Amino acid dipepetide frequency for Intestinibaculum porci

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.059AlaAla: 5.059 ± 0.104
0.948AlaCys: 0.948 ± 0.034
3.517AlaAsp: 3.517 ± 0.066
3.12AlaGlu: 3.12 ± 0.067
3.247AlaPhe: 3.247 ± 0.065
4.358AlaGly: 4.358 ± 0.079
1.957AlaHis: 1.957 ± 0.046
5.998AlaIle: 5.998 ± 0.092
5.822AlaLys: 5.822 ± 0.108
8.03AlaLeu: 8.03 ± 0.116
2.527AlaMet: 2.527 ± 0.052
2.946AlaAsn: 2.946 ± 0.062
2.009AlaPro: 2.009 ± 0.054
2.563AlaGln: 2.563 ± 0.058
2.522AlaArg: 2.522 ± 0.049
4.586AlaSer: 4.586 ± 0.081
3.609AlaThr: 3.609 ± 0.067
4.211AlaVal: 4.211 ± 0.085
0.484AlaTrp: 0.484 ± 0.022
3.443AlaTyr: 3.443 ± 0.073
0.0AlaXaa: 0.0 ± 0.0
Cys
0.895CysAla: 0.895 ± 0.033
0.161CysCys: 0.161 ± 0.014
0.9CysAsp: 0.9 ± 0.036
0.816CysGlu: 0.816 ± 0.032
0.608CysPhe: 0.608 ± 0.026
1.002CysGly: 1.002 ± 0.045
0.365CysHis: 0.365 ± 0.02
0.897CysIle: 0.897 ± 0.035
0.631CysLys: 0.631 ± 0.03
1.23CysLeu: 1.23 ± 0.037
0.348CysMet: 0.348 ± 0.019
0.46CysAsn: 0.46 ± 0.021
0.5CysPro: 0.5 ± 0.024
0.43CysGln: 0.43 ± 0.023
0.443CysArg: 0.443 ± 0.022
0.618CysSer: 0.618 ± 0.026
0.628CysThr: 0.628 ± 0.03
0.877CysVal: 0.877 ± 0.033
0.087CysTrp: 0.087 ± 0.009
0.497CysTyr: 0.497 ± 0.025
0.0CysXaa: 0.0 ± 0.0
Asp
4.254AspAla: 4.254 ± 0.065
0.7AspCys: 0.7 ± 0.031
4.243AspAsp: 4.243 ± 0.077
5.011AspGlu: 5.011 ± 0.085
3.019AspPhe: 3.019 ± 0.063
3.819AspGly: 3.819 ± 0.083
2.32AspHis: 2.32 ± 0.06
4.331AspIle: 4.331 ± 0.077
3.036AspLys: 3.036 ± 0.067
6.203AspLeu: 6.203 ± 0.097
1.712AspMet: 1.712 ± 0.046
2.323AspAsn: 2.323 ± 0.058
2.215AspPro: 2.215 ± 0.052
2.468AspGln: 2.468 ± 0.063
2.429AspArg: 2.429 ± 0.053
2.703AspSer: 2.703 ± 0.062
3.025AspThr: 3.025 ± 0.065
4.368AspVal: 4.368 ± 0.082
0.392AspTrp: 0.392 ± 0.019
3.68AspTyr: 3.68 ± 0.066
0.0AspXaa: 0.0 ± 0.0
Glu
4.958GluAla: 4.958 ± 0.098
0.695GluCys: 0.695 ± 0.029
4.306GluAsp: 4.306 ± 0.086
5.561GluGlu: 5.561 ± 0.098
1.914GluPhe: 1.914 ± 0.049
3.605GluGly: 3.605 ± 0.074
1.47GluHis: 1.47 ± 0.044
4.666GluIle: 4.666 ± 0.082
6.111GluLys: 6.111 ± 0.089
5.051GluLeu: 5.051 ± 0.092
2.184GluMet: 2.184 ± 0.044
3.432GluAsn: 3.432 ± 0.061
1.266GluPro: 1.266 ± 0.042
1.746GluGln: 1.746 ± 0.044
2.604GluArg: 2.604 ± 0.056
2.889GluSer: 2.889 ± 0.065
3.329GluThr: 3.329 ± 0.077
3.881GluVal: 3.881 ± 0.077
0.415GluTrp: 0.415 ± 0.021
2.464GluTyr: 2.464 ± 0.062
0.0GluXaa: 0.0 ± 0.0
Phe
2.895PheAla: 2.895 ± 0.057
0.547PheCys: 0.547 ± 0.027
3.211PheAsp: 3.211 ± 0.064
2.43PheGlu: 2.43 ± 0.056
1.891PhePhe: 1.891 ± 0.051
2.631PheGly: 2.631 ± 0.061
0.987PheHis: 0.987 ± 0.034
3.141PheIle: 3.141 ± 0.072
3.008PheLys: 3.008 ± 0.057
3.649PheLeu: 3.649 ± 0.082
1.278PheMet: 1.278 ± 0.039
2.124PheAsn: 2.124 ± 0.051
1.249PhePro: 1.249 ± 0.035
1.078PheGln: 1.078 ± 0.039
1.354PheArg: 1.354 ± 0.035
2.666PheSer: 2.666 ± 0.058
2.708PheThr: 2.708 ± 0.059
2.918PheVal: 2.918 ± 0.056
0.279PheTrp: 0.279 ± 0.017
2.102PheTyr: 2.102 ± 0.058
0.0PheXaa: 0.0 ± 0.0
Gly
4.182GlyAla: 4.182 ± 0.103
0.89GlyCys: 0.89 ± 0.034
3.486GlyAsp: 3.486 ± 0.07
3.543GlyGlu: 3.543 ± 0.068
2.775GlyPhe: 2.775 ± 0.061
3.643GlyGly: 3.643 ± 0.082
1.74GlyHis: 1.74 ± 0.05
4.99GlyIle: 4.99 ± 0.077
4.902GlyLys: 4.902 ± 0.074
5.422GlyLeu: 5.422 ± 0.084
1.999GlyMet: 1.999 ± 0.051
2.53GlyAsn: 2.53 ± 0.061
1.244GlyPro: 1.244 ± 0.041
1.876GlyGln: 1.876 ± 0.046
2.309GlyArg: 2.309 ± 0.06
3.483GlySer: 3.483 ± 0.072
3.671GlyThr: 3.671 ± 0.087
4.227GlyVal: 4.227 ± 0.074
0.514GlyTrp: 0.514 ± 0.027
3.27GlyTyr: 3.27 ± 0.06
0.0GlyXaa: 0.0 ± 0.0
His
1.607HisAla: 1.607 ± 0.044
0.359HisCys: 0.359 ± 0.021
1.668HisAsp: 1.668 ± 0.044
1.524HisGlu: 1.524 ± 0.043
1.305HisPhe: 1.305 ± 0.046
1.547HisGly: 1.547 ± 0.046
1.075HisHis: 1.075 ± 0.048
1.959HisIle: 1.959 ± 0.049
1.642HisLys: 1.642 ± 0.043
2.605HisLeu: 2.605 ± 0.067
0.774HisMet: 0.774 ± 0.031
1.073HisAsn: 1.073 ± 0.035
1.209HisPro: 1.209 ± 0.038
1.211HisGln: 1.211 ± 0.045
0.981HisArg: 0.981 ± 0.032
1.295HisSer: 1.295 ± 0.038
1.339HisThr: 1.339 ± 0.039
1.741HisVal: 1.741 ± 0.048
0.161HisTrp: 0.161 ± 0.013
1.544HisTyr: 1.544 ± 0.042
0.0HisXaa: 0.0 ± 0.0
Ile
5.851IleAla: 5.851 ± 0.096
1.026IleCys: 1.026 ± 0.039
5.128IleAsp: 5.128 ± 0.081
4.697IleGlu: 4.697 ± 0.085
2.98IlePhe: 2.98 ± 0.07
4.624IleGly: 4.624 ± 0.085
1.907IleHis: 1.907 ± 0.049
5.64IleIle: 5.64 ± 0.099
5.227IleLys: 5.227 ± 0.082
6.466IleLeu: 6.466 ± 0.106
2.04IleMet: 2.04 ± 0.053
3.667IleAsn: 3.667 ± 0.068
2.755IlePro: 2.755 ± 0.062
2.027IleGln: 2.027 ± 0.051
2.99IleArg: 2.99 ± 0.07
4.629IleSer: 4.629 ± 0.084
4.728IleThr: 4.728 ± 0.103
5.149IleVal: 5.149 ± 0.086
0.42IleTrp: 0.42 ± 0.022
3.164IleTyr: 3.164 ± 0.07
0.0IleXaa: 0.0 ± 0.0
Lys
6.355LysAla: 6.355 ± 0.093
0.725LysCys: 0.725 ± 0.031
5.232LysAsp: 5.232 ± 0.08
6.196LysGlu: 6.196 ± 0.083
1.97LysPhe: 1.97 ± 0.045
4.698LysGly: 4.698 ± 0.087
1.776LysHis: 1.776 ± 0.043
5.069LysIle: 5.069 ± 0.072
7.985LysLys: 7.985 ± 0.127
5.511LysLeu: 5.511 ± 0.072
2.592LysMet: 2.592 ± 0.052
4.041LysAsn: 4.041 ± 0.079
2.103LysPro: 2.103 ± 0.051
3.063LysGln: 3.063 ± 0.059
3.641LysArg: 3.641 ± 0.072
3.915LysSer: 3.915 ± 0.071
4.488LysThr: 4.488 ± 0.093
5.249LysVal: 5.249 ± 0.102
0.596LysTrp: 0.596 ± 0.026
3.4LysTyr: 3.4 ± 0.069
0.0LysXaa: 0.0 ± 0.0
Leu
6.717LeuAla: 6.717 ± 0.098
1.325LeuCys: 1.325 ± 0.045
5.462LeuAsp: 5.462 ± 0.094
5.44LeuGlu: 5.44 ± 0.092
4.024LeuPhe: 4.024 ± 0.083
5.457LeuGly: 5.457 ± 0.091
2.046LeuHis: 2.046 ± 0.051
6.38LeuIle: 6.38 ± 0.111
7.719LeuLys: 7.719 ± 0.094
8.338LeuLeu: 8.338 ± 0.128
2.839LeuMet: 2.839 ± 0.058
4.316LeuAsn: 4.316 ± 0.072
3.226LeuPro: 3.226 ± 0.06
2.535LeuGln: 2.535 ± 0.058
3.593LeuArg: 3.593 ± 0.064
6.826LeuSer: 6.826 ± 0.107
5.602LeuThr: 5.602 ± 0.096
5.292LeuVal: 5.292 ± 0.085
0.541LeuTrp: 0.541 ± 0.024
3.981LeuTyr: 3.981 ± 0.075
0.0LeuXaa: 0.0 ± 0.0
Met
2.155MetAla: 2.155 ± 0.062
0.3MetCys: 0.3 ± 0.02
1.812MetAsp: 1.812 ± 0.041
1.511MetGlu: 1.511 ± 0.042
1.023MetPhe: 1.023 ± 0.046
1.612MetGly: 1.612 ± 0.044
0.781MetHis: 0.781 ± 0.03
2.636MetIle: 2.636 ± 0.06
3.024MetLys: 3.024 ± 0.059
2.344MetLeu: 2.344 ± 0.056
1.12MetMet: 1.12 ± 0.038
1.831MetAsn: 1.831 ± 0.052
1.2MetPro: 1.2 ± 0.041
1.07MetGln: 1.07 ± 0.036
1.322MetArg: 1.322 ± 0.043
1.965MetSer: 1.965 ± 0.047
1.851MetThr: 1.851 ± 0.044
1.73MetVal: 1.73 ± 0.045
0.16MetTrp: 0.16 ± 0.013
1.06MetTyr: 1.06 ± 0.036
0.0MetXaa: 0.0 ± 0.0
Asn
3.434AsnAla: 3.434 ± 0.068
0.497AsnCys: 0.497 ± 0.024
3.07AsnAsp: 3.07 ± 0.067
2.979AsnGlu: 2.979 ± 0.066
1.73AsnPhe: 1.73 ± 0.047
3.326AsnGly: 3.326 ± 0.072
1.263AsnHis: 1.263 ± 0.037
3.463AsnIle: 3.463 ± 0.063
3.869AsnLys: 3.869 ± 0.079
3.506AsnLeu: 3.506 ± 0.06
1.265AsnMet: 1.265 ± 0.04
2.344AsnAsn: 2.344 ± 0.064
1.787AsnPro: 1.787 ± 0.047
1.643AsnGln: 1.643 ± 0.039
1.888AsnArg: 1.888 ± 0.046
2.41AsnSer: 2.41 ± 0.071
2.858AsnThr: 2.858 ± 0.073
3.167AsnVal: 3.167 ± 0.066
0.379AsnTrp: 0.379 ± 0.021
2.29AsnTyr: 2.29 ± 0.057
0.0AsnXaa: 0.0 ± 0.0
Pro
2.076ProAla: 2.076 ± 0.049
0.32ProCys: 0.32 ± 0.021
2.02ProAsp: 2.02 ± 0.048
2.32ProGlu: 2.32 ± 0.055
1.588ProPhe: 1.588 ± 0.044
1.831ProGly: 1.831 ± 0.055
0.931ProHis: 0.931 ± 0.032
2.157ProIle: 2.157 ± 0.05
1.985ProLys: 1.985 ± 0.052
3.076ProLeu: 3.076 ± 0.065
0.846ProMet: 0.846 ± 0.032
1.314ProAsn: 1.314 ± 0.038
0.493ProPro: 0.493 ± 0.023
1.107ProGln: 1.107 ± 0.036
1.144ProArg: 1.144 ± 0.041
1.794ProSer: 1.794 ± 0.046
1.749ProThr: 1.749 ± 0.052
2.326ProVal: 2.326 ± 0.062
0.262ProTrp: 0.262 ± 0.02
1.597ProTyr: 1.597 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
2.695GlnAla: 2.695 ± 0.051
0.325GlnCys: 0.325 ± 0.02
1.795GlnAsp: 1.795 ± 0.046
2.286GlnGlu: 2.286 ± 0.055
1.204GlnPhe: 1.204 ± 0.036
2.011GlnGly: 2.011 ± 0.045
0.542GlnHis: 0.542 ± 0.025
2.403GlnIle: 2.403 ± 0.051
2.891GlnLys: 2.891 ± 0.067
3.109GlnLeu: 3.109 ± 0.065
1.113GlnMet: 1.113 ± 0.037
1.497GlnAsn: 1.497 ± 0.042
0.931GlnPro: 0.931 ± 0.031
0.91GlnGln: 0.91 ± 0.029
1.34GlnArg: 1.34 ± 0.041
1.865GlnSer: 1.865 ± 0.047
1.684GlnThr: 1.684 ± 0.04
2.373GlnVal: 2.373 ± 0.052
0.268GlnTrp: 0.268 ± 0.017
1.569GlnTyr: 1.569 ± 0.04
0.0GlnXaa: 0.0 ± 0.0
Arg
2.315ArgAla: 2.315 ± 0.06
0.524ArgCys: 0.524 ± 0.023
2.313ArgAsp: 2.313 ± 0.052
2.54ArgGlu: 2.54 ± 0.055
1.884ArgPhe: 1.884 ± 0.046
2.022ArgGly: 2.022 ± 0.049
1.139ArgHis: 1.139 ± 0.038
3.136ArgIle: 3.136 ± 0.063
3.16ArgLys: 3.16 ± 0.066
3.69ArgLeu: 3.69 ± 0.066
1.26ArgMet: 1.26 ± 0.039
1.981ArgAsn: 1.981 ± 0.057
1.04ArgPro: 1.04 ± 0.033
1.526ArgGln: 1.526 ± 0.05
1.942ArgArg: 1.942 ± 0.058
2.187ArgSer: 2.187 ± 0.047
1.786ArgThr: 1.786 ± 0.049
2.429ArgVal: 2.429 ± 0.053
0.323ArgTrp: 0.323 ± 0.021
2.229ArgTyr: 2.229 ± 0.051
0.0ArgXaa: 0.0 ± 0.0
Ser
3.88SerAla: 3.88 ± 0.071
0.681SerCys: 0.681 ± 0.03
3.52SerAsp: 3.52 ± 0.076
3.327SerGlu: 3.327 ± 0.071
2.952SerPhe: 2.952 ± 0.065
3.84SerGly: 3.84 ± 0.076
1.648SerHis: 1.648 ± 0.039
4.141SerIle: 4.141 ± 0.072
4.049SerLys: 4.049 ± 0.084
6.364SerLeu: 6.364 ± 0.114
1.658SerMet: 1.658 ± 0.048
2.371SerAsn: 2.371 ± 0.059
1.662SerPro: 1.662 ± 0.044
2.203SerGln: 2.203 ± 0.052
2.357SerArg: 2.357 ± 0.05
4.145SerSer: 4.145 ± 0.121
3.066SerThr: 3.066 ± 0.062
3.703SerVal: 3.703 ± 0.066
0.425SerTrp: 0.425 ± 0.025
3.082SerTyr: 3.082 ± 0.071
0.0SerXaa: 0.0 ± 0.0
Thr
3.637ThrAla: 3.637 ± 0.078
0.745ThrCys: 0.745 ± 0.038
2.897ThrAsp: 2.897 ± 0.07
2.179ThrGlu: 2.179 ± 0.055
2.736ThrPhe: 2.736 ± 0.061
3.681ThrGly: 3.681 ± 0.075
1.453ThrHis: 1.453 ± 0.04
4.982ThrIle: 4.982 ± 0.099
4.327ThrLys: 4.327 ± 0.086
5.89ThrLeu: 5.89 ± 0.1
1.542ThrMet: 1.542 ± 0.037
2.753ThrAsn: 2.753 ± 0.079
2.237ThrPro: 2.237 ± 0.067
1.687ThrGln: 1.687 ± 0.05
1.925ThrArg: 1.925 ± 0.046
3.669ThrSer: 3.669 ± 0.105
3.337ThrThr: 3.337 ± 0.084
3.674ThrVal: 3.674 ± 0.08
0.382ThrTrp: 0.382 ± 0.023
3.096ThrTyr: 3.096 ± 0.075
0.0ThrXaa: 0.0 ± 0.0
Val
4.42ValAla: 4.42 ± 0.088
0.877ValCys: 0.877 ± 0.037
3.904ValAsp: 3.904 ± 0.075
3.727ValGlu: 3.727 ± 0.075
2.825ValPhe: 2.825 ± 0.061
3.626ValGly: 3.626 ± 0.072
1.465ValHis: 1.465 ± 0.041
5.396ValIle: 5.396 ± 0.078
5.283ValLys: 5.283 ± 0.087
6.009ValLeu: 6.009 ± 0.098
1.922ValMet: 1.922 ± 0.044
3.429ValAsn: 3.429 ± 0.071
2.102ValPro: 2.102 ± 0.05
1.495ValGln: 1.495 ± 0.043
2.329ValArg: 2.329 ± 0.054
4.302ValSer: 4.302 ± 0.067
4.186ValThr: 4.186 ± 0.105
4.188ValVal: 4.188 ± 0.069
0.386ValTrp: 0.386 ± 0.025
3.013ValTyr: 3.013 ± 0.062
0.0ValXaa: 0.0 ± 0.0
Trp
0.402TrpAla: 0.402 ± 0.023
0.111TrpCys: 0.111 ± 0.013
0.405TrpAsp: 0.405 ± 0.021
0.38TrpGlu: 0.38 ± 0.023
0.272TrpPhe: 0.272 ± 0.017
0.429TrpGly: 0.429 ± 0.024
0.209TrpHis: 0.209 ± 0.014
0.513TrpIle: 0.513 ± 0.025
0.541TrpLys: 0.541 ± 0.026
0.672TrpLeu: 0.672 ± 0.028
0.214TrpMet: 0.214 ± 0.016
0.414TrpAsn: 0.414 ± 0.025
0.18TrpPro: 0.18 ± 0.014
0.335TrpGln: 0.335 ± 0.019
0.251TrpArg: 0.251 ± 0.016
0.408TrpSer: 0.408 ± 0.025
0.343TrpThr: 0.343 ± 0.021
0.365TrpVal: 0.365 ± 0.022
0.08TrpTrp: 0.08 ± 0.01
0.353TrpTyr: 0.353 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.166TyrAla: 3.166 ± 0.063
0.636TyrCys: 0.636 ± 0.027
3.365TyrAsp: 3.365 ± 0.077
2.958TyrGlu: 2.958 ± 0.071
2.2TyrPhe: 2.2 ± 0.055
2.934TyrGly: 2.934 ± 0.069
1.547TyrHis: 1.547 ± 0.051
3.218TyrIle: 3.218 ± 0.062
3.397TyrLys: 3.397 ± 0.071
4.493TyrLeu: 4.493 ± 0.073
1.271TyrMet: 1.271 ± 0.036
2.322TyrAsn: 2.322 ± 0.052
1.529TyrPro: 1.529 ± 0.039
1.837TyrGln: 1.837 ± 0.05
2.06TyrArg: 2.06 ± 0.049
2.719TyrSer: 2.719 ± 0.06
2.843TyrThr: 2.843 ± 0.067
3.015TyrVal: 3.015 ± 0.066
0.325TyrTrp: 0.325 ± 0.019
2.666TyrTyr: 2.666 ± 0.069
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2890 proteins (889665 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski