Amino acid dipepetide frequency for Propionibacterium phage P1.1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.699AlaAla: 10.699 ± 1.843
1.114AlaCys: 1.114 ± 0.461
7.021AlaAsp: 7.021 ± 0.972
5.572AlaGlu: 5.572 ± 0.946
2.675AlaPhe: 2.675 ± 0.55
9.919AlaGly: 9.919 ± 1.381
1.895AlaHis: 1.895 ± 0.521
5.238AlaIle: 5.238 ± 0.738
4.123AlaLys: 4.123 ± 0.592
7.578AlaLeu: 7.578 ± 1.123
3.678AlaMet: 3.678 ± 1.268
2.34AlaAsn: 2.34 ± 0.489
2.117AlaPro: 2.117 ± 0.43
4.346AlaGln: 4.346 ± 0.844
5.907AlaArg: 5.907 ± 1.082
6.575AlaSer: 6.575 ± 0.819
5.907AlaThr: 5.907 ± 0.874
8.693AlaVal: 8.693 ± 1.436
1.449AlaTrp: 1.449 ± 0.384
2.563AlaTyr: 2.563 ± 0.554
0.0AlaXaa: 0.0 ± 0.0
Cys
0.78CysAla: 0.78 ± 0.286
0.111CysCys: 0.111 ± 0.103
1.226CysAsp: 1.226 ± 0.429
1.003CysGlu: 1.003 ± 0.327
0.0CysPhe: 0.0 ± 0.0
1.337CysGly: 1.337 ± 0.424
0.223CysHis: 0.223 ± 0.164
0.223CysIle: 0.223 ± 0.171
0.446CysLys: 0.446 ± 0.278
0.446CysLeu: 0.446 ± 0.224
0.0CysMet: 0.0 ± 0.0
0.223CysAsn: 0.223 ± 0.177
0.78CysPro: 0.78 ± 0.281
0.334CysGln: 0.334 ± 0.182
1.56CysArg: 1.56 ± 0.492
0.557CysSer: 0.557 ± 0.285
0.78CysThr: 0.78 ± 0.271
0.669CysVal: 0.669 ± 0.277
0.334CysTrp: 0.334 ± 0.182
0.223CysTyr: 0.223 ± 0.168
0.0CysXaa: 0.0 ± 0.0
Asp
5.572AspAla: 5.572 ± 0.776
0.78AspCys: 0.78 ± 0.267
5.126AspAsp: 5.126 ± 0.686
3.343AspGlu: 3.343 ± 0.771
1.783AspPhe: 1.783 ± 0.437
6.575AspGly: 6.575 ± 1.554
1.783AspHis: 1.783 ± 0.438
2.452AspIle: 2.452 ± 0.639
2.452AspLys: 2.452 ± 0.608
4.681AspLeu: 4.681 ± 0.861
1.003AspMet: 1.003 ± 0.379
2.786AspAsn: 2.786 ± 0.712
3.678AspPro: 3.678 ± 0.908
1.895AspGln: 1.895 ± 0.515
3.678AspArg: 3.678 ± 0.67
3.678AspSer: 3.678 ± 0.803
5.126AspThr: 5.126 ± 0.757
4.569AspVal: 4.569 ± 0.685
1.895AspTrp: 1.895 ± 0.581
2.452AspTyr: 2.452 ± 0.634
0.0AspXaa: 0.0 ± 0.0
Glu
5.572GluAla: 5.572 ± 1.088
0.557GluCys: 0.557 ± 0.249
1.672GluAsp: 1.672 ± 0.658
2.229GluGlu: 2.229 ± 0.541
1.226GluPhe: 1.226 ± 0.306
3.455GluGly: 3.455 ± 0.599
0.78GluHis: 0.78 ± 0.302
2.452GluIle: 2.452 ± 0.492
1.783GluLys: 1.783 ± 0.529
3.678GluLeu: 3.678 ± 0.743
0.892GluMet: 0.892 ± 0.251
2.006GluAsn: 2.006 ± 0.475
1.449GluPro: 1.449 ± 0.451
2.786GluGln: 2.786 ± 0.442
3.343GluArg: 3.343 ± 0.624
4.458GluSer: 4.458 ± 0.922
2.786GluThr: 2.786 ± 0.646
3.12GluVal: 3.12 ± 0.705
1.56GluTrp: 1.56 ± 0.481
1.895GluTyr: 1.895 ± 0.453
0.0GluXaa: 0.0 ± 0.0
Phe
3.12PheAla: 3.12 ± 0.944
0.334PheCys: 0.334 ± 0.214
1.783PheAsp: 1.783 ± 0.531
1.56PheGlu: 1.56 ± 0.363
1.226PhePhe: 1.226 ± 0.287
2.563PheGly: 2.563 ± 0.565
0.78PheHis: 0.78 ± 0.32
1.337PheIle: 1.337 ± 0.319
1.449PheLys: 1.449 ± 0.446
1.56PheLeu: 1.56 ± 0.379
0.892PheMet: 0.892 ± 0.313
0.78PheAsn: 0.78 ± 0.422
1.337PhePro: 1.337 ± 0.362
0.78PheGln: 0.78 ± 0.25
2.229PheArg: 2.229 ± 0.569
2.006PheSer: 2.006 ± 0.501
1.783PheThr: 1.783 ± 0.376
1.895PheVal: 1.895 ± 0.498
0.557PheTrp: 0.557 ± 0.245
0.111PheTyr: 0.111 ± 0.107
0.0PheXaa: 0.0 ± 0.0
Gly
7.021GlyAla: 7.021 ± 1.367
0.446GlyCys: 0.446 ± 0.221
5.572GlyAsp: 5.572 ± 0.802
4.235GlyGlu: 4.235 ± 0.568
3.009GlyPhe: 3.009 ± 0.743
7.133GlyGly: 7.133 ± 0.949
1.895GlyHis: 1.895 ± 0.509
2.563GlyIle: 2.563 ± 0.684
4.458GlyLys: 4.458 ± 0.63
7.801GlyLeu: 7.801 ± 0.954
2.006GlyMet: 2.006 ± 0.503
2.229GlyAsn: 2.229 ± 0.478
4.123GlyPro: 4.123 ± 1.455
3.566GlyGln: 3.566 ± 0.585
4.904GlyArg: 4.904 ± 0.959
6.687GlySer: 6.687 ± 1.124
4.235GlyThr: 4.235 ± 0.815
8.804GlyVal: 8.804 ± 1.342
2.117GlyTrp: 2.117 ± 0.518
2.898GlyTyr: 2.898 ± 0.553
0.0GlyXaa: 0.0 ± 0.0
His
1.895HisAla: 1.895 ± 0.623
0.892HisCys: 0.892 ± 0.299
1.672HisAsp: 1.672 ± 0.469
0.446HisGlu: 0.446 ± 0.276
0.557HisPhe: 0.557 ± 0.262
1.56HisGly: 1.56 ± 0.332
1.672HisHis: 1.672 ± 0.523
1.783HisIle: 1.783 ± 0.462
1.337HisLys: 1.337 ± 0.523
2.34HisLeu: 2.34 ± 0.553
0.334HisMet: 0.334 ± 0.195
1.449HisAsn: 1.449 ± 0.448
1.337HisPro: 1.337 ± 0.407
1.114HisGln: 1.114 ± 0.428
1.449HisArg: 1.449 ± 0.398
1.226HisSer: 1.226 ± 0.334
1.895HisThr: 1.895 ± 0.479
1.449HisVal: 1.449 ± 0.355
0.334HisTrp: 0.334 ± 0.202
1.003HisTyr: 1.003 ± 0.392
0.0HisXaa: 0.0 ± 0.0
Ile
3.901IleAla: 3.901 ± 0.627
0.557IleCys: 0.557 ± 0.27
4.904IleAsp: 4.904 ± 0.705
2.898IleGlu: 2.898 ± 0.568
1.337IlePhe: 1.337 ± 0.393
2.229IleGly: 2.229 ± 0.718
1.449IleHis: 1.449 ± 0.393
3.901IleIle: 3.901 ± 0.935
1.56IleLys: 1.56 ± 0.358
3.566IleLeu: 3.566 ± 0.589
1.337IleMet: 1.337 ± 0.44
2.229IleAsn: 2.229 ± 0.489
2.898IlePro: 2.898 ± 0.528
1.783IleGln: 1.783 ± 0.464
2.786IleArg: 2.786 ± 0.551
3.009IleSer: 3.009 ± 0.609
4.123IleThr: 4.123 ± 0.842
3.566IleVal: 3.566 ± 0.48
0.334IleTrp: 0.334 ± 0.219
0.892IleTyr: 0.892 ± 0.431
0.0IleXaa: 0.0 ± 0.0
Lys
4.792LysAla: 4.792 ± 0.986
0.223LysCys: 0.223 ± 0.163
3.232LysAsp: 3.232 ± 0.776
1.003LysGlu: 1.003 ± 0.326
0.669LysPhe: 0.669 ± 0.325
3.343LysGly: 3.343 ± 0.638
1.337LysHis: 1.337 ± 0.377
1.56LysIle: 1.56 ± 0.525
1.226LysLys: 1.226 ± 0.391
3.232LysLeu: 3.232 ± 0.534
1.114LysMet: 1.114 ± 0.352
1.783LysAsn: 1.783 ± 0.404
3.009LysPro: 3.009 ± 0.555
2.563LysGln: 2.563 ± 0.657
3.009LysArg: 3.009 ± 0.629
2.229LysSer: 2.229 ± 0.733
3.232LysThr: 3.232 ± 0.681
1.114LysVal: 1.114 ± 0.357
0.669LysTrp: 0.669 ± 0.279
1.226LysTyr: 1.226 ± 0.42
0.0LysXaa: 0.0 ± 0.0
Leu
9.696LeuAla: 9.696 ± 1.178
1.337LeuCys: 1.337 ± 0.37
5.349LeuAsp: 5.349 ± 1.092
3.789LeuGlu: 3.789 ± 0.688
2.117LeuPhe: 2.117 ± 0.537
6.241LeuGly: 6.241 ± 1.213
2.229LeuHis: 2.229 ± 0.534
2.898LeuIle: 2.898 ± 0.731
4.235LeuLys: 4.235 ± 0.634
4.458LeuLeu: 4.458 ± 0.628
1.449LeuMet: 1.449 ± 0.398
3.12LeuAsn: 3.12 ± 0.513
4.235LeuPro: 4.235 ± 0.607
3.343LeuGln: 3.343 ± 0.516
2.675LeuArg: 2.675 ± 0.642
5.572LeuSer: 5.572 ± 0.752
4.458LeuThr: 4.458 ± 0.833
4.458LeuVal: 4.458 ± 0.711
0.892LeuTrp: 0.892 ± 0.344
1.783LeuTyr: 1.783 ± 0.569
0.0LeuXaa: 0.0 ± 0.0
Met
3.12MetAla: 3.12 ± 0.475
0.557MetCys: 0.557 ± 0.223
0.892MetAsp: 0.892 ± 0.408
0.892MetGlu: 0.892 ± 0.306
1.114MetPhe: 1.114 ± 0.356
1.449MetGly: 1.449 ± 0.508
0.557MetHis: 0.557 ± 0.239
2.006MetIle: 2.006 ± 0.478
0.78MetLys: 0.78 ± 0.328
2.563MetLeu: 2.563 ± 0.429
0.446MetMet: 0.446 ± 0.193
1.226MetAsn: 1.226 ± 0.432
1.783MetPro: 1.783 ± 0.714
1.226MetGln: 1.226 ± 0.39
1.226MetArg: 1.226 ± 0.324
1.895MetSer: 1.895 ± 0.467
1.003MetThr: 1.003 ± 0.339
1.783MetVal: 1.783 ± 0.386
0.557MetTrp: 0.557 ± 0.231
0.892MetTyr: 0.892 ± 0.363
0.0MetXaa: 0.0 ± 0.0
Asn
2.563AsnAla: 2.563 ± 0.858
0.111AsnCys: 0.111 ± 0.107
1.449AsnAsp: 1.449 ± 0.304
1.672AsnGlu: 1.672 ± 0.44
0.557AsnPhe: 0.557 ± 0.254
5.015AsnGly: 5.015 ± 0.767
1.226AsnHis: 1.226 ± 0.368
2.229AsnIle: 2.229 ± 0.468
1.672AsnLys: 1.672 ± 0.517
2.117AsnLeu: 2.117 ± 0.488
1.226AsnMet: 1.226 ± 0.274
2.34AsnAsn: 2.34 ± 0.732
2.898AsnPro: 2.898 ± 0.664
1.783AsnGln: 1.783 ± 0.474
2.229AsnArg: 2.229 ± 0.641
1.783AsnSer: 1.783 ± 0.487
2.675AsnThr: 2.675 ± 0.75
3.009AsnVal: 3.009 ± 0.577
0.446AsnTrp: 0.446 ± 0.306
0.78AsnTyr: 0.78 ± 0.303
0.0AsnXaa: 0.0 ± 0.0
Pro
5.238ProAla: 5.238 ± 0.968
0.334ProCys: 0.334 ± 0.208
4.458ProAsp: 4.458 ± 0.678
2.675ProGlu: 2.675 ± 0.607
1.337ProPhe: 1.337 ± 0.393
5.015ProGly: 5.015 ± 0.903
1.449ProHis: 1.449 ± 0.459
2.006ProIle: 2.006 ± 0.441
1.895ProLys: 1.895 ± 0.482
3.232ProLeu: 3.232 ± 0.535
0.669ProMet: 0.669 ± 0.316
2.117ProAsn: 2.117 ± 0.522
3.455ProPro: 3.455 ± 0.871
2.34ProGln: 2.34 ± 0.737
1.337ProArg: 1.337 ± 0.435
3.232ProSer: 3.232 ± 0.618
2.675ProThr: 2.675 ± 0.513
5.461ProVal: 5.461 ± 1.154
1.56ProTrp: 1.56 ± 0.535
0.78ProTyr: 0.78 ± 0.306
0.0ProXaa: 0.0 ± 0.0
Gln
4.569GlnAla: 4.569 ± 1.009
0.557GlnCys: 0.557 ± 0.299
1.56GlnAsp: 1.56 ± 0.365
1.226GlnGlu: 1.226 ± 0.386
0.78GlnPhe: 0.78 ± 0.248
2.452GlnGly: 2.452 ± 0.818
1.783GlnHis: 1.783 ± 0.538
2.786GlnIle: 2.786 ± 0.562
1.337GlnLys: 1.337 ± 0.321
4.012GlnLeu: 4.012 ± 0.735
1.56GlnMet: 1.56 ± 0.431
1.449GlnAsn: 1.449 ± 0.505
3.12GlnPro: 3.12 ± 0.642
3.789GlnGln: 3.789 ± 0.94
3.009GlnArg: 3.009 ± 0.623
1.895GlnSer: 1.895 ± 0.403
3.009GlnThr: 3.009 ± 0.702
2.898GlnVal: 2.898 ± 0.638
1.114GlnTrp: 1.114 ± 0.323
1.337GlnTyr: 1.337 ± 0.333
0.0GlnXaa: 0.0 ± 0.0
Arg
5.572ArgAla: 5.572 ± 0.937
0.223ArgCys: 0.223 ± 0.168
3.009ArgAsp: 3.009 ± 0.493
2.563ArgGlu: 2.563 ± 0.565
2.006ArgPhe: 2.006 ± 0.514
4.123ArgGly: 4.123 ± 0.714
1.449ArgHis: 1.449 ± 0.322
3.343ArgIle: 3.343 ± 0.641
2.675ArgLys: 2.675 ± 0.679
5.684ArgLeu: 5.684 ± 0.911
2.117ArgMet: 2.117 ± 0.552
2.452ArgAsn: 2.452 ± 0.652
1.56ArgPro: 1.56 ± 0.447
3.009ArgGln: 3.009 ± 0.618
5.015ArgArg: 5.015 ± 0.911
4.569ArgSer: 4.569 ± 0.88
2.563ArgThr: 2.563 ± 0.574
5.126ArgVal: 5.126 ± 0.877
1.114ArgTrp: 1.114 ± 0.383
2.229ArgTyr: 2.229 ± 0.502
0.0ArgXaa: 0.0 ± 0.0
Ser
6.91SerAla: 6.91 ± 1.163
0.446SerCys: 0.446 ± 0.217
4.123SerAsp: 4.123 ± 0.721
3.343SerGlu: 3.343 ± 0.633
3.12SerPhe: 3.12 ± 0.557
8.024SerGly: 8.024 ± 1.305
1.114SerHis: 1.114 ± 0.32
3.009SerIle: 3.009 ± 0.581
1.783SerLys: 1.783 ± 0.487
4.458SerLeu: 4.458 ± 0.551
2.675SerMet: 2.675 ± 0.421
2.34SerAsn: 2.34 ± 0.485
3.12SerPro: 3.12 ± 0.697
2.006SerGln: 2.006 ± 0.46
3.678SerArg: 3.678 ± 0.738
4.012SerSer: 4.012 ± 0.81
3.343SerThr: 3.343 ± 0.74
6.129SerVal: 6.129 ± 1.115
1.895SerTrp: 1.895 ± 0.461
0.669SerTyr: 0.669 ± 0.286
0.0SerXaa: 0.0 ± 0.0
Thr
6.464ThrAla: 6.464 ± 0.928
1.003ThrCys: 1.003 ± 0.328
3.789ThrAsp: 3.789 ± 0.469
1.895ThrGlu: 1.895 ± 0.433
1.895ThrPhe: 1.895 ± 0.55
5.238ThrGly: 5.238 ± 0.672
1.114ThrHis: 1.114 ± 0.411
4.792ThrIle: 4.792 ± 0.729
2.34ThrLys: 2.34 ± 0.58
4.012ThrLeu: 4.012 ± 0.987
0.557ThrMet: 0.557 ± 0.237
1.672ThrAsn: 1.672 ± 0.483
4.012ThrPro: 4.012 ± 0.686
2.786ThrGln: 2.786 ± 0.611
3.343ThrArg: 3.343 ± 0.627
3.789ThrSer: 3.789 ± 0.561
3.901ThrThr: 3.901 ± 0.944
5.907ThrVal: 5.907 ± 0.913
1.003ThrTrp: 1.003 ± 0.369
2.117ThrTyr: 2.117 ± 0.484
0.0ThrXaa: 0.0 ± 0.0
Val
7.913ValAla: 7.913 ± 1.315
0.892ValCys: 0.892 ± 0.403
5.349ValAsp: 5.349 ± 0.848
5.126ValGlu: 5.126 ± 0.947
1.895ValPhe: 1.895 ± 0.518
6.129ValGly: 6.129 ± 0.964
1.56ValHis: 1.56 ± 0.348
2.786ValIle: 2.786 ± 0.913
3.566ValLys: 3.566 ± 0.74
6.129ValLeu: 6.129 ± 0.785
2.675ValMet: 2.675 ± 0.619
2.786ValAsn: 2.786 ± 0.603
3.789ValPro: 3.789 ± 0.499
2.229ValGln: 2.229 ± 0.598
4.346ValArg: 4.346 ± 0.769
6.352ValSer: 6.352 ± 0.972
4.458ValThr: 4.458 ± 0.719
6.352ValVal: 6.352 ± 1.045
1.56ValTrp: 1.56 ± 0.509
1.895ValTyr: 1.895 ± 0.455
0.0ValXaa: 0.0 ± 0.0
Trp
1.783TrpAla: 1.783 ± 0.443
0.334TrpCys: 0.334 ± 0.204
0.78TrpAsp: 0.78 ± 0.257
1.003TrpGlu: 1.003 ± 0.341
0.334TrpPhe: 0.334 ± 0.19
1.114TrpGly: 1.114 ± 0.523
0.669TrpHis: 0.669 ± 0.306
0.892TrpIle: 0.892 ± 0.285
0.78TrpLys: 0.78 ± 0.278
1.56TrpLeu: 1.56 ± 0.492
0.892TrpMet: 0.892 ± 0.272
1.337TrpAsn: 1.337 ± 0.411
0.557TrpPro: 0.557 ± 0.22
1.114TrpGln: 1.114 ± 0.382
2.229TrpArg: 2.229 ± 0.595
1.226TrpSer: 1.226 ± 0.442
1.449TrpThr: 1.449 ± 0.396
1.003TrpVal: 1.003 ± 0.373
0.446TrpTrp: 0.446 ± 0.218
0.669TrpTyr: 0.669 ± 0.298
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.229TyrAla: 2.229 ± 0.475
0.446TyrCys: 0.446 ± 0.218
2.34TyrAsp: 2.34 ± 0.51
1.226TyrGlu: 1.226 ± 0.331
0.446TyrPhe: 0.446 ± 0.208
2.786TyrGly: 2.786 ± 0.445
0.78TyrHis: 0.78 ± 0.281
1.003TyrIle: 1.003 ± 0.376
0.669TyrLys: 0.669 ± 0.28
1.226TyrLeu: 1.226 ± 0.357
0.334TyrMet: 0.334 ± 0.192
1.114TyrAsn: 1.114 ± 0.49
2.006TyrPro: 2.006 ± 0.532
1.56TyrGln: 1.56 ± 0.469
2.452TyrArg: 2.452 ± 0.448
1.449TyrSer: 1.449 ± 0.368
2.229TyrThr: 2.229 ± 0.454
1.783TyrVal: 1.783 ± 0.412
0.334TyrTrp: 0.334 ± 0.207
0.78TyrTyr: 0.78 ± 0.27
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 45 proteins (8974 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski