Amino acid dipepetide frequency for Corynebacterium striatum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.124AlaAla: 16.124 ± 0.222
0.951AlaCys: 0.951 ± 0.037
6.594AlaAsp: 6.594 ± 0.106
8.2AlaGlu: 8.2 ± 0.104
3.74AlaPhe: 3.74 ± 0.074
9.711AlaGly: 9.711 ± 0.149
2.405AlaHis: 2.405 ± 0.062
5.672AlaIle: 5.672 ± 0.084
4.316AlaLys: 4.316 ± 0.091
11.723AlaLeu: 11.723 ± 0.142
2.784AlaMet: 2.784 ± 0.058
3.121AlaAsn: 3.121 ± 0.066
5.294AlaPro: 5.294 ± 0.103
4.637AlaGln: 4.637 ± 0.083
6.833AlaArg: 6.833 ± 0.097
6.197AlaSer: 6.197 ± 0.097
6.684AlaThr: 6.684 ± 0.107
9.08AlaVal: 9.08 ± 0.149
1.567AlaTrp: 1.567 ± 0.047
2.291AlaTyr: 2.291 ± 0.055
0.0AlaXaa: 0.0 ± 0.0
Cys
0.885CysAla: 0.885 ± 0.035
0.082CysCys: 0.082 ± 0.01
0.393CysAsp: 0.393 ± 0.022
0.409CysGlu: 0.409 ± 0.022
0.255CysPhe: 0.255 ± 0.017
0.762CysGly: 0.762 ± 0.03
0.183CysHis: 0.183 ± 0.015
0.358CysIle: 0.358 ± 0.022
0.212CysLys: 0.212 ± 0.017
0.612CysLeu: 0.612 ± 0.025
0.159CysMet: 0.159 ± 0.014
0.198CysAsn: 0.198 ± 0.016
0.394CysPro: 0.394 ± 0.021
0.241CysGln: 0.241 ± 0.018
0.369CysArg: 0.369 ± 0.021
0.5CysSer: 0.5 ± 0.026
0.457CysThr: 0.457 ± 0.022
0.569CysVal: 0.569 ± 0.028
0.081CysTrp: 0.081 ± 0.011
0.158CysTyr: 0.158 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
7.05AspAla: 7.05 ± 0.102
0.378AspCys: 0.378 ± 0.018
3.346AspAsp: 3.346 ± 0.089
4.262AspGlu: 4.262 ± 0.085
2.235AspPhe: 2.235 ± 0.055
4.738AspGly: 4.738 ± 0.103
1.222AspHis: 1.222 ± 0.044
3.112AspIle: 3.112 ± 0.074
2.333AspLys: 2.333 ± 0.062
5.221AspLeu: 5.221 ± 0.077
1.198AspMet: 1.198 ± 0.045
1.767AspAsn: 1.767 ± 0.049
3.258AspPro: 3.258 ± 0.068
1.566AspGln: 1.566 ± 0.046
2.98AspArg: 2.98 ± 0.062
3.396AspSer: 3.396 ± 0.067
3.026AspThr: 3.026 ± 0.065
4.714AspVal: 4.714 ± 0.077
0.818AspTrp: 0.818 ± 0.034
1.58AspTyr: 1.58 ± 0.048
0.0AspXaa: 0.0 ± 0.0
Glu
7.008GluAla: 7.008 ± 0.104
0.375GluCys: 0.375 ± 0.018
3.573GluAsp: 3.573 ± 0.075
4.836GluGlu: 4.836 ± 0.084
2.232GluPhe: 2.232 ± 0.069
4.684GluGly: 4.684 ± 0.084
1.63GluHis: 1.63 ± 0.046
3.39GluIle: 3.39 ± 0.067
2.83GluLys: 2.83 ± 0.068
7.068GluLeu: 7.068 ± 0.107
1.322GluMet: 1.322 ± 0.041
2.057GluAsn: 2.057 ± 0.051
2.833GluPro: 2.833 ± 0.066
2.683GluGln: 2.683 ± 0.066
4.231GluArg: 4.231 ± 0.076
3.621GluSer: 3.621 ± 0.066
3.372GluThr: 3.372 ± 0.068
5.029GluVal: 5.029 ± 0.078
0.891GluTrp: 0.891 ± 0.039
1.492GluTyr: 1.492 ± 0.04
0.0GluXaa: 0.0 ± 0.0
Phe
3.958PheAla: 3.958 ± 0.072
0.284PheCys: 0.284 ± 0.018
2.438PheAsp: 2.438 ± 0.056
1.986PheGlu: 1.986 ± 0.051
1.339PhePhe: 1.339 ± 0.043
3.461PheGly: 3.461 ± 0.071
0.746PheHis: 0.746 ± 0.03
1.79PheIle: 1.79 ± 0.046
1.064PheLys: 1.064 ± 0.036
3.112PheLeu: 3.112 ± 0.07
0.76PheMet: 0.76 ± 0.034
1.188PheAsn: 1.188 ± 0.037
1.488PhePro: 1.488 ± 0.045
0.93PheGln: 0.93 ± 0.034
1.719PheArg: 1.719 ± 0.047
2.25PheSer: 2.25 ± 0.052
2.156PheThr: 2.156 ± 0.052
2.673PheVal: 2.673 ± 0.062
0.508PheTrp: 0.508 ± 0.025
0.878PheTyr: 0.878 ± 0.033
0.0PheXaa: 0.0 ± 0.0
Gly
8.692GlyAla: 8.692 ± 0.126
0.704GlyCys: 0.704 ± 0.03
4.221GlyAsp: 4.221 ± 0.078
5.117GlyGlu: 5.117 ± 0.087
3.26GlyPhe: 3.26 ± 0.064
6.458GlyGly: 6.458 ± 0.12
1.854GlyHis: 1.854 ± 0.059
4.769GlyIle: 4.769 ± 0.085
3.492GlyLys: 3.492 ± 0.077
7.913GlyLeu: 7.913 ± 0.102
2.204GlyMet: 2.204 ± 0.057
2.459GlyAsn: 2.459 ± 0.064
3.143GlyPro: 3.143 ± 0.061
2.808GlyGln: 2.808 ± 0.066
4.526GlyArg: 4.526 ± 0.083
4.902GlySer: 4.902 ± 0.076
5.118GlyThr: 5.118 ± 0.094
6.713GlyVal: 6.713 ± 0.086
1.331GlyTrp: 1.331 ± 0.043
2.277GlyTyr: 2.277 ± 0.049
0.0GlyXaa: 0.0 ± 0.0
His
2.382HisAla: 2.382 ± 0.063
0.184HisCys: 0.184 ± 0.016
1.199HisAsp: 1.199 ± 0.039
1.311HisGlu: 1.311 ± 0.044
0.673HisPhe: 0.673 ± 0.031
1.879HisGly: 1.879 ± 0.047
0.556HisHis: 0.556 ± 0.027
1.005HisIle: 1.005 ± 0.036
0.622HisLys: 0.622 ± 0.029
2.012HisLeu: 2.012 ± 0.054
0.529HisMet: 0.529 ± 0.025
0.716HisAsn: 0.716 ± 0.031
1.348HisPro: 1.348 ± 0.047
0.639HisGln: 0.639 ± 0.027
1.336HisArg: 1.336 ± 0.047
1.227HisSer: 1.227 ± 0.033
1.342HisThr: 1.342 ± 0.043
1.614HisVal: 1.614 ± 0.045
0.262HisTrp: 0.262 ± 0.019
0.565HisTyr: 0.565 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
6.54IleAla: 6.54 ± 0.112
0.426IleCys: 0.426 ± 0.021
3.413IleAsp: 3.413 ± 0.066
3.359IleGlu: 3.359 ± 0.064
1.728IlePhe: 1.728 ± 0.048
4.37IleGly: 4.37 ± 0.088
1.017IleHis: 1.017 ± 0.033
2.752IleIle: 2.752 ± 0.073
1.669IleLys: 1.669 ± 0.048
4.131IleLeu: 4.131 ± 0.081
1.056IleMet: 1.056 ± 0.039
1.735IleAsn: 1.735 ± 0.052
2.706IlePro: 2.706 ± 0.059
1.311IleGln: 1.311 ± 0.042
2.505IleArg: 2.505 ± 0.065
3.037IleSer: 3.037 ± 0.061
3.149IleThr: 3.149 ± 0.06
4.379IleVal: 4.379 ± 0.086
0.53IleTrp: 0.53 ± 0.029
1.084IleTyr: 1.084 ± 0.039
0.0IleXaa: 0.0 ± 0.0
Lys
4.253LysAla: 4.253 ± 0.086
0.148LysCys: 0.148 ± 0.014
2.208LysAsp: 2.208 ± 0.073
2.444LysGlu: 2.444 ± 0.062
1.088LysPhe: 1.088 ± 0.04
2.572LysGly: 2.572 ± 0.053
0.807LysHis: 0.807 ± 0.034
1.691LysIle: 1.691 ± 0.054
1.968LysLys: 1.968 ± 0.061
3.577LysLeu: 3.577 ± 0.079
0.894LysMet: 0.894 ± 0.031
1.256LysAsn: 1.256 ± 0.048
1.946LysPro: 1.946 ± 0.058
1.434LysGln: 1.434 ± 0.046
2.378LysArg: 2.378 ± 0.059
1.948LysSer: 1.948 ± 0.051
2.071LysThr: 2.071 ± 0.056
2.945LysVal: 2.945 ± 0.069
0.487LysTrp: 0.487 ± 0.027
0.83LysTyr: 0.83 ± 0.032
0.0LysXaa: 0.0 ± 0.0
Leu
11.915LeuAla: 11.915 ± 0.143
0.729LeuCys: 0.729 ± 0.03
5.919LeuAsp: 5.919 ± 0.092
5.608LeuGlu: 5.608 ± 0.096
3.041LeuPhe: 3.041 ± 0.075
8.394LeuGly: 8.394 ± 0.109
1.954LeuHis: 1.954 ± 0.053
4.843LeuIle: 4.843 ± 0.096
3.206LeuLys: 3.206 ± 0.074
8.692LeuLeu: 8.692 ± 0.127
1.928LeuMet: 1.928 ± 0.052
2.861LeuAsn: 2.861 ± 0.068
5.094LeuPro: 5.094 ± 0.08
2.642LeuGln: 2.642 ± 0.055
6.004LeuArg: 6.004 ± 0.092
5.994LeuSer: 5.994 ± 0.092
5.586LeuThr: 5.586 ± 0.092
7.734LeuVal: 7.734 ± 0.113
1.156LeuTrp: 1.156 ± 0.041
1.906LeuTyr: 1.906 ± 0.042
0.0LeuXaa: 0.0 ± 0.0
Met
2.742MetAla: 2.742 ± 0.062
0.208MetCys: 0.208 ± 0.016
1.134MetAsp: 1.134 ± 0.036
1.181MetGlu: 1.181 ± 0.038
0.743MetPhe: 0.743 ± 0.034
1.817MetGly: 1.817 ± 0.052
0.468MetHis: 0.468 ± 0.027
1.098MetIle: 1.098 ± 0.043
0.783MetLys: 0.783 ± 0.032
2.201MetLeu: 2.201 ± 0.056
0.495MetMet: 0.495 ± 0.022
0.73MetAsn: 0.73 ± 0.03
1.204MetPro: 1.204 ± 0.046
0.667MetGln: 0.667 ± 0.028
1.44MetArg: 1.44 ± 0.041
1.668MetSer: 1.668 ± 0.044
1.735MetThr: 1.735 ± 0.046
1.733MetVal: 1.733 ± 0.042
0.333MetTrp: 0.333 ± 0.019
0.455MetTyr: 0.455 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
3.389AsnAla: 3.389 ± 0.065
0.18AsnCys: 0.18 ± 0.014
1.646AsnAsp: 1.646 ± 0.054
1.899AsnGlu: 1.899 ± 0.049
1.085AsnPhe: 1.085 ± 0.037
2.438AsnGly: 2.438 ± 0.064
0.652AsnHis: 0.652 ± 0.033
1.502AsnIle: 1.502 ± 0.042
1.146AsnLys: 1.146 ± 0.04
2.776AsnLeu: 2.776 ± 0.054
0.708AsnMet: 0.708 ± 0.029
1.152AsnAsn: 1.152 ± 0.046
2.19AsnPro: 2.19 ± 0.053
1.055AsnGln: 1.055 ± 0.036
1.714AsnArg: 1.714 ± 0.049
1.928AsnSer: 1.928 ± 0.057
1.624AsnThr: 1.624 ± 0.046
2.227AsnVal: 2.227 ± 0.052
0.458AsnTrp: 0.458 ± 0.022
0.87AsnTyr: 0.87 ± 0.032
0.0AsnXaa: 0.0 ± 0.0
Pro
5.81ProAla: 5.81 ± 0.112
0.267ProCys: 0.267 ± 0.019
3.145ProAsp: 3.145 ± 0.065
4.192ProGlu: 4.192 ± 0.093
1.639ProPhe: 1.639 ± 0.046
4.238ProGly: 4.238 ± 0.076
1.068ProHis: 1.068 ± 0.035
2.133ProIle: 2.133 ± 0.046
1.725ProLys: 1.725 ± 0.057
4.289ProLeu: 4.289 ± 0.063
1.035ProMet: 1.035 ± 0.038
1.554ProAsn: 1.554 ± 0.048
1.681ProPro: 1.681 ± 0.048
1.924ProGln: 1.924 ± 0.059
2.772ProArg: 2.772 ± 0.066
2.755ProSer: 2.755 ± 0.059
3.139ProThr: 3.139 ± 0.07
4.113ProVal: 4.113 ± 0.071
0.725ProTrp: 0.725 ± 0.033
1.081ProTyr: 1.081 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
4.061GlnAla: 4.061 ± 0.08
0.176GlnCys: 0.176 ± 0.014
1.64GlnAsp: 1.64 ± 0.047
2.088GlnGlu: 2.088 ± 0.047
1.068GlnPhe: 1.068 ± 0.03
2.364GlnGly: 2.364 ± 0.059
0.723GlnHis: 0.723 ± 0.031
1.656GlnIle: 1.656 ± 0.046
1.195GlnLys: 1.195 ± 0.039
3.838GlnLeu: 3.838 ± 0.08
0.756GlnMet: 0.756 ± 0.031
0.925GlnAsn: 0.925 ± 0.036
1.761GlnPro: 1.761 ± 0.054
1.526GlnGln: 1.526 ± 0.063
2.51GlnArg: 2.51 ± 0.058
1.774GlnSer: 1.774 ± 0.053
1.589GlnThr: 1.589 ± 0.041
2.607GlnVal: 2.607 ± 0.056
0.523GlnTrp: 0.523 ± 0.024
0.7GlnTyr: 0.7 ± 0.028
0.0GlnXaa: 0.0 ± 0.0
Arg
6.229ArgAla: 6.229 ± 0.096
0.364ArgCys: 0.364 ± 0.023
3.467ArgAsp: 3.467 ± 0.074
4.192ArgGlu: 4.192 ± 0.082
2.07ArgPhe: 2.07 ± 0.049
4.37ArgGly: 4.37 ± 0.077
1.268ArgHis: 1.268 ± 0.039
3.248ArgIle: 3.248 ± 0.061
2.349ArgLys: 2.349 ± 0.061
5.434ArgLeu: 5.434 ± 0.09
1.594ArgMet: 1.594 ± 0.047
1.899ArgAsn: 1.899 ± 0.053
2.771ArgPro: 2.771 ± 0.061
2.089ArgGln: 2.089 ± 0.052
4.609ArgArg: 4.609 ± 0.105
3.152ArgSer: 3.152 ± 0.061
3.468ArgThr: 3.468 ± 0.064
4.275ArgVal: 4.275 ± 0.086
0.829ArgTrp: 0.829 ± 0.031
1.568ArgTyr: 1.568 ± 0.041
0.0ArgXaa: 0.0 ± 0.0
Ser
6.694SerAla: 6.694 ± 0.104
0.366SerCys: 0.366 ± 0.023
3.12SerAsp: 3.12 ± 0.07
3.44SerGlu: 3.44 ± 0.065
2.25SerPhe: 2.25 ± 0.055
5.236SerGly: 5.236 ± 0.089
1.264SerHis: 1.264 ± 0.035
2.884SerIle: 2.884 ± 0.064
2.09SerLys: 2.09 ± 0.053
5.496SerLeu: 5.496 ± 0.082
1.571SerMet: 1.571 ± 0.042
1.756SerAsn: 1.756 ± 0.046
2.888SerPro: 2.888 ± 0.064
2.088SerGln: 2.088 ± 0.055
3.406SerArg: 3.406 ± 0.068
3.811SerSer: 3.811 ± 0.086
3.83SerThr: 3.83 ± 0.078
4.429SerVal: 4.429 ± 0.075
0.851SerTrp: 0.851 ± 0.031
1.446SerTyr: 1.446 ± 0.045
0.0SerXaa: 0.0 ± 0.0
Thr
6.737ThrAla: 6.737 ± 0.108
0.426ThrCys: 0.426 ± 0.025
3.287ThrAsp: 3.287 ± 0.069
3.325ThrGlu: 3.325 ± 0.07
2.026ThrPhe: 2.026 ± 0.045
5.168ThrGly: 5.168 ± 0.078
1.259ThrHis: 1.259 ± 0.038
2.973ThrIle: 2.973 ± 0.056
2.107ThrLys: 2.107 ± 0.066
5.597ThrLeu: 5.597 ± 0.086
1.314ThrMet: 1.314 ± 0.043
1.714ThrAsn: 1.714 ± 0.049
3.584ThrPro: 3.584 ± 0.061
1.832ThrGln: 1.832 ± 0.051
3.187ThrArg: 3.187 ± 0.059
3.446ThrSer: 3.446 ± 0.073
3.702ThrThr: 3.702 ± 0.071
5.112ThrVal: 5.112 ± 0.092
0.877ThrTrp: 0.877 ± 0.031
1.472ThrTyr: 1.472 ± 0.044
0.0ThrXaa: 0.0 ± 0.0
Val
9.542ValAla: 9.542 ± 0.124
0.66ValCys: 0.66 ± 0.028
5.277ValAsp: 5.277 ± 0.087
5.191ValGlu: 5.191 ± 0.087
2.71ValPhe: 2.71 ± 0.064
6.322ValGly: 6.322 ± 0.109
1.535ValHis: 1.535 ± 0.047
4.309ValIle: 4.309 ± 0.089
2.617ValLys: 2.617 ± 0.06
7.667ValLeu: 7.667 ± 0.111
1.72ValMet: 1.72 ± 0.046
2.309ValAsn: 2.309 ± 0.055
3.885ValPro: 3.885 ± 0.078
2.109ValGln: 2.109 ± 0.045
4.32ValArg: 4.32 ± 0.076
4.865ValSer: 4.865 ± 0.08
4.986ValThr: 4.986 ± 0.089
6.974ValVal: 6.974 ± 0.109
0.948ValTrp: 0.948 ± 0.04
1.697ValTyr: 1.697 ± 0.044
0.0ValXaa: 0.0 ± 0.0
Trp
1.492TrpAla: 1.492 ± 0.043
0.161TrpCys: 0.161 ± 0.016
0.732TrpAsp: 0.732 ± 0.032
0.775TrpGlu: 0.775 ± 0.031
0.547TrpPhe: 0.547 ± 0.026
0.937TrpGly: 0.937 ± 0.035
0.321TrpHis: 0.321 ± 0.019
0.749TrpIle: 0.749 ± 0.032
0.515TrpLys: 0.515 ± 0.027
1.5TrpLeu: 1.5 ± 0.047
0.388TrpMet: 0.388 ± 0.023
0.492TrpAsn: 0.492 ± 0.025
0.634TrpPro: 0.634 ± 0.029
0.523TrpGln: 0.523 ± 0.025
0.896TrpArg: 0.896 ± 0.033
0.781TrpSer: 0.781 ± 0.031
0.758TrpThr: 0.758 ± 0.028
1.038TrpVal: 1.038 ± 0.039
0.301TrpTrp: 0.301 ± 0.023
0.279TrpTyr: 0.279 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.425TyrAla: 2.425 ± 0.058
0.209TyrCys: 0.209 ± 0.014
1.447TyrAsp: 1.447 ± 0.044
1.345TyrGlu: 1.345 ± 0.04
0.996TyrPhe: 0.996 ± 0.041
2.04TyrGly: 2.04 ± 0.052
0.47TyrHis: 0.47 ± 0.024
0.962TyrIle: 0.962 ± 0.035
0.704TyrLys: 0.704 ± 0.03
2.35TyrLeu: 2.35 ± 0.054
0.419TyrMet: 0.419 ± 0.022
0.75TyrAsn: 0.75 ± 0.032
1.186TyrPro: 1.186 ± 0.041
0.777TyrGln: 0.777 ± 0.031
1.512TyrArg: 1.512 ± 0.043
1.663TyrSer: 1.663 ± 0.045
1.352TyrThr: 1.352 ± 0.035
1.68TyrVal: 1.68 ± 0.045
0.343TyrTrp: 0.343 ± 0.019
0.664TyrTyr: 0.664 ± 0.036
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2642 proteins (831499 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski