Amino acid dipepetide frequency for Streptomyces xinghaiensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.076AlaAla: 23.076 ± 0.18	1.075AlaCys: 1.075 ± 0.025	8.173AlaAsp: 8.173 ± 0.073	9.638AlaGlu: 9.638 ± 0.097	3.296AlaPhe: 3.296 ± 0.036	15.27AlaGly: 15.27 ± 0.13	2.847AlaHis: 2.847 ± 0.045	2.977AlaIle: 2.977 ± 0.046	2.418AlaLys: 2.418 ± 0.041	14.121AlaLeu: 14.121 ± 0.113	2.333AlaMet: 2.333 ± 0.032	1.771AlaAsn: 1.771 ± 0.031	7.932AlaPro: 7.932 ± 0.094	3.311AlaGln: 3.311 ± 0.047	10.987AlaArg: 10.987 ± 0.089	5.502AlaSer: 5.502 ± 0.058	6.427AlaThr: 6.427 ± 0.069	12.391AlaVal: 12.391 ± 0.098	1.827AlaTrp: 1.827 ± 0.03	2.552AlaTyr: 2.552 ± 0.034	0.0AlaXaa: 0.0 ± 0.0
Cys	1.06CysAla: 1.06 ± 0.028	0.096CysCys: 0.096 ± 0.007	0.475CysAsp: 0.475 ± 0.016	0.427CysGlu: 0.427 ± 0.014	0.224CysPhe: 0.224 ± 0.01	1.021CysGly: 1.021 ± 0.024	0.195CysHis: 0.195 ± 0.01	0.154CysIle: 0.154 ± 0.009	0.106CysLys: 0.106 ± 0.006	0.709CysLeu: 0.709 ± 0.02	0.125CysMet: 0.125 ± 0.007	0.124CysAsn: 0.124 ± 0.009	0.535CysPro: 0.535 ± 0.017	0.154CysGln: 0.154 ± 0.009	0.677CysArg: 0.677 ± 0.02	0.44CysSer: 0.44 ± 0.015	0.503CysThr: 0.503 ± 0.018	0.626CysVal: 0.626 ± 0.018	0.123CysTrp: 0.123 ± 0.008	0.146CysTyr: 0.146 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.304AspAla: 7.304 ± 0.064	0.415AspCys: 0.415 ± 0.013	3.276AspAsp: 3.276 ± 0.042	3.805AspGlu: 3.805 ± 0.045	1.531AspPhe: 1.531 ± 0.028	6.92AspGly: 6.92 ± 0.065	1.385AspHis: 1.385 ± 0.025	1.813AspIle: 1.813 ± 0.036	1.025AspLys: 1.025 ± 0.026	5.914AspLeu: 5.914 ± 0.054	0.772AspMet: 0.772 ± 0.018	0.875AspAsn: 0.875 ± 0.02	4.63AspPro: 4.63 ± 0.055	1.349AspGln: 1.349 ± 0.029	5.295AspArg: 5.295 ± 0.049	2.493AspSer: 2.493 ± 0.04	3.25AspThr: 3.25 ± 0.049	4.189AspVal: 4.189 ± 0.044	0.981AspTrp: 0.981 ± 0.022	1.096AspTyr: 1.096 ± 0.027	0.0AspXaa: 0.0 ± 0.0
Glu	7.857GluAla: 7.857 ± 0.074	0.382GluCys: 0.382 ± 0.014	3.143GluAsp: 3.143 ± 0.044	4.105GluGlu: 4.105 ± 0.056	1.407GluPhe: 1.407 ± 0.026	4.511GluGly: 4.511 ± 0.05	1.622GluHis: 1.622 ± 0.031	2.31GluIle: 2.31 ± 0.038	1.571GluLys: 1.571 ± 0.039	6.957GluLeu: 6.957 ± 0.07	0.906GluMet: 0.906 ± 0.023	1.098GluAsn: 1.098 ± 0.027	3.99GluPro: 3.99 ± 0.057	2.317GluGln: 2.317 ± 0.04	6.206GluArg: 6.206 ± 0.064	2.653GluSer: 2.653 ± 0.039	3.271GluThr: 3.271 ± 0.039	4.344GluVal: 4.344 ± 0.048	0.769GluTrp: 0.769 ± 0.021	1.12GluTyr: 1.12 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	3.41PheAla: 3.41 ± 0.044	0.252PheCys: 0.252 ± 0.011	1.806PheAsp: 1.806 ± 0.031	1.349PheGlu: 1.349 ± 0.024	0.818PhePhe: 0.818 ± 0.022	2.869PheGly: 2.869 ± 0.042	0.62PheHis: 0.62 ± 0.018	0.692PheIle: 0.692 ± 0.02	0.457PheLys: 0.457 ± 0.017	2.504PheLeu: 2.504 ± 0.04	0.37PheMet: 0.37 ± 0.015	0.535PheAsn: 0.535 ± 0.017	1.416PhePro: 1.416 ± 0.026	0.6PheGln: 0.6 ± 0.019	1.905PheArg: 1.905 ± 0.028	1.405PheSer: 1.405 ± 0.029	2.036PheThr: 2.036 ± 0.042	1.869PheVal: 1.869 ± 0.032	0.402PheTrp: 0.402 ± 0.014	0.523PheTyr: 0.523 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	11.911GlyAla: 11.911 ± 0.102	0.863GlyCys: 0.863 ± 0.021	5.501GlyAsp: 5.501 ± 0.063	5.977GlyGlu: 5.977 ± 0.068	2.708GlyPhe: 2.708 ± 0.041	10.436GlyGly: 10.436 ± 0.115	2.48GlyHis: 2.48 ± 0.036	3.308GlyIle: 3.308 ± 0.041	2.325GlyLys: 2.325 ± 0.042	9.447GlyLeu: 9.447 ± 0.076	2.019GlyMet: 2.019 ± 0.03	1.757GlyAsn: 1.757 ± 0.034	6.508GlyPro: 6.508 ± 0.075	2.511GlyGln: 2.511 ± 0.039	9.094GlyArg: 9.094 ± 0.083	5.702GlySer: 5.702 ± 0.065	6.933GlyThr: 6.933 ± 0.088	7.108GlyVal: 7.108 ± 0.058	1.657GlyTrp: 1.657 ± 0.031	2.249GlyTyr: 2.249 ± 0.036	0.0GlyXaa: 0.0 ± 0.0
His	2.728HisAla: 2.728 ± 0.04	0.215HisCys: 0.215 ± 0.01	1.324HisAsp: 1.324 ± 0.026	1.176HisGlu: 1.176 ± 0.025	0.605HisPhe: 0.605 ± 0.017	2.499HisGly: 2.499 ± 0.039	0.773HisHis: 0.773 ± 0.021	0.693HisIle: 0.693 ± 0.017	0.319HisLys: 0.319 ± 0.011	2.419HisLeu: 2.419 ± 0.034	0.319HisMet: 0.319 ± 0.011	0.376HisAsn: 0.376 ± 0.014	1.941HisPro: 1.941 ± 0.03	0.653HisGln: 0.653 ± 0.02	2.396HisArg: 2.396 ± 0.041	0.981HisSer: 0.981 ± 0.022	1.392HisThr: 1.392 ± 0.031	1.527HisVal: 1.527 ± 0.026	0.39HisTrp: 0.39 ± 0.013	0.478HisTyr: 0.478 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	4.479IleAla: 4.479 ± 0.05	0.28IleCys: 0.28 ± 0.012	2.067IleAsp: 2.067 ± 0.033	1.856IleGlu: 1.856 ± 0.032	0.622IlePhe: 0.622 ± 0.023	3.296IleGly: 3.296 ± 0.049	0.575IleHis: 0.575 ± 0.015	0.828IleIle: 0.828 ± 0.022	0.655IleLys: 0.655 ± 0.021	2.215IleLeu: 2.215 ± 0.045	0.416IleMet: 0.416 ± 0.013	0.632IleAsn: 0.632 ± 0.02	1.712IlePro: 1.712 ± 0.031	0.638IleGln: 0.638 ± 0.019	2.283IleArg: 2.283 ± 0.036	1.559IleSer: 1.559 ± 0.028	2.157IleThr: 2.157 ± 0.033	2.406IleVal: 2.406 ± 0.041	0.344IleTrp: 0.344 ± 0.013	0.471IleTyr: 0.471 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	2.616LysAla: 2.616 ± 0.053	0.114LysCys: 0.114 ± 0.008	1.154LysAsp: 1.154 ± 0.029	1.177LysGlu: 1.177 ± 0.029	0.408LysPhe: 0.408 ± 0.013	1.646LysGly: 1.646 ± 0.044	0.397LysHis: 0.397 ± 0.014	0.834LysIle: 0.834 ± 0.021	0.768LysLys: 0.768 ± 0.032	1.858LysLeu: 1.858 ± 0.031	0.344LysMet: 0.344 ± 0.015	0.489LysAsn: 0.489 ± 0.019	1.283LysPro: 1.283 ± 0.028	0.603LysGln: 0.603 ± 0.018	1.432LysArg: 1.432 ± 0.029	1.024LysSer: 1.024 ± 0.026	1.219LysThr: 1.219 ± 0.027	1.571LysVal: 1.571 ± 0.035	0.217LysTrp: 0.217 ± 0.01	0.406LysTyr: 0.406 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	14.767LeuAla: 14.767 ± 0.102	0.839LeuCys: 0.839 ± 0.025	6.463LeuAsp: 6.463 ± 0.064	4.798LeuGlu: 4.798 ± 0.057	2.527LeuPhe: 2.527 ± 0.037	8.929LeuGly: 8.929 ± 0.076	2.348LeuHis: 2.348 ± 0.033	2.963LeuIle: 2.963 ± 0.041	1.777LeuLys: 1.777 ± 0.035	11.525LeuLeu: 11.525 ± 0.105	1.594LeuMet: 1.594 ± 0.027	1.557LeuAsn: 1.557 ± 0.028	6.728LeuPro: 6.728 ± 0.065	2.026LeuGln: 2.026 ± 0.036	9.457LeuArg: 9.457 ± 0.081	5.277LeuSer: 5.277 ± 0.056	6.574LeuThr: 6.574 ± 0.054	8.242LeuVal: 8.242 ± 0.078	1.274LeuTrp: 1.274 ± 0.026	1.788LeuTyr: 1.788 ± 0.029	0.0LeuXaa: 0.0 ± 0.0
Met	2.285MetAla: 2.285 ± 0.038	0.126MetCys: 0.126 ± 0.007	0.858MetAsp: 0.858 ± 0.023	0.797MetGlu: 0.797 ± 0.02	0.416MetPhe: 0.416 ± 0.015	1.206MetGly: 1.206 ± 0.028	0.315MetHis: 0.315 ± 0.012	0.589MetIle: 0.589 ± 0.018	0.385MetLys: 0.385 ± 0.016	1.617MetLeu: 1.617 ± 0.027	0.273MetMet: 0.273 ± 0.012	0.385MetAsn: 0.385 ± 0.015	1.128MetPro: 1.128 ± 0.023	0.383MetGln: 0.383 ± 0.012	1.455MetArg: 1.455 ± 0.025	1.206MetSer: 1.206 ± 0.021	1.454MetThr: 1.454 ± 0.024	1.198MetVal: 1.198 ± 0.024	0.195MetTrp: 0.195 ± 0.01	0.305MetTyr: 0.305 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.113AsnAla: 2.113 ± 0.034	0.16AsnCys: 0.16 ± 0.009	0.904AsnAsp: 0.904 ± 0.021	0.791AsnGlu: 0.791 ± 0.021	0.44AsnPhe: 0.44 ± 0.016	1.871AsnGly: 1.871 ± 0.034	0.388AsnHis: 0.388 ± 0.014	0.609AsnIle: 0.609 ± 0.019	0.381AsnLys: 0.381 ± 0.014	1.549AsnLeu: 1.549 ± 0.03	0.278AsnMet: 0.278 ± 0.012	0.38AsnAsn: 0.38 ± 0.016	1.344AsnPro: 1.344 ± 0.03	0.448AsnGln: 0.448 ± 0.017	1.276AsnArg: 1.276 ± 0.027	0.84AsnSer: 0.84 ± 0.023	1.09AsnThr: 1.09 ± 0.025	1.222AsnVal: 1.222 ± 0.023	0.255AsnTrp: 0.255 ± 0.011	0.372AsnTyr: 0.372 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	10.199ProAla: 10.199 ± 0.1	0.346ProCys: 0.346 ± 0.014	4.752ProAsp: 4.752 ± 0.052	5.072ProGlu: 5.072 ± 0.052	1.504ProPhe: 1.504 ± 0.026	8.592ProGly: 8.592 ± 0.095	1.458ProHis: 1.458 ± 0.03	1.056ProIle: 1.056 ± 0.023	0.998ProLys: 0.998 ± 0.028	5.423ProLeu: 5.423 ± 0.057	0.915ProMet: 0.915 ± 0.023	0.822ProAsn: 0.822 ± 0.02	4.451ProPro: 4.451 ± 0.07	1.686ProGln: 1.686 ± 0.041	4.559ProArg: 4.559 ± 0.05	3.27ProSer: 3.27 ± 0.06	2.702ProThr: 2.702 ± 0.044	5.767ProVal: 5.767 ± 0.062	0.91ProTrp: 0.91 ± 0.023	1.435ProTyr: 1.435 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.301GlnAla: 3.301 ± 0.049	0.172GlnCys: 0.172 ± 0.01	1.276GlnAsp: 1.276 ± 0.028	1.413GlnGlu: 1.413 ± 0.03	0.624GlnPhe: 0.624 ± 0.016	2.038GlnGly: 2.038 ± 0.034	0.614GlnHis: 0.614 ± 0.017	1.001GlnIle: 1.001 ± 0.024	0.565GlnLys: 0.565 ± 0.018	2.815GlnLeu: 2.815 ± 0.041	0.435GlnMet: 0.435 ± 0.016	0.475GlnAsn: 0.475 ± 0.019	1.742GlnPro: 1.742 ± 0.045	1.183GlnGln: 1.183 ± 0.032	2.385GlnArg: 2.385 ± 0.039	1.163GlnSer: 1.163 ± 0.026	1.23GlnThr: 1.23 ± 0.029	2.041GlnVal: 2.041 ± 0.035	0.408GlnTrp: 0.408 ± 0.015	0.548GlnTyr: 0.548 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	10.706ArgAla: 10.706 ± 0.097	0.667ArgCys: 0.667 ± 0.018	4.617ArgAsp: 4.617 ± 0.052	5.557ArgGlu: 5.557 ± 0.067	2.353ArgPhe: 2.353 ± 0.038	6.546ArgGly: 6.546 ± 0.063	2.331ArgHis: 2.331 ± 0.038	3.242ArgIle: 3.242 ± 0.038	1.728ArgLys: 1.728 ± 0.031	9.339ArgLeu: 9.339 ± 0.084	1.832ArgMet: 1.832 ± 0.03	1.422ArgAsn: 1.422 ± 0.028	5.903ArgPro: 5.903 ± 0.071	2.368ArgGln: 2.368 ± 0.034	8.762ArgArg: 8.762 ± 0.086	4.303ArgSer: 4.303 ± 0.045	5.632ArgThr: 5.632 ± 0.052	6.079ArgVal: 6.079 ± 0.057	1.407ArgTrp: 1.407 ± 0.028	1.876ArgTyr: 1.876 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	6.67SerAla: 6.67 ± 0.066	0.454SerCys: 0.454 ± 0.016	2.478SerAsp: 2.478 ± 0.039	2.48SerGlu: 2.48 ± 0.039	1.454SerPhe: 1.454 ± 0.027	6.364SerGly: 6.364 ± 0.076	1.017SerHis: 1.017 ± 0.023	1.202SerIle: 1.202 ± 0.026	0.875SerLys: 0.875 ± 0.025	4.547SerLeu: 4.547 ± 0.05	0.925SerMet: 0.925 ± 0.02	0.779SerAsn: 0.779 ± 0.022	3.408SerPro: 3.408 ± 0.051	1.117SerGln: 1.117 ± 0.027	3.984SerArg: 3.984 ± 0.046	2.685SerSer: 2.685 ± 0.053	2.754SerThr: 2.754 ± 0.04	4.09SerVal: 4.09 ± 0.045	0.867SerTrp: 0.867 ± 0.021	1.106SerTyr: 1.106 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	9.516ThrAla: 9.516 ± 0.088	0.393ThrCys: 0.393 ± 0.015	3.47ThrAsp: 3.47 ± 0.045	3.464ThrGlu: 3.464 ± 0.046	1.474ThrPhe: 1.474 ± 0.034	7.507ThrGly: 7.507 ± 0.075	1.159ThrHis: 1.159 ± 0.027	1.488ThrIle: 1.488 ± 0.027	0.952ThrLys: 0.952 ± 0.025	5.334ThrLeu: 5.334 ± 0.06	0.851ThrMet: 0.851 ± 0.02	0.888ThrAsn: 0.888 ± 0.024	4.014ThrPro: 4.014 ± 0.054	1.138ThrGln: 1.138 ± 0.025	3.922ThrArg: 3.922 ± 0.04	2.786ThrSer: 2.786 ± 0.041	3.66ThrThr: 3.66 ± 0.077	5.984ThrVal: 5.984 ± 0.081	0.804ThrTrp: 0.804 ± 0.021	1.139ThrTyr: 1.139 ± 0.025	0.0ThrXaa: 0.0 ± 0.0
Val	9.749ValAla: 9.749 ± 0.081	0.741ValCys: 0.741 ± 0.017	4.339ValAsp: 4.339 ± 0.048	4.608ValGlu: 4.608 ± 0.048	2.352ValPhe: 2.352 ± 0.03	5.716ValGly: 5.716 ± 0.056	1.953ValHis: 1.953 ± 0.026	2.729ValIle: 2.729 ± 0.037	1.549ValLys: 1.549 ± 0.031	9.494ValLeu: 9.494 ± 0.082	1.375ValMet: 1.375 ± 0.026	1.606ValAsn: 1.606 ± 0.027	5.458ValPro: 5.458 ± 0.06	1.799ValGln: 1.799 ± 0.028	7.308ValArg: 7.308 ± 0.072	4.188ValSer: 4.188 ± 0.047	5.528ValThr: 5.528 ± 0.074	7.328ValVal: 7.328 ± 0.08	1.068ValTrp: 1.068 ± 0.026	1.492ValTyr: 1.492 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	1.572TrpAla: 1.572 ± 0.027	0.163TrpCys: 0.163 ± 0.009	0.797TrpAsp: 0.797 ± 0.024	0.778TrpGlu: 0.778 ± 0.02	0.478TrpPhe: 0.478 ± 0.017	0.998TrpGly: 0.998 ± 0.021	0.349TrpHis: 0.349 ± 0.013	0.52TrpIle: 0.52 ± 0.017	0.347TrpLys: 0.347 ± 0.015	1.669TrpLeu: 1.669 ± 0.031	0.263TrpMet: 0.263 ± 0.011	0.369TrpAsn: 0.369 ± 0.015	0.789TrpPro: 0.789 ± 0.02	0.589TrpGln: 0.589 ± 0.018	1.405TrpArg: 1.405 ± 0.027	0.91TrpSer: 0.91 ± 0.023	0.973TrpThr: 0.973 ± 0.025	0.917TrpVal: 0.917 ± 0.022	0.329TrpTrp: 0.329 ± 0.014	0.324TrpTyr: 0.324 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.606TyrAla: 2.606 ± 0.04	0.165TyrCys: 0.165 ± 0.008	1.445TyrAsp: 1.445 ± 0.034	1.27TyrGlu: 1.27 ± 0.025	0.596TyrPhe: 0.596 ± 0.018	2.262TyrGly: 2.262 ± 0.036	0.376TyrHis: 0.376 ± 0.014	0.484TyrIle: 0.484 ± 0.016	0.357TyrLys: 0.357 ± 0.016	1.997TyrLeu: 1.997 ± 0.033	0.23TyrMet: 0.23 ± 0.01	0.372TyrAsn: 0.372 ± 0.015	1.006TyrPro: 1.006 ± 0.026	0.555TyrGln: 0.555 ± 0.018	1.883TyrArg: 1.883 ± 0.03	0.868TyrSer: 0.868 ± 0.021	1.159TyrThr: 1.159 ± 0.026	1.479TyrVal: 1.479 ± 0.03	0.314TyrTrp: 0.314 ± 0.013	0.413TyrTyr: 0.413 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6234 proteins (2095627 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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