Amino acid dipepetide frequency for Heliorestis convoluta

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.352AlaAla: 6.352 ± 0.117	0.816AlaCys: 0.816 ± 0.035	3.293AlaAsp: 3.293 ± 0.066	5.296AlaGlu: 5.296 ± 0.082	3.317AlaPhe: 3.317 ± 0.078	5.545AlaGly: 5.545 ± 0.09	1.489AlaHis: 1.489 ± 0.036	6.258AlaIle: 6.258 ± 0.077	4.207AlaLys: 4.207 ± 0.067	9.825AlaLeu: 9.825 ± 0.113	2.436AlaMet: 2.436 ± 0.056	2.403AlaAsn: 2.403 ± 0.054	2.663AlaPro: 2.663 ± 0.074	3.556AlaGln: 3.556 ± 0.075	4.107AlaArg: 4.107 ± 0.071	4.386AlaSer: 4.386 ± 0.087	4.306AlaThr: 4.306 ± 0.076	5.552AlaVal: 5.552 ± 0.079	0.801AlaTrp: 0.801 ± 0.031	2.461AlaTyr: 2.461 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.657CysAla: 0.657 ± 0.032	0.184CysCys: 0.184 ± 0.017	0.459CysAsp: 0.459 ± 0.023	0.491CysGlu: 0.491 ± 0.027	0.35CysPhe: 0.35 ± 0.022	0.899CysGly: 0.899 ± 0.039	0.338CysHis: 0.338 ± 0.024	0.547CysIle: 0.547 ± 0.028	0.481CysLys: 0.481 ± 0.027	0.849CysLeu: 0.849 ± 0.03	0.214CysMet: 0.214 ± 0.015	0.445CysAsn: 0.445 ± 0.024	0.655CysPro: 0.655 ± 0.037	0.506CysGln: 0.506 ± 0.029	0.566CysArg: 0.566 ± 0.023	0.62CysSer: 0.62 ± 0.027	0.507CysThr: 0.507 ± 0.026	0.438CysVal: 0.438 ± 0.023	0.092CysTrp: 0.092 ± 0.01	0.35CysTyr: 0.35 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	2.995AspAla: 2.995 ± 0.06	0.556AspCys: 0.556 ± 0.025	2.313AspAsp: 2.313 ± 0.065	3.683AspGlu: 3.683 ± 0.065	2.325AspPhe: 2.325 ± 0.051	3.309AspGly: 3.309 ± 0.06	1.067AspHis: 1.067 ± 0.034	3.568AspIle: 3.568 ± 0.063	2.84AspLys: 2.84 ± 0.063	5.495AspLeu: 5.495 ± 0.091	1.229AspMet: 1.229 ± 0.039	1.658AspAsn: 1.658 ± 0.051	2.171AspPro: 2.171 ± 0.054	2.218AspGln: 2.218 ± 0.053	2.863AspArg: 2.863 ± 0.061	2.651AspSer: 2.651 ± 0.056	2.057AspThr: 2.057 ± 0.048	3.238AspVal: 3.238 ± 0.06	0.619AspTrp: 0.619 ± 0.027	1.859AspTyr: 1.859 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	6.78GluAla: 6.78 ± 0.09	0.389GluCys: 0.389 ± 0.022	3.361GluAsp: 3.361 ± 0.06	8.198GluGlu: 8.198 ± 0.131	1.901GluPhe: 1.901 ± 0.055	5.041GluGly: 5.041 ± 0.086	1.234GluHis: 1.234 ± 0.039	5.392GluIle: 5.392 ± 0.081	7.418GluLys: 7.418 ± 0.125	6.929GluLeu: 6.929 ± 0.105	2.15GluMet: 2.15 ± 0.051	2.708GluAsn: 2.708 ± 0.059	2.314GluPro: 2.314 ± 0.048	3.79GluGln: 3.79 ± 0.076	4.714GluArg: 4.714 ± 0.092	3.717GluSer: 3.717 ± 0.061	3.088GluThr: 3.088 ± 0.061	5.644GluVal: 5.644 ± 0.086	0.715GluTrp: 0.715 ± 0.028	1.858GluTyr: 1.858 ± 0.054	0.0GluXaa: 0.0 ± 0.0
Phe	2.802PheAla: 2.802 ± 0.059	0.439PheCys: 0.439 ± 0.021	2.008PheAsp: 2.008 ± 0.048	2.299PheGlu: 2.299 ± 0.057	2.207PhePhe: 2.207 ± 0.06	2.761PheGly: 2.761 ± 0.054	0.929PheHis: 0.929 ± 0.033	2.587PheIle: 2.587 ± 0.058	1.469PheLys: 1.469 ± 0.044	4.465PheLeu: 4.465 ± 0.094	1.012PheMet: 1.012 ± 0.035	1.364PheAsn: 1.364 ± 0.045	1.512PhePro: 1.512 ± 0.044	1.695PheGln: 1.695 ± 0.042	1.895PheArg: 1.895 ± 0.046	2.676PheSer: 2.676 ± 0.057	2.199PheThr: 2.199 ± 0.063	2.514PheVal: 2.514 ± 0.056	0.467PheTrp: 0.467 ± 0.019	1.522PheTyr: 1.522 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	5.293GlyAla: 5.293 ± 0.099	0.796GlyCys: 0.796 ± 0.033	3.235GlyAsp: 3.235 ± 0.07	4.451GlyGlu: 4.451 ± 0.069	2.855GlyPhe: 2.855 ± 0.06	4.387GlyGly: 4.387 ± 0.094	1.637GlyHis: 1.637 ± 0.048	4.958GlyIle: 4.958 ± 0.085	4.5GlyLys: 4.5 ± 0.073	7.19GlyLeu: 7.19 ± 0.109	1.909GlyMet: 1.909 ± 0.048	2.268GlyAsn: 2.268 ± 0.049	2.192GlyPro: 2.192 ± 0.063	3.198GlyGln: 3.198 ± 0.073	3.724GlyArg: 3.724 ± 0.066	3.766GlySer: 3.766 ± 0.071	4.275GlyThr: 4.275 ± 0.078	4.26GlyVal: 4.26 ± 0.082	0.785GlyTrp: 0.785 ± 0.029	2.557GlyTyr: 2.557 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	1.143HisAla: 1.143 ± 0.038	0.393HisCys: 0.393 ± 0.021	0.992HisAsp: 0.992 ± 0.034	1.154HisGlu: 1.154 ± 0.035	0.908HisPhe: 0.908 ± 0.032	1.478HisGly: 1.478 ± 0.04	0.689HisHis: 0.689 ± 0.028	1.405HisIle: 1.405 ± 0.038	1.025HisLys: 1.025 ± 0.033	2.286HisLeu: 2.286 ± 0.051	0.437HisMet: 0.437 ± 0.024	0.818HisAsn: 0.818 ± 0.028	1.201HisPro: 1.201 ± 0.032	1.052HisGln: 1.052 ± 0.034	1.361HisArg: 1.361 ± 0.036	1.222HisSer: 1.222 ± 0.039	0.907HisThr: 0.907 ± 0.032	1.168HisVal: 1.168 ± 0.039	0.317HisTrp: 0.317 ± 0.019	0.822HisTyr: 0.822 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.29IleAla: 6.29 ± 0.08	0.685IleCys: 0.685 ± 0.029	4.27IleAsp: 4.27 ± 0.066	5.881IleGlu: 5.881 ± 0.08	2.665IlePhe: 2.665 ± 0.063	4.905IleGly: 4.905 ± 0.092	1.526IleHis: 1.526 ± 0.041	4.723IleIle: 4.723 ± 0.079	3.622IleLys: 3.622 ± 0.064	6.422IleLeu: 6.422 ± 0.092	1.547IleMet: 1.547 ± 0.048	2.661IleAsn: 2.661 ± 0.059	3.121IlePro: 3.121 ± 0.058	2.662IleGln: 2.662 ± 0.054	3.457IleArg: 3.457 ± 0.061	3.992IleSer: 3.992 ± 0.061	4.137IleThr: 4.137 ± 0.067	5.062IleVal: 5.062 ± 0.071	0.573IleTrp: 0.573 ± 0.026	2.248IleTyr: 2.248 ± 0.054	0.0IleXaa: 0.0 ± 0.0
Lys	5.641LysAla: 5.641 ± 0.093	0.389LysCys: 0.389 ± 0.027	3.172LysAsp: 3.172 ± 0.058	6.253LysGlu: 6.253 ± 0.104	1.354LysPhe: 1.354 ± 0.041	4.32LysGly: 4.32 ± 0.08	0.892LysHis: 0.892 ± 0.031	4.328LysIle: 4.328 ± 0.076	5.383LysLys: 5.383 ± 0.089	4.701LysLeu: 4.701 ± 0.08	1.697LysMet: 1.697 ± 0.039	2.647LysAsn: 2.647 ± 0.057	2.209LysPro: 2.209 ± 0.05	2.0LysGln: 2.0 ± 0.044	3.039LysArg: 3.039 ± 0.063	3.27LysSer: 3.27 ± 0.06	2.967LysThr: 2.967 ± 0.056	4.781LysVal: 4.781 ± 0.079	0.557LysTrp: 0.557 ± 0.021	1.581LysTyr: 1.581 ± 0.045	0.0LysXaa: 0.0 ± 0.0
Leu	8.611LeuAla: 8.611 ± 0.115	1.052LeuCys: 1.052 ± 0.038	4.817LeuAsp: 4.817 ± 0.063	7.663LeuGlu: 7.663 ± 0.118	4.42LeuPhe: 4.42 ± 0.083	6.617LeuGly: 6.617 ± 0.094	2.206LeuHis: 2.206 ± 0.055	6.319LeuIle: 6.319 ± 0.09	5.21LeuLys: 5.21 ± 0.084	11.732LeuLeu: 11.732 ± 0.172	2.325LeuMet: 2.325 ± 0.052	3.362LeuAsn: 3.362 ± 0.062	4.67LeuPro: 4.67 ± 0.076	5.48LeuGln: 5.48 ± 0.099	5.671LeuArg: 5.671 ± 0.092	6.867LeuSer: 6.867 ± 0.101	5.641LeuThr: 5.641 ± 0.084	6.297LeuVal: 6.297 ± 0.078	1.069LeuTrp: 1.069 ± 0.035	3.186LeuTyr: 3.186 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	2.645MetAla: 2.645 ± 0.055	0.123MetCys: 0.123 ± 0.012	1.386MetAsp: 1.386 ± 0.039	2.004MetGlu: 2.004 ± 0.039	0.67MetPhe: 0.67 ± 0.029	1.853MetGly: 1.853 ± 0.049	0.393MetHis: 0.393 ± 0.02	1.933MetIle: 1.933 ± 0.047	1.792MetLys: 1.792 ± 0.048	2.27MetLeu: 2.27 ± 0.054	0.788MetMet: 0.788 ± 0.031	1.295MetAsn: 1.295 ± 0.041	1.083MetPro: 1.083 ± 0.032	0.933MetGln: 0.933 ± 0.038	1.202MetArg: 1.202 ± 0.036	1.421MetSer: 1.421 ± 0.04	1.692MetThr: 1.692 ± 0.046	1.908MetVal: 1.908 ± 0.051	0.123MetTrp: 0.123 ± 0.011	0.519MetTyr: 0.519 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	2.395AsnAla: 2.395 ± 0.06	0.378AsnCys: 0.378 ± 0.023	1.699AsnAsp: 1.699 ± 0.049	2.394AsnGlu: 2.394 ± 0.055	1.424AsnPhe: 1.424 ± 0.039	2.262AsnGly: 2.262 ± 0.051	0.937AsnHis: 0.937 ± 0.033	2.678AsnIle: 2.678 ± 0.059	2.3AsnLys: 2.3 ± 0.052	3.853AsnLeu: 3.853 ± 0.07	0.881AsnMet: 0.881 ± 0.035	1.695AsnAsn: 1.695 ± 0.052	2.013AsnPro: 2.013 ± 0.048	1.861AsnGln: 1.861 ± 0.051	2.349AsnArg: 2.349 ± 0.057	1.984AsnSer: 1.984 ± 0.054	1.488AsnThr: 1.488 ± 0.044	2.275AsnVal: 2.275 ± 0.058	0.478AsnTrp: 0.478 ± 0.025	1.303AsnTyr: 1.303 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	2.857ProAla: 2.857 ± 0.06	0.417ProCys: 0.417 ± 0.026	1.909ProAsp: 1.909 ± 0.054	3.401ProGlu: 3.401 ± 0.065	1.949ProPhe: 1.949 ± 0.049	2.737ProGly: 2.737 ± 0.059	0.844ProHis: 0.844 ± 0.032	2.714ProIle: 2.714 ± 0.05	1.939ProLys: 1.939 ± 0.05	4.405ProLeu: 4.405 ± 0.072	0.994ProMet: 0.994 ± 0.035	1.252ProAsn: 1.252 ± 0.044	1.575ProPro: 1.575 ± 0.057	1.844ProGln: 1.844 ± 0.063	1.695ProArg: 1.695 ± 0.046	2.416ProSer: 2.416 ± 0.053	2.258ProThr: 2.258 ± 0.058	3.118ProVal: 3.118 ± 0.061	0.507ProTrp: 0.507 ± 0.026	1.461ProTyr: 1.461 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	3.972GlnAla: 3.972 ± 0.088	0.36GlnCys: 0.36 ± 0.021	2.098GlnAsp: 2.098 ± 0.049	4.417GlnGlu: 4.417 ± 0.093	1.209GlnPhe: 1.209 ± 0.041	3.264GlnGly: 3.264 ± 0.071	0.712GlnHis: 0.712 ± 0.028	2.963GlnIle: 2.963 ± 0.063	3.446GlnLys: 3.446 ± 0.07	4.023GlnLeu: 4.023 ± 0.08	1.069GlnMet: 1.069 ± 0.038	1.653GlnAsn: 1.653 ± 0.054	1.441GlnPro: 1.441 ± 0.069	2.477GlnGln: 2.477 ± 0.113	2.552GlnArg: 2.552 ± 0.055	2.793GlnSer: 2.793 ± 0.076	1.704GlnThr: 1.704 ± 0.043	3.311GlnVal: 3.311 ± 0.063	0.646GlnTrp: 0.646 ± 0.025	1.229GlnTyr: 1.229 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	3.647ArgAla: 3.647 ± 0.067	0.516ArgCys: 0.516 ± 0.026	2.636ArgAsp: 2.636 ± 0.055	4.203ArgGlu: 4.203 ± 0.122	2.215ArgPhe: 2.215 ± 0.05	3.157ArgGly: 3.157 ± 0.059	1.158ArgHis: 1.158 ± 0.032	3.854ArgIle: 3.854 ± 0.065	3.584ArgLys: 3.584 ± 0.074	5.553ArgLeu: 5.553 ± 0.092	1.496ArgMet: 1.496 ± 0.047	2.14ArgAsn: 2.14 ± 0.046	2.087ArgPro: 2.087 ± 0.054	2.841ArgGln: 2.841 ± 0.059	3.038ArgArg: 3.038 ± 0.068	3.0ArgSer: 3.0 ± 0.065	2.48ArgThr: 2.48 ± 0.057	3.104ArgVal: 3.104 ± 0.063	0.733ArgTrp: 0.733 ± 0.024	1.975ArgTyr: 1.975 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	3.968SerAla: 3.968 ± 0.072	0.601SerCys: 0.601 ± 0.03	2.623SerAsp: 2.623 ± 0.054	3.444SerGlu: 3.444 ± 0.073	2.704SerPhe: 2.704 ± 0.057	3.931SerGly: 3.931 ± 0.063	1.282SerHis: 1.282 ± 0.036	4.213SerIle: 4.213 ± 0.073	3.253SerLys: 3.253 ± 0.059	6.436SerLeu: 6.436 ± 0.092	1.729SerMet: 1.729 ± 0.043	2.238SerAsn: 2.238 ± 0.053	2.477SerPro: 2.477 ± 0.064	2.513SerGln: 2.513 ± 0.056	3.012SerArg: 3.012 ± 0.064	3.785SerSer: 3.785 ± 0.082	3.318SerThr: 3.318 ± 0.062	3.449SerVal: 3.449 ± 0.067	0.679SerTrp: 0.679 ± 0.029	2.057SerTyr: 2.057 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	4.188ThrAla: 4.188 ± 0.082	0.443ThrCys: 0.443 ± 0.021	2.303ThrAsp: 2.303 ± 0.053	3.746ThrGlu: 3.746 ± 0.076	2.297ThrPhe: 2.297 ± 0.049	4.065ThrGly: 4.065 ± 0.069	0.924ThrHis: 0.924 ± 0.029	4.275ThrIle: 4.275 ± 0.077	2.66ThrLys: 2.66 ± 0.06	5.518ThrLeu: 5.518 ± 0.074	1.478ThrMet: 1.478 ± 0.042	1.78ThrAsn: 1.78 ± 0.052	2.188ThrPro: 2.188 ± 0.057	1.671ThrGln: 1.671 ± 0.077	2.2ThrArg: 2.2 ± 0.053	2.955ThrSer: 2.955 ± 0.06	2.964ThrThr: 2.964 ± 0.07	4.202ThrVal: 4.202 ± 0.072	0.535ThrTrp: 0.535 ± 0.027	1.713ThrTyr: 1.713 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	6.051ValAla: 6.051 ± 0.096	0.602ValCys: 0.602 ± 0.024	3.779ValAsp: 3.779 ± 0.074	5.387ValGlu: 5.387 ± 0.094	2.359ValPhe: 2.359 ± 0.062	4.561ValGly: 4.561 ± 0.077	1.359ValHis: 1.359 ± 0.04	5.004ValIle: 5.004 ± 0.075	3.726ValLys: 3.726 ± 0.059	6.655ValLeu: 6.655 ± 0.093	1.696ValMet: 1.696 ± 0.042	2.536ValAsn: 2.536 ± 0.058	2.855ValPro: 2.855 ± 0.062	2.833ValGln: 2.833 ± 0.059	3.334ValArg: 3.334 ± 0.069	3.728ValSer: 3.728 ± 0.062	4.185ValThr: 4.185 ± 0.07	5.112ValVal: 5.112 ± 0.091	0.489ValTrp: 0.489 ± 0.025	1.859ValTyr: 1.859 ± 0.053	0.0ValXaa: 0.0 ± 0.0
Trp	0.759TrpAla: 0.759 ± 0.03	0.075TrpCys: 0.075 ± 0.009	0.551TrpAsp: 0.551 ± 0.023	0.734TrpGlu: 0.734 ± 0.026	0.412TrpPhe: 0.412 ± 0.023	0.659TrpGly: 0.659 ± 0.028	0.279TrpHis: 0.279 ± 0.015	0.704TrpIle: 0.704 ± 0.03	0.634TrpLys: 0.634 ± 0.028	1.194TrpLeu: 1.194 ± 0.041	0.303TrpMet: 0.303 ± 0.021	0.459TrpAsn: 0.459 ± 0.023	0.466TrpPro: 0.466 ± 0.023	0.59TrpGln: 0.59 ± 0.025	0.566TrpArg: 0.566 ± 0.026	0.67TrpSer: 0.67 ± 0.027	0.538TrpThr: 0.538 ± 0.028	0.649TrpVal: 0.649 ± 0.029	0.151TrpTrp: 0.151 ± 0.013	0.341TrpTyr: 0.341 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.024TyrAla: 2.024 ± 0.049	0.436TyrCys: 0.436 ± 0.022	1.809TyrAsp: 1.809 ± 0.046	2.243TyrGlu: 2.243 ± 0.054	1.282TyrPhe: 1.282 ± 0.04	2.481TyrGly: 2.481 ± 0.055	0.883TyrHis: 0.883 ± 0.031	2.027TyrIle: 2.027 ± 0.048	1.691TyrLys: 1.691 ± 0.048	3.415TyrLeu: 3.415 ± 0.066	0.64TyrMet: 0.64 ± 0.024	1.263TyrAsn: 1.263 ± 0.036	1.402TyrPro: 1.402 ± 0.045	1.62TyrGln: 1.62 ± 0.052	2.072TyrArg: 2.072 ± 0.057	1.793TyrSer: 1.793 ± 0.05	1.394TyrThr: 1.394 ± 0.043	2.024TyrVal: 2.024 ± 0.051	0.401TyrTrp: 0.401 ± 0.022	1.264TyrTyr: 1.264 ± 0.043	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3259 proteins (928659 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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