Amino acid dipepetide frequency for [Clostridium] innocuum 2959

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.154AlaAla: 6.154 ± 0.084	1.287AlaCys: 1.287 ± 0.035	4.128AlaAsp: 4.128 ± 0.059	4.189AlaGlu: 4.189 ± 0.068	3.325AlaPhe: 3.325 ± 0.052	4.907AlaGly: 4.907 ± 0.077	1.421AlaHis: 1.421 ± 0.033	5.332AlaIle: 5.332 ± 0.076	4.327AlaLys: 4.327 ± 0.069	7.466AlaLeu: 7.466 ± 0.086	2.665AlaMet: 2.665 ± 0.045	2.585AlaAsn: 2.585 ± 0.044	1.596AlaPro: 1.596 ± 0.041	2.801AlaGln: 2.801 ± 0.05	2.829AlaArg: 2.829 ± 0.048	4.064AlaSer: 4.064 ± 0.057	3.065AlaThr: 3.065 ± 0.061	5.9AlaVal: 5.9 ± 0.083	0.721AlaTrp: 0.721 ± 0.027	3.047AlaTyr: 3.047 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.121CysAla: 1.121 ± 0.029	0.359CysCys: 0.359 ± 0.019	0.991CysAsp: 0.991 ± 0.026	1.12CysGlu: 1.12 ± 0.032	0.718CysPhe: 0.718 ± 0.025	1.331CysGly: 1.331 ± 0.039	0.331CysHis: 0.331 ± 0.017	1.38CysIle: 1.38 ± 0.032	0.803CysLys: 0.803 ± 0.027	1.255CysLeu: 1.255 ± 0.033	0.605CysMet: 0.605 ± 0.023	0.611CysAsn: 0.611 ± 0.021	0.538CysPro: 0.538 ± 0.023	0.354CysGln: 0.354 ± 0.016	0.823CysArg: 0.823 ± 0.025	1.071CysSer: 1.071 ± 0.026	0.781CysThr: 0.781 ± 0.026	1.093CysVal: 1.093 ± 0.03	0.127CysTrp: 0.127 ± 0.01	0.598CysTyr: 0.598 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	4.423AspAla: 4.423 ± 0.058	0.854AspCys: 0.854 ± 0.027	3.143AspAsp: 3.143 ± 0.046	4.656AspGlu: 4.656 ± 0.07	2.756AspPhe: 2.756 ± 0.05	3.676AspGly: 3.676 ± 0.069	1.166AspHis: 1.166 ± 0.029	5.164AspIle: 5.164 ± 0.064	3.464AspLys: 3.464 ± 0.065	4.655AspLeu: 4.655 ± 0.066	2.099AspMet: 2.099 ± 0.034	2.015AspAsn: 2.015 ± 0.036	1.712AspPro: 1.712 ± 0.032	1.491AspGln: 1.491 ± 0.029	2.26AspArg: 2.26 ± 0.045	2.937AspSer: 2.937 ± 0.047	3.39AspThr: 3.39 ± 0.051	3.987AspVal: 3.987 ± 0.056	0.536AspTrp: 0.536 ± 0.024	2.648AspTyr: 2.648 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	5.32GluAla: 5.32 ± 0.07	0.842GluCys: 0.842 ± 0.024	4.272GluAsp: 4.272 ± 0.062	6.597GluGlu: 6.597 ± 0.081	2.351GluPhe: 2.351 ± 0.039	3.775GluGly: 3.775 ± 0.06	1.794GluHis: 1.794 ± 0.036	5.336GluIle: 5.336 ± 0.069	5.935GluLys: 5.935 ± 0.075	6.906GluLeu: 6.906 ± 0.083	2.269GluMet: 2.269 ± 0.044	3.57GluAsn: 3.57 ± 0.049	1.62GluPro: 1.62 ± 0.034	3.563GluGln: 3.563 ± 0.064	3.392GluArg: 3.392 ± 0.057	3.035GluSer: 3.035 ± 0.048	3.356GluThr: 3.356 ± 0.05	4.076GluVal: 4.076 ± 0.058	0.567GluTrp: 0.567 ± 0.026	2.831GluTyr: 2.831 ± 0.051	0.0GluXaa: 0.0 ± 0.0
Phe	2.978PheAla: 2.978 ± 0.052	0.673PheCys: 0.673 ± 0.02	2.677PheAsp: 2.677 ± 0.045	2.569PheGlu: 2.569 ± 0.05	1.894PhePhe: 1.894 ± 0.047	2.584PheGly: 2.584 ± 0.043	1.225PheHis: 1.225 ± 0.032	3.035PheIle: 3.035 ± 0.057	2.027PheLys: 2.027 ± 0.039	4.585PheLeu: 4.585 ± 0.063	1.303PheMet: 1.303 ± 0.037	1.515PheAsn: 1.515 ± 0.039	1.323PhePro: 1.323 ± 0.032	1.712PheGln: 1.712 ± 0.032	1.505PheArg: 1.505 ± 0.035	2.835PheSer: 2.835 ± 0.048	2.589PheThr: 2.589 ± 0.046	2.749PheVal: 2.749 ± 0.049	0.357PheTrp: 0.357 ± 0.017	1.834PheTyr: 1.834 ± 0.045	0.0PheXaa: 0.0 ± 0.0
Gly	4.203GlyAla: 4.203 ± 0.087	1.284GlyCys: 1.284 ± 0.035	2.945GlyAsp: 2.945 ± 0.054	3.519GlyGlu: 3.519 ± 0.064	2.986GlyPhe: 2.986 ± 0.045	4.017GlyGly: 4.017 ± 0.066	1.135GlyHis: 1.135 ± 0.035	5.899GlyIle: 5.899 ± 0.078	4.56GlyLys: 4.56 ± 0.065	5.217GlyLeu: 5.217 ± 0.077	2.374GlyMet: 2.374 ± 0.039	2.923GlyAsn: 2.923 ± 0.054	1.185GlyPro: 1.185 ± 0.051	1.598GlyGln: 1.598 ± 0.034	2.499GlyArg: 2.499 ± 0.048	3.72GlySer: 3.72 ± 0.051	3.505GlyThr: 3.505 ± 0.067	4.265GlyVal: 4.265 ± 0.066	0.657GlyTrp: 0.657 ± 0.025	3.265GlyTyr: 3.265 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	1.808HisAla: 1.808 ± 0.036	0.373HisCys: 0.373 ± 0.018	1.237HisAsp: 1.237 ± 0.035	1.491HisGlu: 1.491 ± 0.035	0.882HisPhe: 0.882 ± 0.025	1.541HisGly: 1.541 ± 0.039	0.626HisHis: 0.626 ± 0.024	1.951HisIle: 1.951 ± 0.041	1.221HisLys: 1.221 ± 0.03	1.933HisLeu: 1.933 ± 0.039	0.85HisMet: 0.85 ± 0.022	0.832HisAsn: 0.832 ± 0.026	1.032HisPro: 1.032 ± 0.026	0.748HisGln: 0.748 ± 0.024	1.026HisArg: 1.026 ± 0.026	1.173HisSer: 1.173 ± 0.032	1.364HisThr: 1.364 ± 0.032	1.569HisVal: 1.569 ± 0.033	0.193HisTrp: 0.193 ± 0.011	0.931HisTyr: 0.931 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	6.049IleAla: 6.049 ± 0.074	1.346IleCys: 1.346 ± 0.035	4.307IleAsp: 4.307 ± 0.053	4.78IleGlu: 4.78 ± 0.067	2.875IlePhe: 2.875 ± 0.059	4.837IleGly: 4.837 ± 0.077	1.8IleHis: 1.8 ± 0.043	5.106IleIle: 5.106 ± 0.074	3.989IleLys: 3.989 ± 0.062	7.713IleLeu: 7.713 ± 0.09	2.239IleMet: 2.239 ± 0.041	2.944IleAsn: 2.944 ± 0.057	3.101IlePro: 3.101 ± 0.049	3.129IleGln: 3.129 ± 0.052	4.007IleArg: 4.007 ± 0.056	5.128IleSer: 5.128 ± 0.074	4.375IleThr: 4.375 ± 0.064	4.973IleVal: 4.973 ± 0.066	0.583IleTrp: 0.583 ± 0.023	2.831IleTyr: 2.831 ± 0.045	0.0IleXaa: 0.0 ± 0.0
Lys	4.856LysAla: 4.856 ± 0.067	0.611LysCys: 0.611 ± 0.025	4.506LysAsp: 4.506 ± 0.059	7.065LysGlu: 7.065 ± 0.069	1.677LysPhe: 1.677 ± 0.04	4.012LysGly: 4.012 ± 0.059	1.412LysHis: 1.412 ± 0.036	4.095LysIle: 4.095 ± 0.059	6.444LysLys: 6.444 ± 0.088	5.67LysLeu: 5.67 ± 0.069	1.966LysMet: 1.966 ± 0.042	3.386LysAsn: 3.386 ± 0.059	1.924LysPro: 1.924 ± 0.037	3.471LysGln: 3.471 ± 0.058	3.429LysArg: 3.429 ± 0.053	3.34LysSer: 3.34 ± 0.056	3.817LysThr: 3.817 ± 0.06	3.602LysVal: 3.602 ± 0.06	0.511LysTrp: 0.511 ± 0.021	2.454LysTyr: 2.454 ± 0.048	0.0LysXaa: 0.0 ± 0.0
Leu	6.464LeuAla: 6.464 ± 0.078	1.928LeuCys: 1.928 ± 0.046	5.268LeuAsp: 5.268 ± 0.063	6.025LeuGlu: 6.025 ± 0.081	4.307LeuPhe: 4.307 ± 0.073	5.317LeuGly: 5.317 ± 0.074	2.768LeuHis: 2.768 ± 0.051	6.525LeuIle: 6.525 ± 0.076	6.852LeuLys: 6.852 ± 0.067	10.633LeuLeu: 10.633 ± 0.14	3.054LeuMet: 3.054 ± 0.057	4.028LeuAsn: 4.028 ± 0.063	3.616LeuPro: 3.616 ± 0.051	4.733LeuGln: 4.733 ± 0.075	4.192LeuArg: 4.192 ± 0.064	6.508LeuSer: 6.508 ± 0.072	4.586LeuThr: 4.586 ± 0.065	5.253LeuVal: 5.253 ± 0.073	0.791LeuTrp: 0.791 ± 0.029	4.07LeuTyr: 4.07 ± 0.071	0.001LeuXaa: 0.001 ± 0.001
Met	2.112MetAla: 2.112 ± 0.041	0.379MetCys: 0.379 ± 0.017	1.99MetAsp: 1.99 ± 0.039	2.764MetGlu: 2.764 ± 0.045	1.123MetPhe: 1.123 ± 0.028	1.892MetGly: 1.892 ± 0.036	0.686MetHis: 0.686 ± 0.022	2.498MetIle: 2.498 ± 0.048	3.327MetLys: 3.327 ± 0.05	3.232MetLeu: 3.232 ± 0.057	1.146MetMet: 1.146 ± 0.033	1.728MetAsn: 1.728 ± 0.035	1.0MetPro: 1.0 ± 0.025	1.602MetGln: 1.602 ± 0.037	1.431MetArg: 1.431 ± 0.033	1.801MetSer: 1.801 ± 0.037	1.484MetThr: 1.484 ± 0.033	1.859MetVal: 1.859 ± 0.038	0.187MetTrp: 0.187 ± 0.012	0.995MetTyr: 0.995 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	3.289AsnAla: 3.289 ± 0.059	0.581AsnCys: 0.581 ± 0.021	2.377AsnAsp: 2.377 ± 0.046	3.053AsnGlu: 3.053 ± 0.049	1.461AsnPhe: 1.461 ± 0.038	3.159AsnGly: 3.159 ± 0.055	0.929AsnHis: 0.929 ± 0.025	3.381AsnIle: 3.381 ± 0.055	2.653AsnLys: 2.653 ± 0.051	3.583AsnLeu: 3.583 ± 0.051	1.334AsnMet: 1.334 ± 0.031	1.754AsnAsn: 1.754 ± 0.045	1.664AsnPro: 1.664 ± 0.035	1.466AsnGln: 1.466 ± 0.031	2.125AsnArg: 2.125 ± 0.039	2.234AsnSer: 2.234 ± 0.042	2.438AsnThr: 2.438 ± 0.045	2.729AsnVal: 2.729 ± 0.043	0.376AsnTrp: 0.376 ± 0.017	1.686AsnTyr: 1.686 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	2.112ProAla: 2.112 ± 0.04	0.468ProCys: 0.468 ± 0.019	1.842ProAsp: 1.842 ± 0.037	2.071ProGlu: 2.071 ± 0.043	1.591ProPhe: 1.591 ± 0.035	1.607ProGly: 1.607 ± 0.038	0.706ProHis: 0.706 ± 0.024	2.231ProIle: 2.231 ± 0.044	1.927ProLys: 1.927 ± 0.037	2.998ProLeu: 2.998 ± 0.053	0.927ProMet: 0.927 ± 0.028	1.283ProAsn: 1.283 ± 0.031	0.596ProPro: 0.596 ± 0.022	1.316ProGln: 1.316 ± 0.035	0.925ProArg: 0.925 ± 0.027	1.761ProSer: 1.761 ± 0.036	1.425ProThr: 1.425 ± 0.039	2.548ProVal: 2.548 ± 0.053	0.313ProTrp: 0.313 ± 0.016	1.543ProTyr: 1.543 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	2.684GlnAla: 2.684 ± 0.049	0.462GlnCys: 0.462 ± 0.019	2.162GlnAsp: 2.162 ± 0.041	3.577GlnGlu: 3.577 ± 0.066	1.39GlnPhe: 1.39 ± 0.035	2.278GlnGly: 2.278 ± 0.044	0.943GlnHis: 0.943 ± 0.028	2.758GlnIle: 2.758 ± 0.056	3.25GlnLys: 3.25 ± 0.051	4.288GlnLeu: 4.288 ± 0.069	1.222GlnMet: 1.222 ± 0.031	1.718GlnAsn: 1.718 ± 0.035	1.091GlnPro: 1.091 ± 0.029	1.884GlnGln: 1.884 ± 0.053	2.074GlnArg: 2.074 ± 0.045	1.957GlnSer: 1.957 ± 0.041	1.912GlnThr: 1.912 ± 0.042	2.122GlnVal: 2.122 ± 0.04	0.332GlnTrp: 0.332 ± 0.015	1.481GlnTyr: 1.481 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	2.394ArgAla: 2.394 ± 0.048	0.722ArgCys: 0.722 ± 0.024	2.38ArgAsp: 2.38 ± 0.043	3.489ArgGlu: 3.489 ± 0.057	1.943ArgPhe: 1.943 ± 0.037	2.135ArgGly: 2.135 ± 0.045	0.949ArgHis: 0.949 ± 0.029	3.906ArgIle: 3.906 ± 0.053	3.69ArgLys: 3.69 ± 0.058	4.315ArgLeu: 4.315 ± 0.065	1.773ArgMet: 1.773 ± 0.037	2.268ArgAsn: 2.268 ± 0.046	1.08ArgPro: 1.08 ± 0.029	1.755ArgGln: 1.755 ± 0.042	2.307ArgArg: 2.307 ± 0.043	2.543ArgSer: 2.543 ± 0.051	1.984ArgThr: 1.984 ± 0.035	2.653ArgVal: 2.653 ± 0.049	0.409ArgTrp: 0.409 ± 0.019	2.275ArgTyr: 2.275 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	3.986SerAla: 3.986 ± 0.053	1.028SerCys: 1.028 ± 0.026	3.266SerAsp: 3.266 ± 0.059	3.517SerGlu: 3.517 ± 0.058	3.143SerPhe: 3.143 ± 0.054	4.281SerGly: 4.281 ± 0.057	1.092SerHis: 1.092 ± 0.025	4.69SerIle: 4.69 ± 0.073	3.216SerLys: 3.216 ± 0.056	5.546SerLeu: 5.546 ± 0.075	2.082SerMet: 2.082 ± 0.043	2.246SerAsn: 2.246 ± 0.049	1.406SerPro: 1.406 ± 0.036	1.751SerGln: 1.751 ± 0.04	2.658SerArg: 2.658 ± 0.045	3.741SerSer: 3.741 ± 0.057	2.841SerThr: 2.841 ± 0.046	3.998SerVal: 3.998 ± 0.052	0.616SerTrp: 0.616 ± 0.023	2.855SerTyr: 2.855 ± 0.052	0.0SerXaa: 0.0 ± 0.0
Thr	4.135ThrAla: 4.135 ± 0.061	0.763ThrCys: 0.763 ± 0.026	2.676ThrAsp: 2.676 ± 0.046	2.817ThrGlu: 2.817 ± 0.053	2.269ThrPhe: 2.269 ± 0.043	3.782ThrGly: 3.782 ± 0.112	1.033ThrHis: 1.033 ± 0.029	4.216ThrIle: 4.216 ± 0.061	3.029ThrLys: 3.029 ± 0.057	5.37ThrLeu: 5.37 ± 0.07	1.661ThrMet: 1.661 ± 0.035	1.899ThrAsn: 1.899 ± 0.039	1.98ThrPro: 1.98 ± 0.044	1.762ThrGln: 1.762 ± 0.037	2.1ThrArg: 2.1 ± 0.043	3.025ThrSer: 3.025 ± 0.056	2.685ThrThr: 2.685 ± 0.047	3.675ThrVal: 3.675 ± 0.069	0.513ThrTrp: 0.513 ± 0.019	2.35ThrTyr: 2.35 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	4.087ValAla: 4.087 ± 0.066	1.279ValCys: 1.279 ± 0.032	3.572ValAsp: 3.572 ± 0.056	4.339ValGlu: 4.339 ± 0.062	3.058ValPhe: 3.058 ± 0.053	3.299ValGly: 3.299 ± 0.05	1.404ValHis: 1.404 ± 0.036	4.962ValIle: 4.962 ± 0.069	4.422ValLys: 4.422 ± 0.072	6.582ValLeu: 6.582 ± 0.074	2.033ValMet: 2.033 ± 0.038	2.834ValAsn: 2.834 ± 0.053	1.965ValPro: 1.965 ± 0.038	2.316ValGln: 2.316 ± 0.05	2.77ValArg: 2.77 ± 0.047	4.417ValSer: 4.417 ± 0.065	3.451ValThr: 3.451 ± 0.056	4.085ValVal: 4.085 ± 0.073	0.567ValTrp: 0.567 ± 0.024	2.83ValTyr: 2.83 ± 0.055	0.0ValXaa: 0.0 ± 0.0
Trp	0.442TrpAla: 0.442 ± 0.02	0.151TrpCys: 0.151 ± 0.011	0.48TrpAsp: 0.48 ± 0.022	0.568TrpGlu: 0.568 ± 0.019	0.404TrpPhe: 0.404 ± 0.018	0.521TrpGly: 0.521 ± 0.021	0.197TrpHis: 0.197 ± 0.014	0.745TrpIle: 0.745 ± 0.027	0.808TrpLys: 0.808 ± 0.026	0.923TrpLeu: 0.923 ± 0.027	0.369TrpMet: 0.369 ± 0.017	0.523TrpAsn: 0.523 ± 0.019	0.158TrpPro: 0.158 ± 0.011	0.345TrpGln: 0.345 ± 0.015	0.334TrpArg: 0.334 ± 0.018	0.468TrpSer: 0.468 ± 0.021	0.395TrpThr: 0.395 ± 0.02	0.449TrpVal: 0.449 ± 0.018	0.102TrpTrp: 0.102 ± 0.008	0.439TrpTyr: 0.439 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.196TyrAla: 3.196 ± 0.052	0.616TyrCys: 0.616 ± 0.021	2.816TyrAsp: 2.816 ± 0.047	3.201TyrGlu: 3.201 ± 0.054	1.816TyrPhe: 1.816 ± 0.04	2.803TyrGly: 2.803 ± 0.054	1.164TyrHis: 1.164 ± 0.031	2.903TyrIle: 2.903 ± 0.05	2.306TyrLys: 2.306 ± 0.05	4.052TyrLeu: 4.052 ± 0.053	1.266TyrMet: 1.266 ± 0.036	1.61TyrAsn: 1.61 ± 0.037	1.601TyrPro: 1.601 ± 0.039	1.785TyrGln: 1.785 ± 0.037	2.28TyrArg: 2.28 ± 0.042	2.201TyrSer: 2.201 ± 0.05	2.298TyrThr: 2.298 ± 0.046	2.688TyrVal: 2.688 ± 0.049	0.361TyrTrp: 0.361 ± 0.017	1.954TyrTyr: 1.954 ± 0.042	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4653 proteins (1343130 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---