Amino acid dipepetide frequency for Celeribacter manganoxidans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.443AlaAla: 18.443 ± 0.192
1.132AlaCys: 1.132 ± 0.035
7.489AlaAsp: 7.489 ± 0.082
8.9AlaGlu: 8.9 ± 0.108
3.989AlaPhe: 3.989 ± 0.055
11.233AlaGly: 11.233 ± 0.124
2.37AlaHis: 2.37 ± 0.046
5.743AlaIle: 5.743 ± 0.075
3.023AlaLys: 3.023 ± 0.06
14.722AlaLeu: 14.722 ± 0.128
3.752AlaMet: 3.752 ± 0.061
2.51AlaAsn: 2.51 ± 0.049
7.119AlaPro: 7.119 ± 0.111
5.114AlaGln: 5.114 ± 0.077
10.213AlaArg: 10.213 ± 0.137
5.51AlaSer: 5.51 ± 0.08
6.61AlaThr: 6.61 ± 0.084
8.656AlaVal: 8.656 ± 0.096
1.514AlaTrp: 1.514 ± 0.041
2.48AlaTyr: 2.48 ± 0.046
0.0AlaXaa: 0.0 ± 0.0
Cys
1.179CysAla: 1.179 ± 0.037
0.101CysCys: 0.101 ± 0.01
0.591CysAsp: 0.591 ± 0.024
0.404CysGlu: 0.404 ± 0.017
0.32CysPhe: 0.32 ± 0.018
0.92CysGly: 0.92 ± 0.03
0.253CysHis: 0.253 ± 0.015
0.394CysIle: 0.394 ± 0.02
0.152CysLys: 0.152 ± 0.012
0.802CysLeu: 0.802 ± 0.029
0.152CysMet: 0.152 ± 0.01
0.189CysAsn: 0.189 ± 0.012
0.467CysPro: 0.467 ± 0.022
0.202CysGln: 0.202 ± 0.012
0.585CysArg: 0.585 ± 0.024
0.417CysSer: 0.417 ± 0.021
0.458CysThr: 0.458 ± 0.023
0.633CysVal: 0.633 ± 0.023
0.096CysTrp: 0.096 ± 0.009
0.188CysTyr: 0.188 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
8.251AspAla: 8.251 ± 0.094
0.486AspCys: 0.486 ± 0.023
3.66AspAsp: 3.66 ± 0.084
3.377AspGlu: 3.377 ± 0.061
2.173AspPhe: 2.173 ± 0.046
5.826AspGly: 5.826 ± 0.093
1.386AspHis: 1.386 ± 0.037
2.888AspIle: 2.888 ± 0.047
1.361AspLys: 1.361 ± 0.039
7.035AspLeu: 7.035 ± 0.084
1.744AspMet: 1.744 ± 0.039
1.199AspAsn: 1.199 ± 0.047
3.962AspPro: 3.962 ± 0.066
1.806AspGln: 1.806 ± 0.044
4.852AspArg: 4.852 ± 0.077
2.338AspSer: 2.338 ± 0.052
3.439AspThr: 3.439 ± 0.071
4.0AspVal: 4.0 ± 0.071
1.173AspTrp: 1.173 ± 0.031
1.543AspTyr: 1.543 ± 0.04
0.0AspXaa: 0.0 ± 0.0
Glu
8.127GluAla: 8.127 ± 0.101
0.331GluCys: 0.331 ± 0.017
3.482GluAsp: 3.482 ± 0.061
3.197GluGlu: 3.197 ± 0.069
1.769GluPhe: 1.769 ± 0.037
4.758GluGly: 4.758 ± 0.075
1.055GluHis: 1.055 ± 0.029
3.502GluIle: 3.502 ± 0.058
1.783GluLys: 1.783 ± 0.047
5.073GluLeu: 5.073 ± 0.074
1.72GluMet: 1.72 ± 0.045
1.499GluAsn: 1.499 ± 0.037
2.704GluPro: 2.704 ± 0.055
2.027GluGln: 2.027 ± 0.044
4.246GluArg: 4.246 ± 0.073
2.01GluSer: 2.01 ± 0.045
3.881GluThr: 3.881 ± 0.055
4.199GluVal: 4.199 ± 0.059
0.666GluTrp: 0.666 ± 0.023
0.924GluTyr: 0.924 ± 0.027
0.0GluXaa: 0.0 ± 0.0
Phe
4.467PheAla: 4.467 ± 0.07
0.4PheCys: 0.4 ± 0.016
2.782PheAsp: 2.782 ± 0.056
1.982PheGlu: 1.982 ± 0.047
1.289PhePhe: 1.289 ± 0.04
3.588PheGly: 3.588 ± 0.069
0.692PheHis: 0.692 ± 0.032
1.458PheIle: 1.458 ± 0.038
0.733PheLys: 0.733 ± 0.028
3.175PheLeu: 3.175 ± 0.061
0.772PheMet: 0.772 ± 0.026
0.911PheAsn: 0.911 ± 0.026
1.486PhePro: 1.486 ± 0.034
0.918PheGln: 0.918 ± 0.03
2.19PheArg: 2.19 ± 0.042
1.919PheSer: 1.919 ± 0.043
2.022PheThr: 2.022 ± 0.043
2.541PheVal: 2.541 ± 0.055
0.524PheTrp: 0.524 ± 0.021
0.884PheTyr: 0.884 ± 0.027
0.0PheXaa: 0.0 ± 0.0
Gly
10.889GlyAla: 10.889 ± 0.127
0.826GlyCys: 0.826 ± 0.028
4.896GlyAsp: 4.896 ± 0.09
4.622GlyGlu: 4.622 ± 0.066
3.55GlyPhe: 3.55 ± 0.061
7.799GlyGly: 7.799 ± 0.151
1.979GlyHis: 1.979 ± 0.049
4.384GlyIle: 4.384 ± 0.076
2.543GlyLys: 2.543 ± 0.051
9.429GlyLeu: 9.429 ± 0.117
2.647GlyMet: 2.647 ± 0.055
1.939GlyAsn: 1.939 ± 0.055
4.01GlyPro: 4.01 ± 0.062
3.118GlyGln: 3.118 ± 0.057
6.136GlyArg: 6.136 ± 0.085
4.428GlySer: 4.428 ± 0.089
5.154GlyThr: 5.154 ± 0.121
6.576GlyVal: 6.576 ± 0.088
1.492GlyTrp: 1.492 ± 0.035
2.255GlyTyr: 2.255 ± 0.046
0.0GlyXaa: 0.0 ± 0.0
His
2.52HisAla: 2.52 ± 0.048
0.243HisCys: 0.243 ± 0.015
1.369HisAsp: 1.369 ± 0.033
0.986HisGlu: 0.986 ± 0.031
0.722HisPhe: 0.722 ± 0.024
1.945HisGly: 1.945 ± 0.045
0.532HisHis: 0.532 ± 0.023
0.852HisIle: 0.852 ± 0.028
0.438HisLys: 0.438 ± 0.021
2.109HisLeu: 2.109 ± 0.047
0.534HisMet: 0.534 ± 0.023
0.394HisAsn: 0.394 ± 0.02
1.508HisPro: 1.508 ± 0.047
0.518HisGln: 0.518 ± 0.021
1.442HisArg: 1.442 ± 0.04
0.874HisSer: 0.874 ± 0.031
0.843HisThr: 0.843 ± 0.031
1.428HisVal: 1.428 ± 0.035
0.326HisTrp: 0.326 ± 0.018
0.57HisTyr: 0.57 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
7.138IleAla: 7.138 ± 0.081
0.57IleCys: 0.57 ± 0.022
3.583IleAsp: 3.583 ± 0.064
3.257IleGlu: 3.257 ± 0.051
1.622IlePhe: 1.622 ± 0.043
4.821IleGly: 4.821 ± 0.067
0.907IleHis: 0.907 ± 0.027
2.008IleIle: 2.008 ± 0.055
1.08IleLys: 1.08 ± 0.035
4.407IleLeu: 4.407 ± 0.07
0.961IleMet: 0.961 ± 0.026
1.23IleAsn: 1.23 ± 0.036
2.301IlePro: 2.301 ± 0.041
0.969IleGln: 0.969 ± 0.032
3.345IleArg: 3.345 ± 0.053
2.733IleSer: 2.733 ± 0.058
2.997IleThr: 2.997 ± 0.062
3.708IleVal: 3.708 ± 0.068
0.675IleTrp: 0.675 ± 0.026
1.18IleTyr: 1.18 ± 0.037
0.0IleXaa: 0.0 ± 0.0
Lys
2.997LysAla: 2.997 ± 0.065
0.155LysCys: 0.155 ± 0.01
1.277LysAsp: 1.277 ± 0.035
1.169LysGlu: 1.169 ± 0.037
0.805LysPhe: 0.805 ± 0.027
2.208LysGly: 2.208 ± 0.044
0.468LysHis: 0.468 ± 0.022
1.343LysIle: 1.343 ± 0.04
0.927LysLys: 0.927 ± 0.034
2.58LysLeu: 2.58 ± 0.052
0.691LysMet: 0.691 ± 0.024
0.582LysAsn: 0.582 ± 0.022
1.542LysPro: 1.542 ± 0.043
0.761LysGln: 0.761 ± 0.026
1.876LysArg: 1.876 ± 0.044
1.493LysSer: 1.493 ± 0.038
1.593LysThr: 1.593 ± 0.041
1.896LysVal: 1.896 ± 0.047
0.299LysTrp: 0.299 ± 0.016
0.517LysTyr: 0.517 ± 0.021
0.0LysXaa: 0.0 ± 0.0
Leu
13.32LeuAla: 13.32 ± 0.126
0.9LeuCys: 0.9 ± 0.027
6.478LeuAsp: 6.478 ± 0.08
5.13LeuGlu: 5.13 ± 0.068
3.344LeuPhe: 3.344 ± 0.055
8.784LeuGly: 8.784 ± 0.117
1.994LeuHis: 1.994 ± 0.047
5.464LeuIle: 5.464 ± 0.078
2.612LeuLys: 2.612 ± 0.054
9.47LeuLeu: 9.47 ± 0.132
2.577LeuMet: 2.577 ± 0.051
2.442LeuAsn: 2.442 ± 0.053
5.954LeuPro: 5.954 ± 0.09
2.662LeuGln: 2.662 ± 0.05
7.8LeuArg: 7.8 ± 0.098
6.453LeuSer: 6.453 ± 0.08
6.489LeuThr: 6.489 ± 0.092
6.715LeuVal: 6.715 ± 0.086
1.265LeuTrp: 1.265 ± 0.043
1.941LeuTyr: 1.941 ± 0.049
0.0LeuXaa: 0.0 ± 0.0
Met
3.338MetAla: 3.338 ± 0.058
0.194MetCys: 0.194 ± 0.013
1.339MetAsp: 1.339 ± 0.038
1.28MetGlu: 1.28 ± 0.034
0.803MetPhe: 0.803 ± 0.027
2.195MetGly: 2.195 ± 0.046
0.445MetHis: 0.445 ± 0.02
1.477MetIle: 1.477 ± 0.04
0.868MetLys: 0.868 ± 0.03
2.62MetLeu: 2.62 ± 0.054
0.729MetMet: 0.729 ± 0.03
0.75MetAsn: 0.75 ± 0.025
1.633MetPro: 1.633 ± 0.036
0.958MetGln: 0.958 ± 0.03
1.835MetArg: 1.835 ± 0.041
1.694MetSer: 1.694 ± 0.036
2.175MetThr: 2.175 ± 0.045
1.816MetVal: 1.816 ± 0.038
0.217MetTrp: 0.217 ± 0.015
0.315MetTyr: 0.315 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
2.912AsnAla: 2.912 ± 0.056
0.237AsnCys: 0.237 ± 0.017
1.353AsnAsp: 1.353 ± 0.052
1.046AsnGlu: 1.046 ± 0.032
0.856AsnPhe: 0.856 ± 0.024
2.224AsnGly: 2.224 ± 0.056
0.451AsnHis: 0.451 ± 0.02
1.172AsnIle: 1.172 ± 0.025
0.5AsnLys: 0.5 ± 0.021
2.288AsnLeu: 2.288 ± 0.046
0.593AsnMet: 0.593 ± 0.023
0.603AsnAsn: 0.603 ± 0.027
1.688AsnPro: 1.688 ± 0.042
0.591AsnGln: 0.591 ± 0.025
1.672AsnArg: 1.672 ± 0.043
1.112AsnSer: 1.112 ± 0.042
1.283AsnThr: 1.283 ± 0.043
1.692AsnVal: 1.692 ± 0.038
0.399AsnTrp: 0.399 ± 0.017
0.579AsnTyr: 0.579 ± 0.023
0.0AsnXaa: 0.0 ± 0.0
Pro
7.039ProAla: 7.039 ± 0.124
0.351ProCys: 0.351 ± 0.019
4.631ProAsp: 4.631 ± 0.075
4.198ProGlu: 4.198 ± 0.077
1.845ProPhe: 1.845 ± 0.039
5.006ProGly: 5.006 ± 0.071
1.159ProHis: 1.159 ± 0.031
2.231ProIle: 2.231 ± 0.043
1.291ProLys: 1.291 ± 0.04
4.965ProLeu: 4.965 ± 0.081
1.282ProMet: 1.282 ± 0.038
1.176ProAsn: 1.176 ± 0.03
2.69ProPro: 2.69 ± 0.06
1.76ProGln: 1.76 ± 0.039
3.466ProArg: 3.466 ± 0.068
2.437ProSer: 2.437 ± 0.05
2.539ProThr: 2.539 ± 0.046
4.624ProVal: 4.624 ± 0.076
0.677ProTrp: 0.677 ± 0.024
1.155ProTyr: 1.155 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
4.2GlnAla: 4.2 ± 0.063
0.2GlnCys: 0.2 ± 0.013
1.698GlnAsp: 1.698 ± 0.039
1.432GlnGlu: 1.432 ± 0.034
1.011GlnPhe: 1.011 ± 0.03
2.621GlnGly: 2.621 ± 0.05
0.532GlnHis: 0.532 ± 0.022
2.02GlnIle: 2.02 ± 0.042
0.913GlnLys: 0.913 ± 0.03
2.835GlnLeu: 2.835 ± 0.059
1.076GlnMet: 1.076 ± 0.033
0.812GlnAsn: 0.812 ± 0.029
1.686GlnPro: 1.686 ± 0.043
1.16GlnGln: 1.16 ± 0.043
2.223GlnArg: 2.223 ± 0.053
1.683GlnSer: 1.683 ± 0.042
1.802GlnThr: 1.802 ± 0.041
2.583GlnVal: 2.583 ± 0.044
0.362GlnTrp: 0.362 ± 0.017
0.531GlnTyr: 0.531 ± 0.024
0.0GlnXaa: 0.0 ± 0.0
Arg
9.493ArgAla: 9.493 ± 0.112
0.522ArgCys: 0.522 ± 0.023
4.77ArgAsp: 4.77 ± 0.079
3.875ArgGlu: 3.875 ± 0.071
2.711ArgPhe: 2.711 ± 0.047
5.179ArgGly: 5.179 ± 0.08
1.718ArgHis: 1.718 ± 0.049
3.888ArgIle: 3.888 ± 0.067
2.002ArgLys: 2.002 ± 0.043
7.83ArgLeu: 7.83 ± 0.115
2.103ArgMet: 2.103 ± 0.043
1.769ArgAsn: 1.769 ± 0.043
3.678ArgPro: 3.678 ± 0.072
2.37ArgGln: 2.37 ± 0.046
5.794ArgArg: 5.794 ± 0.094
3.493ArgSer: 3.493 ± 0.069
3.234ArgThr: 3.234 ± 0.056
5.097ArgVal: 5.097 ± 0.079
0.98ArgTrp: 0.98 ± 0.029
1.566ArgTyr: 1.566 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
6.153SerAla: 6.153 ± 0.081
0.4SerCys: 0.4 ± 0.021
3.292SerAsp: 3.292 ± 0.056
2.661SerGlu: 2.661 ± 0.055
2.102SerPhe: 2.102 ± 0.046
5.3SerGly: 5.3 ± 0.096
0.97SerHis: 0.97 ± 0.031
2.239SerIle: 2.239 ± 0.049
1.176SerLys: 1.176 ± 0.032
4.837SerLeu: 4.837 ± 0.062
1.237SerMet: 1.237 ± 0.033
1.257SerAsn: 1.257 ± 0.035
2.504SerPro: 2.504 ± 0.053
1.479SerGln: 1.479 ± 0.04
3.349SerArg: 3.349 ± 0.054
2.46SerSer: 2.46 ± 0.054
2.492SerThr: 2.492 ± 0.059
3.738SerVal: 3.738 ± 0.061
0.657SerTrp: 0.657 ± 0.026
1.317SerTyr: 1.317 ± 0.036
0.0SerXaa: 0.0 ± 0.0
Thr
7.002ThrAla: 7.002 ± 0.091
0.492ThrCys: 0.492 ± 0.022
3.448ThrAsp: 3.448 ± 0.063
3.163ThrGlu: 3.163 ± 0.057
1.848ThrPhe: 1.848 ± 0.049
5.949ThrGly: 5.949 ± 0.102
1.119ThrHis: 1.119 ± 0.03
2.595ThrIle: 2.595 ± 0.061
1.123ThrLys: 1.123 ± 0.036
6.165ThrLeu: 6.165 ± 0.095
1.196ThrMet: 1.196 ± 0.032
1.163ThrAsn: 1.163 ± 0.056
4.023ThrPro: 4.023 ± 0.067
1.584ThrGln: 1.584 ± 0.031
3.976ThrArg: 3.976 ± 0.061
2.634ThrSer: 2.634 ± 0.058
2.926ThrThr: 2.926 ± 0.068
4.528ThrVal: 4.528 ± 0.086
0.651ThrTrp: 0.651 ± 0.024
1.248ThrTyr: 1.248 ± 0.037
0.0ThrXaa: 0.0 ± 0.0
Val
9.157ValAla: 9.157 ± 0.105
0.619ValCys: 0.619 ± 0.023
4.006ValAsp: 4.006 ± 0.069
4.445ValGlu: 4.445 ± 0.063
2.651ValPhe: 2.651 ± 0.05
5.265ValGly: 5.265 ± 0.073
1.31ValHis: 1.31 ± 0.036
4.242ValIle: 4.242 ± 0.067
1.817ValLys: 1.817 ± 0.044
7.625ValLeu: 7.625 ± 0.09
2.073ValMet: 2.073 ± 0.048
1.889ValAsn: 1.889 ± 0.044
3.797ValPro: 3.797 ± 0.06
2.072ValGln: 2.072 ± 0.045
4.346ValArg: 4.346 ± 0.07
4.09ValSer: 4.09 ± 0.061
5.078ValThr: 5.078 ± 0.091
5.557ValVal: 5.557 ± 0.088
0.897ValTrp: 0.897 ± 0.026
1.402ValTyr: 1.402 ± 0.036
0.0ValXaa: 0.0 ± 0.0
Trp
1.331TrpAla: 1.331 ± 0.034
0.131TrpCys: 0.131 ± 0.01
0.766TrpAsp: 0.766 ± 0.03
0.641TrpGlu: 0.641 ± 0.021
0.489TrpPhe: 0.489 ± 0.021
0.986TrpGly: 0.986 ± 0.036
0.318TrpHis: 0.318 ± 0.019
0.677TrpIle: 0.677 ± 0.021
0.365TrpLys: 0.365 ± 0.019
1.652TrpLeu: 1.652 ± 0.045
0.387TrpMet: 0.387 ± 0.019
0.378TrpAsn: 0.378 ± 0.02
0.712TrpPro: 0.712 ± 0.025
0.63TrpGln: 0.63 ± 0.027
1.103TrpArg: 1.103 ± 0.032
0.789TrpSer: 0.789 ± 0.021
0.726TrpThr: 0.726 ± 0.026
0.853TrpVal: 0.853 ± 0.027
0.221TrpTrp: 0.221 ± 0.013
0.252TrpTyr: 0.252 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.565TyrAla: 2.565 ± 0.052
0.216TyrCys: 0.216 ± 0.014
1.586TyrAsp: 1.586 ± 0.039
1.187TyrGlu: 1.187 ± 0.034
0.833TyrPhe: 0.833 ± 0.029
2.066TyrGly: 2.066 ± 0.047
0.495TyrHis: 0.495 ± 0.02
0.914TyrIle: 0.914 ± 0.03
0.476TyrLys: 0.476 ± 0.02
2.173TyrLeu: 2.173 ± 0.047
0.452TyrMet: 0.452 ± 0.019
0.562TyrAsn: 0.562 ± 0.021
1.054TyrPro: 1.054 ± 0.027
0.683TyrGln: 0.683 ± 0.024
1.621TyrArg: 1.621 ± 0.036
1.052TyrSer: 1.052 ± 0.031
1.095TyrThr: 1.095 ± 0.032
1.499TyrVal: 1.499 ± 0.032
0.319TyrTrp: 0.319 ± 0.017
0.543TyrTyr: 0.543 ± 0.025
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3510 proteins (1141079 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski