Amino acid dipepetide frequency for Clostridium chromiireducens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.171AlaAla: 4.171 ± 0.069	0.736AlaCys: 0.736 ± 0.02	2.805AlaAsp: 2.805 ± 0.045	3.603AlaGlu: 3.603 ± 0.05	2.567AlaPhe: 2.567 ± 0.042	3.925AlaGly: 3.925 ± 0.057	0.851AlaHis: 0.851 ± 0.025	5.756AlaIle: 5.756 ± 0.074	4.654AlaLys: 4.654 ± 0.064	5.896AlaLeu: 5.896 ± 0.071	1.714AlaMet: 1.714 ± 0.036	2.812AlaAsn: 2.812 ± 0.056	1.467AlaPro: 1.467 ± 0.034	1.634AlaGln: 1.634 ± 0.042	1.871AlaArg: 1.871 ± 0.036	3.644AlaSer: 3.644 ± 0.058	2.943AlaThr: 2.943 ± 0.056	4.038AlaVal: 4.038 ± 0.055	0.409AlaTrp: 0.409 ± 0.018	2.117AlaTyr: 2.117 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.645CysAla: 0.645 ± 0.022	0.189CysCys: 0.189 ± 0.015	0.702CysAsp: 0.702 ± 0.022	0.799CysGlu: 0.799 ± 0.026	0.482CysPhe: 0.482 ± 0.019	1.085CysGly: 1.085 ± 0.027	0.207CysHis: 0.207 ± 0.012	1.137CysIle: 1.137 ± 0.027	0.869CysLys: 0.869 ± 0.027	0.883CysLeu: 0.883 ± 0.024	0.28CysMet: 0.28 ± 0.015	0.765CysAsn: 0.765 ± 0.024	0.47CysPro: 0.47 ± 0.023	0.205CysGln: 0.205 ± 0.012	0.402CysArg: 0.402 ± 0.017	0.779CysSer: 0.779 ± 0.025	0.582CysThr: 0.582 ± 0.023	0.654CysVal: 0.654 ± 0.021	0.074CysTrp: 0.074 ± 0.007	0.444CysTyr: 0.444 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	2.878AspAla: 2.878 ± 0.05	0.61AspCys: 0.61 ± 0.022	2.909AspAsp: 2.909 ± 0.048	4.767AspGlu: 4.767 ± 0.063	2.675AspPhe: 2.675 ± 0.045	3.711AspGly: 3.711 ± 0.07	0.604AspHis: 0.604 ± 0.02	5.988AspIle: 5.988 ± 0.078	5.258AspLys: 5.258 ± 0.066	4.884AspLeu: 4.884 ± 0.07	1.449AspMet: 1.449 ± 0.034	3.626AspAsn: 3.626 ± 0.059	1.37AspPro: 1.37 ± 0.035	0.914AspGln: 0.914 ± 0.025	1.788AspArg: 1.788 ± 0.041	3.464AspSer: 3.464 ± 0.053	2.578AspThr: 2.578 ± 0.042	3.484AspVal: 3.484 ± 0.049	0.416AspTrp: 0.416 ± 0.017	2.556AspTyr: 2.556 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	4.177GluAla: 4.177 ± 0.057	0.764GluCys: 0.764 ± 0.023	4.144GluAsp: 4.144 ± 0.063	6.81GluGlu: 6.81 ± 0.084	3.168GluPhe: 3.168 ± 0.058	4.026GluGly: 4.026 ± 0.061	0.981GluHis: 0.981 ± 0.027	7.438GluIle: 7.438 ± 0.088	7.378GluLys: 7.378 ± 0.077	6.904GluLeu: 6.904 ± 0.075	1.954GluMet: 1.954 ± 0.039	5.416GluAsn: 5.416 ± 0.075	1.428GluPro: 1.428 ± 0.03	2.02GluGln: 2.02 ± 0.043	2.608GluArg: 2.608 ± 0.04	3.795GluSer: 3.795 ± 0.051	3.012GluThr: 3.012 ± 0.044	4.839GluVal: 4.839 ± 0.063	0.566GluTrp: 0.566 ± 0.019	3.088GluTyr: 3.088 ± 0.045	0.0GluXaa: 0.0 ± 0.0
Phe	2.382PheAla: 2.382 ± 0.049	0.519PheCys: 0.519 ± 0.018	2.622PheAsp: 2.622 ± 0.039	2.908PheGlu: 2.908 ± 0.045	1.994PhePhe: 1.994 ± 0.043	2.958PheGly: 2.958 ± 0.055	0.563PheHis: 0.563 ± 0.02	4.492PheIle: 4.492 ± 0.061	3.479PheLys: 3.479 ± 0.056	3.745PheLeu: 3.745 ± 0.058	1.174PheMet: 1.174 ± 0.032	2.892PheAsn: 2.892 ± 0.05	1.154PhePro: 1.154 ± 0.029	0.923PheGln: 0.923 ± 0.025	1.323PheArg: 1.323 ± 0.031	3.18PheSer: 3.18 ± 0.048	2.352PheThr: 2.352 ± 0.033	2.549PheVal: 2.549 ± 0.046	0.347PheTrp: 0.347 ± 0.016	1.792PheTyr: 1.792 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	4.139GlyAla: 4.139 ± 0.065	0.953GlyCys: 0.953 ± 0.031	3.302GlyAsp: 3.302 ± 0.05	4.206GlyGlu: 4.206 ± 0.057	3.087GlyPhe: 3.087 ± 0.047	4.202GlyGly: 4.202 ± 0.072	1.001GlyHis: 1.001 ± 0.027	6.878GlyIle: 6.878 ± 0.075	5.314GlyLys: 5.314 ± 0.062	5.36GlyLeu: 5.36 ± 0.074	1.807GlyMet: 1.807 ± 0.038	3.398GlyAsn: 3.398 ± 0.056	1.248GlyPro: 1.248 ± 0.037	1.521GlyGln: 1.521 ± 0.034	2.102GlyArg: 2.102 ± 0.037	3.754GlySer: 3.754 ± 0.06	3.643GlyThr: 3.643 ± 0.064	4.578GlyVal: 4.578 ± 0.059	0.703GlyTrp: 0.703 ± 0.033	3.043GlyTyr: 3.043 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	0.697HisAla: 0.697 ± 0.022	0.213HisCys: 0.213 ± 0.013	0.762HisAsp: 0.762 ± 0.023	0.945HisGlu: 0.945 ± 0.027	0.641HisPhe: 0.641 ± 0.021	1.032HisGly: 1.032 ± 0.029	0.293HisHis: 0.293 ± 0.016	1.306HisIle: 1.306 ± 0.032	1.064HisLys: 1.064 ± 0.028	1.202HisLeu: 1.202 ± 0.031	0.333HisMet: 0.333 ± 0.014	0.806HisAsn: 0.806 ± 0.022	0.578HisPro: 0.578 ± 0.021	0.335HisGln: 0.335 ± 0.014	0.521HisArg: 0.521 ± 0.021	0.921HisSer: 0.921 ± 0.026	0.645HisThr: 0.645 ± 0.021	0.742HisVal: 0.742 ± 0.024	0.126HisTrp: 0.126 ± 0.008	0.581HisTyr: 0.581 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	5.829IleAla: 5.829 ± 0.077	1.223IleCys: 1.223 ± 0.032	5.888IleAsp: 5.888 ± 0.073	7.152IleGlu: 7.152 ± 0.08	4.15IlePhe: 4.15 ± 0.065	6.19IleGly: 6.19 ± 0.075	1.271IleHis: 1.271 ± 0.031	9.549IleIle: 9.549 ± 0.114	8.494IleLys: 8.494 ± 0.084	8.982IleLeu: 8.982 ± 0.118	2.359IleMet: 2.359 ± 0.043	6.675IleAsn: 6.675 ± 0.081	3.333IlePro: 3.333 ± 0.048	2.393IleGln: 2.393 ± 0.043	3.138IleArg: 3.138 ± 0.049	7.285IleSer: 7.285 ± 0.093	5.091IleThr: 5.091 ± 0.065	6.024IleVal: 6.024 ± 0.079	0.575IleTrp: 0.575 ± 0.024	3.476IleTyr: 3.476 ± 0.058	0.0IleXaa: 0.0 ± 0.0
Lys	4.812LysAla: 4.812 ± 0.065	0.87LysCys: 0.87 ± 0.028	5.65LysAsp: 5.65 ± 0.059	8.25LysGlu: 8.25 ± 0.096	3.077LysPhe: 3.077 ± 0.048	4.808LysGly: 4.808 ± 0.064	1.132LysHis: 1.132 ± 0.026	8.018LysIle: 8.018 ± 0.08	7.222LysLys: 7.222 ± 0.074	7.457LysLeu: 7.457 ± 0.067	2.311LysMet: 2.311 ± 0.042	6.046LysAsn: 6.046 ± 0.067	1.959LysPro: 1.959 ± 0.038	2.182LysGln: 2.182 ± 0.041	2.866LysArg: 2.866 ± 0.049	5.285LysSer: 5.285 ± 0.065	3.937LysThr: 3.937 ± 0.049	5.764LysVal: 5.764 ± 0.06	0.711LysTrp: 0.711 ± 0.025	3.894LysTyr: 3.894 ± 0.055	0.0LysXaa: 0.0 ± 0.0
Leu	5.32LeuAla: 5.32 ± 0.075	1.035LeuCys: 1.035 ± 0.025	5.119LeuAsp: 5.119 ± 0.061	6.44LeuGlu: 6.44 ± 0.075	3.643LeuPhe: 3.643 ± 0.062	5.94LeuGly: 5.94 ± 0.077	1.14LeuHis: 1.14 ± 0.03	8.396LeuIle: 8.396 ± 0.112	8.154LeuLys: 8.154 ± 0.085	7.893LeuLeu: 7.893 ± 0.092	2.324LeuMet: 2.324 ± 0.04	5.913LeuAsn: 5.913 ± 0.066	2.761LeuPro: 2.761 ± 0.047	2.13LeuGln: 2.13 ± 0.033	3.143LeuArg: 3.143 ± 0.05	6.817LeuSer: 6.817 ± 0.074	4.489LeuThr: 4.489 ± 0.062	5.324LeuVal: 5.324 ± 0.069	0.612LeuTrp: 0.612 ± 0.023	3.141LeuTyr: 3.141 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	1.749MetAla: 1.749 ± 0.037	0.278MetCys: 0.278 ± 0.014	1.432MetAsp: 1.432 ± 0.032	1.811MetGlu: 1.811 ± 0.036	1.027MetPhe: 1.027 ± 0.031	1.67MetGly: 1.67 ± 0.035	0.389MetHis: 0.389 ± 0.019	2.288MetIle: 2.288 ± 0.038	2.53MetLys: 2.53 ± 0.041	2.287MetLeu: 2.287 ± 0.039	0.717MetMet: 0.717 ± 0.023	1.738MetAsn: 1.738 ± 0.035	0.928MetPro: 0.928 ± 0.026	0.712MetGln: 0.712 ± 0.023	0.902MetArg: 0.902 ± 0.021	1.801MetSer: 1.801 ± 0.039	1.244MetThr: 1.244 ± 0.031	1.594MetVal: 1.594 ± 0.031	0.164MetTrp: 0.164 ± 0.011	0.875MetTyr: 0.875 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.195AsnAla: 3.195 ± 0.051	0.722AsnCys: 0.722 ± 0.02	3.391AsnAsp: 3.391 ± 0.055	4.847AsnGlu: 4.847 ± 0.065	2.656AsnPhe: 2.656 ± 0.041	3.902AsnGly: 3.902 ± 0.063	0.833AsnHis: 0.833 ± 0.025	7.059AsnIle: 7.059 ± 0.077	5.906AsnLys: 5.906 ± 0.07	5.665AsnLeu: 5.665 ± 0.063	1.675AsnMet: 1.675 ± 0.035	4.734AsnAsn: 4.734 ± 0.072	2.126AsnPro: 2.126 ± 0.037	1.481AsnGln: 1.481 ± 0.033	1.983AsnArg: 1.983 ± 0.034	4.428AsnSer: 4.428 ± 0.072	3.08AsnThr: 3.08 ± 0.05	3.711AsnVal: 3.711 ± 0.055	0.528AsnTrp: 0.528 ± 0.022	2.757AsnTyr: 2.757 ± 0.053	0.0AsnXaa: 0.0 ± 0.0
Pro	1.442ProAla: 1.442 ± 0.032	0.308ProCys: 0.308 ± 0.013	1.521ProAsp: 1.521 ± 0.041	2.174ProGlu: 2.174 ± 0.039	1.384ProPhe: 1.384 ± 0.035	1.68ProGly: 1.68 ± 0.034	0.475ProHis: 0.475 ± 0.021	2.724ProIle: 2.724 ± 0.047	2.143ProLys: 2.143 ± 0.038	2.523ProLeu: 2.523 ± 0.042	0.722ProMet: 0.722 ± 0.022	1.617ProAsn: 1.617 ± 0.037	0.589ProPro: 0.589 ± 0.02	0.797ProGln: 0.797 ± 0.023	0.829ProArg: 0.829 ± 0.023	1.794ProSer: 1.794 ± 0.037	1.455ProThr: 1.455 ± 0.033	1.952ProVal: 1.952 ± 0.056	0.286ProTrp: 0.286 ± 0.015	1.221ProTyr: 1.221 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	1.514GlnAla: 1.514 ± 0.037	0.258GlnCys: 0.258 ± 0.014	1.256GlnAsp: 1.256 ± 0.032	1.838GlnGlu: 1.838 ± 0.036	0.991GlnPhe: 0.991 ± 0.026	1.654GlnGly: 1.654 ± 0.038	0.313GlnHis: 0.313 ± 0.016	2.278GlnIle: 2.278 ± 0.038	2.102GlnLys: 2.102 ± 0.04	2.155GlnLeu: 2.155 ± 0.042	0.696GlnMet: 0.696 ± 0.022	1.673GlnAsn: 1.673 ± 0.037	0.543GlnPro: 0.543 ± 0.019	0.718GlnGln: 0.718 ± 0.025	0.928GlnArg: 0.928 ± 0.027	1.509GlnSer: 1.509 ± 0.031	1.183GlnThr: 1.183 ± 0.028	1.556GlnVal: 1.556 ± 0.034	0.248GlnTrp: 0.248 ± 0.015	1.072GlnTyr: 1.072 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	1.832ArgAla: 1.832 ± 0.036	0.384ArgCys: 0.384 ± 0.018	1.872ArgAsp: 1.872 ± 0.035	2.775ArgGlu: 2.775 ± 0.045	1.419ArgPhe: 1.419 ± 0.032	1.932ArgGly: 1.932 ± 0.037	0.471ArgHis: 0.471 ± 0.02	3.259ArgIle: 3.259 ± 0.044	2.911ArgLys: 2.911 ± 0.043	2.933ArgLeu: 2.933 ± 0.049	0.91ArgMet: 0.91 ± 0.026	2.14ArgAsn: 2.14 ± 0.038	0.82ArgPro: 0.82 ± 0.026	0.918ArgGln: 0.918 ± 0.024	1.327ArgArg: 1.327 ± 0.034	1.665ArgSer: 1.665 ± 0.033	1.629ArgThr: 1.629 ± 0.033	2.143ArgVal: 2.143 ± 0.037	0.276ArgTrp: 0.276 ± 0.014	1.419ArgTyr: 1.419 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	3.561SerAla: 3.561 ± 0.055	0.643SerCys: 0.643 ± 0.02	3.55SerAsp: 3.55 ± 0.053	4.465SerGlu: 4.465 ± 0.063	3.075SerPhe: 3.075 ± 0.055	4.536SerGly: 4.536 ± 0.068	0.936SerHis: 0.936 ± 0.026	6.82SerIle: 6.82 ± 0.077	5.742SerLys: 5.742 ± 0.057	6.056SerLeu: 6.056 ± 0.072	1.725SerMet: 1.725 ± 0.032	4.121SerAsn: 4.121 ± 0.061	1.75SerPro: 1.75 ± 0.038	1.702SerGln: 1.702 ± 0.036	2.107SerArg: 2.107 ± 0.036	4.747SerSer: 4.747 ± 0.078	3.433SerThr: 3.433 ± 0.056	3.997SerVal: 3.997 ± 0.052	0.46SerTrp: 0.46 ± 0.019	2.623SerTyr: 2.623 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	3.039ThrAla: 3.039 ± 0.051	0.517ThrCys: 0.517 ± 0.02	2.464ThrAsp: 2.464 ± 0.05	3.083ThrGlu: 3.083 ± 0.045	2.253ThrPhe: 2.253 ± 0.034	3.827ThrGly: 3.827 ± 0.07	0.747ThrHis: 0.747 ± 0.021	4.857ThrIle: 4.857 ± 0.06	3.783ThrLys: 3.783 ± 0.051	4.832ThrLeu: 4.832 ± 0.057	1.196ThrMet: 1.196 ± 0.033	2.999ThrAsn: 2.999 ± 0.042	1.8ThrPro: 1.8 ± 0.035	1.298ThrGln: 1.298 ± 0.029	1.467ThrArg: 1.467 ± 0.037	3.432ThrSer: 3.432 ± 0.051	2.816ThrThr: 2.816 ± 0.058	3.269ThrVal: 3.269 ± 0.053	0.395ThrTrp: 0.395 ± 0.02	1.931ThrTyr: 1.931 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	3.835ValAla: 3.835 ± 0.061	0.808ValCys: 0.808 ± 0.024	3.67ValAsp: 3.67 ± 0.053	4.254ValGlu: 4.254 ± 0.057	2.73ValPhe: 2.73 ± 0.045	4.078ValGly: 4.078 ± 0.059	0.808ValHis: 0.808 ± 0.024	6.158ValIle: 6.158 ± 0.069	5.188ValLys: 5.188 ± 0.057	5.706ValLeu: 5.706 ± 0.066	1.599ValMet: 1.599 ± 0.037	3.898ValAsn: 3.898 ± 0.049	1.9ValPro: 1.9 ± 0.039	1.524ValGln: 1.524 ± 0.029	1.996ValArg: 1.996 ± 0.037	4.511ValSer: 4.511 ± 0.066	3.454ValThr: 3.454 ± 0.056	4.355ValVal: 4.355 ± 0.061	0.414ValTrp: 0.414 ± 0.02	2.396ValTyr: 2.396 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	0.401TrpAla: 0.401 ± 0.018	0.113TrpCys: 0.113 ± 0.008	0.42TrpAsp: 0.42 ± 0.018	0.445TrpGlu: 0.445 ± 0.018	0.349TrpPhe: 0.349 ± 0.017	0.524TrpGly: 0.524 ± 0.02	0.141TrpHis: 0.141 ± 0.009	0.766TrpIle: 0.766 ± 0.025	0.564TrpLys: 0.564 ± 0.022	0.631TrpLeu: 0.631 ± 0.024	0.241TrpMet: 0.241 ± 0.013	0.547TrpAsn: 0.547 ± 0.021	0.198TrpPro: 0.198 ± 0.012	0.251TrpGln: 0.251 ± 0.014	0.268TrpArg: 0.268 ± 0.013	0.461TrpSer: 0.461 ± 0.022	0.387TrpThr: 0.387 ± 0.016	0.461TrpVal: 0.461 ± 0.023	0.108TrpTrp: 0.108 ± 0.009	0.46TrpTyr: 0.46 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.996TyrAla: 1.996 ± 0.041	0.51TyrCys: 0.51 ± 0.02	2.45TyrAsp: 2.45 ± 0.045	2.947TyrGlu: 2.947 ± 0.055	1.981TyrPhe: 1.981 ± 0.042	2.557TyrGly: 2.557 ± 0.049	0.589TyrHis: 0.589 ± 0.02	3.911TyrIle: 3.911 ± 0.054	3.496TyrLys: 3.496 ± 0.047	3.74TyrLeu: 3.74 ± 0.057	0.95TyrMet: 0.95 ± 0.026	2.862TyrAsn: 2.862 ± 0.05	1.211TyrPro: 1.211 ± 0.031	0.825TyrGln: 0.825 ± 0.024	1.465TyrArg: 1.465 ± 0.03	2.776TyrSer: 2.776 ± 0.047	2.054TyrThr: 2.054 ± 0.045	2.247TyrVal: 2.247 ± 0.04	0.321TyrTrp: 0.321 ± 0.018	1.971TyrTyr: 1.971 ± 0.043	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4771 proteins (1479602 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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