Amino acid dipepetide frequency for Candidatus Scalindua rubra

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.553AlaAla: 3.553 ± 0.064	0.832AlaCys: 0.832 ± 0.025	2.91AlaAsp: 2.91 ± 0.049	3.839AlaGlu: 3.839 ± 0.06	2.72AlaPhe: 2.72 ± 0.045	3.921AlaGly: 3.921 ± 0.066	1.157AlaHis: 1.157 ± 0.032	5.548AlaIle: 5.548 ± 0.074	4.502AlaLys: 4.502 ± 0.067	5.81AlaLeu: 5.81 ± 0.076	1.487AlaMet: 1.487 ± 0.035	2.434AlaAsn: 2.434 ± 0.048	1.532AlaPro: 1.532 ± 0.038	1.664AlaGln: 1.664 ± 0.042	2.912AlaArg: 2.912 ± 0.051	3.537AlaSer: 3.537 ± 0.06	2.702AlaThr: 2.702 ± 0.051	3.922AlaVal: 3.922 ± 0.065	0.569AlaTrp: 0.569 ± 0.024	2.118AlaTyr: 2.118 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.662CysAla: 0.662 ± 0.022	0.21CysCys: 0.21 ± 0.013	0.684CysAsp: 0.684 ± 0.022	0.774CysGlu: 0.774 ± 0.023	0.649CysPhe: 0.649 ± 0.024	1.013CysGly: 1.013 ± 0.032	0.47CysHis: 0.47 ± 0.029	0.988CysIle: 0.988 ± 0.029	0.915CysLys: 0.915 ± 0.029	1.106CysLeu: 1.106 ± 0.025	0.318CysMet: 0.318 ± 0.017	0.652CysAsn: 0.652 ± 0.022	0.657CysPro: 0.657 ± 0.024	0.363CysGln: 0.363 ± 0.017	0.59CysArg: 0.59 ± 0.023	0.818CysSer: 0.818 ± 0.027	0.54CysThr: 0.54 ± 0.02	0.739CysVal: 0.739 ± 0.025	0.102CysTrp: 0.102 ± 0.008	0.49CysTyr: 0.49 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	2.959AspAla: 2.959 ± 0.054	0.687AspCys: 0.687 ± 0.024	2.938AspAsp: 2.938 ± 0.063	4.354AspGlu: 4.354 ± 0.064	2.783AspPhe: 2.783 ± 0.052	3.175AspGly: 3.175 ± 0.047	0.885AspHis: 0.885 ± 0.033	5.591AspIle: 5.591 ± 0.081	4.498AspLys: 4.498 ± 0.064	4.953AspLeu: 4.953 ± 0.069	1.258AspMet: 1.258 ± 0.033	2.53AspAsn: 2.53 ± 0.043	1.935AspPro: 1.935 ± 0.039	1.173AspGln: 1.173 ± 0.035	2.459AspArg: 2.459 ± 0.04	3.183AspSer: 3.183 ± 0.057	2.673AspThr: 2.673 ± 0.052	3.806AspVal: 3.806 ± 0.059	0.69AspTrp: 0.69 ± 0.024	2.448AspTyr: 2.448 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	4.401GluAla: 4.401 ± 0.067	0.728GluCys: 0.728 ± 0.021	4.049GluAsp: 4.049 ± 0.061	6.124GluGlu: 6.124 ± 0.09	2.881GluPhe: 2.881 ± 0.044	4.133GluGly: 4.133 ± 0.055	1.307GluHis: 1.307 ± 0.031	6.949GluIle: 6.949 ± 0.08	7.209GluLys: 7.209 ± 0.096	6.718GluLeu: 6.718 ± 0.072	1.85GluMet: 1.85 ± 0.036	3.661GluAsn: 3.661 ± 0.055	1.902GluPro: 1.902 ± 0.039	2.085GluGln: 2.085 ± 0.05	3.845GluArg: 3.845 ± 0.052	3.839GluSer: 3.839 ± 0.051	3.554GluThr: 3.554 ± 0.054	4.389GluVal: 4.389 ± 0.066	0.745GluTrp: 0.745 ± 0.023	2.643GluTyr: 2.643 ± 0.045	0.0GluXaa: 0.0 ± 0.0
Phe	2.577PheAla: 2.577 ± 0.046	0.731PheCys: 0.731 ± 0.024	2.672PheAsp: 2.672 ± 0.052	3.015PheGlu: 3.015 ± 0.048	2.414PhePhe: 2.414 ± 0.054	3.101PheGly: 3.101 ± 0.049	0.917PheHis: 0.917 ± 0.029	3.715PheIle: 3.715 ± 0.06	3.289PheLys: 3.289 ± 0.06	4.612PheLeu: 4.612 ± 0.067	0.98PheMet: 0.98 ± 0.027	2.215PheAsn: 2.215 ± 0.043	1.685PhePro: 1.685 ± 0.034	1.231PheGln: 1.231 ± 0.031	2.01PheArg: 2.01 ± 0.039	3.231PheSer: 3.231 ± 0.058	2.314PheThr: 2.314 ± 0.041	2.906PheVal: 2.906 ± 0.045	0.535PheTrp: 0.535 ± 0.021	1.736PheTyr: 1.736 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	3.556GlyAla: 3.556 ± 0.067	0.937GlyCys: 0.937 ± 0.027	3.061GlyAsp: 3.061 ± 0.054	4.135GlyGlu: 4.135 ± 0.057	3.2GlyPhe: 3.2 ± 0.065	4.118GlyGly: 4.118 ± 0.075	1.364GlyHis: 1.364 ± 0.037	6.076GlyIle: 6.076 ± 0.069	5.727GlyLys: 5.727 ± 0.064	5.703GlyLeu: 5.703 ± 0.077	1.71GlyMet: 1.71 ± 0.034	2.917GlyAsn: 2.917 ± 0.051	1.454GlyPro: 1.454 ± 0.032	1.623GlyGln: 1.623 ± 0.038	3.11GlyArg: 3.11 ± 0.052	3.726GlySer: 3.726 ± 0.046	3.423GlyThr: 3.423 ± 0.055	4.14GlyVal: 4.14 ± 0.061	0.767GlyTrp: 0.767 ± 0.025	2.664GlyTyr: 2.664 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	1.068HisAla: 1.068 ± 0.031	0.288HisCys: 0.288 ± 0.017	0.974HisAsp: 0.974 ± 0.026	1.192HisGlu: 1.192 ± 0.033	0.989HisPhe: 0.989 ± 0.026	1.277HisGly: 1.277 ± 0.032	0.491HisHis: 0.491 ± 0.018	1.612HisIle: 1.612 ± 0.036	1.445HisLys: 1.445 ± 0.03	1.932HisLeu: 1.932 ± 0.036	0.382HisMet: 0.382 ± 0.018	1.014HisAsn: 1.014 ± 0.026	1.064HisPro: 1.064 ± 0.028	0.55HisGln: 0.55 ± 0.022	0.911HisArg: 0.911 ± 0.028	1.287HisSer: 1.287 ± 0.031	0.964HisThr: 0.964 ± 0.029	1.092HisVal: 1.092 ± 0.027	0.218HisTrp: 0.218 ± 0.013	0.851HisTyr: 0.851 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.425IleAla: 5.425 ± 0.068	1.155IleCys: 1.155 ± 0.03	5.166IleAsp: 5.166 ± 0.07	6.504IleGlu: 6.504 ± 0.076	3.756IlePhe: 3.756 ± 0.064	5.44IleGly: 5.44 ± 0.068	1.537IleHis: 1.537 ± 0.03	7.312IleIle: 7.312 ± 0.087	7.192IleLys: 7.192 ± 0.081	7.861IleLeu: 7.861 ± 0.072	1.801IleMet: 1.801 ± 0.038	4.343IleAsn: 4.343 ± 0.058	3.723IlePro: 3.723 ± 0.057	2.346IleGln: 2.346 ± 0.042	4.031IleArg: 4.031 ± 0.049	6.095IleSer: 6.095 ± 0.07	4.7IleThr: 4.7 ± 0.058	5.534IleVal: 5.534 ± 0.073	0.716IleTrp: 0.716 ± 0.024	2.757IleTyr: 2.757 ± 0.051	0.0IleXaa: 0.0 ± 0.0
Lys	4.904LysAla: 4.904 ± 0.072	0.827LysCys: 0.827 ± 0.027	5.139LysAsp: 5.139 ± 0.067	7.551LysGlu: 7.551 ± 0.09	2.717LysPhe: 2.717 ± 0.047	5.176LysGly: 5.176 ± 0.064	1.561LysHis: 1.561 ± 0.036	7.172LysIle: 7.172 ± 0.084	8.174LysLys: 8.174 ± 0.103	7.053LysLeu: 7.053 ± 0.077	2.079LysMet: 2.079 ± 0.04	4.274LysAsn: 4.274 ± 0.069	2.732LysPro: 2.732 ± 0.045	2.549LysGln: 2.549 ± 0.048	4.533LysArg: 4.533 ± 0.069	4.664LysSer: 4.664 ± 0.07	4.387LysThr: 4.387 ± 0.056	5.033LysVal: 5.033 ± 0.064	0.823LysTrp: 0.823 ± 0.029	3.263LysTyr: 3.263 ± 0.048	0.0LysXaa: 0.0 ± 0.0
Leu	5.676LeuAla: 5.676 ± 0.076	1.214LeuCys: 1.214 ± 0.031	5.003LeuAsp: 5.003 ± 0.069	6.625LeuGlu: 6.625 ± 0.064	4.264LeuPhe: 4.264 ± 0.061	5.863LeuGly: 5.863 ± 0.078	1.685LeuHis: 1.685 ± 0.036	7.374LeuIle: 7.374 ± 0.088	8.371LeuLys: 8.371 ± 0.09	8.559LeuLeu: 8.559 ± 0.101	2.066LeuMet: 2.066 ± 0.035	4.839LeuAsn: 4.839 ± 0.062	3.657LeuPro: 3.657 ± 0.051	2.676LeuGln: 2.676 ± 0.051	4.874LeuArg: 4.874 ± 0.069	6.659LeuSer: 6.659 ± 0.079	4.716LeuThr: 4.716 ± 0.066	5.264LeuVal: 5.264 ± 0.072	0.898LeuTrp: 0.898 ± 0.028	3.059LeuTyr: 3.059 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	1.574MetAla: 1.574 ± 0.033	0.246MetCys: 0.246 ± 0.014	1.261MetAsp: 1.261 ± 0.032	1.684MetGlu: 1.684 ± 0.036	0.905MetPhe: 0.905 ± 0.026	1.573MetGly: 1.573 ± 0.035	0.393MetHis: 0.393 ± 0.017	1.799MetIle: 1.799 ± 0.036	2.171MetLys: 2.171 ± 0.045	2.022MetLeu: 2.022 ± 0.041	0.558MetMet: 0.558 ± 0.021	1.187MetAsn: 1.187 ± 0.03	0.996MetPro: 0.996 ± 0.028	0.668MetGln: 0.668 ± 0.024	1.091MetArg: 1.091 ± 0.027	1.57MetSer: 1.57 ± 0.034	1.193MetThr: 1.193 ± 0.029	1.517MetVal: 1.517 ± 0.031	0.19MetTrp: 0.19 ± 0.01	0.572MetTyr: 0.572 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.659AsnAla: 2.659 ± 0.051	0.572AsnCys: 0.572 ± 0.021	2.376AsnAsp: 2.376 ± 0.047	3.241AsnGlu: 3.241 ± 0.055	2.096AsnPhe: 2.096 ± 0.043	2.911AsnGly: 2.911 ± 0.056	0.916AsnHis: 0.916 ± 0.027	4.841AsnIle: 4.841 ± 0.062	3.997AsnLys: 3.997 ± 0.055	4.927AsnLeu: 4.927 ± 0.062	1.125AsnMet: 1.125 ± 0.027	2.677AsnAsn: 2.677 ± 0.049	2.305AsnPro: 2.305 ± 0.045	1.345AsnGln: 1.345 ± 0.038	2.272AsnArg: 2.272 ± 0.041	2.758AsnSer: 2.758 ± 0.055	2.388AsnThr: 2.388 ± 0.048	3.093AsnVal: 3.093 ± 0.053	0.518AsnTrp: 0.518 ± 0.021	1.952AsnTyr: 1.952 ± 0.047	0.0AsnXaa: 0.0 ± 0.0
Pro	1.852ProAla: 1.852 ± 0.041	0.395ProCys: 0.395 ± 0.019	2.444ProAsp: 2.444 ± 0.049	3.142ProGlu: 3.142 ± 0.047	1.937ProPhe: 1.937 ± 0.039	2.278ProGly: 2.278 ± 0.048	0.807ProHis: 0.807 ± 0.026	2.818ProIle: 2.818 ± 0.04	2.514ProLys: 2.514 ± 0.043	3.277ProLeu: 3.277 ± 0.057	0.715ProMet: 0.715 ± 0.025	1.603ProAsn: 1.603 ± 0.037	1.355ProPro: 1.355 ± 0.038	1.019ProGln: 1.019 ± 0.032	1.463ProArg: 1.463 ± 0.031	2.141ProSer: 2.141 ± 0.044	1.761ProThr: 1.761 ± 0.034	2.555ProVal: 2.555 ± 0.049	0.404ProTrp: 0.404 ± 0.019	1.336ProTyr: 1.336 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	1.749GlnAla: 1.749 ± 0.034	0.297GlnCys: 0.297 ± 0.015	1.432GlnAsp: 1.432 ± 0.037	2.151GlnGlu: 2.151 ± 0.039	1.217GlnPhe: 1.217 ± 0.029	1.609GlnGly: 1.609 ± 0.033	0.516GlnHis: 0.516 ± 0.02	2.452GlnIle: 2.452 ± 0.044	2.71GlnLys: 2.71 ± 0.044	2.529GlnLeu: 2.529 ± 0.037	0.687GlnMet: 0.687 ± 0.022	1.431GlnAsn: 1.431 ± 0.039	0.871GlnPro: 0.871 ± 0.025	0.901GlnGln: 0.901 ± 0.032	1.498GlnArg: 1.498 ± 0.036	1.601GlnSer: 1.601 ± 0.035	1.456GlnThr: 1.456 ± 0.034	1.676GlnVal: 1.676 ± 0.035	0.276GlnTrp: 0.276 ± 0.014	1.028GlnTyr: 1.028 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	2.539ArgAla: 2.539 ± 0.049	0.602ArgCys: 0.602 ± 0.024	2.599ArgAsp: 2.599 ± 0.049	3.709ArgGlu: 3.709 ± 0.059	2.381ArgPhe: 2.381 ± 0.043	2.833ArgGly: 2.833 ± 0.05	0.995ArgHis: 0.995 ± 0.027	4.273ArgIle: 4.273 ± 0.06	4.474ArgLys: 4.474 ± 0.058	4.788ArgLeu: 4.788 ± 0.067	1.26ArgMet: 1.26 ± 0.028	2.5ArgAsn: 2.5 ± 0.043	1.541ArgPro: 1.541 ± 0.034	1.485ArgGln: 1.485 ± 0.028	2.652ArgArg: 2.652 ± 0.044	2.532ArgSer: 2.532 ± 0.047	2.272ArgThr: 2.272 ± 0.037	2.906ArgVal: 2.906 ± 0.05	0.556ArgTrp: 0.556 ± 0.023	2.031ArgTyr: 2.031 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	3.246SerAla: 3.246 ± 0.055	0.801SerCys: 0.801 ± 0.022	3.21SerAsp: 3.21 ± 0.05	4.195SerGlu: 4.195 ± 0.051	3.147SerPhe: 3.147 ± 0.051	4.295SerGly: 4.295 ± 0.067	1.292SerHis: 1.292 ± 0.031	5.396SerIle: 5.396 ± 0.066	4.937SerLys: 4.937 ± 0.071	6.214SerLeu: 6.214 ± 0.072	1.461SerMet: 1.461 ± 0.032	2.95SerAsn: 2.95 ± 0.047	2.316SerPro: 2.316 ± 0.047	1.85SerGln: 1.85 ± 0.042	3.01SerArg: 3.01 ± 0.039	4.049SerSer: 4.049 ± 0.062	3.126SerThr: 3.126 ± 0.043	3.674SerVal: 3.674 ± 0.05	0.638SerTrp: 0.638 ± 0.023	2.251SerTyr: 2.251 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	2.928ThrAla: 2.928 ± 0.051	0.61ThrCys: 0.61 ± 0.023	2.684ThrAsp: 2.684 ± 0.043	3.152ThrGlu: 3.152 ± 0.049	2.362ThrPhe: 2.362 ± 0.045	3.765ThrGly: 3.765 ± 0.053	1.054ThrHis: 1.054 ± 0.025	4.515ThrIle: 4.515 ± 0.06	3.685ThrLys: 3.685 ± 0.055	4.797ThrLeu: 4.797 ± 0.059	1.093ThrMet: 1.093 ± 0.028	2.385ThrAsn: 2.385 ± 0.049	2.116ThrPro: 2.116 ± 0.039	1.404ThrGln: 1.404 ± 0.033	2.232ThrArg: 2.232 ± 0.04	3.13ThrSer: 3.13 ± 0.053	2.798ThrThr: 2.798 ± 0.06	3.299ThrVal: 3.299 ± 0.055	0.487ThrTrp: 0.487 ± 0.018	1.695ThrTyr: 1.695 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	3.782ValAla: 3.782 ± 0.056	0.899ValCys: 0.899 ± 0.026	3.598ValAsp: 3.598 ± 0.054	4.401ValGlu: 4.401 ± 0.063	3.117ValPhe: 3.117 ± 0.049	3.834ValGly: 3.834 ± 0.059	1.147ValHis: 1.147 ± 0.032	5.405ValIle: 5.405 ± 0.065	4.982ValLys: 4.982 ± 0.074	5.746ValLeu: 5.746 ± 0.07	1.378ValMet: 1.378 ± 0.032	3.021ValAsn: 3.021 ± 0.048	2.187ValPro: 2.187 ± 0.044	1.597ValGln: 1.597 ± 0.033	2.983ValArg: 2.983 ± 0.056	4.313ValSer: 4.313 ± 0.064	3.161ValThr: 3.161 ± 0.054	4.434ValVal: 4.434 ± 0.068	0.605ValTrp: 0.605 ± 0.023	2.183ValTyr: 2.183 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	0.536TrpAla: 0.536 ± 0.021	0.13TrpCys: 0.13 ± 0.01	0.62TrpAsp: 0.62 ± 0.023	0.705TrpGlu: 0.705 ± 0.025	0.479TrpPhe: 0.479 ± 0.021	0.669TrpGly: 0.669 ± 0.023	0.247TrpHis: 0.247 ± 0.015	0.826TrpIle: 0.826 ± 0.026	0.824TrpLys: 0.824 ± 0.027	1.032TrpLeu: 1.032 ± 0.031	0.261TrpMet: 0.261 ± 0.014	0.531TrpAsn: 0.531 ± 0.021	0.298TrpPro: 0.298 ± 0.015	0.4TrpGln: 0.4 ± 0.016	0.573TrpArg: 0.573 ± 0.021	0.628TrpSer: 0.628 ± 0.023	0.443TrpThr: 0.443 ± 0.018	0.599TrpVal: 0.599 ± 0.024	0.149TrpTrp: 0.149 ± 0.01	0.374TrpTyr: 0.374 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.02TyrAla: 2.02 ± 0.043	0.577TyrCys: 0.577 ± 0.023	2.159TyrAsp: 2.159 ± 0.043	2.52TyrGlu: 2.52 ± 0.039	1.871TyrPhe: 1.871 ± 0.042	2.426TyrGly: 2.426 ± 0.04	0.861TyrHis: 0.861 ± 0.024	2.733TyrIle: 2.733 ± 0.049	2.997TyrLys: 2.997 ± 0.052	3.703TyrLeu: 3.703 ± 0.053	0.701TyrMet: 0.701 ± 0.023	1.803TyrAsn: 1.803 ± 0.045	1.489TyrPro: 1.489 ± 0.035	1.157TyrGln: 1.157 ± 0.031	1.878TyrArg: 1.878 ± 0.043	2.298TyrSer: 2.298 ± 0.043	1.62TyrThr: 1.62 ± 0.034	2.196TyrVal: 2.196 ± 0.039	0.439TyrTrp: 0.439 ± 0.017	1.598TyrTyr: 1.598 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5207 proteins (1364589 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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