Amino acid dipepetide frequency for Mycobacterium phage Baee

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.184AlaAla: 16.184 ± 1.352
1.105AlaCys: 1.105 ± 0.293
6.677AlaAsp: 6.677 ± 0.572
9.109AlaGlu: 9.109 ± 0.75
2.388AlaPhe: 2.388 ± 0.285
11.099AlaGly: 11.099 ± 1.023
2.122AlaHis: 2.122 ± 0.358
5.35AlaIle: 5.35 ± 0.617
3.14AlaLys: 3.14 ± 0.406
10.126AlaLeu: 10.126 ± 0.743
2.565AlaMet: 2.565 ± 0.352
3.007AlaAsn: 3.007 ± 0.39
6.677AlaPro: 6.677 ± 0.651
3.714AlaGln: 3.714 ± 0.442
8.18AlaArg: 8.18 ± 0.725
7.606AlaSer: 7.606 ± 0.548
7.694AlaThr: 7.694 ± 0.527
8.49AlaVal: 8.49 ± 0.625
1.901AlaTrp: 1.901 ± 0.222
3.095AlaTyr: 3.095 ± 0.375
0.0AlaXaa: 0.0 ± 0.0
Cys
0.707CysAla: 0.707 ± 0.188
0.133CysCys: 0.133 ± 0.075
0.796CysAsp: 0.796 ± 0.198
0.531CysGlu: 0.531 ± 0.16
0.31CysPhe: 0.31 ± 0.135
1.548CysGly: 1.548 ± 0.274
0.265CysHis: 0.265 ± 0.101
0.31CysIle: 0.31 ± 0.108
0.177CysLys: 0.177 ± 0.092
0.752CysLeu: 0.752 ± 0.187
0.044CysMet: 0.044 ± 0.042
0.177CysAsn: 0.177 ± 0.077
0.619CysPro: 0.619 ± 0.166
0.221CysGln: 0.221 ± 0.09
1.061CysArg: 1.061 ± 0.286
0.531CysSer: 0.531 ± 0.156
0.796CysThr: 0.796 ± 0.208
0.663CysVal: 0.663 ± 0.193
0.265CysTrp: 0.265 ± 0.098
0.177CysTyr: 0.177 ± 0.099
0.0CysXaa: 0.0 ± 0.0
Asp
7.075AspAla: 7.075 ± 0.563
0.619AspCys: 0.619 ± 0.214
5.483AspAsp: 5.483 ± 0.613
3.759AspGlu: 3.759 ± 0.411
1.238AspPhe: 1.238 ± 0.194
7.163AspGly: 7.163 ± 0.602
1.503AspHis: 1.503 ± 0.276
3.184AspIle: 3.184 ± 0.385
1.68AspLys: 1.68 ± 0.261
5.129AspLeu: 5.129 ± 0.424
1.327AspMet: 1.327 ± 0.231
1.548AspAsn: 1.548 ± 0.254
4.554AspPro: 4.554 ± 0.39
2.52AspGln: 2.52 ± 0.322
4.997AspArg: 4.997 ± 0.469
2.742AspSer: 2.742 ± 0.255
3.759AspThr: 3.759 ± 0.42
4.82AspVal: 4.82 ± 0.519
1.238AspTrp: 1.238 ± 0.21
1.194AspTyr: 1.194 ± 0.222
0.0AspXaa: 0.0 ± 0.0
Glu
8.49GluAla: 8.49 ± 0.673
0.531GluCys: 0.531 ± 0.188
2.653GluAsp: 2.653 ± 0.338
3.316GluGlu: 3.316 ± 0.498
2.122GluPhe: 2.122 ± 0.277
3.67GluGly: 3.67 ± 0.402
0.973GluHis: 0.973 ± 0.184
3.626GluIle: 3.626 ± 0.456
1.282GluLys: 1.282 ± 0.243
4.776GluLeu: 4.776 ± 0.423
1.592GluMet: 1.592 ± 0.264
0.796GluAsn: 0.796 ± 0.159
3.803GluPro: 3.803 ± 0.443
2.432GluGln: 2.432 ± 0.377
4.245GluArg: 4.245 ± 0.447
2.034GluSer: 2.034 ± 0.289
4.997GluThr: 4.997 ± 0.495
4.997GluVal: 4.997 ± 0.419
1.548GluTrp: 1.548 ± 0.256
1.238GluTyr: 1.238 ± 0.215
0.0GluXaa: 0.0 ± 0.0
Phe
3.095PheAla: 3.095 ± 0.345
0.177PheCys: 0.177 ± 0.081
2.344PheAsp: 2.344 ± 0.308
1.725PheGlu: 1.725 ± 0.251
0.619PhePhe: 0.619 ± 0.156
2.786PheGly: 2.786 ± 0.372
0.486PheHis: 0.486 ± 0.138
1.017PheIle: 1.017 ± 0.206
0.796PheLys: 0.796 ± 0.173
1.503PheLeu: 1.503 ± 0.248
0.133PheMet: 0.133 ± 0.075
0.619PheAsn: 0.619 ± 0.213
1.371PhePro: 1.371 ± 0.165
0.398PheGln: 0.398 ± 0.143
1.68PheArg: 1.68 ± 0.269
1.061PheSer: 1.061 ± 0.239
1.99PheThr: 1.99 ± 0.329
1.592PheVal: 1.592 ± 0.311
0.354PheTrp: 0.354 ± 0.135
0.531PheTyr: 0.531 ± 0.18
0.0PheXaa: 0.0 ± 0.0
Gly
9.507GlyAla: 9.507 ± 1.236
1.017GlyCys: 1.017 ± 0.32
6.81GlyAsp: 6.81 ± 0.571
5.483GlyGlu: 5.483 ± 0.497
2.609GlyPhe: 2.609 ± 0.351
12.956GlyGly: 12.956 ± 2.153
1.813GlyHis: 1.813 ± 0.294
4.245GlyIle: 4.245 ± 0.681
3.007GlyLys: 3.007 ± 0.376
8.446GlyLeu: 8.446 ± 0.98
1.769GlyMet: 1.769 ± 0.307
2.918GlyAsn: 2.918 ± 0.498
4.422GlyPro: 4.422 ± 0.472
3.184GlyGln: 3.184 ± 0.423
5.527GlyArg: 5.527 ± 0.554
5.837GlySer: 5.837 ± 0.563
6.235GlyThr: 6.235 ± 0.561
6.102GlyVal: 6.102 ± 0.525
2.52GlyTrp: 2.52 ± 0.398
3.228GlyTyr: 3.228 ± 0.434
0.0GlyXaa: 0.0 ± 0.0
His
1.769HisAla: 1.769 ± 0.287
0.221HisCys: 0.221 ± 0.092
1.548HisAsp: 1.548 ± 0.277
0.929HisGlu: 0.929 ± 0.205
0.752HisPhe: 0.752 ± 0.171
1.548HisGly: 1.548 ± 0.247
0.663HisHis: 0.663 ± 0.165
0.575HisIle: 0.575 ± 0.132
0.354HisLys: 0.354 ± 0.145
1.503HisLeu: 1.503 ± 0.251
0.221HisMet: 0.221 ± 0.086
0.486HisAsn: 0.486 ± 0.148
1.371HisPro: 1.371 ± 0.334
0.663HisGln: 0.663 ± 0.131
1.769HisArg: 1.769 ± 0.288
0.884HisSer: 0.884 ± 0.204
1.371HisThr: 1.371 ± 0.279
1.282HisVal: 1.282 ± 0.224
0.398HisTrp: 0.398 ± 0.125
0.619HisTyr: 0.619 ± 0.166
0.0HisXaa: 0.0 ± 0.0
Ile
7.34IleAla: 7.34 ± 0.564
0.486IleCys: 0.486 ± 0.152
3.98IleAsp: 3.98 ± 0.424
3.935IleGlu: 3.935 ± 0.422
0.707IlePhe: 0.707 ± 0.162
4.245IleGly: 4.245 ± 0.688
0.575IleHis: 0.575 ± 0.142
2.167IleIle: 2.167 ± 0.342
1.725IleLys: 1.725 ± 0.297
2.653IleLeu: 2.653 ± 0.32
0.486IleMet: 0.486 ± 0.14
2.211IleAsn: 2.211 ± 0.326
2.211IlePro: 2.211 ± 0.273
1.238IleGln: 1.238 ± 0.252
2.344IleArg: 2.344 ± 0.297
2.122IleSer: 2.122 ± 0.32
3.98IleThr: 3.98 ± 0.421
3.228IleVal: 3.228 ± 0.347
0.707IleTrp: 0.707 ± 0.21
0.619IleTyr: 0.619 ± 0.13
0.0IleXaa: 0.0 ± 0.0
Lys
3.582LysAla: 3.582 ± 0.47
0.221LysCys: 0.221 ± 0.093
1.282LysAsp: 1.282 ± 0.281
0.884LysGlu: 0.884 ± 0.205
0.707LysPhe: 0.707 ± 0.16
2.83LysGly: 2.83 ± 0.346
0.531LysHis: 0.531 ± 0.16
1.592LysIle: 1.592 ± 0.274
0.575LysLys: 0.575 ± 0.219
2.918LysLeu: 2.918 ± 0.379
0.486LysMet: 0.486 ± 0.138
1.327LysAsn: 1.327 ± 0.233
1.238LysPro: 1.238 ± 0.234
1.15LysGln: 1.15 ± 0.208
1.636LysArg: 1.636 ± 0.262
1.813LysSer: 1.813 ± 0.243
1.725LysThr: 1.725 ± 0.267
2.874LysVal: 2.874 ± 0.383
0.619LysTrp: 0.619 ± 0.187
0.707LysTyr: 0.707 ± 0.188
0.0LysXaa: 0.0 ± 0.0
Leu
9.993LeuAla: 9.993 ± 0.791
0.707LeuCys: 0.707 ± 0.191
6.456LeuAsp: 6.456 ± 0.712
3.095LeuGlu: 3.095 ± 0.321
2.034LeuPhe: 2.034 ± 0.355
8.446LeuGly: 8.446 ± 0.993
1.592LeuHis: 1.592 ± 0.265
3.361LeuIle: 3.361 ± 0.413
2.078LeuLys: 2.078 ± 0.368
6.014LeuLeu: 6.014 ± 0.631
1.68LeuMet: 1.68 ± 0.282
2.963LeuAsn: 2.963 ± 0.408
5.969LeuPro: 5.969 ± 0.51
3.007LeuGln: 3.007 ± 0.41
4.157LeuArg: 4.157 ± 0.474
4.599LeuSer: 4.599 ± 0.467
5.66LeuThr: 5.66 ± 0.503
5.35LeuVal: 5.35 ± 0.532
1.371LeuTrp: 1.371 ± 0.255
1.725LeuTyr: 1.725 ± 0.246
0.0LeuXaa: 0.0 ± 0.0
Met
2.432MetAla: 2.432 ± 0.252
0.265MetCys: 0.265 ± 0.105
0.973MetAsp: 0.973 ± 0.24
0.707MetGlu: 0.707 ± 0.223
0.707MetPhe: 0.707 ± 0.174
1.769MetGly: 1.769 ± 0.249
0.442MetHis: 0.442 ± 0.138
1.238MetIle: 1.238 ± 0.222
0.84MetLys: 0.84 ± 0.168
1.503MetLeu: 1.503 ± 0.23
0.398MetMet: 0.398 ± 0.13
0.31MetAsn: 0.31 ± 0.104
1.371MetPro: 1.371 ± 0.233
0.486MetGln: 0.486 ± 0.136
1.459MetArg: 1.459 ± 0.296
1.592MetSer: 1.592 ± 0.258
2.476MetThr: 2.476 ± 0.302
0.663MetVal: 0.663 ± 0.139
0.177MetTrp: 0.177 ± 0.084
0.531MetTyr: 0.531 ± 0.161
0.0MetXaa: 0.0 ± 0.0
Asn
3.67AsnAla: 3.67 ± 0.475
0.354AsnCys: 0.354 ± 0.118
2.078AsnAsp: 2.078 ± 0.264
1.636AsnGlu: 1.636 ± 0.249
0.354AsnPhe: 0.354 ± 0.122
3.095AsnGly: 3.095 ± 0.524
0.619AsnHis: 0.619 ± 0.18
1.061AsnIle: 1.061 ± 0.237
1.017AsnLys: 1.017 ± 0.248
2.653AsnLeu: 2.653 ± 0.407
0.663AsnMet: 0.663 ± 0.192
0.663AsnAsn: 0.663 ± 0.18
2.476AsnPro: 2.476 ± 0.371
0.575AsnGln: 0.575 ± 0.153
1.68AsnArg: 1.68 ± 0.264
1.238AsnSer: 1.238 ± 0.235
1.503AsnThr: 1.503 ± 0.327
2.299AsnVal: 2.299 ± 0.336
0.486AsnTrp: 0.486 ± 0.135
0.796AsnTyr: 0.796 ± 0.183
0.0AsnXaa: 0.0 ± 0.0
Pro
7.252ProAla: 7.252 ± 0.664
0.531ProCys: 0.531 ± 0.201
4.466ProAsp: 4.466 ± 0.565
4.51ProGlu: 4.51 ± 0.46
1.68ProPhe: 1.68 ± 0.324
6.721ProGly: 6.721 ± 0.562
1.017ProHis: 1.017 ± 0.228
3.272ProIle: 3.272 ± 0.505
1.194ProLys: 1.194 ± 0.209
3.847ProLeu: 3.847 ± 0.38
1.459ProMet: 1.459 ± 0.246
1.503ProAsn: 1.503 ± 0.251
4.687ProPro: 4.687 ± 0.689
1.327ProGln: 1.327 ± 0.258
3.405ProArg: 3.405 ± 0.377
3.095ProSer: 3.095 ± 0.369
3.98ProThr: 3.98 ± 0.466
5.041ProVal: 5.041 ± 0.435
1.061ProTrp: 1.061 ± 0.272
1.061ProTyr: 1.061 ± 0.219
0.0ProXaa: 0.0 ± 0.0
Gln
4.068GlnAla: 4.068 ± 0.445
0.265GlnCys: 0.265 ± 0.101
1.371GlnAsp: 1.371 ± 0.261
1.15GlnGlu: 1.15 ± 0.196
1.15GlnPhe: 1.15 ± 0.216
2.344GlnGly: 2.344 ± 0.4
0.619GlnHis: 0.619 ± 0.181
1.946GlnIle: 1.946 ± 0.325
0.884GlnLys: 0.884 ± 0.233
3.449GlnLeu: 3.449 ± 0.361
0.929GlnMet: 0.929 ± 0.171
0.663GlnAsn: 0.663 ± 0.183
1.548GlnPro: 1.548 ± 0.288
1.327GlnGln: 1.327 ± 0.278
2.52GlnArg: 2.52 ± 0.338
1.636GlnSer: 1.636 ± 0.229
2.034GlnThr: 2.034 ± 0.283
2.476GlnVal: 2.476 ± 0.355
0.796GlnTrp: 0.796 ± 0.203
0.796GlnTyr: 0.796 ± 0.2
0.0GlnXaa: 0.0 ± 0.0
Arg
7.208ArgAla: 7.208 ± 0.721
0.929ArgCys: 0.929 ± 0.195
3.891ArgAsp: 3.891 ± 0.413
4.554ArgGlu: 4.554 ± 0.419
1.459ArgPhe: 1.459 ± 0.244
4.51ArgGly: 4.51 ± 0.54
1.415ArgHis: 1.415 ± 0.23
2.874ArgIle: 2.874 ± 0.398
2.255ArgLys: 2.255 ± 0.381
5.616ArgLeu: 5.616 ± 0.541
1.769ArgMet: 1.769 ± 0.216
2.078ArgAsn: 2.078 ± 0.284
4.068ArgPro: 4.068 ± 0.546
1.857ArgGln: 1.857 ± 0.273
6.81ArgArg: 6.81 ± 0.834
3.272ArgSer: 3.272 ± 0.427
3.935ArgThr: 3.935 ± 0.533
5.395ArgVal: 5.395 ± 0.645
1.503ArgTrp: 1.503 ± 0.282
2.078ArgTyr: 2.078 ± 0.4
0.0ArgXaa: 0.0 ± 0.0
Ser
6.633SerAla: 6.633 ± 0.489
0.973SerCys: 0.973 ± 0.249
2.963SerAsp: 2.963 ± 0.378
2.476SerGlu: 2.476 ± 0.331
0.929SerPhe: 0.929 ± 0.243
6.765SerGly: 6.765 ± 0.737
0.929SerHis: 0.929 ± 0.19
2.167SerIle: 2.167 ± 0.354
1.99SerLys: 1.99 ± 0.302
4.466SerLeu: 4.466 ± 0.482
1.105SerMet: 1.105 ± 0.231
1.946SerAsn: 1.946 ± 0.294
2.918SerPro: 2.918 ± 0.404
1.946SerGln: 1.946 ± 0.341
3.67SerArg: 3.67 ± 0.386
2.83SerSer: 2.83 ± 0.458
3.537SerThr: 3.537 ± 0.404
3.361SerVal: 3.361 ± 0.408
1.017SerTrp: 1.017 ± 0.204
1.503SerTyr: 1.503 ± 0.267
0.0SerXaa: 0.0 ± 0.0
Thr
7.827ThrAla: 7.827 ± 0.642
0.398ThrCys: 0.398 ± 0.124
4.068ThrAsp: 4.068 ± 0.468
3.714ThrGlu: 3.714 ± 0.488
1.636ThrPhe: 1.636 ± 0.269
7.075ThrGly: 7.075 ± 0.583
0.884ThrHis: 0.884 ± 0.182
3.095ThrIle: 3.095 ± 0.343
1.946ThrLys: 1.946 ± 0.256
5.218ThrLeu: 5.218 ± 0.49
1.636ThrMet: 1.636 ± 0.277
1.901ThrAsn: 1.901 ± 0.273
5.439ThrPro: 5.439 ± 0.56
2.034ThrGln: 2.034 ± 0.281
4.466ThrArg: 4.466 ± 0.558
4.201ThrSer: 4.201 ± 0.493
4.599ThrThr: 4.599 ± 0.43
5.837ThrVal: 5.837 ± 0.67
1.327ThrTrp: 1.327 ± 0.259
1.061ThrTyr: 1.061 ± 0.236
0.0ThrXaa: 0.0 ± 0.0
Val
7.827ValAla: 7.827 ± 0.711
0.707ValCys: 0.707 ± 0.175
4.554ValAsp: 4.554 ± 0.418
5.085ValGlu: 5.085 ± 0.304
1.548ValPhe: 1.548 ± 0.24
6.323ValGly: 6.323 ± 0.493
1.327ValHis: 1.327 ± 0.235
4.51ValIle: 4.51 ± 0.402
2.167ValLys: 2.167 ± 0.297
6.102ValLeu: 6.102 ± 0.514
1.459ValMet: 1.459 ± 0.235
2.874ValAsn: 2.874 ± 0.378
4.157ValPro: 4.157 ± 0.39
2.565ValGln: 2.565 ± 0.28
4.201ValArg: 4.201 ± 0.452
4.643ValSer: 4.643 ± 0.5
5.262ValThr: 5.262 ± 0.507
4.51ValVal: 4.51 ± 0.493
1.327ValTrp: 1.327 ± 0.227
1.813ValTyr: 1.813 ± 0.273
0.0ValXaa: 0.0 ± 0.0
Trp
2.255TrpAla: 2.255 ± 0.417
0.31TrpCys: 0.31 ± 0.143
1.282TrpAsp: 1.282 ± 0.243
0.884TrpGlu: 0.884 ± 0.218
0.752TrpPhe: 0.752 ± 0.3
0.929TrpGly: 0.929 ± 0.183
0.796TrpHis: 0.796 ± 0.212
0.752TrpIle: 0.752 ± 0.178
0.752TrpLys: 0.752 ± 0.179
1.459TrpLeu: 1.459 ± 0.223
0.354TrpMet: 0.354 ± 0.114
0.442TrpAsn: 0.442 ± 0.125
1.061TrpPro: 1.061 ± 0.222
0.752TrpGln: 0.752 ± 0.171
1.194TrpArg: 1.194 ± 0.252
1.415TrpSer: 1.415 ± 0.293
1.592TrpThr: 1.592 ± 0.348
1.636TrpVal: 1.636 ± 0.325
0.619TrpTrp: 0.619 ± 0.165
0.354TrpTyr: 0.354 ± 0.104
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.316TyrAla: 3.316 ± 0.419
0.133TyrCys: 0.133 ± 0.08
1.857TyrAsp: 1.857 ± 0.277
1.636TyrGlu: 1.636 ± 0.256
0.575TyrPhe: 0.575 ± 0.138
1.813TyrGly: 1.813 ± 0.337
0.354TyrHis: 0.354 ± 0.147
0.619TyrIle: 0.619 ± 0.177
0.84TyrLys: 0.84 ± 0.182
2.122TyrLeu: 2.122 ± 0.239
0.221TyrMet: 0.221 ± 0.107
0.486TyrAsn: 0.486 ± 0.137
1.15TyrPro: 1.15 ± 0.262
0.575TyrGln: 0.575 ± 0.152
2.476TyrArg: 2.476 ± 0.405
0.973TyrSer: 0.973 ± 0.237
1.282TyrThr: 1.282 ± 0.246
2.344TyrVal: 2.344 ± 0.389
0.354TyrTrp: 0.354 ± 0.132
0.31TyrTyr: 0.31 ± 0.102
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 96 proteins (22616 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski