Amino acid dipepetide frequency for Halhan virus 2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.667AlaAla: 7.667 ± 1.449
1.211AlaCys: 1.211 ± 0.746
4.036AlaAsp: 4.036 ± 1.265
1.614AlaGlu: 1.614 ± 0.995
3.632AlaPhe: 3.632 ± 0.886
4.439AlaGly: 4.439 ± 1.279
2.018AlaHis: 2.018 ± 0.893
7.264AlaIle: 7.264 ± 1.525
3.632AlaLys: 3.632 ± 0.707
6.86AlaLeu: 6.86 ± 1.444
2.018AlaMet: 2.018 ± 0.338
4.036AlaAsn: 4.036 ± 0.893
5.65AlaPro: 5.65 ± 1.017
4.843AlaGln: 4.843 ± 0.966
2.421AlaArg: 2.421 ± 1.119
4.036AlaSer: 4.036 ± 0.911
4.439AlaThr: 4.439 ± 1.542
5.65AlaVal: 5.65 ± 2.273
0.404AlaTrp: 0.404 ± 0.249
2.825AlaTyr: 2.825 ± 1.037
0.0AlaXaa: 0.0 ± 0.0
Cys
1.614CysAla: 1.614 ± 0.544
0.404CysCys: 0.404 ± 0.249
1.211CysAsp: 1.211 ± 0.746
0.807CysGlu: 0.807 ± 0.325
0.404CysPhe: 0.404 ± 0.249
0.807CysGly: 0.807 ± 0.497
0.404CysHis: 0.404 ± 0.611
0.404CysIle: 0.404 ± 0.249
1.211CysLys: 1.211 ± 0.373
0.404CysLeu: 0.404 ± 0.443
0.807CysMet: 0.807 ± 0.497
1.211CysAsn: 1.211 ± 0.373
0.404CysPro: 0.404 ± 0.249
0.0CysGln: 0.0 ± 0.0
1.211CysArg: 1.211 ± 0.746
0.807CysSer: 0.807 ± 0.497
0.807CysThr: 0.807 ± 0.497
1.614CysVal: 1.614 ± 0.544
0.0CysTrp: 0.0 ± 0.0
0.404CysTyr: 0.404 ± 0.611
0.0CysXaa: 0.0 ± 0.0
Asp
4.843AspAla: 4.843 ± 1.075
0.807AspCys: 0.807 ± 0.497
3.632AspAsp: 3.632 ± 0.962
4.036AspGlu: 4.036 ± 1.087
5.65AspPhe: 5.65 ± 1.437
2.018AspGly: 2.018 ± 1.104
0.807AspHis: 0.807 ± 0.423
2.018AspIle: 2.018 ± 0.562
4.036AspLys: 4.036 ± 1.451
4.843AspLeu: 4.843 ± 1.863
2.421AspMet: 2.421 ± 0.99
2.018AspAsn: 2.018 ± 0.458
2.421AspPro: 2.421 ± 0.206
2.018AspGln: 2.018 ± 0.913
2.018AspArg: 2.018 ± 0.796
4.439AspSer: 4.439 ± 1.435
4.439AspThr: 4.439 ± 0.64
5.246AspVal: 5.246 ± 1.051
0.404AspTrp: 0.404 ± 0.469
2.825AspTyr: 2.825 ± 0.898
0.0AspXaa: 0.0 ± 0.0
Glu
2.825GluAla: 2.825 ± 0.266
0.404GluCys: 0.404 ± 0.249
1.211GluAsp: 1.211 ± 0.373
2.018GluGlu: 2.018 ± 1.244
4.036GluPhe: 4.036 ± 0.898
3.632GluGly: 3.632 ± 0.812
0.807GluHis: 0.807 ± 0.325
4.843GluIle: 4.843 ± 0.816
4.036GluLys: 4.036 ± 0.948
5.246GluLeu: 5.246 ± 1.564
1.211GluMet: 1.211 ± 0.373
2.421GluAsn: 2.421 ± 0.705
2.421GluPro: 2.421 ± 1.119
2.825GluGln: 2.825 ± 0.828
3.632GluArg: 3.632 ± 1.288
2.421GluSer: 2.421 ± 0.934
0.404GluThr: 0.404 ± 0.249
3.228GluVal: 3.228 ± 0.473
0.0GluTrp: 0.0 ± 0.0
2.018GluTyr: 2.018 ± 0.893
0.0GluXaa: 0.0 ± 0.0
Phe
4.036PheAla: 4.036 ± 0.904
1.211PheCys: 1.211 ± 0.373
2.421PheAsp: 2.421 ± 0.716
6.457PheGlu: 6.457 ± 1.061
2.825PhePhe: 2.825 ± 0.963
2.825PheGly: 2.825 ± 0.403
2.421PheHis: 2.421 ± 1.665
1.614PheIle: 1.614 ± 1.13
3.228PheLys: 3.228 ± 0.784
3.228PheLeu: 3.228 ± 0.822
1.614PheMet: 1.614 ± 0.44
0.807PheAsn: 0.807 ± 0.325
1.211PhePro: 1.211 ± 0.473
1.614PheGln: 1.614 ± 0.544
2.018PheArg: 2.018 ± 0.78
2.421PheSer: 2.421 ± 0.206
6.457PheThr: 6.457 ± 1.821
2.825PheVal: 2.825 ± 0.403
0.404PheTrp: 0.404 ± 0.443
4.036PheTyr: 4.036 ± 1.362
0.0PheXaa: 0.0 ± 0.0
Gly
6.053GlyAla: 6.053 ± 2.371
1.211GlyCys: 1.211 ± 0.373
4.036GlyAsp: 4.036 ± 1.282
2.421GlyGlu: 2.421 ± 1.119
2.825GlyPhe: 2.825 ± 1.152
3.632GlyGly: 3.632 ± 1.794
0.404GlyHis: 0.404 ± 0.611
2.018GlyIle: 2.018 ± 0.662
4.843GlyLys: 4.843 ± 1.692
3.632GlyLeu: 3.632 ± 1.226
0.807GlyMet: 0.807 ± 0.887
2.018GlyAsn: 2.018 ± 1.221
0.807GlyPro: 0.807 ± 0.423
2.825GlyGln: 2.825 ± 1.228
1.211GlyArg: 1.211 ± 0.564
4.843GlySer: 4.843 ± 2.431
5.65GlyThr: 5.65 ± 1.085
4.036GlyVal: 4.036 ± 0.557
0.0GlyTrp: 0.0 ± 0.0
2.825GlyTyr: 2.825 ± 1.806
0.0GlyXaa: 0.0 ± 0.0
His
2.421HisAla: 2.421 ± 0.583
0.807HisCys: 0.807 ± 0.497
1.211HisAsp: 1.211 ± 0.564
1.211HisGlu: 1.211 ± 0.512
1.614HisPhe: 1.614 ± 1.291
2.421HisGly: 2.421 ± 0.745
0.807HisHis: 0.807 ± 0.423
0.404HisIle: 0.404 ± 0.611
0.404HisLys: 0.404 ± 0.249
1.211HisLeu: 1.211 ± 1.046
0.404HisMet: 0.404 ± 0.443
1.211HisAsn: 1.211 ± 0.746
1.211HisPro: 1.211 ± 0.568
1.211HisGln: 1.211 ± 1.003
0.404HisArg: 0.404 ± 0.611
1.614HisSer: 1.614 ± 0.846
1.211HisThr: 1.211 ± 0.512
2.421HisVal: 2.421 ± 0.206
0.0HisTrp: 0.0 ± 0.0
0.404HisTyr: 0.404 ± 0.249
0.0HisXaa: 0.0 ± 0.0
Ile
3.632IleAla: 3.632 ± 1.562
0.807IleCys: 0.807 ± 0.325
6.053IleAsp: 6.053 ± 0.149
2.018IleGlu: 2.018 ± 1.006
2.825IlePhe: 2.825 ± 0.93
1.211IleGly: 1.211 ± 0.746
0.807IleHis: 0.807 ± 0.325
2.421IleIle: 2.421 ± 0.99
6.457IleLys: 6.457 ± 0.945
2.018IleLeu: 2.018 ± 0.654
0.404IleMet: 0.404 ± 0.249
2.018IleAsn: 2.018 ± 1.049
6.86IlePro: 6.86 ± 1.574
1.614IleGln: 1.614 ± 0.862
2.018IleArg: 2.018 ± 1.244
3.228IleSer: 3.228 ± 1.397
7.264IleThr: 7.264 ± 2.536
2.018IleVal: 2.018 ± 1.076
0.0IleTrp: 0.0 ± 0.0
3.632IleTyr: 3.632 ± 0.993
0.0IleXaa: 0.0 ± 0.0
Lys
5.246LysAla: 5.246 ± 1.259
1.211LysCys: 1.211 ± 0.568
2.825LysAsp: 2.825 ± 0.561
3.228LysGlu: 3.228 ± 1.054
3.632LysPhe: 3.632 ± 0.922
2.421LysGly: 2.421 ± 1.084
0.404LysHis: 0.404 ± 0.469
6.053LysIle: 6.053 ± 3.191
3.632LysLys: 3.632 ± 2.238
4.843LysLeu: 4.843 ± 0.702
0.404LysMet: 0.404 ± 0.249
3.632LysAsn: 3.632 ± 0.707
2.825LysPro: 2.825 ± 1.228
2.825LysGln: 2.825 ± 1.741
0.404LysArg: 0.404 ± 0.249
3.632LysSer: 3.632 ± 1.772
6.457LysThr: 6.457 ± 1.933
4.843LysVal: 4.843 ± 0.619
0.404LysTrp: 0.404 ± 0.249
1.614LysTyr: 1.614 ± 0.392
0.0LysXaa: 0.0 ± 0.0
Leu
6.457LeuAla: 6.457 ± 2.213
0.0LeuCys: 0.0 ± 0.0
5.246LeuAsp: 5.246 ± 0.874
4.036LeuGlu: 4.036 ± 1.123
4.036LeuPhe: 4.036 ± 1.99
5.246LeuGly: 5.246 ± 2.915
1.614LeuHis: 1.614 ± 0.597
1.211LeuIle: 1.211 ± 0.373
3.632LeuLys: 3.632 ± 1.216
10.089LeuLeu: 10.089 ± 0.676
1.614LeuMet: 1.614 ± 0.392
2.421LeuAsn: 2.421 ± 0.574
3.632LeuPro: 3.632 ± 0.456
3.228LeuGln: 3.228 ± 1.322
4.439LeuArg: 4.439 ± 0.64
2.825LeuSer: 2.825 ± 0.403
6.86LeuThr: 6.86 ± 3.463
5.65LeuVal: 5.65 ± 0.995
0.807LeuTrp: 0.807 ± 0.325
2.421LeuTyr: 2.421 ± 0.206
0.0LeuXaa: 0.0 ± 0.0
Met
1.211MetAla: 1.211 ± 0.512
0.0MetCys: 0.0 ± 0.0
2.421MetAsp: 2.421 ± 0.64
1.211MetGlu: 1.211 ± 0.746
1.211MetPhe: 1.211 ± 0.564
0.0MetGly: 0.0 ± 0.0
1.211MetHis: 1.211 ± 0.746
1.614MetIle: 1.614 ± 0.544
2.018MetLys: 2.018 ± 1.244
2.018MetLeu: 2.018 ± 0.654
0.807MetMet: 0.807 ± 0.325
0.807MetAsn: 0.807 ± 0.497
2.018MetPro: 2.018 ± 0.759
0.0MetGln: 0.0 ± 0.0
1.211MetArg: 1.211 ± 0.746
2.018MetSer: 2.018 ± 0.884
1.614MetThr: 1.614 ± 0.392
0.807MetVal: 0.807 ± 0.497
0.0MetTrp: 0.0 ± 0.0
0.404MetTyr: 0.404 ± 0.443
0.0MetXaa: 0.0 ± 0.0
Asn
3.228AsnAla: 3.228 ± 1.109
0.807AsnCys: 0.807 ± 0.325
2.018AsnAsp: 2.018 ± 0.759
0.807AsnGlu: 0.807 ± 0.497
2.421AsnPhe: 2.421 ± 1.648
2.421AsnGly: 2.421 ± 0.748
0.807AsnHis: 0.807 ± 0.423
2.825AsnIle: 2.825 ± 1.678
2.421AsnLys: 2.421 ± 0.99
2.825AsnLeu: 2.825 ± 1.741
0.404AsnMet: 0.404 ± 0.249
1.614AsnAsn: 1.614 ± 0.392
0.807AsnPro: 0.807 ± 0.646
0.807AsnGln: 0.807 ± 0.497
3.632AsnArg: 3.632 ± 1.648
2.018AsnSer: 2.018 ± 1.648
4.439AsnThr: 4.439 ± 1.209
4.036AsnVal: 4.036 ± 1.711
1.211AsnTrp: 1.211 ± 1.038
2.018AsnTyr: 2.018 ± 0.654
0.0AsnXaa: 0.0 ± 0.0
Pro
3.632ProAla: 3.632 ± 0.974
0.404ProCys: 0.404 ± 0.249
2.018ProAsp: 2.018 ± 0.455
4.439ProGlu: 4.439 ± 0.872
2.018ProPhe: 2.018 ± 0.458
2.421ProGly: 2.421 ± 0.945
0.404ProHis: 0.404 ± 0.443
3.228ProIle: 3.228 ± 1.013
1.614ProLys: 1.614 ± 0.684
5.246ProLeu: 5.246 ± 0.78
0.807ProMet: 0.807 ± 0.325
3.228ProAsn: 3.228 ± 1.014
5.246ProPro: 5.246 ± 1.442
2.825ProGln: 2.825 ± 0.816
3.228ProArg: 3.228 ± 2.106
3.632ProSer: 3.632 ± 1.042
3.632ProThr: 3.632 ± 0.538
3.228ProVal: 3.228 ± 0.859
0.0ProTrp: 0.0 ± 0.0
2.018ProTyr: 2.018 ± 0.455
0.0ProXaa: 0.0 ± 0.0
Gln
2.018GlnAla: 2.018 ± 0.78
0.807GlnCys: 0.807 ± 0.497
4.036GlnAsp: 4.036 ± 0.979
2.018GlnGlu: 2.018 ± 0.371
2.421GlnPhe: 2.421 ± 0.574
3.632GlnGly: 3.632 ± 0.962
0.807GlnHis: 0.807 ± 0.423
2.018GlnIle: 2.018 ± 0.562
2.018GlnLys: 2.018 ± 0.689
1.614GlnLeu: 1.614 ± 0.684
2.018GlnMet: 2.018 ± 0.759
2.421GlnAsn: 2.421 ± 0.574
2.018GlnPro: 2.018 ± 0.662
2.825GlnGln: 2.825 ± 1.388
2.421GlnArg: 2.421 ± 0.583
0.807GlnSer: 0.807 ± 0.497
3.228GlnThr: 3.228 ± 0.988
3.228GlnVal: 3.228 ± 0.9
0.0GlnTrp: 0.0 ± 0.0
2.825GlnTyr: 2.825 ± 0.403
0.0GlnXaa: 0.0 ± 0.0
Arg
3.632ArgAla: 3.632 ± 0.707
0.404ArgCys: 0.404 ± 0.249
3.632ArgAsp: 3.632 ± 0.771
2.018ArgGlu: 2.018 ± 0.759
2.018ArgPhe: 2.018 ± 1.104
1.614ArgGly: 1.614 ± 0.896
0.807ArgHis: 0.807 ± 0.497
2.825ArgIle: 2.825 ± 0.828
3.228ArgLys: 3.228 ± 0.988
1.614ArgLeu: 1.614 ± 0.651
0.0ArgMet: 0.0 ± 0.0
1.614ArgAsn: 1.614 ± 0.508
4.036ArgPro: 4.036 ± 1.282
2.825ArgGln: 2.825 ± 1.5
2.018ArgArg: 2.018 ± 0.562
3.228ArgSer: 3.228 ± 1.087
2.018ArgThr: 2.018 ± 0.913
3.632ArgVal: 3.632 ± 0.771
0.807ArgTrp: 0.807 ± 0.717
1.211ArgTyr: 1.211 ± 0.746
0.0ArgXaa: 0.0 ± 0.0
Ser
5.65SerAla: 5.65 ± 1.67
1.614SerCys: 1.614 ± 0.544
3.632SerAsp: 3.632 ± 1.042
3.228SerGlu: 3.228 ± 1.216
3.632SerPhe: 3.632 ± 0.856
2.825SerGly: 2.825 ± 1.573
0.807SerHis: 0.807 ± 0.747
4.843SerIle: 4.843 ± 1.149
2.421SerLys: 2.421 ± 1.084
3.228SerLeu: 3.228 ± 1.461
0.807SerMet: 0.807 ± 0.459
2.018SerAsn: 2.018 ± 0.78
2.018SerPro: 2.018 ± 1.69
2.421SerGln: 2.421 ± 0.62
3.228SerArg: 3.228 ± 0.71
5.65SerSer: 5.65 ± 2.238
5.246SerThr: 5.246 ± 0.461
4.036SerVal: 4.036 ± 2.006
0.0SerTrp: 0.0 ± 0.0
4.439SerTyr: 4.439 ± 0.545
0.0SerXaa: 0.0 ± 0.0
Thr
6.457ThrAla: 6.457 ± 0.795
1.211ThrCys: 1.211 ± 0.568
5.246ThrAsp: 5.246 ± 1.807
1.614ThrGlu: 1.614 ± 0.392
3.228ThrPhe: 3.228 ± 0.659
5.246ThrGly: 5.246 ± 1.872
2.421ThrHis: 2.421 ± 1.023
4.843ThrIle: 4.843 ± 1.879
4.036ThrLys: 4.036 ± 1.282
8.475ThrLeu: 8.475 ± 1.743
2.421ThrMet: 2.421 ± 1.119
3.228ThrAsn: 3.228 ± 1.218
3.632ThrPro: 3.632 ± 0.886
4.439ThrGln: 4.439 ± 0.947
2.825ThrArg: 2.825 ± 1.182
6.053ThrSer: 6.053 ± 2.068
10.089ThrThr: 10.089 ± 2.044
5.246ThrVal: 5.246 ± 0.728
0.404ThrTrp: 0.404 ± 0.249
2.018ThrTyr: 2.018 ± 1.244
0.0ThrXaa: 0.0 ± 0.0
Val
4.439ValAla: 4.439 ± 0.466
1.211ValCys: 1.211 ± 0.373
3.632ValAsp: 3.632 ± 0.812
2.825ValGlu: 2.825 ± 0.773
3.228ValPhe: 3.228 ± 1.048
5.65ValGly: 5.65 ± 1.208
2.018ValHis: 2.018 ± 0.562
4.036ValIle: 4.036 ± 2.028
5.246ValLys: 5.246 ± 1.557
4.036ValLeu: 4.036 ± 1.431
2.018ValMet: 2.018 ± 0.458
3.228ValAsn: 3.228 ± 1.087
4.439ValPro: 4.439 ± 0.947
2.421ValGln: 2.421 ± 0.206
3.228ValArg: 3.228 ± 2.34
6.053ValSer: 6.053 ± 0.658
3.632ValThr: 3.632 ± 0.538
8.878ValVal: 8.878 ± 1.626
0.404ValTrp: 0.404 ± 0.443
2.018ValTyr: 2.018 ± 0.759
0.0ValXaa: 0.0 ± 0.0
Trp
1.211TrpAla: 1.211 ± 0.746
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
0.0TrpGlu: 0.0 ± 0.0
0.404TrpPhe: 0.404 ± 0.469
0.0TrpGly: 0.0 ± 0.0
0.807TrpHis: 0.807 ± 0.646
0.404TrpIle: 0.404 ± 0.443
0.404TrpLys: 0.404 ± 0.469
1.211TrpLeu: 1.211 ± 0.473
0.0TrpMet: 0.0 ± 0.0
0.404TrpAsn: 0.404 ± 0.443
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
0.0TrpSer: 0.0 ± 0.0
0.0TrpThr: 0.0 ± 0.0
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.807TrpTyr: 0.807 ± 0.747
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.825TyrAla: 2.825 ± 0.828
0.404TyrCys: 0.404 ± 0.249
2.421TyrAsp: 2.421 ± 1.068
3.632TyrGlu: 3.632 ± 0.456
1.614TyrPhe: 1.614 ± 0.896
3.632TyrGly: 3.632 ± 0.712
2.018TyrHis: 2.018 ± 0.455
2.421TyrIle: 2.421 ± 0.574
2.018TyrLys: 2.018 ± 0.876
2.825TyrLeu: 2.825 ± 0.266
1.211TyrMet: 1.211 ± 0.373
1.211TyrAsn: 1.211 ± 0.746
1.614TyrPro: 1.614 ± 0.544
1.614TyrGln: 1.614 ± 1.451
1.614TyrArg: 1.614 ± 0.544
2.018TyrSer: 2.018 ± 0.913
5.246TyrThr: 5.246 ± 1.975
2.018TyrVal: 2.018 ± 0.371
0.404TyrTrp: 0.404 ± 0.443
2.421TyrTyr: 2.421 ± 1.474
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (2479 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski