Amino acid dipepetide frequency for Catellicoccus marimammalium M35/04/3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.627AlaAla: 4.627 ± 0.167
0.679AlaCys: 0.679 ± 0.043
3.07AlaAsp: 3.07 ± 0.1
4.541AlaGlu: 4.541 ± 0.146
2.796AlaPhe: 2.796 ± 0.104
4.076AlaGly: 4.076 ± 0.114
1.285AlaHis: 1.285 ± 0.054
5.267AlaIle: 5.267 ± 0.126
5.912AlaLys: 5.912 ± 0.159
7.01AlaLeu: 7.01 ± 0.163
2.213AlaMet: 2.213 ± 0.074
2.871AlaAsn: 2.871 ± 0.108
2.208AlaPro: 2.208 ± 0.071
3.417AlaGln: 3.417 ± 0.097
2.477AlaArg: 2.477 ± 0.082
3.561AlaSer: 3.561 ± 0.108
3.906AlaThr: 3.906 ± 0.115
4.251AlaVal: 4.251 ± 0.131
0.611AlaTrp: 0.611 ± 0.042
2.469AlaTyr: 2.469 ± 0.083
0.0AlaXaa: 0.0 ± 0.0
Cys
0.651CysAla: 0.651 ± 0.041
0.112CysCys: 0.112 ± 0.021
0.533CysAsp: 0.533 ± 0.042
0.507CysGlu: 0.507 ± 0.041
0.52CysPhe: 0.52 ± 0.041
0.794CysGly: 0.794 ± 0.049
0.274CysHis: 0.274 ± 0.036
0.685CysIle: 0.685 ± 0.045
0.337CysLys: 0.337 ± 0.034
0.862CysLeu: 0.862 ± 0.049
0.162CysMet: 0.162 ± 0.02
0.337CysAsn: 0.337 ± 0.029
0.431CysPro: 0.431 ± 0.037
0.476CysGln: 0.476 ± 0.036
0.298CysArg: 0.298 ± 0.03
0.598CysSer: 0.598 ± 0.038
0.496CysThr: 0.496 ± 0.035
0.515CysVal: 0.515 ± 0.041
0.068CysTrp: 0.068 ± 0.015
0.423CysTyr: 0.423 ± 0.032
0.0CysXaa: 0.0 ± 0.0
Asp
3.624AspAla: 3.624 ± 0.112
0.473AspCys: 0.473 ± 0.043
2.315AspAsp: 2.315 ± 0.09
4.562AspGlu: 4.562 ± 0.116
2.547AspPhe: 2.547 ± 0.087
3.417AspGly: 3.417 ± 0.116
1.293AspHis: 1.293 ± 0.051
3.498AspIle: 3.498 ± 0.088
3.514AspLys: 3.514 ± 0.141
4.998AspLeu: 4.998 ± 0.112
1.257AspMet: 1.257 ± 0.067
1.858AspAsn: 1.858 ± 0.082
1.818AspPro: 1.818 ± 0.079
2.336AspGln: 2.336 ± 0.092
1.983AspArg: 1.983 ± 0.084
2.359AspSer: 2.359 ± 0.093
2.722AspThr: 2.722 ± 0.097
3.404AspVal: 3.404 ± 0.111
0.771AspTrp: 0.771 ± 0.046
2.466AspTyr: 2.466 ± 0.083
0.0AspXaa: 0.0 ± 0.0
Glu
5.944GluAla: 5.944 ± 0.169
0.523GluCys: 0.523 ± 0.041
4.28GluAsp: 4.28 ± 0.12
9.868GluGlu: 9.868 ± 0.271
2.315GluPhe: 2.315 ± 0.086
4.596GluGly: 4.596 ± 0.115
1.458GluHis: 1.458 ± 0.066
6.027GluIle: 6.027 ± 0.133
8.729GluLys: 8.729 ± 0.186
6.866GluLeu: 6.866 ± 0.148
2.495GluMet: 2.495 ± 0.07
4.478GluAsn: 4.478 ± 0.112
1.892GluPro: 1.892 ± 0.07
4.178GluGln: 4.178 ± 0.124
3.336GluArg: 3.336 ± 0.111
3.14GluSer: 3.14 ± 0.102
3.817GluThr: 3.817 ± 0.109
6.048GluVal: 6.048 ± 0.12
1.011GluTrp: 1.011 ± 0.055
2.777GluTyr: 2.777 ± 0.087
0.0GluXaa: 0.0 ± 0.0
Phe
2.892PheAla: 2.892 ± 0.09
0.517PheCys: 0.517 ± 0.038
2.291PheAsp: 2.291 ± 0.081
2.148PheGlu: 2.148 ± 0.069
2.249PhePhe: 2.249 ± 0.086
2.772PheGly: 2.772 ± 0.092
1.029PheHis: 1.029 ± 0.056
3.425PheIle: 3.425 ± 0.126
2.048PheLys: 2.048 ± 0.089
4.549PheLeu: 4.549 ± 0.153
1.066PheMet: 1.066 ± 0.059
1.628PheAsn: 1.628 ± 0.069
1.602PhePro: 1.602 ± 0.074
1.847PheGln: 1.847 ± 0.069
1.194PheArg: 1.194 ± 0.054
3.052PheSer: 3.052 ± 0.093
2.411PheThr: 2.411 ± 0.085
2.845PheVal: 2.845 ± 0.091
0.494PheTrp: 0.494 ± 0.039
2.001PheTyr: 2.001 ± 0.081
0.0PheXaa: 0.0 ± 0.0
Gly
3.948GlyAla: 3.948 ± 0.123
0.575GlyCys: 0.575 ± 0.04
3.036GlyAsp: 3.036 ± 0.109
4.308GlyGlu: 4.308 ± 0.115
2.566GlyPhe: 2.566 ± 0.105
3.937GlyGly: 3.937 ± 0.119
1.312GlyHis: 1.312 ± 0.056
5.183GlyIle: 5.183 ± 0.132
5.421GlyLys: 5.421 ± 0.135
5.562GlyLeu: 5.562 ± 0.149
2.166GlyMet: 2.166 ± 0.089
2.741GlyAsn: 2.741 ± 0.095
1.379GlyPro: 1.379 ± 0.071
2.32GlyGln: 2.32 ± 0.068
2.33GlyArg: 2.33 ± 0.084
3.344GlySer: 3.344 ± 0.091
3.903GlyThr: 3.903 ± 0.136
4.324GlyVal: 4.324 ± 0.119
0.635GlyTrp: 0.635 ± 0.042
2.801GlyTyr: 2.801 ± 0.09
0.0GlyXaa: 0.0 ± 0.0
His
1.202HisAla: 1.202 ± 0.068
0.272HisCys: 0.272 ± 0.027
0.967HisAsp: 0.967 ± 0.054
1.306HisGlu: 1.306 ± 0.055
1.191HisPhe: 1.191 ± 0.061
1.267HisGly: 1.267 ± 0.056
0.76HisHis: 0.76 ± 0.049
1.507HisIle: 1.507 ± 0.053
1.16HisLys: 1.16 ± 0.057
2.613HisLeu: 2.613 ± 0.104
0.507HisMet: 0.507 ± 0.036
0.752HisAsn: 0.752 ± 0.046
1.225HisPro: 1.225 ± 0.064
1.087HisGln: 1.087 ± 0.053
1.045HisArg: 1.045 ± 0.05
1.134HisSer: 1.134 ± 0.049
1.053HisThr: 1.053 ± 0.056
1.204HisVal: 1.204 ± 0.064
0.35HisTrp: 0.35 ± 0.031
1.157HisTyr: 1.157 ± 0.057
0.0HisXaa: 0.0 ± 0.0
Ile
5.638IleAla: 5.638 ± 0.146
0.818IleCys: 0.818 ± 0.045
4.243IleAsp: 4.243 ± 0.104
5.471IleGlu: 5.471 ± 0.115
3.229IlePhe: 3.229 ± 0.12
4.771IleGly: 4.771 ± 0.132
1.787IleHis: 1.787 ± 0.078
5.183IleIle: 5.183 ± 0.153
3.804IleLys: 3.804 ± 0.108
6.871IleLeu: 6.871 ± 0.165
1.607IleMet: 1.607 ± 0.072
2.749IleAsn: 2.749 ± 0.112
3.292IlePro: 3.292 ± 0.101
3.914IleGln: 3.914 ± 0.115
2.762IleArg: 2.762 ± 0.099
4.089IleSer: 4.089 ± 0.109
3.893IleThr: 3.893 ± 0.108
4.907IleVal: 4.907 ± 0.133
0.562IleTrp: 0.562 ± 0.034
2.853IleTyr: 2.853 ± 0.092
0.0IleXaa: 0.0 ± 0.0
Lys
5.374LysAla: 5.374 ± 0.166
0.334LysCys: 0.334 ± 0.03
4.745LysAsp: 4.745 ± 0.171
11.671LysGlu: 11.671 ± 0.248
1.758LysPhe: 1.758 ± 0.071
4.598LysGly: 4.598 ± 0.115
1.147LysHis: 1.147 ± 0.058
4.961LysIle: 4.961 ± 0.123
8.047LysLys: 8.047 ± 0.239
4.948LysLeu: 4.948 ± 0.129
2.508LysMet: 2.508 ± 0.082
3.935LysAsn: 3.935 ± 0.12
2.244LysPro: 2.244 ± 0.121
3.425LysGln: 3.425 ± 0.105
3.112LysArg: 3.112 ± 0.076
3.01LysSer: 3.01 ± 0.11
3.846LysThr: 3.846 ± 0.088
5.142LysVal: 5.142 ± 0.116
0.698LysTrp: 0.698 ± 0.042
2.398LysTyr: 2.398 ± 0.094
0.0LysXaa: 0.0 ± 0.0
Leu
6.989LeuAla: 6.989 ± 0.149
1.11LeuCys: 1.11 ± 0.058
4.784LeuAsp: 4.784 ± 0.12
7.571LeuGlu: 7.571 ± 0.179
4.651LeuPhe: 4.651 ± 0.135
5.991LeuGly: 5.991 ± 0.147
1.92LeuHis: 1.92 ± 0.08
5.602LeuIle: 5.602 ± 0.147
6.213LeuLys: 6.213 ± 0.141
9.829LeuLeu: 9.829 ± 0.221
2.304LeuMet: 2.304 ± 0.078
4.12LeuAsn: 4.12 ± 0.109
4.185LeuPro: 4.185 ± 0.117
4.823LeuGln: 4.823 ± 0.155
3.524LeuArg: 3.524 ± 0.1
6.485LeuSer: 6.485 ± 0.131
5.084LeuThr: 5.084 ± 0.142
5.445LeuVal: 5.445 ± 0.152
1.061LeuTrp: 1.061 ± 0.058
3.386LeuTyr: 3.386 ± 0.106
0.0LeuXaa: 0.0 ± 0.0
Met
1.821MetAla: 1.821 ± 0.071
0.159MetCys: 0.159 ± 0.021
1.669MetAsp: 1.669 ± 0.07
1.965MetGlu: 1.965 ± 0.071
0.802MetPhe: 0.802 ± 0.048
1.581MetGly: 1.581 ± 0.065
0.483MetHis: 0.483 ± 0.04
2.315MetIle: 2.315 ± 0.08
2.704MetLys: 2.704 ± 0.093
2.124MetLeu: 2.124 ± 0.087
0.951MetMet: 0.951 ± 0.058
1.696MetAsn: 1.696 ± 0.066
0.982MetPro: 0.982 ± 0.06
1.137MetGln: 1.137 ± 0.054
0.988MetArg: 0.988 ± 0.047
1.586MetSer: 1.586 ± 0.066
1.696MetThr: 1.696 ± 0.072
1.735MetVal: 1.735 ± 0.068
0.141MetTrp: 0.141 ± 0.019
0.786MetTyr: 0.786 ± 0.046
0.0MetXaa: 0.0 ± 0.0
Asn
2.798AsnAla: 2.798 ± 0.09
0.332AsnCys: 0.332 ± 0.032
2.255AsnAsp: 2.255 ± 0.092
3.538AsnGlu: 3.538 ± 0.092
1.748AsnPhe: 1.748 ± 0.073
3.065AsnGly: 3.065 ± 0.113
1.285AsnHis: 1.285 ± 0.053
3.297AsnIle: 3.297 ± 0.107
3.284AsnLys: 3.284 ± 0.121
3.556AsnLeu: 3.556 ± 0.105
1.108AsnMet: 1.108 ± 0.055
2.182AsnAsn: 2.182 ± 0.108
1.939AsnPro: 1.939 ± 0.069
2.524AsnGln: 2.524 ± 0.094
1.85AsnArg: 1.85 ± 0.076
2.001AsnSer: 2.001 ± 0.078
2.383AsnThr: 2.383 ± 0.089
2.733AsnVal: 2.733 ± 0.082
0.465AsnTrp: 0.465 ± 0.037
1.973AsnTyr: 1.973 ± 0.078
0.0AsnXaa: 0.0 ± 0.0
Pro
2.017ProAla: 2.017 ± 0.074
0.311ProCys: 0.311 ± 0.029
1.659ProAsp: 1.659 ± 0.084
2.929ProGlu: 2.929 ± 0.098
1.816ProPhe: 1.816 ± 0.072
1.8ProGly: 1.8 ± 0.079
0.726ProHis: 0.726 ± 0.045
2.539ProIle: 2.539 ± 0.081
3.106ProLys: 3.106 ± 0.096
3.579ProLeu: 3.579 ± 0.093
0.925ProMet: 0.925 ± 0.047
1.792ProAsn: 1.792 ± 0.067
0.58ProPro: 0.58 ± 0.046
1.536ProGln: 1.536 ± 0.062
0.977ProArg: 0.977 ± 0.053
2.174ProSer: 2.174 ± 0.083
2.192ProThr: 2.192 ± 0.077
2.492ProVal: 2.492 ± 0.102
0.413ProTrp: 0.413 ± 0.038
1.581ProTyr: 1.581 ± 0.063
0.0ProXaa: 0.0 ± 0.0
Gln
3.19GlnAla: 3.19 ± 0.109
0.397GlnCys: 0.397 ± 0.037
1.865GlnAsp: 1.865 ± 0.077
4.46GlnGlu: 4.46 ± 0.14
1.863GlnPhe: 1.863 ± 0.085
2.576GlnGly: 2.576 ± 0.092
0.844GlnHis: 0.844 ± 0.044
2.827GlnIle: 2.827 ± 0.091
5.079GlnLys: 5.079 ± 0.157
5.042GlnLeu: 5.042 ± 0.132
1.22GlnMet: 1.22 ± 0.056
2.283GlnAsn: 2.283 ± 0.095
1.528GlnPro: 1.528 ± 0.064
2.918GlnGln: 2.918 ± 0.133
2.213GlnArg: 2.213 ± 0.09
2.297GlnSer: 2.297 ± 0.076
2.338GlnThr: 2.338 ± 0.084
2.715GlnVal: 2.715 ± 0.084
0.797GlnTrp: 0.797 ± 0.052
1.876GlnTyr: 1.876 ± 0.078
0.0GlnXaa: 0.0 ± 0.0
Arg
2.2ArgAla: 2.2 ± 0.08
0.434ArgCys: 0.434 ± 0.035
1.761ArgAsp: 1.761 ± 0.072
2.772ArgGlu: 2.772 ± 0.092
1.852ArgPhe: 1.852 ± 0.073
2.226ArgGly: 2.226 ± 0.088
0.922ArgHis: 0.922 ± 0.047
2.696ArgIle: 2.696 ± 0.097
3.148ArgLys: 3.148 ± 0.1
3.895ArgLeu: 3.895 ± 0.103
1.008ArgMet: 1.008 ± 0.055
1.761ArgAsn: 1.761 ± 0.073
1.335ArgPro: 1.335 ± 0.075
1.899ArgGln: 1.899 ± 0.078
1.865ArgArg: 1.865 ± 0.086
1.847ArgSer: 1.847 ± 0.072
1.826ArgThr: 1.826 ± 0.067
2.315ArgVal: 2.315 ± 0.084
0.468ArgTrp: 0.468 ± 0.034
1.931ArgTyr: 1.931 ± 0.076
0.0ArgXaa: 0.0 ± 0.0
Ser
3.342SerAla: 3.342 ± 0.108
0.452SerCys: 0.452 ± 0.038
2.665SerAsp: 2.665 ± 0.1
3.561SerGlu: 3.561 ± 0.111
2.879SerPhe: 2.879 ± 0.096
3.472SerGly: 3.472 ± 0.124
1.207SerHis: 1.207 ± 0.053
4.253SerIle: 4.253 ± 0.129
3.451SerLys: 3.451 ± 0.11
5.923SerLeu: 5.923 ± 0.129
1.419SerMet: 1.419 ± 0.051
2.174SerAsn: 2.174 ± 0.104
1.594SerPro: 1.594 ± 0.065
2.158SerGln: 2.158 ± 0.075
1.75SerArg: 1.75 ± 0.071
3.517SerSer: 3.517 ± 0.181
3.334SerThr: 3.334 ± 0.109
3.488SerVal: 3.488 ± 0.111
0.559SerTrp: 0.559 ± 0.04
2.349SerTyr: 2.349 ± 0.088
0.0SerXaa: 0.0 ± 0.0
Thr
3.334ThrAla: 3.334 ± 0.098
0.439ThrCys: 0.439 ± 0.04
2.542ThrAsp: 2.542 ± 0.086
3.817ThrGlu: 3.817 ± 0.094
2.388ThrPhe: 2.388 ± 0.083
3.621ThrGly: 3.621 ± 0.107
1.092ThrHis: 1.092 ± 0.061
4.525ThrIle: 4.525 ± 0.111
4.781ThrLys: 4.781 ± 0.13
5.521ThrLeu: 5.521 ± 0.108
1.434ThrMet: 1.434 ± 0.065
2.195ThrAsn: 2.195 ± 0.085
2.626ThrPro: 2.626 ± 0.091
2.004ThrGln: 2.004 ± 0.082
1.722ThrArg: 1.722 ± 0.071
3.164ThrSer: 3.164 ± 0.11
3.373ThrThr: 3.373 ± 0.119
3.673ThrVal: 3.673 ± 0.108
0.549ThrTrp: 0.549 ± 0.036
2.135ThrTyr: 2.135 ± 0.079
0.0ThrXaa: 0.0 ± 0.0
Val
4.81ValAla: 4.81 ± 0.128
0.645ValCys: 0.645 ± 0.043
3.817ValAsp: 3.817 ± 0.101
5.275ValGlu: 5.275 ± 0.128
2.458ValPhe: 2.458 ± 0.092
4.217ValGly: 4.217 ± 0.104
1.374ValHis: 1.374 ± 0.07
4.995ValIle: 4.995 ± 0.139
4.272ValLys: 4.272 ± 0.132
6.061ValLeu: 6.061 ± 0.123
1.696ValMet: 1.696 ± 0.065
2.634ValAsn: 2.634 ± 0.089
2.466ValPro: 2.466 ± 0.079
2.869ValGln: 2.869 ± 0.091
2.435ValArg: 2.435 ± 0.091
3.611ValSer: 3.611 ± 0.104
3.854ValThr: 3.854 ± 0.096
4.671ValVal: 4.671 ± 0.137
0.556ValTrp: 0.556 ± 0.041
2.344ValTyr: 2.344 ± 0.084
0.0ValXaa: 0.0 ± 0.0
Trp
0.468TrpAla: 0.468 ± 0.039
0.063TrpCys: 0.063 ± 0.016
0.517TrpAsp: 0.517 ± 0.041
0.739TrpGlu: 0.739 ± 0.048
0.496TrpPhe: 0.496 ± 0.039
0.562TrpGly: 0.562 ± 0.042
0.314TrpHis: 0.314 ± 0.029
0.954TrpIle: 0.954 ± 0.053
0.954TrpLys: 0.954 ± 0.056
1.126TrpLeu: 1.126 ± 0.057
0.345TrpMet: 0.345 ± 0.032
0.648TrpAsn: 0.648 ± 0.043
0.269TrpPro: 0.269 ± 0.034
0.802TrpGln: 0.802 ± 0.051
0.384TrpArg: 0.384 ± 0.035
0.504TrpSer: 0.504 ± 0.039
0.549TrpThr: 0.549 ± 0.035
0.635TrpVal: 0.635 ± 0.042
0.12TrpTrp: 0.12 ± 0.02
0.334TrpTyr: 0.334 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.38TyrAla: 2.38 ± 0.08
0.434TyrCys: 0.434 ± 0.037
2.202TyrAsp: 2.202 ± 0.081
2.769TyrGlu: 2.769 ± 0.092
1.936TyrPhe: 1.936 ± 0.082
2.453TyrGly: 2.453 ± 0.083
1.246TyrHis: 1.246 ± 0.059
2.699TyrIle: 2.699 ± 0.101
1.936TyrLys: 1.936 ± 0.084
4.141TyrLeu: 4.141 ± 0.113
0.927TyrMet: 0.927 ± 0.054
1.484TyrAsn: 1.484 ± 0.079
1.549TyrPro: 1.549 ± 0.064
2.66TyrGln: 2.66 ± 0.098
1.918TyrArg: 1.918 ± 0.082
2.074TyrSer: 2.074 ± 0.082
2.257TyrThr: 2.257 ± 0.096
2.519TyrVal: 2.519 ± 0.084
0.455TyrTrp: 0.455 ± 0.033
2.017TyrTyr: 2.017 ± 0.09
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1196 proteins (382755 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski