Amino acid dipepetide frequency for Devosia sp. Root436

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.384AlaAla: 17.384 ± 0.148	0.773AlaCys: 0.773 ± 0.027	7.245AlaAsp: 7.245 ± 0.085	7.793AlaGlu: 7.793 ± 0.096	4.451AlaPhe: 4.451 ± 0.071	10.948AlaGly: 10.948 ± 0.104	2.165AlaHis: 2.165 ± 0.041	7.356AlaIle: 7.356 ± 0.09	3.534AlaLys: 3.534 ± 0.063	13.917AlaLeu: 13.917 ± 0.133	3.886AlaMet: 3.886 ± 0.063	3.41AlaAsn: 3.41 ± 0.061	5.46AlaPro: 5.46 ± 0.09	4.109AlaGln: 4.109 ± 0.067	8.329AlaArg: 8.329 ± 0.103	6.166AlaSer: 6.166 ± 0.071	6.288AlaThr: 6.288 ± 0.08	9.007AlaVal: 9.007 ± 0.096	1.43AlaTrp: 1.43 ± 0.042	2.553AlaTyr: 2.553 ± 0.045	0.001AlaXaa: 0.001 ± 0.001
Cys	0.793CysAla: 0.793 ± 0.029	0.078CysCys: 0.078 ± 0.008	0.428CysAsp: 0.428 ± 0.021	0.352CysGlu: 0.352 ± 0.021	0.262CysPhe: 0.262 ± 0.017	0.731CysGly: 0.731 ± 0.025	0.207CysHis: 0.207 ± 0.014	0.334CysIle: 0.334 ± 0.018	0.152CysLys: 0.152 ± 0.012	0.669CysLeu: 0.669 ± 0.023	0.119CysMet: 0.119 ± 0.012	0.167CysAsn: 0.167 ± 0.014	0.317CysPro: 0.317 ± 0.02	0.212CysGln: 0.212 ± 0.016	0.423CysArg: 0.423 ± 0.018	0.385CysSer: 0.385 ± 0.016	0.325CysThr: 0.325 ± 0.017	0.48CysVal: 0.48 ± 0.022	0.104CysTrp: 0.104 ± 0.01	0.148CysTyr: 0.148 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.067AspAla: 7.067 ± 0.095	0.424AspCys: 0.424 ± 0.021	3.296AspAsp: 3.296 ± 0.061	3.483AspGlu: 3.483 ± 0.062	2.307AspPhe: 2.307 ± 0.045	5.341AspGly: 5.341 ± 0.079	1.214AspHis: 1.214 ± 0.038	3.647AspIle: 3.647 ± 0.054	1.797AspLys: 1.797 ± 0.038	6.038AspLeu: 6.038 ± 0.083	1.489AspMet: 1.489 ± 0.035	1.437AspAsn: 1.437 ± 0.036	3.334AspPro: 3.334 ± 0.052	1.708AspGln: 1.708 ± 0.044	3.969AspArg: 3.969 ± 0.069	2.277AspSer: 2.277 ± 0.042	2.734AspThr: 2.734 ± 0.053	4.176AspVal: 4.176 ± 0.064	1.022AspTrp: 1.022 ± 0.034	1.583AspTyr: 1.583 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	7.666GluAla: 7.666 ± 0.094	0.284GluCys: 0.284 ± 0.018	2.707GluAsp: 2.707 ± 0.056	2.869GluGlu: 2.869 ± 0.055	1.807GluPhe: 1.807 ± 0.041	4.134GluGly: 4.134 ± 0.066	1.174GluHis: 1.174 ± 0.034	3.315GluIle: 3.315 ± 0.053	1.945GluLys: 1.945 ± 0.048	5.462GluLeu: 5.462 ± 0.075	1.543GluMet: 1.543 ± 0.036	1.486GluAsn: 1.486 ± 0.035	2.751GluPro: 2.751 ± 0.062	2.159GluGln: 2.159 ± 0.046	4.434GluArg: 4.434 ± 0.07	2.313GluSer: 2.313 ± 0.05	3.468GluThr: 3.468 ± 0.056	3.9GluVal: 3.9 ± 0.065	0.692GluTrp: 0.692 ± 0.025	1.0GluTyr: 1.0 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.838PheAla: 4.838 ± 0.066	0.346PheCys: 0.346 ± 0.017	2.671PheAsp: 2.671 ± 0.046	2.191PheGlu: 2.191 ± 0.045	1.48PhePhe: 1.48 ± 0.047	3.938PheGly: 3.938 ± 0.073	0.734PheHis: 0.734 ± 0.023	1.885PheIle: 1.885 ± 0.041	1.065PheLys: 1.065 ± 0.036	3.289PheLeu: 3.289 ± 0.06	0.837PheMet: 0.837 ± 0.033	1.154PheAsn: 1.154 ± 0.031	1.549PhePro: 1.549 ± 0.034	0.975PheGln: 0.975 ± 0.026	2.046PheArg: 2.046 ± 0.046	2.218PheSer: 2.218 ± 0.047	2.077PheThr: 2.077 ± 0.043	2.971PheVal: 2.971 ± 0.055	0.548PheTrp: 0.548 ± 0.022	0.93PheTyr: 0.93 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	9.403GlyAla: 9.403 ± 0.114	0.649GlyCys: 0.649 ± 0.025	4.593GlyAsp: 4.593 ± 0.073	4.677GlyGlu: 4.677 ± 0.07	3.656GlyPhe: 3.656 ± 0.053	7.267GlyGly: 7.267 ± 0.112	1.867GlyHis: 1.867 ± 0.045	4.943GlyIle: 4.943 ± 0.071	3.516GlyLys: 3.516 ± 0.065	9.311GlyLeu: 9.311 ± 0.112	2.506GlyMet: 2.506 ± 0.045	2.403GlyAsn: 2.403 ± 0.047	3.478GlyPro: 3.478 ± 0.054	3.228GlyGln: 3.228 ± 0.06	5.622GlyArg: 5.622 ± 0.075	4.589GlySer: 4.589 ± 0.065	4.819GlyThr: 4.819 ± 0.08	6.389GlyVal: 6.389 ± 0.078	1.386GlyTrp: 1.386 ± 0.038	2.412GlyTyr: 2.412 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.196HisAla: 2.196 ± 0.046	0.166HisCys: 0.166 ± 0.012	1.223HisAsp: 1.223 ± 0.036	1.026HisGlu: 1.026 ± 0.033	0.905HisPhe: 0.905 ± 0.026	1.789HisGly: 1.789 ± 0.044	0.553HisHis: 0.553 ± 0.027	1.139HisIle: 1.139 ± 0.033	0.528HisLys: 0.528 ± 0.019	2.042HisLeu: 2.042 ± 0.045	0.52HisMet: 0.52 ± 0.023	0.518HisAsn: 0.518 ± 0.022	1.218HisPro: 1.218 ± 0.032	0.622HisGln: 0.622 ± 0.025	1.374HisArg: 1.374 ± 0.039	0.89HisSer: 0.89 ± 0.032	0.87HisThr: 0.87 ± 0.027	1.483HisVal: 1.483 ± 0.04	0.317HisTrp: 0.317 ± 0.02	0.568HisTyr: 0.568 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	8.062IleAla: 8.062 ± 0.086	0.448IleCys: 0.448 ± 0.024	3.906IleAsp: 3.906 ± 0.063	3.694IleGlu: 3.694 ± 0.059	1.907IlePhe: 1.907 ± 0.047	5.405IleGly: 5.405 ± 0.082	0.95IleHis: 0.95 ± 0.032	2.695IleIle: 2.695 ± 0.056	1.6IleLys: 1.6 ± 0.041	4.698IleLeu: 4.698 ± 0.066	1.113IleMet: 1.113 ± 0.034	1.549IleAsn: 1.549 ± 0.036	2.434IlePro: 2.434 ± 0.055	1.241IleGln: 1.241 ± 0.031	3.17IleArg: 3.17 ± 0.058	3.073IleSer: 3.073 ± 0.055	2.885IleThr: 2.885 ± 0.053	4.602IleVal: 4.602 ± 0.069	0.652IleTrp: 0.652 ± 0.024	1.281IleTyr: 1.281 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	4.17LysAla: 4.17 ± 0.065	0.119LysCys: 0.119 ± 0.009	1.62LysAsp: 1.62 ± 0.041	1.322LysGlu: 1.322 ± 0.044	0.963LysPhe: 0.963 ± 0.027	2.509LysGly: 2.509 ± 0.052	0.613LysHis: 0.613 ± 0.023	1.561LysIle: 1.561 ± 0.036	1.084LysLys: 1.084 ± 0.038	3.232LysLeu: 3.232 ± 0.06	0.711LysMet: 0.711 ± 0.031	0.742LysAsn: 0.742 ± 0.028	1.976LysPro: 1.976 ± 0.051	0.935LysGln: 0.935 ± 0.028	2.135LysArg: 2.135 ± 0.042	1.874LysSer: 1.874 ± 0.042	1.768LysThr: 1.768 ± 0.042	2.48LysVal: 2.48 ± 0.056	0.376LysTrp: 0.376 ± 0.021	0.592LysTyr: 0.592 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	14.261LeuAla: 14.261 ± 0.135	0.737LeuCys: 0.737 ± 0.029	6.486LeuAsp: 6.486 ± 0.084	5.091LeuGlu: 5.091 ± 0.07	3.641LeuPhe: 3.641 ± 0.056	8.973LeuGly: 8.973 ± 0.104	1.838LeuHis: 1.838 ± 0.043	5.108LeuIle: 5.108 ± 0.074	3.277LeuLys: 3.277 ± 0.052	9.947LeuLeu: 9.947 ± 0.129	2.38LeuMet: 2.38 ± 0.051	2.713LeuAsn: 2.713 ± 0.046	5.575LeuPro: 5.575 ± 0.073	2.669LeuGln: 2.669 ± 0.054	6.605LeuArg: 6.605 ± 0.093	6.285LeuSer: 6.285 ± 0.081	5.873LeuThr: 5.873 ± 0.083	8.155LeuVal: 8.155 ± 0.102	1.158LeuTrp: 1.158 ± 0.029	2.086LeuTyr: 2.086 ± 0.043	0.001LeuXaa: 0.001 ± 0.001
Met	3.46MetAla: 3.46 ± 0.055	0.115MetCys: 0.115 ± 0.009	1.265MetAsp: 1.265 ± 0.034	1.113MetGlu: 1.113 ± 0.037	0.752MetPhe: 0.752 ± 0.026	1.986MetGly: 1.986 ± 0.041	0.446MetHis: 0.446 ± 0.023	1.383MetIle: 1.383 ± 0.034	0.856MetLys: 0.856 ± 0.03	2.783MetLeu: 2.783 ± 0.054	0.635MetMet: 0.635 ± 0.027	0.746MetAsn: 0.746 ± 0.025	1.521MetPro: 1.521 ± 0.035	0.868MetGln: 0.868 ± 0.025	1.754MetArg: 1.754 ± 0.041	1.712MetSer: 1.712 ± 0.038	2.023MetThr: 2.023 ± 0.045	1.998MetVal: 1.998 ± 0.047	0.218MetTrp: 0.218 ± 0.015	0.315MetTyr: 0.315 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.309AsnAla: 3.309 ± 0.057	0.215AsnCys: 0.215 ± 0.015	1.437AsnAsp: 1.437 ± 0.04	1.293AsnGlu: 1.293 ± 0.033	1.045AsnPhe: 1.045 ± 0.033	2.493AsnGly: 2.493 ± 0.052	0.539AsnHis: 0.539 ± 0.021	1.506AsnIle: 1.506 ± 0.035	0.736AsnLys: 0.736 ± 0.027	2.77AsnLeu: 2.77 ± 0.055	0.694AsnMet: 0.694 ± 0.024	0.748AsnAsn: 0.748 ± 0.029	1.899AsnPro: 1.899 ± 0.046	0.816AsnGln: 0.816 ± 0.024	1.814AsnArg: 1.814 ± 0.042	1.36AsnSer: 1.36 ± 0.038	1.31AsnThr: 1.31 ± 0.036	1.992AsnVal: 1.992 ± 0.045	0.481AsnTrp: 0.481 ± 0.019	0.774AsnTyr: 0.774 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	6.408ProAla: 6.408 ± 0.11	0.233ProCys: 0.233 ± 0.014	3.718ProAsp: 3.718 ± 0.058	3.472ProGlu: 3.472 ± 0.063	1.928ProPhe: 1.928 ± 0.044	4.325ProGly: 4.325 ± 0.054	1.072ProHis: 1.072 ± 0.031	2.476ProIle: 2.476 ± 0.049	1.486ProLys: 1.486 ± 0.041	4.756ProLeu: 4.756 ± 0.068	1.254ProMet: 1.254 ± 0.035	1.419ProAsn: 1.419 ± 0.037	2.214ProPro: 2.214 ± 0.049	1.587ProGln: 1.587 ± 0.038	2.68ProArg: 2.68 ± 0.051	2.671ProSer: 2.671 ± 0.053	2.537ProThr: 2.537 ± 0.052	4.203ProVal: 4.203 ± 0.064	0.601ProTrp: 0.601 ± 0.023	1.193ProTyr: 1.193 ± 0.034	0.001ProXaa: 0.001 ± 0.001
Gln	4.079GlnAla: 4.079 ± 0.062	0.18GlnCys: 0.18 ± 0.013	1.506GlnAsp: 1.506 ± 0.035	1.332GlnGlu: 1.332 ± 0.032	1.243GlnPhe: 1.243 ± 0.035	2.438GlnGly: 2.438 ± 0.051	0.677GlnHis: 0.677 ± 0.022	1.808GlnIle: 1.808 ± 0.047	0.957GlnLys: 0.957 ± 0.026	3.172GlnLeu: 3.172 ± 0.056	0.999GlnMet: 0.999 ± 0.028	0.838GlnAsn: 0.838 ± 0.029	1.694GlnPro: 1.694 ± 0.042	1.27GlnGln: 1.27 ± 0.037	2.496GlnArg: 2.496 ± 0.049	1.811GlnSer: 1.811 ± 0.039	1.739GlnThr: 1.739 ± 0.042	2.388GlnVal: 2.388 ± 0.047	0.386GlnTrp: 0.386 ± 0.019	0.659GlnTyr: 0.659 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	7.315ArgAla: 7.315 ± 0.088	0.391ArgCys: 0.391 ± 0.018	3.907ArgAsp: 3.907 ± 0.064	3.604ArgGlu: 3.604 ± 0.068	2.79ArgPhe: 2.79 ± 0.049	4.533ArgGly: 4.533 ± 0.073	1.576ArgHis: 1.576 ± 0.041	3.889ArgIle: 3.889 ± 0.062	2.196ArgLys: 2.196 ± 0.039	7.553ArgLeu: 7.553 ± 0.099	1.759ArgMet: 1.759 ± 0.043	1.922ArgAsn: 1.922 ± 0.042	3.244ArgPro: 3.244 ± 0.054	2.734ArgGln: 2.734 ± 0.048	4.864ArgArg: 4.864 ± 0.087	3.363ArgSer: 3.363 ± 0.054	3.208ArgThr: 3.208 ± 0.06	4.407ArgVal: 4.407 ± 0.068	0.827ArgTrp: 0.827 ± 0.03	1.612ArgTyr: 1.612 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	6.022SerAla: 6.022 ± 0.076	0.317SerCys: 0.317 ± 0.018	2.892SerAsp: 2.892 ± 0.049	2.696SerGlu: 2.696 ± 0.054	2.343SerPhe: 2.343 ± 0.048	5.617SerGly: 5.617 ± 0.081	1.06SerHis: 1.06 ± 0.031	3.029SerIle: 3.029 ± 0.052	1.545SerLys: 1.545 ± 0.038	5.353SerLeu: 5.353 ± 0.07	1.332SerMet: 1.332 ± 0.033	1.408SerAsn: 1.408 ± 0.041	2.574SerPro: 2.574 ± 0.052	1.761SerGln: 1.761 ± 0.036	3.349SerArg: 3.349 ± 0.058	2.85SerSer: 2.85 ± 0.054	2.727SerThr: 2.727 ± 0.047	4.142SerVal: 4.142 ± 0.061	0.761SerTrp: 0.761 ± 0.026	1.324SerTyr: 1.324 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	6.271ThrAla: 6.271 ± 0.083	0.348ThrCys: 0.348 ± 0.018	2.975ThrAsp: 2.975 ± 0.048	2.73ThrGlu: 2.73 ± 0.052	1.981ThrPhe: 1.981 ± 0.041	5.251ThrGly: 5.251 ± 0.069	1.043ThrHis: 1.043 ± 0.032	3.403ThrIle: 3.403 ± 0.054	1.393ThrLys: 1.393 ± 0.033	6.111ThrLeu: 6.111 ± 0.078	1.299ThrMet: 1.299 ± 0.035	1.428ThrAsn: 1.428 ± 0.039	3.274ThrPro: 3.274 ± 0.051	1.486ThrGln: 1.486 ± 0.034	3.34ThrArg: 3.34 ± 0.047	2.917ThrSer: 2.917 ± 0.046	3.079ThrThr: 3.079 ± 0.056	4.301ThrVal: 4.301 ± 0.067	0.668ThrTrp: 0.668 ± 0.025	1.207ThrTyr: 1.207 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	9.588ValAla: 9.588 ± 0.104	0.54ValCys: 0.54 ± 0.024	4.33ValAsp: 4.33 ± 0.067	4.558ValGlu: 4.558 ± 0.068	2.763ValPhe: 2.763 ± 0.058	6.003ValGly: 6.003 ± 0.078	1.413ValHis: 1.413 ± 0.039	4.337ValIle: 4.337 ± 0.067	2.15ValLys: 2.15 ± 0.05	7.848ValLeu: 7.848 ± 0.087	2.013ValMet: 2.013 ± 0.048	2.035ValAsn: 2.035 ± 0.042	3.871ValPro: 3.871 ± 0.067	1.97ValGln: 1.97 ± 0.047	4.591ValArg: 4.591 ± 0.057	4.347ValSer: 4.347 ± 0.06	4.873ValThr: 4.873 ± 0.066	6.331ValVal: 6.331 ± 0.082	0.89ValTrp: 0.89 ± 0.03	1.562ValTyr: 1.562 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.294TrpAla: 1.294 ± 0.038	0.114TrpCys: 0.114 ± 0.009	0.674TrpAsp: 0.674 ± 0.024	0.533TrpGlu: 0.533 ± 0.023	0.507TrpPhe: 0.507 ± 0.023	0.876TrpGly: 0.876 ± 0.036	0.322TrpHis: 0.322 ± 0.015	0.649TrpIle: 0.649 ± 0.023	0.382TrpLys: 0.382 ± 0.018	1.582TrpLeu: 1.582 ± 0.041	0.366TrpMet: 0.366 ± 0.02	0.468TrpAsn: 0.468 ± 0.019	0.728TrpPro: 0.728 ± 0.025	0.607TrpGln: 0.607 ± 0.026	0.995TrpArg: 0.995 ± 0.032	0.832TrpSer: 0.832 ± 0.029	0.784TrpThr: 0.784 ± 0.025	0.889TrpVal: 0.889 ± 0.031	0.239TrpTrp: 0.239 ± 0.017	0.292TrpTyr: 0.292 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.617TyrAla: 2.617 ± 0.046	0.207TyrCys: 0.207 ± 0.013	1.466TyrAsp: 1.466 ± 0.041	1.279TyrGlu: 1.279 ± 0.036	1.012TyrPhe: 1.012 ± 0.028	2.157TyrGly: 2.157 ± 0.04	0.481TyrHis: 0.481 ± 0.022	0.902TyrIle: 0.902 ± 0.028	0.586TyrLys: 0.586 ± 0.023	2.329TyrLeu: 2.329 ± 0.047	0.494TyrMet: 0.494 ± 0.02	0.638TyrAsn: 0.638 ± 0.025	1.123TyrPro: 1.123 ± 0.032	0.715TyrGln: 0.715 ± 0.022	1.702TyrArg: 1.702 ± 0.038	1.166TyrSer: 1.166 ± 0.033	1.12TyrThr: 1.12 ± 0.031	1.723TyrVal: 1.723 ± 0.041	0.373TyrTrp: 0.373 ± 0.019	0.617TyrTyr: 0.617 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3690 proteins (1134231 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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