Amino acid dipepetide frequency for Pea stem necrosis virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.009AlaAla: 9.009 ± 3.413
1.386AlaCys: 1.386 ± 1.164
2.079AlaAsp: 2.079 ± 0.965
2.079AlaGlu: 2.079 ± 0.862
4.851AlaPhe: 4.851 ± 1.209
7.623AlaGly: 7.623 ± 2.181
0.693AlaHis: 0.693 ± 0.415
6.237AlaIle: 6.237 ± 2.013
4.851AlaLys: 4.851 ± 1.785
4.851AlaLeu: 4.851 ± 1.147
0.0AlaMet: 0.0 ± 0.0
1.386AlaAsn: 1.386 ± 1.208
5.544AlaPro: 5.544 ± 1.331
0.693AlaGln: 0.693 ± 0.415
0.693AlaArg: 0.693 ± 0.415
9.009AlaSer: 9.009 ± 2.011
1.386AlaThr: 1.386 ± 1.418
3.465AlaVal: 3.465 ± 1.439
2.079AlaTrp: 2.079 ± 0.862
4.158AlaTyr: 4.158 ± 1.723
0.0AlaXaa: 0.0 ± 0.0
Cys
4.158CysAla: 4.158 ± 1.723
2.079CysCys: 2.079 ± 1.23
0.693CysAsp: 0.693 ± 0.709
0.693CysGlu: 0.693 ± 0.415
0.0CysPhe: 0.0 ± 0.0
2.772CysGly: 2.772 ± 1.04
0.693CysHis: 0.693 ± 1.206
2.772CysIle: 2.772 ± 1.637
1.386CysLys: 1.386 ± 0.772
2.079CysLeu: 2.079 ± 1.245
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.693CysPro: 0.693 ± 0.709
0.693CysGln: 0.693 ± 0.415
2.079CysArg: 2.079 ± 0.862
0.0CysSer: 0.0 ± 0.0
1.386CysThr: 1.386 ± 0.52
0.693CysVal: 0.693 ± 0.415
0.0CysTrp: 0.0 ± 0.0
1.386CysTyr: 1.386 ± 0.52
0.0CysXaa: 0.0 ± 0.0
Asp
6.237AspAla: 6.237 ± 1.272
0.693AspCys: 0.693 ± 0.415
3.465AspAsp: 3.465 ± 0.773
0.693AspGlu: 0.693 ± 0.917
2.772AspPhe: 2.772 ± 0.408
3.465AspGly: 3.465 ± 1.582
0.0AspHis: 0.0 ± 0.0
2.079AspIle: 2.079 ± 0.862
0.693AspLys: 0.693 ± 0.415
3.465AspLeu: 3.465 ± 1.669
1.386AspMet: 1.386 ± 0.83
2.772AspAsn: 2.772 ± 1.297
0.693AspPro: 0.693 ± 0.415
0.693AspGln: 0.693 ± 0.415
3.465AspArg: 3.465 ± 1.761
8.316AspSer: 8.316 ± 1.618
3.465AspThr: 3.465 ± 1.454
2.079AspVal: 2.079 ± 2.128
0.0AspTrp: 0.0 ± 0.0
1.386AspTyr: 1.386 ± 0.772
0.0AspXaa: 0.0 ± 0.0
Glu
1.386GluAla: 1.386 ± 0.83
0.693GluCys: 0.693 ± 0.415
3.465GluAsp: 3.465 ± 0.504
3.465GluGlu: 3.465 ± 1.439
1.386GluPhe: 1.386 ± 0.83
0.693GluGly: 0.693 ± 0.415
3.465GluHis: 3.465 ± 1.439
1.386GluIle: 1.386 ± 1.833
0.693GluLys: 0.693 ± 0.415
4.851GluLeu: 4.851 ± 1.209
0.0GluMet: 0.0 ± 0.0
2.079GluAsn: 2.079 ± 0.862
0.0GluPro: 0.0 ± 0.0
2.079GluGln: 2.079 ± 1.245
4.851GluArg: 4.851 ± 1.954
2.772GluSer: 2.772 ± 1.167
0.693GluThr: 0.693 ± 0.415
3.465GluVal: 3.465 ± 0.504
1.386GluTrp: 1.386 ± 0.52
2.772GluTyr: 2.772 ± 1.122
0.0GluXaa: 0.0 ± 0.0
Phe
2.079PheAla: 2.079 ± 0.618
0.693PheCys: 0.693 ± 0.415
4.851PheAsp: 4.851 ± 1.945
1.386PheGlu: 1.386 ± 0.83
1.386PhePhe: 1.386 ± 0.52
4.158PheGly: 4.158 ± 1.803
0.0PheHis: 0.0 ± 0.0
4.158PheIle: 4.158 ± 1.723
0.0PheLys: 0.0 ± 0.0
5.544PheLeu: 5.544 ± 2.116
0.693PheMet: 0.693 ± 0.817
2.772PheAsn: 2.772 ± 1.467
1.386PhePro: 1.386 ± 0.772
0.693PheGln: 0.693 ± 0.415
2.079PheArg: 2.079 ± 0.618
2.079PheSer: 2.079 ± 1.172
2.772PheThr: 2.772 ± 1.866
4.158PheVal: 4.158 ± 2.344
0.693PheTrp: 0.693 ± 0.709
1.386PheTyr: 1.386 ± 0.83
0.0PheXaa: 0.0 ± 0.0
Gly
2.079GlyAla: 2.079 ± 0.97
3.465GlyCys: 3.465 ± 0.504
2.079GlyAsp: 2.079 ± 1.245
1.386GlyGlu: 1.386 ± 0.52
3.465GlyPhe: 3.465 ± 1.28
4.851GlyGly: 4.851 ± 1.506
0.0GlyHis: 0.0 ± 0.0
4.851GlyIle: 4.851 ± 1.804
3.465GlyLys: 3.465 ± 1.556
5.544GlyLeu: 5.544 ± 1.607
1.386GlyMet: 1.386 ± 0.848
2.079GlyAsn: 2.079 ± 1.172
6.93GlyPro: 6.93 ± 1.499
2.772GlyGln: 2.772 ± 1.637
4.158GlyArg: 4.158 ± 1.149
5.544GlySer: 5.544 ± 0.965
2.772GlyThr: 2.772 ± 1.866
10.395GlyVal: 10.395 ± 1.073
1.386GlyTrp: 1.386 ± 1.418
3.465GlyTyr: 3.465 ± 1.582
0.0GlyXaa: 0.0 ± 0.0
His
2.079HisAla: 2.079 ± 1.245
0.0HisCys: 0.0 ± 0.0
0.693HisAsp: 0.693 ± 1.206
0.0HisGlu: 0.0 ± 0.0
1.386HisPhe: 1.386 ± 0.772
1.386HisGly: 1.386 ± 0.772
0.693HisHis: 0.693 ± 1.206
0.693HisIle: 0.693 ± 1.206
1.386HisLys: 1.386 ± 0.772
1.386HisLeu: 1.386 ± 0.52
1.386HisMet: 1.386 ± 0.772
0.693HisAsn: 0.693 ± 0.415
0.693HisPro: 0.693 ± 0.415
0.0HisGln: 0.0 ± 0.0
1.386HisArg: 1.386 ± 0.52
2.079HisSer: 2.079 ± 0.618
0.0HisThr: 0.0 ± 0.0
2.772HisVal: 2.772 ± 1.66
0.693HisTrp: 0.693 ± 0.415
0.693HisTyr: 0.693 ± 0.415
0.0HisXaa: 0.0 ± 0.0
Ile
2.079IleAla: 2.079 ± 0.652
0.693IleCys: 0.693 ± 1.206
2.079IleAsp: 2.079 ± 1.23
2.772IleGlu: 2.772 ± 1.111
1.386IlePhe: 1.386 ± 0.83
4.158IleGly: 4.158 ± 0.828
0.0IleHis: 0.0 ± 0.0
2.772IleIle: 2.772 ± 2.328
4.851IleLys: 4.851 ± 1.618
6.237IleLeu: 6.237 ± 2.267
2.079IleMet: 2.079 ± 0.862
4.158IleAsn: 4.158 ± 0.777
0.693IlePro: 0.693 ± 0.709
2.079IleGln: 2.079 ± 0.618
3.465IleArg: 3.465 ± 0.504
6.93IleSer: 6.93 ± 3.342
2.079IleThr: 2.079 ± 0.862
4.851IleVal: 4.851 ± 0.861
0.0IleTrp: 0.0 ± 0.0
1.386IleTyr: 1.386 ± 0.52
0.0IleXaa: 0.0 ± 0.0
Lys
4.158LysAla: 4.158 ± 0.828
0.0LysCys: 0.0 ± 0.0
2.079LysAsp: 2.079 ± 0.862
2.772LysGlu: 2.772 ± 1.98
2.079LysPhe: 2.079 ± 0.652
1.386LysGly: 1.386 ± 0.83
1.386LysHis: 1.386 ± 0.772
2.772LysIle: 2.772 ± 1.66
1.386LysLys: 1.386 ± 0.83
6.237LysLeu: 6.237 ± 1.573
3.465LysMet: 3.465 ± 1.553
0.693LysAsn: 0.693 ± 0.917
4.158LysPro: 4.158 ± 1.723
2.079LysGln: 2.079 ± 1.191
2.772LysArg: 2.772 ± 1.111
3.465LysSer: 3.465 ± 0.504
2.079LysThr: 2.079 ± 1.265
6.237LysVal: 6.237 ± 1.913
0.693LysTrp: 0.693 ± 0.415
0.693LysTyr: 0.693 ± 0.415
0.693LysXaa: 0.693 ± 0.415
Leu
7.623LeuAla: 7.623 ± 0.993
1.386LeuCys: 1.386 ± 0.83
0.693LeuAsp: 0.693 ± 0.415
2.772LeuGlu: 2.772 ± 1.66
0.0LeuPhe: 0.0 ± 0.0
4.851LeuGly: 4.851 ± 1.804
1.386LeuHis: 1.386 ± 0.83
6.93LeuIle: 6.93 ± 3.013
4.851LeuLys: 4.851 ± 1.703
5.544LeuLeu: 5.544 ± 2.039
1.386LeuMet: 1.386 ± 0.772
3.465LeuAsn: 3.465 ± 0.504
6.237LeuPro: 6.237 ± 1.573
3.465LeuGln: 3.465 ± 0.504
3.465LeuArg: 3.465 ± 1.28
12.474LeuSer: 12.474 ± 1.583
2.079LeuThr: 2.079 ± 2.128
6.93LeuVal: 6.93 ± 1.09
0.0LeuTrp: 0.0 ± 0.0
2.772LeuTyr: 2.772 ± 0.408
0.0LeuXaa: 0.0 ± 0.0
Met
2.079MetAla: 2.079 ± 1.339
0.693MetCys: 0.693 ± 0.709
0.0MetAsp: 0.0 ± 0.0
0.0MetGlu: 0.0 ± 0.0
0.0MetPhe: 0.0 ± 0.0
4.158MetGly: 4.158 ± 1.771
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
2.079MetLys: 2.079 ± 0.862
1.386MetLeu: 1.386 ± 0.772
1.386MetMet: 1.386 ± 0.848
0.693MetAsn: 0.693 ± 0.415
1.386MetPro: 1.386 ± 0.772
0.693MetGln: 0.693 ± 0.415
0.693MetArg: 0.693 ± 0.415
4.851MetSer: 4.851 ± 1.785
0.0MetThr: 0.0 ± 0.0
2.079MetVal: 2.079 ± 0.862
0.0MetTrp: 0.0 ± 0.0
1.386MetTyr: 1.386 ± 0.772
0.0MetXaa: 0.0 ± 0.0
Asn
1.386AsnAla: 1.386 ± 0.772
1.386AsnCys: 1.386 ± 0.52
1.386AsnAsp: 1.386 ± 0.848
0.0AsnGlu: 0.0 ± 0.0
2.772AsnPhe: 2.772 ± 1.81
2.079AsnGly: 2.079 ± 1.265
2.079AsnHis: 2.079 ± 0.862
1.386AsnIle: 1.386 ± 1.208
2.079AsnLys: 2.079 ± 0.618
4.158AsnLeu: 4.158 ± 1.165
0.0AsnMet: 0.0 ± 0.0
3.465AsnAsn: 3.465 ± 1.064
1.386AsnPro: 1.386 ± 0.52
2.079AsnGln: 2.079 ± 1.191
0.693AsnArg: 0.693 ± 0.415
9.009AsnSer: 9.009 ± 1.993
5.544AsnThr: 5.544 ± 2.837
0.693AsnVal: 0.693 ± 0.415
1.386AsnTrp: 1.386 ± 0.52
1.386AsnTyr: 1.386 ± 0.83
0.0AsnXaa: 0.0 ± 0.0
Pro
4.851ProAla: 4.851 ± 0.552
0.693ProCys: 0.693 ± 0.709
4.851ProAsp: 4.851 ± 1.147
4.158ProGlu: 4.158 ± 1.736
2.079ProPhe: 2.079 ± 1.339
1.386ProGly: 1.386 ± 1.418
0.693ProHis: 0.693 ± 0.415
0.693ProIle: 0.693 ± 0.415
4.158ProLys: 4.158 ± 1.723
4.158ProLeu: 4.158 ± 1.723
0.0ProMet: 0.0 ± 0.0
1.386ProAsn: 1.386 ± 1.418
1.386ProPro: 1.386 ± 0.52
1.386ProGln: 1.386 ± 0.52
3.465ProArg: 3.465 ± 1.374
2.772ProSer: 2.772 ± 1.04
2.772ProThr: 2.772 ± 0.408
5.544ProVal: 5.544 ± 1.312
1.386ProTrp: 1.386 ± 0.52
0.693ProTyr: 0.693 ± 0.709
0.0ProXaa: 0.0 ± 0.0
Gln
2.079GlnAla: 2.079 ± 0.618
1.386GlnCys: 1.386 ± 0.83
2.079GlnAsp: 2.079 ± 0.618
0.693GlnGlu: 0.693 ± 1.206
2.079GlnPhe: 2.079 ± 1.172
2.079GlnGly: 2.079 ± 0.97
0.693GlnHis: 0.693 ± 0.415
2.079GlnIle: 2.079 ± 0.862
0.693GlnLys: 0.693 ± 0.415
2.079GlnLeu: 2.079 ± 0.618
2.079GlnMet: 2.079 ± 0.862
0.693GlnAsn: 0.693 ± 0.415
4.158GlnPro: 4.158 ± 1.559
1.386GlnGln: 1.386 ± 1.164
2.079GlnArg: 2.079 ± 0.862
2.772GlnSer: 2.772 ± 1.127
1.386GlnThr: 1.386 ± 0.772
1.386GlnVal: 1.386 ± 0.52
0.0GlnTrp: 0.0 ± 0.0
1.386GlnTyr: 1.386 ± 1.421
0.0GlnXaa: 0.0 ± 0.0
Arg
7.623ArgAla: 7.623 ± 2.326
0.693ArgCys: 0.693 ± 0.709
0.693ArgAsp: 0.693 ± 1.206
3.465ArgGlu: 3.465 ± 1.669
5.544ArgPhe: 5.544 ± 0.822
4.851ArgGly: 4.851 ± 0.552
1.386ArgHis: 1.386 ± 0.52
0.693ArgIle: 0.693 ± 0.709
3.465ArgLys: 3.465 ± 0.9
2.772ArgLeu: 2.772 ± 0.916
2.079ArgMet: 2.079 ± 0.862
4.851ArgAsn: 4.851 ± 1.209
0.693ArgPro: 0.693 ± 0.415
2.772ArgGln: 2.772 ± 0.916
9.702ArgArg: 9.702 ± 3.019
3.465ArgSer: 3.465 ± 2.23
2.772ArgThr: 2.772 ± 1.127
9.702ArgVal: 9.702 ± 1.754
0.0ArgTrp: 0.0 ± 0.0
2.079ArgTyr: 2.079 ± 1.245
0.0ArgXaa: 0.0 ± 0.0
Ser
2.079SerAla: 2.079 ± 1.756
3.465SerCys: 3.465 ± 0.504
4.158SerAsp: 4.158 ± 1.426
3.465SerGlu: 3.465 ± 1.064
4.851SerPhe: 4.851 ± 1.42
7.623SerGly: 7.623 ± 2.087
0.693SerHis: 0.693 ± 0.415
6.237SerIle: 6.237 ± 3.025
4.158SerLys: 4.158 ± 1.418
3.465SerLeu: 3.465 ± 1.28
3.465SerMet: 3.465 ± 0.924
5.544SerAsn: 5.544 ± 1.829
4.158SerPro: 4.158 ± 0.777
4.158SerGln: 4.158 ± 0.528
8.316SerArg: 8.316 ± 2.356
8.316SerSer: 8.316 ± 5.573
3.465SerThr: 3.465 ± 1.074
10.395SerVal: 10.395 ± 2.6
2.079SerTrp: 2.079 ± 0.862
4.158SerTyr: 4.158 ± 2.833
0.0SerXaa: 0.0 ± 0.0
Thr
0.693ThrAla: 0.693 ± 0.709
0.693ThrCys: 0.693 ± 0.709
2.772ThrAsp: 2.772 ± 1.122
1.386ThrGlu: 1.386 ± 0.772
1.386ThrPhe: 1.386 ± 0.52
4.158ThrGly: 4.158 ± 1.839
1.386ThrHis: 1.386 ± 0.52
3.465ThrIle: 3.465 ± 1.439
2.079ThrLys: 2.079 ± 0.862
3.465ThrLeu: 3.465 ± 2.202
0.0ThrMet: 0.0 ± 0.0
1.386ThrAsn: 1.386 ± 1.421
0.693ThrPro: 0.693 ± 0.709
0.693ThrGln: 0.693 ± 1.206
5.544ThrArg: 5.544 ± 0.817
4.851ThrSer: 4.851 ± 2.176
1.386ThrThr: 1.386 ± 1.418
4.851ThrVal: 4.851 ± 1.144
0.693ThrTrp: 0.693 ± 0.709
0.693ThrTyr: 0.693 ± 0.709
0.0ThrXaa: 0.0 ± 0.0
Val
6.93ValAla: 6.93 ± 1.971
2.772ValCys: 2.772 ± 0.408
8.316ValAsp: 8.316 ± 2.429
7.623ValGlu: 7.623 ± 1.319
3.465ValPhe: 3.465 ± 1.669
6.237ValGly: 6.237 ± 0.952
3.465ValHis: 3.465 ± 1.439
4.158ValIle: 4.158 ± 0.528
7.623ValLys: 7.623 ± 2.162
4.851ValLeu: 4.851 ± 1.147
1.386ValMet: 1.386 ± 0.772
4.158ValAsn: 4.158 ± 1.931
6.237ValPro: 6.237 ± 1.222
2.772ValGln: 2.772 ± 1.04
4.851ValArg: 4.851 ± 1.144
2.772ValSer: 2.772 ± 0.916
4.851ValThr: 4.851 ± 1.693
5.544ValVal: 5.544 ± 1.324
0.693ValTrp: 0.693 ± 0.709
1.386ValTyr: 1.386 ± 1.208
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.693TrpAsp: 0.693 ± 0.709
1.386TrpGlu: 1.386 ± 0.83
1.386TrpPhe: 1.386 ± 0.772
0.693TrpGly: 0.693 ± 0.709
0.0TrpHis: 0.0 ± 0.0
0.693TrpIle: 0.693 ± 0.415
0.693TrpLys: 0.693 ± 0.709
0.693TrpLeu: 0.693 ± 0.709
0.0TrpMet: 0.0 ± 0.0
1.386TrpAsn: 1.386 ± 0.83
0.0TrpPro: 0.0 ± 0.0
0.693TrpGln: 0.693 ± 0.415
3.465TrpArg: 3.465 ± 0.773
0.0TrpSer: 0.0 ± 0.0
0.693TrpThr: 0.693 ± 0.709
0.693TrpVal: 0.693 ± 0.709
0.693TrpTrp: 0.693 ± 0.709
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.465TyrAla: 3.465 ± 1.521
1.386TyrCys: 1.386 ± 0.772
0.693TyrAsp: 0.693 ± 0.709
1.386TyrGlu: 1.386 ± 0.83
0.693TyrPhe: 0.693 ± 0.415
2.772TyrGly: 2.772 ± 1.111
1.386TyrHis: 1.386 ± 1.421
0.693TyrIle: 0.693 ± 0.415
1.386TyrLys: 1.386 ± 0.52
5.544TyrLeu: 5.544 ± 0.822
0.693TyrMet: 0.693 ± 0.709
0.693TyrAsn: 0.693 ± 0.415
1.386TyrPro: 1.386 ± 0.772
1.386TyrGln: 1.386 ± 0.772
2.079TyrArg: 2.079 ± 0.862
2.772TyrSer: 2.772 ± 1.04
0.693TyrThr: 0.693 ± 0.415
4.158TyrVal: 4.158 ± 2.117
0.0TyrTrp: 0.0 ± 0.0
1.386TyrTyr: 1.386 ± 0.848
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.693XaaGly: 0.693 ± 0.415
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (1444 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski