Amino acid dipepetide frequency for Butyricicoccus sp. 1XD8-22

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.809AlaAla: 9.809 ± 0.117	1.159AlaCys: 1.159 ± 0.027	4.443AlaAsp: 4.443 ± 0.048	6.132AlaGlu: 6.132 ± 0.061	3.353AlaPhe: 3.353 ± 0.044	6.667AlaGly: 6.667 ± 0.07	1.444AlaHis: 1.444 ± 0.024	5.287AlaIle: 5.287 ± 0.057	4.537AlaLys: 4.537 ± 0.051	8.612AlaLeu: 8.612 ± 0.075	2.295AlaMet: 2.295 ± 0.03	2.81AlaAsn: 2.81 ± 0.033	3.058AlaPro: 3.058 ± 0.052	3.172AlaGln: 3.172 ± 0.045	4.062AlaArg: 4.062 ± 0.05	4.308AlaSer: 4.308 ± 0.053	3.644AlaThr: 3.644 ± 0.048	6.67AlaVal: 6.67 ± 0.067	0.726AlaTrp: 0.726 ± 0.023	2.651AlaTyr: 2.651 ± 0.033	0.0AlaXaa: 0.0 ± 0.0
Cys	1.165CysAla: 1.165 ± 0.024	0.253CysCys: 0.253 ± 0.014	0.68CysAsp: 0.68 ± 0.02	0.824CysGlu: 0.824 ± 0.019	0.506CysPhe: 0.506 ± 0.016	1.404CysGly: 1.404 ± 0.03	0.241CysHis: 0.241 ± 0.01	0.778CysIle: 0.778 ± 0.021	0.586CysLys: 0.586 ± 0.018	0.981CysLeu: 0.981 ± 0.021	0.289CysMet: 0.289 ± 0.012	0.404CysAsn: 0.404 ± 0.014	0.633CysPro: 0.633 ± 0.021	0.338CysGln: 0.338 ± 0.014	0.716CysArg: 0.716 ± 0.02	0.751CysSer: 0.751 ± 0.02	0.715CysThr: 0.715 ± 0.02	0.783CysVal: 0.783 ± 0.02	0.129CysTrp: 0.129 ± 0.008	0.431CysTyr: 0.431 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	4.488AspAla: 4.488 ± 0.051	0.735AspCys: 0.735 ± 0.02	2.763AspAsp: 2.763 ± 0.041	4.339AspGlu: 4.339 ± 0.05	2.59AspPhe: 2.59 ± 0.039	4.577AspGly: 4.577 ± 0.056	0.898AspHis: 0.898 ± 0.021	3.677AspIle: 3.677 ± 0.043	2.774AspLys: 2.774 ± 0.037	4.842AspLeu: 4.842 ± 0.049	1.377AspMet: 1.377 ± 0.026	1.929AspAsn: 1.929 ± 0.032	2.202AspPro: 2.202 ± 0.036	1.463AspGln: 1.463 ± 0.027	2.606AspArg: 2.606 ± 0.038	2.951AspSer: 2.951 ± 0.044	2.869AspThr: 2.869 ± 0.041	3.527AspVal: 3.527 ± 0.042	0.623AspTrp: 0.623 ± 0.019	2.291AspTyr: 2.291 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	5.763GluAla: 5.763 ± 0.053	0.636GluCys: 0.636 ± 0.017	3.669GluAsp: 3.669 ± 0.042	6.018GluGlu: 6.018 ± 0.067	2.486GluPhe: 2.486 ± 0.035	4.451GluGly: 4.451 ± 0.038	1.41GluHis: 1.41 ± 0.029	5.376GluIle: 5.376 ± 0.05	5.297GluLys: 5.297 ± 0.059	7.054GluLeu: 7.054 ± 0.07	2.146GluMet: 2.146 ± 0.036	3.65GluAsn: 3.65 ± 0.048	2.334GluPro: 2.334 ± 0.044	3.462GluGln: 3.462 ± 0.049	4.075GluArg: 4.075 ± 0.049	3.441GluSer: 3.441 ± 0.037	3.896GluThr: 3.896 ± 0.045	4.716GluVal: 4.716 ± 0.048	0.756GluTrp: 0.756 ± 0.016	2.474GluTyr: 2.474 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	3.423PheAla: 3.423 ± 0.042	0.66PheCys: 0.66 ± 0.017	2.591PheAsp: 2.591 ± 0.035	2.77PheGlu: 2.77 ± 0.035	1.895PhePhe: 1.895 ± 0.035	3.179PheGly: 3.179 ± 0.043	0.805PheHis: 0.805 ± 0.021	2.961PheIle: 2.961 ± 0.046	1.97PheLys: 1.97 ± 0.031	4.044PheLeu: 4.044 ± 0.054	0.965PheMet: 0.965 ± 0.024	1.664PheAsn: 1.664 ± 0.03	1.597PhePro: 1.597 ± 0.028	1.377PheGln: 1.377 ± 0.025	1.948PheArg: 1.948 ± 0.029	2.949PheSer: 2.949 ± 0.038	2.522PheThr: 2.522 ± 0.041	2.77PheVal: 2.77 ± 0.039	0.441PheTrp: 0.441 ± 0.016	1.546PheTyr: 1.546 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	5.908GlyAla: 5.908 ± 0.068	1.13GlyCys: 1.13 ± 0.029	3.483GlyAsp: 3.483 ± 0.047	4.851GlyGlu: 4.851 ± 0.048	3.247GlyPhe: 3.247 ± 0.043	5.576GlyGly: 5.576 ± 0.075	1.35GlyHis: 1.35 ± 0.025	5.212GlyIle: 5.212 ± 0.052	4.705GlyLys: 4.705 ± 0.052	6.727GlyLeu: 6.727 ± 0.071	2.239GlyMet: 2.239 ± 0.033	2.725GlyAsn: 2.725 ± 0.043	1.533GlyPro: 1.533 ± 0.03	2.489GlyGln: 2.489 ± 0.035	3.709GlyArg: 3.709 ± 0.051	4.176GlySer: 4.176 ± 0.055	4.275GlyThr: 4.275 ± 0.063	5.255GlyVal: 5.255 ± 0.061	0.889GlyTrp: 0.889 ± 0.021	3.039GlyTyr: 3.039 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	1.373HisAla: 1.373 ± 0.026	0.292HisCys: 0.292 ± 0.012	1.002HisAsp: 1.002 ± 0.023	1.239HisGlu: 1.239 ± 0.027	0.934HisPhe: 0.934 ± 0.02	1.37HisGly: 1.37 ± 0.029	0.514HisHis: 0.514 ± 0.018	1.39HisIle: 1.39 ± 0.025	0.929HisLys: 0.929 ± 0.022	1.787HisLeu: 1.787 ± 0.032	0.422HisMet: 0.422 ± 0.014	0.694HisAsn: 0.694 ± 0.019	1.044HisPro: 1.044 ± 0.025	0.628HisGln: 0.628 ± 0.018	0.948HisArg: 0.948 ± 0.021	1.071HisSer: 1.071 ± 0.023	1.03HisThr: 1.03 ± 0.023	1.168HisVal: 1.168 ± 0.023	0.204HisTrp: 0.204 ± 0.01	0.803HisTyr: 0.803 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	5.674IleAla: 5.674 ± 0.051	0.861IleCys: 0.861 ± 0.017	4.039IleAsp: 4.039 ± 0.043	4.959IleGlu: 4.959 ± 0.05	2.74IlePhe: 2.74 ± 0.042	4.91IleGly: 4.91 ± 0.06	1.308IleHis: 1.308 ± 0.023	4.585IleIle: 4.585 ± 0.061	3.432IleLys: 3.432 ± 0.045	6.255IleLeu: 6.255 ± 0.062	1.546IleMet: 1.546 ± 0.029	2.724IleAsn: 2.724 ± 0.042	3.065IlePro: 3.065 ± 0.039	2.405IleGln: 2.405 ± 0.033	3.261IleArg: 3.261 ± 0.039	4.503IleSer: 4.503 ± 0.051	3.982IleThr: 3.982 ± 0.054	4.798IleVal: 4.798 ± 0.055	0.584IleTrp: 0.584 ± 0.015	2.277IleTyr: 2.277 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	4.441LysAla: 4.441 ± 0.051	0.515LysCys: 0.515 ± 0.017	3.001LysAsp: 3.001 ± 0.041	4.893LysGlu: 4.893 ± 0.063	1.807LysPhe: 1.807 ± 0.029	3.715LysGly: 3.715 ± 0.044	0.992LysHis: 0.992 ± 0.022	3.938LysIle: 3.938 ± 0.054	4.352LysLys: 4.352 ± 0.043	5.197LysLeu: 5.197 ± 0.051	1.679LysMet: 1.679 ± 0.028	2.817LysAsn: 2.817 ± 0.037	2.172LysPro: 2.172 ± 0.038	2.355LysGln: 2.355 ± 0.035	3.085LysArg: 3.085 ± 0.042	3.212LysSer: 3.212 ± 0.042	3.309LysThr: 3.309 ± 0.042	3.686LysVal: 3.686 ± 0.047	0.658LysTrp: 0.658 ± 0.016	2.14LysTyr: 2.14 ± 0.034	0.0LysXaa: 0.0 ± 0.0
Leu	8.286LeuAla: 8.286 ± 0.076	1.386LeuCys: 1.386 ± 0.032	5.265LeuAsp: 5.265 ± 0.052	6.47LeuGlu: 6.47 ± 0.063	4.143LeuPhe: 4.143 ± 0.056	6.357LeuGly: 6.357 ± 0.066	1.881LeuHis: 1.881 ± 0.028	5.94LeuIle: 5.94 ± 0.063	5.374LeuLys: 5.374 ± 0.059	9.822LeuLeu: 9.822 ± 0.101	2.4LeuMet: 2.4 ± 0.033	3.91LeuAsn: 3.91 ± 0.047	4.388LeuPro: 4.388 ± 0.052	3.211LeuGln: 3.211 ± 0.038	5.103LeuArg: 5.103 ± 0.056	6.686LeuSer: 6.686 ± 0.058	5.661LeuThr: 5.661 ± 0.067	5.721LeuVal: 5.721 ± 0.053	0.84LeuTrp: 0.84 ± 0.022	3.146LeuTyr: 3.146 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	2.192MetAla: 2.192 ± 0.035	0.261MetCys: 0.261 ± 0.011	1.478MetAsp: 1.478 ± 0.027	1.991MetGlu: 1.991 ± 0.031	0.938MetPhe: 0.938 ± 0.022	1.795MetGly: 1.795 ± 0.03	0.404MetHis: 0.404 ± 0.015	1.693MetIle: 1.693 ± 0.032	1.982MetLys: 1.982 ± 0.03	2.599MetLeu: 2.599 ± 0.038	0.783MetMet: 0.783 ± 0.023	1.285MetAsn: 1.285 ± 0.025	1.073MetPro: 1.073 ± 0.025	1.01MetGln: 1.01 ± 0.02	1.323MetArg: 1.323 ± 0.025	1.57MetSer: 1.57 ± 0.03	1.582MetThr: 1.582 ± 0.029	1.655MetVal: 1.655 ± 0.026	0.177MetTrp: 0.177 ± 0.008	0.7MetTyr: 0.7 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.138AsnAla: 3.138 ± 0.041	0.439AsnCys: 0.439 ± 0.016	2.092AsnAsp: 2.092 ± 0.033	2.903AsnGlu: 2.903 ± 0.035	1.549AsnPhe: 1.549 ± 0.029	3.399AsnGly: 3.399 ± 0.052	0.851AsnHis: 0.851 ± 0.021	2.921AsnIle: 2.921 ± 0.043	2.237AsnLys: 2.237 ± 0.036	3.57AsnLeu: 3.57 ± 0.038	1.043AsnMet: 1.043 ± 0.021	1.781AsnAsn: 1.781 ± 0.033	2.029AsnPro: 2.029 ± 0.029	1.52AsnGln: 1.52 ± 0.029	2.132AsnArg: 2.132 ± 0.032	2.219AsnSer: 2.219 ± 0.039	2.184AsnThr: 2.184 ± 0.033	2.595AsnVal: 2.595 ± 0.045	0.446AsnTrp: 0.446 ± 0.016	1.526AsnTyr: 1.526 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	3.546ProAla: 3.546 ± 0.054	0.456ProCys: 0.456 ± 0.013	2.454ProAsp: 2.454 ± 0.036	3.55ProGlu: 3.55 ± 0.048	1.775ProPhe: 1.775 ± 0.03	2.582ProGly: 2.582 ± 0.038	0.783ProHis: 0.783 ± 0.02	2.453ProIle: 2.453 ± 0.033	2.004ProLys: 2.004 ± 0.03	3.496ProLeu: 3.496 ± 0.042	0.934ProMet: 0.934 ± 0.021	1.515ProAsn: 1.515 ± 0.028	1.461ProPro: 1.461 ± 0.038	1.38ProGln: 1.38 ± 0.029	1.551ProArg: 1.551 ± 0.028	2.398ProSer: 2.398 ± 0.036	1.999ProThr: 1.999 ± 0.029	2.998ProVal: 2.998 ± 0.044	0.357ProTrp: 0.357 ± 0.013	1.426ProTyr: 1.426 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.19GlnAla: 3.19 ± 0.048	0.311GlnCys: 0.311 ± 0.013	1.597GlnAsp: 1.597 ± 0.025	2.635GlnGlu: 2.635 ± 0.04	1.468GlnPhe: 1.468 ± 0.023	2.147GlnGly: 2.147 ± 0.032	0.662GlnHis: 0.662 ± 0.02	2.462GlnIle: 2.462 ± 0.034	2.386GlnLys: 2.386 ± 0.038	3.787GlnLeu: 3.787 ± 0.047	1.119GlnMet: 1.119 ± 0.026	1.571GlnAsn: 1.571 ± 0.03	1.376GlnPro: 1.376 ± 0.027	1.689GlnGln: 1.689 ± 0.033	1.872GlnArg: 1.872 ± 0.032	2.107GlnSer: 2.107 ± 0.034	1.937GlnThr: 1.937 ± 0.034	2.232GlnVal: 2.232 ± 0.034	0.371GlnTrp: 0.371 ± 0.014	1.406GlnTyr: 1.406 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	4.233ArgAla: 4.233 ± 0.054	0.672ArgCys: 0.672 ± 0.02	2.607ArgAsp: 2.607 ± 0.034	4.07ArgGlu: 4.07 ± 0.051	2.248ArgPhe: 2.248 ± 0.038	3.176ArgGly: 3.176 ± 0.044	0.944ArgHis: 0.944 ± 0.023	3.339ArgIle: 3.339 ± 0.037	3.177ArgLys: 3.177 ± 0.048	5.072ArgLeu: 5.072 ± 0.058	1.5ArgMet: 1.5 ± 0.022	1.884ArgAsn: 1.884 ± 0.029	1.854ArgPro: 1.854 ± 0.026	2.09ArgGln: 2.09 ± 0.036	3.279ArgArg: 3.279 ± 0.056	2.573ArgSer: 2.573 ± 0.034	2.494ArgThr: 2.494 ± 0.038	3.176ArgVal: 3.176 ± 0.038	0.576ArgTrp: 0.576 ± 0.016	1.89ArgTyr: 1.89 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	4.766SerAla: 4.766 ± 0.058	0.665SerCys: 0.665 ± 0.02	3.02SerAsp: 3.02 ± 0.04	3.864SerGlu: 3.864 ± 0.044	2.849SerPhe: 2.849 ± 0.038	5.015SerGly: 5.015 ± 0.059	1.12SerHis: 1.12 ± 0.022	4.34SerIle: 4.34 ± 0.051	3.169SerLys: 3.169 ± 0.038	5.523SerLeu: 5.523 ± 0.058	1.593SerMet: 1.593 ± 0.027	2.388SerAsn: 2.388 ± 0.041	2.246SerPro: 2.246 ± 0.032	1.91SerGln: 1.91 ± 0.029	2.857SerArg: 2.857 ± 0.034	3.549SerSer: 3.549 ± 0.047	3.057SerThr: 3.057 ± 0.041	4.007SerVal: 4.007 ± 0.048	0.605SerTrp: 0.605 ± 0.018	2.17SerTyr: 2.17 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	5.083ThrAla: 5.083 ± 0.058	0.508ThrCys: 0.508 ± 0.014	2.956ThrAsp: 2.956 ± 0.044	3.687ThrGlu: 3.687 ± 0.042	2.34ThrPhe: 2.34 ± 0.04	4.453ThrGly: 4.453 ± 0.047	0.985ThrHis: 0.985 ± 0.022	3.927ThrIle: 3.927 ± 0.042	2.715ThrLys: 2.715 ± 0.038	5.395ThrLeu: 5.395 ± 0.059	1.289ThrMet: 1.289 ± 0.026	2.109ThrAsn: 2.109 ± 0.037	2.61ThrPro: 2.61 ± 0.039	1.521ThrGln: 1.521 ± 0.028	2.36ThrArg: 2.36 ± 0.037	3.012ThrSer: 3.012 ± 0.041	2.942ThrThr: 2.942 ± 0.049	4.569ThrVal: 4.569 ± 0.058	0.473ThrTrp: 0.473 ± 0.018	1.889ThrTyr: 1.889 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	4.965ValAla: 4.965 ± 0.049	0.993ValCys: 0.993 ± 0.024	3.635ValAsp: 3.635 ± 0.04	4.637ValGlu: 4.637 ± 0.047	2.996ValPhe: 2.996 ± 0.038	4.477ValGly: 4.477 ± 0.056	1.218ValHis: 1.218 ± 0.025	4.627ValIle: 4.627 ± 0.05	3.896ValLys: 3.896 ± 0.053	6.691ValLeu: 6.691 ± 0.065	1.803ValMet: 1.803 ± 0.026	2.692ValAsn: 2.692 ± 0.038	2.771ValPro: 2.771 ± 0.032	2.469ValGln: 2.469 ± 0.029	3.526ValArg: 3.526 ± 0.044	4.545ValSer: 4.545 ± 0.043	4.181ValThr: 4.181 ± 0.055	4.702ValVal: 4.702 ± 0.054	0.644ValTrp: 0.644 ± 0.018	2.297ValTyr: 2.297 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	0.747TrpAla: 0.747 ± 0.019	0.157TrpCys: 0.157 ± 0.01	0.573TrpAsp: 0.573 ± 0.016	0.705TrpGlu: 0.705 ± 0.018	0.465TrpPhe: 0.465 ± 0.015	0.695TrpGly: 0.695 ± 0.02	0.22TrpHis: 0.22 ± 0.01	0.629TrpIle: 0.629 ± 0.019	0.638TrpLys: 0.638 ± 0.017	1.053TrpLeu: 1.053 ± 0.024	0.28TrpMet: 0.28 ± 0.013	0.503TrpAsn: 0.503 ± 0.016	0.249TrpPro: 0.249 ± 0.011	0.422TrpGln: 0.422 ± 0.014	0.514TrpArg: 0.514 ± 0.015	0.54TrpSer: 0.54 ± 0.017	0.51TrpThr: 0.51 ± 0.016	0.611TrpVal: 0.611 ± 0.017	0.122TrpTrp: 0.122 ± 0.008	0.377TrpTyr: 0.377 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.648TyrAla: 2.648 ± 0.035	0.516TyrCys: 0.516 ± 0.018	2.176TyrAsp: 2.176 ± 0.038	2.569TyrGlu: 2.569 ± 0.035	1.746TyrPhe: 1.746 ± 0.031	2.572TyrGly: 2.572 ± 0.032	0.809TyrHis: 0.809 ± 0.018	2.371TyrIle: 2.371 ± 0.038	1.802TyrLys: 1.802 ± 0.03	3.486TyrLeu: 3.486 ± 0.044	0.79TyrMet: 0.79 ± 0.019	1.52TyrAsn: 1.52 ± 0.027	1.426TyrPro: 1.426 ± 0.025	1.413TyrGln: 1.413 ± 0.024	1.93TyrArg: 1.93 ± 0.034	2.153TyrSer: 2.153 ± 0.032	2.035TyrThr: 2.035 ± 0.035	2.13TyrVal: 2.13 ± 0.035	0.388TyrTrp: 0.388 ± 0.015	1.462TyrTyr: 1.462 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 10148 proteins (2192787 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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