Amino acid dipepetide frequency for Polaribacter irgensii 23-P

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.475AlaAla: 5.475 ± 0.114
0.577AlaCys: 0.577 ± 0.029
3.348AlaAsp: 3.348 ± 0.073
3.915AlaGlu: 3.915 ± 0.07
3.691AlaPhe: 3.691 ± 0.076
4.445AlaGly: 4.445 ± 0.091
1.196AlaHis: 1.196 ± 0.044
6.347AlaIle: 6.347 ± 0.102
5.203AlaLys: 5.203 ± 0.079
6.713AlaLeu: 6.713 ± 0.109
1.628AlaMet: 1.628 ± 0.055
3.521AlaAsn: 3.521 ± 0.073
2.026AlaPro: 2.026 ± 0.05
2.541AlaGln: 2.541 ± 0.058
2.153AlaArg: 2.153 ± 0.058
4.546AlaSer: 4.546 ± 0.086
4.046AlaThr: 4.046 ± 0.083
4.925AlaVal: 4.925 ± 0.09
0.616AlaTrp: 0.616 ± 0.029
2.496AlaTyr: 2.496 ± 0.057
0.0AlaXaa: 0.0 ± 0.0
Cys
0.504CysAla: 0.504 ± 0.023
0.1CysCys: 0.1 ± 0.011
0.366CysAsp: 0.366 ± 0.022
0.433CysGlu: 0.433 ± 0.021
0.442CysPhe: 0.442 ± 0.024
0.609CysGly: 0.609 ± 0.035
0.153CysHis: 0.153 ± 0.015
0.608CysIle: 0.608 ± 0.029
0.496CysLys: 0.496 ± 0.027
0.613CysLeu: 0.613 ± 0.025
0.163CysMet: 0.163 ± 0.014
0.386CysAsn: 0.386 ± 0.023
0.242CysPro: 0.242 ± 0.02
0.237CysGln: 0.237 ± 0.019
0.185CysArg: 0.185 ± 0.016
0.516CysSer: 0.516 ± 0.025
0.413CysThr: 0.413 ± 0.026
0.47CysVal: 0.47 ± 0.024
0.058CysTrp: 0.058 ± 0.01
0.256CysTyr: 0.256 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
4.216AspAla: 4.216 ± 0.079
0.399AspCys: 0.399 ± 0.024
2.131AspAsp: 2.131 ± 0.065
2.984AspGlu: 2.984 ± 0.066
3.63AspPhe: 3.63 ± 0.071
3.053AspGly: 3.053 ± 0.083
0.781AspHis: 0.781 ± 0.033
4.256AspIle: 4.256 ± 0.078
3.759AspLys: 3.759 ± 0.078
5.059AspLeu: 5.059 ± 0.087
0.945AspMet: 0.945 ± 0.034
2.497AspAsn: 2.497 ± 0.064
1.423AspPro: 1.423 ± 0.049
1.329AspGln: 1.329 ± 0.042
1.719AspArg: 1.719 ± 0.048
2.773AspSer: 2.773 ± 0.06
2.834AspThr: 2.834 ± 0.066
3.382AspVal: 3.382 ± 0.065
0.645AspTrp: 0.645 ± 0.034
2.187AspTyr: 2.187 ± 0.05
0.0AspXaa: 0.0 ± 0.0
Glu
4.247GluAla: 4.247 ± 0.081
0.324GluCys: 0.324 ± 0.019
3.302GluAsp: 3.302 ± 0.064
4.701GluGlu: 4.701 ± 0.106
2.887GluPhe: 2.887 ± 0.06
3.611GluGly: 3.611 ± 0.079
1.118GluHis: 1.118 ± 0.042
6.14GluIle: 6.14 ± 0.086
6.558GluLys: 6.558 ± 0.121
5.771GluLeu: 5.771 ± 0.107
1.64GluMet: 1.64 ± 0.045
5.033GluAsn: 5.033 ± 0.08
1.183GluPro: 1.183 ± 0.039
1.953GluGln: 1.953 ± 0.052
2.484GluArg: 2.484 ± 0.058
3.136GluSer: 3.136 ± 0.055
3.653GluThr: 3.653 ± 0.076
4.335GluVal: 4.335 ± 0.078
0.524GluTrp: 0.524 ± 0.029
2.134GluTyr: 2.134 ± 0.052
0.0GluXaa: 0.0 ± 0.0
Phe
3.169PheAla: 3.169 ± 0.07
0.456PheCys: 0.456 ± 0.024
3.22PheAsp: 3.22 ± 0.064
3.391PheGlu: 3.391 ± 0.06
3.022PhePhe: 3.022 ± 0.075
3.975PheGly: 3.975 ± 0.072
0.816PheHis: 0.816 ± 0.035
4.421PheIle: 4.421 ± 0.08
4.268PheLys: 4.268 ± 0.065
5.354PheLeu: 5.354 ± 0.086
1.12PheMet: 1.12 ± 0.038
3.308PheAsn: 3.308 ± 0.083
1.697PhePro: 1.697 ± 0.048
1.664PheGln: 1.664 ± 0.043
1.648PheArg: 1.648 ± 0.05
4.431PheSer: 4.431 ± 0.087
3.289PheThr: 3.289 ± 0.069
3.216PheVal: 3.216 ± 0.074
0.54PheTrp: 0.54 ± 0.031
2.158PheTyr: 2.158 ± 0.055
0.0PheXaa: 0.0 ± 0.0
Gly
4.693GlyAla: 4.693 ± 0.096
0.533GlyCys: 0.533 ± 0.028
3.064GlyAsp: 3.064 ± 0.064
3.345GlyGlu: 3.345 ± 0.083
3.965GlyPhe: 3.965 ± 0.074
4.53GlyGly: 4.53 ± 0.094
1.05GlyHis: 1.05 ± 0.037
5.659GlyIle: 5.659 ± 0.09
4.988GlyLys: 4.988 ± 0.087
5.584GlyLeu: 5.584 ± 0.092
1.578GlyMet: 1.578 ± 0.05
3.464GlyAsn: 3.464 ± 0.069
1.261GlyPro: 1.261 ± 0.045
1.745GlyGln: 1.745 ± 0.061
2.13GlyArg: 2.13 ± 0.06
3.947GlySer: 3.947 ± 0.086
4.012GlyThr: 4.012 ± 0.082
4.508GlyVal: 4.508 ± 0.095
0.668GlyTrp: 0.668 ± 0.029
2.573GlyTyr: 2.573 ± 0.061
0.0GlyXaa: 0.0 ± 0.0
His
1.116HisAla: 1.116 ± 0.034
0.153HisCys: 0.153 ± 0.015
0.726HisAsp: 0.726 ± 0.03
0.966HisGlu: 0.966 ± 0.043
1.187HisPhe: 1.187 ± 0.045
1.034HisGly: 1.034 ± 0.041
0.464HisHis: 0.464 ± 0.026
1.354HisIle: 1.354 ± 0.043
1.335HisLys: 1.335 ± 0.039
1.829HisLeu: 1.829 ± 0.061
0.284HisMet: 0.284 ± 0.019
0.885HisAsn: 0.885 ± 0.033
0.88HisPro: 0.88 ± 0.034
0.773HisGln: 0.773 ± 0.034
0.648HisArg: 0.648 ± 0.027
1.04HisSer: 1.04 ± 0.035
1.025HisThr: 1.025 ± 0.033
0.909HisVal: 0.909 ± 0.038
0.189HisTrp: 0.189 ± 0.015
0.728HisTyr: 0.728 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
6.543IleAla: 6.543 ± 0.093
0.658IleCys: 0.658 ± 0.029
4.745IleAsp: 4.745 ± 0.078
5.581IleGlu: 5.581 ± 0.09
3.897IlePhe: 3.897 ± 0.078
5.478IleGly: 5.478 ± 0.082
1.509IleHis: 1.509 ± 0.044
6.526IleIle: 6.526 ± 0.119
6.241IleLys: 6.241 ± 0.105
7.765IleLeu: 7.765 ± 0.11
1.418IleMet: 1.418 ± 0.045
4.452IleAsn: 4.452 ± 0.084
3.245IlePro: 3.245 ± 0.071
2.815IleGln: 2.815 ± 0.065
2.764IleArg: 2.764 ± 0.06
6.213IleSer: 6.213 ± 0.088
4.955IleThr: 4.955 ± 0.082
5.033IleVal: 5.033 ± 0.077
0.68IleTrp: 0.68 ± 0.036
2.725IleTyr: 2.725 ± 0.06
0.0IleXaa: 0.0 ± 0.0
Lys
5.132LysAla: 5.132 ± 0.066
0.361LysCys: 0.361 ± 0.024
4.096LysAsp: 4.096 ± 0.072
7.444LysGlu: 7.444 ± 0.129
3.089LysPhe: 3.089 ± 0.07
4.885LysGly: 4.885 ± 0.074
1.421LysHis: 1.421 ± 0.04
7.301LysIle: 7.301 ± 0.102
8.287LysLys: 8.287 ± 0.12
6.599LysLeu: 6.599 ± 0.102
2.264LysMet: 2.264 ± 0.049
6.117LysAsn: 6.117 ± 0.099
2.243LysPro: 2.243 ± 0.063
2.72LysGln: 2.72 ± 0.067
3.13LysArg: 3.13 ± 0.064
4.664LysSer: 4.664 ± 0.074
5.187LysThr: 5.187 ± 0.078
4.832LysVal: 4.832 ± 0.092
0.728LysTrp: 0.728 ± 0.03
3.149LysTyr: 3.149 ± 0.067
0.0LysXaa: 0.0 ± 0.0
Leu
6.004LeuAla: 6.004 ± 0.098
0.652LeuCys: 0.652 ± 0.032
4.744LeuAsp: 4.744 ± 0.088
6.491LeuGlu: 6.491 ± 0.106
5.475LeuPhe: 5.475 ± 0.088
6.019LeuGly: 6.019 ± 0.101
1.629LeuHis: 1.629 ± 0.048
7.109LeuIle: 7.109 ± 0.113
8.777LeuLys: 8.777 ± 0.124
9.158LeuLeu: 9.158 ± 0.121
2.053LeuMet: 2.053 ± 0.052
5.549LeuAsn: 5.549 ± 0.094
3.281LeuPro: 3.281 ± 0.076
3.474LeuGln: 3.474 ± 0.076
3.144LeuArg: 3.144 ± 0.053
6.585LeuSer: 6.585 ± 0.093
4.923LeuThr: 4.923 ± 0.086
5.459LeuVal: 5.459 ± 0.084
0.764LeuTrp: 0.764 ± 0.034
2.903LeuTyr: 2.903 ± 0.062
0.0LeuXaa: 0.0 ± 0.0
Met
1.547MetAla: 1.547 ± 0.053
0.154MetCys: 0.154 ± 0.014
1.064MetAsp: 1.064 ± 0.037
1.253MetGlu: 1.253 ± 0.044
0.909MetPhe: 0.909 ± 0.04
1.369MetGly: 1.369 ± 0.041
0.451MetHis: 0.451 ± 0.023
1.616MetIle: 1.616 ± 0.05
2.201MetLys: 2.201 ± 0.05
2.012MetLeu: 2.012 ± 0.054
0.58MetMet: 0.58 ± 0.03
1.34MetAsn: 1.34 ± 0.045
0.791MetPro: 0.791 ± 0.032
0.858MetGln: 0.858 ± 0.031
0.878MetArg: 0.878 ± 0.035
1.462MetSer: 1.462 ± 0.04
1.088MetThr: 1.088 ± 0.039
1.288MetVal: 1.288 ± 0.038
0.154MetTrp: 0.154 ± 0.011
0.761MetTyr: 0.761 ± 0.033
0.0MetXaa: 0.0 ± 0.0
Asn
4.135AsnAla: 4.135 ± 0.079
0.447AsnCys: 0.447 ± 0.026
2.63AsnAsp: 2.63 ± 0.078
3.399AsnGlu: 3.399 ± 0.071
3.316AsnPhe: 3.316 ± 0.079
3.606AsnGly: 3.606 ± 0.079
0.972AsnHis: 0.972 ± 0.034
5.002AsnIle: 5.002 ± 0.093
4.763AsnLys: 4.763 ± 0.083
5.497AsnLeu: 5.497 ± 0.097
1.263AsnMet: 1.263 ± 0.042
3.499AsnAsn: 3.499 ± 0.079
2.497AsnPro: 2.497 ± 0.058
2.043AsnGln: 2.043 ± 0.048
1.964AsnArg: 1.964 ± 0.052
3.865AsnSer: 3.865 ± 0.082
3.916AsnThr: 3.916 ± 0.067
3.345AsnVal: 3.345 ± 0.067
0.723AsnTrp: 0.723 ± 0.031
2.615AsnTyr: 2.615 ± 0.064
0.0AsnXaa: 0.0 ± 0.0
Pro
1.878ProAla: 1.878 ± 0.051
0.22ProCys: 0.22 ± 0.018
1.558ProAsp: 1.558 ± 0.048
2.479ProGlu: 2.479 ± 0.05
1.905ProPhe: 1.905 ± 0.05
1.748ProGly: 1.748 ± 0.052
0.556ProHis: 0.556 ± 0.032
2.873ProIle: 2.873 ± 0.058
2.6ProLys: 2.6 ± 0.055
2.873ProLeu: 2.873 ± 0.062
0.706ProMet: 0.706 ± 0.029
2.117ProAsn: 2.117 ± 0.061
0.649ProPro: 0.649 ± 0.025
0.958ProGln: 0.958 ± 0.034
0.904ProArg: 0.904 ± 0.038
1.996ProSer: 1.996 ± 0.057
1.912ProThr: 1.912 ± 0.051
1.898ProVal: 1.898 ± 0.053
0.314ProTrp: 0.314 ± 0.022
1.167ProTyr: 1.167 ± 0.037
0.0ProXaa: 0.0 ± 0.0
Gln
1.909GlnAla: 1.909 ± 0.049
0.162GlnCys: 0.162 ± 0.014
1.521GlnAsp: 1.521 ± 0.051
2.426GlnGlu: 2.426 ± 0.061
1.777GlnPhe: 1.777 ± 0.051
1.739GlnGly: 1.739 ± 0.044
0.602GlnHis: 0.602 ± 0.03
2.816GlnIle: 2.816 ± 0.062
3.212GlnLys: 3.212 ± 0.073
3.379GlnLeu: 3.379 ± 0.061
0.78GlnMet: 0.78 ± 0.035
2.116GlnAsn: 2.116 ± 0.054
0.923GlnPro: 0.923 ± 0.033
1.523GlnGln: 1.523 ± 0.047
1.295GlnArg: 1.295 ± 0.041
1.671GlnSer: 1.671 ± 0.047
1.876GlnThr: 1.876 ± 0.052
2.019GlnVal: 2.019 ± 0.058
0.304GlnTrp: 0.304 ± 0.02
1.237GlnTyr: 1.237 ± 0.039
0.0GlnXaa: 0.0 ± 0.0
Arg
2.325ArgAla: 2.325 ± 0.058
0.199ArgCys: 0.199 ± 0.016
1.635ArgAsp: 1.635 ± 0.047
2.126ArgGlu: 2.126 ± 0.064
1.948ArgPhe: 1.948 ± 0.059
2.035ArgGly: 2.035 ± 0.053
0.564ArgHis: 0.564 ± 0.029
2.968ArgIle: 2.968 ± 0.063
3.013ArgLys: 3.013 ± 0.068
3.158ArgLeu: 3.158 ± 0.071
0.887ArgMet: 0.887 ± 0.035
2.081ArgAsn: 2.081 ± 0.062
1.011ArgPro: 1.011 ± 0.037
1.042ArgGln: 1.042 ± 0.036
1.234ArgArg: 1.234 ± 0.042
1.948ArgSer: 1.948 ± 0.054
1.92ArgThr: 1.92 ± 0.048
2.059ArgVal: 2.059 ± 0.057
0.328ArgTrp: 0.328 ± 0.019
1.48ArgTyr: 1.48 ± 0.046
0.0ArgXaa: 0.0 ± 0.0
Ser
4.23SerAla: 4.23 ± 0.069
0.586SerCys: 0.586 ± 0.03
3.2SerAsp: 3.2 ± 0.064
4.261SerGlu: 4.261 ± 0.072
4.283SerPhe: 4.283 ± 0.074
4.445SerGly: 4.445 ± 0.078
1.024SerHis: 1.024 ± 0.036
5.187SerIle: 5.187 ± 0.088
5.394SerLys: 5.394 ± 0.086
6.152SerLeu: 6.152 ± 0.101
1.268SerMet: 1.268 ± 0.041
3.659SerAsn: 3.659 ± 0.076
1.879SerPro: 1.879 ± 0.043
1.979SerGln: 1.979 ± 0.045
1.947SerArg: 1.947 ± 0.051
4.146SerSer: 4.146 ± 0.079
3.449SerThr: 3.449 ± 0.07
3.859SerVal: 3.859 ± 0.067
0.7SerTrp: 0.7 ± 0.031
2.716SerTyr: 2.716 ± 0.059
0.0SerXaa: 0.0 ± 0.0
Thr
4.475ThrAla: 4.475 ± 0.084
0.349ThrCys: 0.349 ± 0.022
2.978ThrAsp: 2.978 ± 0.053
3.435ThrGlu: 3.435 ± 0.063
3.115ThrPhe: 3.115 ± 0.064
3.883ThrGly: 3.883 ± 0.079
1.082ThrHis: 1.082 ± 0.039
5.063ThrIle: 5.063 ± 0.087
4.249ThrLys: 4.249 ± 0.081
5.449ThrLeu: 5.449 ± 0.09
0.973ThrMet: 0.973 ± 0.037
3.256ThrAsn: 3.256 ± 0.08
2.349ThrPro: 2.349 ± 0.055
1.821ThrGln: 1.821 ± 0.049
1.729ThrArg: 1.729 ± 0.047
3.922ThrSer: 3.922 ± 0.065
3.548ThrThr: 3.548 ± 0.068
3.763ThrVal: 3.763 ± 0.075
0.525ThrTrp: 0.525 ± 0.026
2.165ThrTyr: 2.165 ± 0.053
0.0ThrXaa: 0.0 ± 0.0
Val
4.854ValAla: 4.854 ± 0.093
0.486ValCys: 0.486 ± 0.027
3.237ValAsp: 3.237 ± 0.063
3.48ValGlu: 3.48 ± 0.078
3.691ValPhe: 3.691 ± 0.082
3.845ValGly: 3.845 ± 0.077
1.192ValHis: 1.192 ± 0.043
4.725ValIle: 4.725 ± 0.078
4.356ValLys: 4.356 ± 0.081
6.703ValLeu: 6.703 ± 0.109
1.212ValMet: 1.212 ± 0.044
3.282ValAsn: 3.282 ± 0.068
2.14ValPro: 2.14 ± 0.056
1.947ValGln: 1.947 ± 0.053
2.117ValArg: 2.117 ± 0.058
4.492ValSer: 4.492 ± 0.088
3.345ValThr: 3.345 ± 0.062
4.239ValVal: 4.239 ± 0.09
0.609ValTrp: 0.609 ± 0.03
2.165ValTyr: 2.165 ± 0.044
0.0ValXaa: 0.0 ± 0.0
Trp
0.511TrpAla: 0.511 ± 0.026
0.089TrpCys: 0.089 ± 0.011
0.491TrpAsp: 0.491 ± 0.025
0.637TrpGlu: 0.637 ± 0.032
0.576TrpPhe: 0.576 ± 0.026
0.59TrpGly: 0.59 ± 0.03
0.195TrpHis: 0.195 ± 0.015
0.745TrpIle: 0.745 ± 0.035
0.802TrpLys: 0.802 ± 0.035
0.873TrpLeu: 0.873 ± 0.038
0.302TrpMet: 0.302 ± 0.02
0.649TrpAsn: 0.649 ± 0.029
0.209TrpPro: 0.209 ± 0.02
0.346TrpGln: 0.346 ± 0.02
0.413TrpArg: 0.413 ± 0.024
0.628TrpSer: 0.628 ± 0.028
0.48TrpThr: 0.48 ± 0.029
0.556TrpVal: 0.556 ± 0.03
0.12TrpTrp: 0.12 ± 0.013
0.363TrpTyr: 0.363 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.444TyrAla: 2.444 ± 0.056
0.343TyrCys: 0.343 ± 0.021
1.945TyrAsp: 1.945 ± 0.059
1.986TyrGlu: 1.986 ± 0.051
2.36TyrPhe: 2.36 ± 0.057
2.4TyrGly: 2.4 ± 0.055
0.749TyrHis: 0.749 ± 0.029
2.527TyrIle: 2.527 ± 0.056
3.146TyrLys: 3.146 ± 0.064
3.655TyrLeu: 3.655 ± 0.063
0.711TyrMet: 0.711 ± 0.03
2.283TyrAsn: 2.283 ± 0.06
1.383TyrPro: 1.383 ± 0.045
1.517TyrGln: 1.517 ± 0.046
1.476TyrArg: 1.476 ± 0.045
2.382TyrSer: 2.382 ± 0.065
2.259TyrThr: 2.259 ± 0.053
2.024TyrVal: 2.024 ± 0.048
0.385TyrTrp: 0.385 ± 0.02
1.55TyrTyr: 1.55 ± 0.051
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2556 proteins (790124 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski