 2.217 ± 0.254
4.542ValGly: 4.542 ± 0.575
1.73ValHis: 1.73 ± 0.339
2.217ValIle: 2.217 ± 0.373
3.514ValLys: 3.514 ± 0.345
5.569ValLeu: 5.569 ± 0.672
2.001ValMet: 2.001 ± 0.385
2.001ValAsn: 2.001 ± 0.329
3.677ValPro: 3.677 ± 0.471
2.974ValGln: 2.974 ± 0.357
5.191ValArg: 5.191 ± 0.521
4.001ValSer: 4.001 ± 0.577
4.596ValThr: 4.596 ± 0.492
6.326ValVal: 6.326 ± 0.646
1.46ValTrp: 1.46 ± 0.301
1.622ValTyr: 1.622 ± 0.312
0.0ValXaa: 0.0 ± 0.0
Trp
1.676TrpAla: 1.676 ± 0.297
0.216TrpCys: 0.216 ± 0.114
1.514TrpAsp: 1.514 ± 0.261
1.676TrpGlu: 1.676 ± 0.313
0.865TrpPhe: 0.865 ± 0.196
0.811TrpGly: 0.811 ± 0.253
0.27TrpHis: 0.27 ± 0.122
0.649TrpIle: 0.649 ± 0.18
0.919TrpLys: 0.919 ± 0.216
1.46TrpLeu: 1.46 ± 0.278
0.324TrpMet: 0.324 ± 0.184
0.487TrpAsn: 0.487 ± 0.187
0.703TrpPro: 0.703 ± 0.209
0.919TrpGln: 0.919 ± 0.233
1.676TrpArg: 1.676 ± 0.37
1.352TrpSer: 1.352 ± 0.256
1.081TrpThr: 1.081 ± 0.281
1.298TrpVal: 1.298 ± 0.186
0.378TrpTrp: 0.378 ± 0.155
1.027TrpTyr: 1.027 ± 0.2
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.649TyrAla: 2.649 ± 0.322
0.649TyrCys: 0.649 ± 0.177
1.73TyrAsp: 1.73 ± 0.371
1.892TyrGlu: 1.892 ± 0.355
0.27TyrPhe: 0.27 ± 0.155
2.487TyrGly: 2.487 ± 0.358
0.811TyrHis: 0.811 ± 0.171
0.919TyrIle: 0.919 ± 0.199
1.244TyrLys: 1.244 ± 0.322
2.271TyrLeu: 2.271 ± 0.408
0.649TyrMet: 0.649 ± 0.178
0.703TyrAsn: 0.703 ± 0.17
1.19TyrPro: 1.19 ± 0.262
1.244TyrGln: 1.244 ± 0.223
2.055TyrArg: 2.055 ± 0.345
1.352TyrSer: 1.352 ± 0.305
1.46TyrThr: 1.46 ± 0.293
1.946TyrVal: 1.946 ± 0.328
0.378TyrTrp: 0.378 ± 0.141
0.649TyrTyr: 0.649 ± 0.18
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 79 proteins (18496 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski