Amino acid dipepetide frequency for Streptomyces sp. Tu 6176

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.965AlaAla: 22.965 ± 0.164	1.11AlaCys: 1.11 ± 0.026	8.678AlaAsp: 8.678 ± 0.077	8.799AlaGlu: 8.799 ± 0.1	3.517AlaPhe: 3.517 ± 0.045	13.576AlaGly: 13.576 ± 0.103	3.23AlaHis: 3.23 ± 0.045	2.956AlaIle: 2.956 ± 0.038	2.675AlaLys: 2.675 ± 0.042	15.226AlaLeu: 15.226 ± 0.115	2.377AlaMet: 2.377 ± 0.034	1.752AlaAsn: 1.752 ± 0.031	7.421AlaPro: 7.421 ± 0.069	3.881AlaGln: 3.881 ± 0.044	11.211AlaArg: 11.211 ± 0.091	5.792AlaSer: 5.792 ± 0.057	6.89AlaThr: 6.89 ± 0.062	12.923AlaVal: 12.923 ± 0.091	1.812AlaTrp: 1.812 ± 0.027	2.807AlaTyr: 2.807 ± 0.036	0.0AlaXaa: 0.0 ± 0.0
Cys	1.187CysAla: 1.187 ± 0.026	0.093CysCys: 0.093 ± 0.007	0.478CysAsp: 0.478 ± 0.017	0.408CysGlu: 0.408 ± 0.014	0.236CysPhe: 0.236 ± 0.012	0.991CysGly: 0.991 ± 0.025	0.208CysHis: 0.208 ± 0.01	0.14CysIle: 0.14 ± 0.008	0.1CysLys: 0.1 ± 0.007	0.799CysLeu: 0.799 ± 0.022	0.135CysMet: 0.135 ± 0.008	0.134CysAsn: 0.134 ± 0.009	0.519CysPro: 0.519 ± 0.019	0.149CysGln: 0.149 ± 0.008	0.62CysArg: 0.62 ± 0.018	0.441CysSer: 0.441 ± 0.016	0.547CysThr: 0.547 ± 0.016	0.695CysVal: 0.695 ± 0.019	0.12CysTrp: 0.12 ± 0.008	0.151CysTyr: 0.151 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.825AspAla: 7.825 ± 0.072	0.441AspCys: 0.441 ± 0.015	3.512AspAsp: 3.512 ± 0.046	3.694AspGlu: 3.694 ± 0.045	1.646AspPhe: 1.646 ± 0.032	6.563AspGly: 6.563 ± 0.064	1.478AspHis: 1.478 ± 0.024	1.873AspIle: 1.873 ± 0.035	1.157AspLys: 1.157 ± 0.024	6.292AspLeu: 6.292 ± 0.053	0.769AspMet: 0.769 ± 0.017	0.933AspAsn: 0.933 ± 0.022	4.57AspPro: 4.57 ± 0.054	1.481AspGln: 1.481 ± 0.027	5.183AspArg: 5.183 ± 0.058	2.426AspSer: 2.426 ± 0.032	3.409AspThr: 3.409 ± 0.044	4.693AspVal: 4.693 ± 0.049	1.011AspTrp: 1.011 ± 0.021	1.065AspTyr: 1.065 ± 0.025	0.0AspXaa: 0.0 ± 0.0
Glu	7.17GluAla: 7.17 ± 0.084	0.341GluCys: 0.341 ± 0.013	2.87GluAsp: 2.87 ± 0.04	3.536GluGlu: 3.536 ± 0.059	1.409GluPhe: 1.409 ± 0.03	4.244GluGly: 4.244 ± 0.044	1.587GluHis: 1.587 ± 0.03	2.143GluIle: 2.143 ± 0.039	1.332GluLys: 1.332 ± 0.03	6.539GluLeu: 6.539 ± 0.07	0.843GluMet: 0.843 ± 0.02	0.999GluAsn: 0.999 ± 0.024	3.234GluPro: 3.234 ± 0.044	2.274GluGln: 2.274 ± 0.037	5.603GluArg: 5.603 ± 0.062	2.413GluSer: 2.413 ± 0.038	2.805GluThr: 2.805 ± 0.039	4.233GluVal: 4.233 ± 0.051	0.702GluTrp: 0.702 ± 0.016	1.059GluTyr: 1.059 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	3.698PheAla: 3.698 ± 0.043	0.264PheCys: 0.264 ± 0.012	1.905PheAsp: 1.905 ± 0.032	1.369PheGlu: 1.369 ± 0.025	0.874PhePhe: 0.874 ± 0.024	2.955PheGly: 2.955 ± 0.048	0.649PheHis: 0.649 ± 0.019	0.617PheIle: 0.617 ± 0.02	0.5PheLys: 0.5 ± 0.018	2.637PheLeu: 2.637 ± 0.041	0.379PheMet: 0.379 ± 0.014	0.514PheAsn: 0.514 ± 0.018	1.429PhePro: 1.429 ± 0.024	0.629PheGln: 0.629 ± 0.017	1.886PheArg: 1.886 ± 0.032	1.446PheSer: 1.446 ± 0.024	2.071PheThr: 2.071 ± 0.036	2.243PheVal: 2.243 ± 0.035	0.425PheTrp: 0.425 ± 0.012	0.585PheTyr: 0.585 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	11.819GlyAla: 11.819 ± 0.087	0.877GlyCys: 0.877 ± 0.024	5.282GlyAsp: 5.282 ± 0.055	5.018GlyGlu: 5.018 ± 0.053	2.884GlyPhe: 2.884 ± 0.038	9.061GlyGly: 9.061 ± 0.102	2.51GlyHis: 2.51 ± 0.037	3.29GlyIle: 3.29 ± 0.045	2.315GlyLys: 2.315 ± 0.038	9.479GlyLeu: 9.479 ± 0.083	1.898GlyMet: 1.898 ± 0.025	1.666GlyAsn: 1.666 ± 0.031	5.429GlyPro: 5.429 ± 0.065	2.688GlyGln: 2.688 ± 0.043	8.179GlyArg: 8.179 ± 0.058	5.346GlySer: 5.346 ± 0.057	6.927GlyThr: 6.927 ± 0.067	7.577GlyVal: 7.577 ± 0.07	1.67GlyTrp: 1.67 ± 0.034	2.311GlyTyr: 2.311 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	2.757HisAla: 2.757 ± 0.039	0.223HisCys: 0.223 ± 0.01	1.442HisAsp: 1.442 ± 0.026	1.249HisGlu: 1.249 ± 0.028	0.669HisPhe: 0.669 ± 0.017	2.624HisGly: 2.624 ± 0.035	0.717HisHis: 0.717 ± 0.022	0.657HisIle: 0.657 ± 0.017	0.347HisLys: 0.347 ± 0.012	2.51HisLeu: 2.51 ± 0.037	0.332HisMet: 0.332 ± 0.015	0.36HisAsn: 0.36 ± 0.014	1.892HisPro: 1.892 ± 0.035	0.646HisGln: 0.646 ± 0.016	2.337HisArg: 2.337 ± 0.038	1.034HisSer: 1.034 ± 0.02	1.458HisThr: 1.458 ± 0.028	1.703HisVal: 1.703 ± 0.027	0.384HisTrp: 0.384 ± 0.013	0.488HisTyr: 0.488 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	4.408IleAla: 4.408 ± 0.051	0.266IleCys: 0.266 ± 0.013	2.077IleAsp: 2.077 ± 0.032	1.787IleGlu: 1.787 ± 0.034	0.606IlePhe: 0.606 ± 0.019	3.444IleGly: 3.444 ± 0.045	0.557IleHis: 0.557 ± 0.016	0.762IleIle: 0.762 ± 0.024	0.669IleLys: 0.669 ± 0.019	2.263IleLeu: 2.263 ± 0.037	0.41IleMet: 0.41 ± 0.015	0.609IleAsn: 0.609 ± 0.017	1.537IlePro: 1.537 ± 0.027	0.643IleGln: 0.643 ± 0.017	2.115IleArg: 2.115 ± 0.037	1.522IleSer: 1.522 ± 0.029	2.027IleThr: 2.027 ± 0.034	2.576IleVal: 2.576 ± 0.037	0.353IleTrp: 0.353 ± 0.013	0.481IleTyr: 0.481 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	2.743LysAla: 2.743 ± 0.041	0.133LysCys: 0.133 ± 0.009	1.353LysAsp: 1.353 ± 0.026	1.162LysGlu: 1.162 ± 0.028	0.428LysPhe: 0.428 ± 0.016	1.756LysGly: 1.756 ± 0.033	0.382LysHis: 0.382 ± 0.013	0.799LysIle: 0.799 ± 0.017	0.83LysLys: 0.83 ± 0.024	1.855LysLeu: 1.855 ± 0.035	0.342LysMet: 0.342 ± 0.015	0.551LysAsn: 0.551 ± 0.02	1.167LysPro: 1.167 ± 0.027	0.687LysGln: 0.687 ± 0.02	1.319LysArg: 1.319 ± 0.028	1.053LysSer: 1.053 ± 0.024	1.178LysThr: 1.178 ± 0.025	1.782LysVal: 1.782 ± 0.031	0.258LysTrp: 0.258 ± 0.01	0.436LysTyr: 0.436 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	15.598LeuAla: 15.598 ± 0.12	0.891LeuCys: 0.891 ± 0.022	6.853LeuAsp: 6.853 ± 0.062	4.648LeuGlu: 4.648 ± 0.062	2.62LeuPhe: 2.62 ± 0.04	9.496LeuGly: 9.496 ± 0.073	2.357LeuHis: 2.357 ± 0.039	3.006LeuIle: 3.006 ± 0.042	1.98LeuLys: 1.98 ± 0.036	11.627LeuLeu: 11.627 ± 0.106	1.567LeuMet: 1.567 ± 0.033	1.555LeuAsn: 1.555 ± 0.029	6.55LeuPro: 6.55 ± 0.056	2.052LeuGln: 2.052 ± 0.029	9.036LeuArg: 9.036 ± 0.083	5.2LeuSer: 5.2 ± 0.053	7.02LeuThr: 7.02 ± 0.074	8.987LeuVal: 8.987 ± 0.074	1.335LeuTrp: 1.335 ± 0.028	1.937LeuTyr: 1.937 ± 0.033	0.0LeuXaa: 0.0 ± 0.0
Met	2.163MetAla: 2.163 ± 0.035	0.142MetCys: 0.142 ± 0.008	0.853MetAsp: 0.853 ± 0.02	0.726MetGlu: 0.726 ± 0.02	0.429MetPhe: 0.429 ± 0.018	1.251MetGly: 1.251 ± 0.027	0.328MetHis: 0.328 ± 0.012	0.613MetIle: 0.613 ± 0.019	0.387MetLys: 0.387 ± 0.014	1.536MetLeu: 1.536 ± 0.028	0.279MetMet: 0.279 ± 0.012	0.407MetAsn: 0.407 ± 0.013	1.062MetPro: 1.062 ± 0.022	0.439MetGln: 0.439 ± 0.015	1.385MetArg: 1.385 ± 0.026	1.276MetSer: 1.276 ± 0.024	1.483MetThr: 1.483 ± 0.026	1.194MetVal: 1.194 ± 0.027	0.189MetTrp: 0.189 ± 0.01	0.333MetTyr: 0.333 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.038AsnAla: 2.038 ± 0.032	0.16AsnCys: 0.16 ± 0.009	0.883AsnAsp: 0.883 ± 0.021	0.706AsnGlu: 0.706 ± 0.018	0.453AsnPhe: 0.453 ± 0.017	1.723AsnGly: 1.723 ± 0.037	0.369AsnHis: 0.369 ± 0.014	0.605AsnIle: 0.605 ± 0.017	0.37AsnLys: 0.37 ± 0.014	1.569AsnLeu: 1.569 ± 0.029	0.282AsnMet: 0.282 ± 0.013	0.392AsnAsn: 0.392 ± 0.014	1.234AsnPro: 1.234 ± 0.026	0.484AsnGln: 0.484 ± 0.015	1.178AsnArg: 1.178 ± 0.028	0.886AsnSer: 0.886 ± 0.022	1.105AsnThr: 1.105 ± 0.024	1.29AsnVal: 1.29 ± 0.03	0.269AsnTrp: 0.269 ± 0.011	0.416AsnTyr: 0.416 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	9.146ProAla: 9.146 ± 0.077	0.367ProCys: 0.367 ± 0.015	4.539ProAsp: 4.539 ± 0.051	4.213ProGlu: 4.213 ± 0.049	1.494ProPhe: 1.494 ± 0.029	6.997ProGly: 6.997 ± 0.065	1.427ProHis: 1.427 ± 0.027	1.039ProIle: 1.039 ± 0.022	1.025ProLys: 1.025 ± 0.022	5.446ProLeu: 5.446 ± 0.05	0.944ProMet: 0.944 ± 0.018	0.777ProAsn: 0.777 ± 0.021	3.42ProPro: 3.42 ± 0.053	1.635ProGln: 1.635 ± 0.03	4.299ProArg: 4.299 ± 0.051	3.056ProSer: 3.056 ± 0.042	2.881ProThr: 2.881 ± 0.041	5.67ProVal: 5.67 ± 0.051	0.871ProTrp: 0.871 ± 0.022	1.457ProTyr: 1.457 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.614GlnAla: 3.614 ± 0.052	0.17GlnCys: 0.17 ± 0.008	1.48GlnAsp: 1.48 ± 0.027	1.478GlnGlu: 1.478 ± 0.029	0.659GlnPhe: 0.659 ± 0.018	2.374GlnGly: 2.374 ± 0.037	0.691GlnHis: 0.691 ± 0.018	1.062GlnIle: 1.062 ± 0.023	0.62GlnLys: 0.62 ± 0.017	2.855GlnLeu: 2.855 ± 0.036	0.451GlnMet: 0.451 ± 0.015	0.487GlnAsn: 0.487 ± 0.016	1.546GlnPro: 1.546 ± 0.03	1.191GlnGln: 1.191 ± 0.032	2.316GlnArg: 2.316 ± 0.035	1.251GlnSer: 1.251 ± 0.025	1.323GlnThr: 1.323 ± 0.022	2.412GlnVal: 2.412 ± 0.036	0.436GlnTrp: 0.436 ± 0.016	0.609GlnTyr: 0.609 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	10.788ArgAla: 10.788 ± 0.086	0.647ArgCys: 0.647 ± 0.02	4.45ArgAsp: 4.45 ± 0.053	4.733ArgGlu: 4.733 ± 0.062	2.423ArgPhe: 2.423 ± 0.035	6.083ArgGly: 6.083 ± 0.049	2.231ArgHis: 2.231 ± 0.036	3.228ArgIle: 3.228 ± 0.042	1.48ArgLys: 1.48 ± 0.03	9.386ArgLeu: 9.386 ± 0.087	1.733ArgMet: 1.733 ± 0.028	1.246ArgAsn: 1.246 ± 0.026	5.315ArgPro: 5.315 ± 0.054	2.394ArgGln: 2.394 ± 0.036	8.211ArgArg: 8.211 ± 0.078	4.018ArgSer: 4.018 ± 0.047	5.879ArgThr: 5.879 ± 0.053	6.138ArgVal: 6.138 ± 0.056	1.394ArgTrp: 1.394 ± 0.027	1.826ArgTyr: 1.826 ± 0.025	0.0ArgXaa: 0.0 ± 0.0
Ser	6.791SerAla: 6.791 ± 0.06	0.397SerCys: 0.397 ± 0.013	2.509SerAsp: 2.509 ± 0.04	2.133SerGlu: 2.133 ± 0.033	1.536SerPhe: 1.536 ± 0.031	6.052SerGly: 6.052 ± 0.066	0.963SerHis: 0.963 ± 0.023	1.263SerIle: 1.263 ± 0.027	0.936SerLys: 0.936 ± 0.02	4.742SerLeu: 4.742 ± 0.051	0.976SerMet: 0.976 ± 0.022	0.757SerAsn: 0.757 ± 0.019	3.084SerPro: 3.084 ± 0.043	1.162SerGln: 1.162 ± 0.023	3.702SerArg: 3.702 ± 0.039	2.746SerSer: 2.746 ± 0.046	2.945SerThr: 2.945 ± 0.046	4.271SerVal: 4.271 ± 0.048	0.874SerTrp: 0.874 ± 0.021	1.226SerTyr: 1.226 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	9.541ThrAla: 9.541 ± 0.086	0.476ThrCys: 0.476 ± 0.016	3.642ThrAsp: 3.642 ± 0.039	3.276ThrGlu: 3.276 ± 0.041	1.583ThrPhe: 1.583 ± 0.025	7.313ThrGly: 7.313 ± 0.072	1.257ThrHis: 1.257 ± 0.027	1.429ThrIle: 1.429 ± 0.028	1.043ThrLys: 1.043 ± 0.025	5.731ThrLeu: 5.731 ± 0.063	0.868ThrMet: 0.868 ± 0.023	0.898ThrAsn: 0.898 ± 0.022	3.948ThrPro: 3.948 ± 0.043	1.292ThrGln: 1.292 ± 0.025	4.129ThrArg: 4.129 ± 0.043	2.989ThrSer: 2.989 ± 0.045	3.696ThrThr: 3.696 ± 0.053	6.333ThrVal: 6.333 ± 0.072	0.888ThrTrp: 0.888 ± 0.022	1.372ThrTyr: 1.372 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	10.865ValAla: 10.865 ± 0.084	0.807ValCys: 0.807 ± 0.02	4.901ValAsp: 4.901 ± 0.052	4.465ValGlu: 4.465 ± 0.046	2.461ValPhe: 2.461 ± 0.036	6.387ValGly: 6.387 ± 0.069	2.095ValHis: 2.095 ± 0.028	2.648ValIle: 2.648 ± 0.037	1.683ValLys: 1.683 ± 0.034	10.001ValLeu: 10.001 ± 0.088	1.36ValMet: 1.36 ± 0.025	1.567ValAsn: 1.567 ± 0.03	5.542ValPro: 5.542 ± 0.057	2.055ValGln: 2.055 ± 0.034	7.686ValArg: 7.686 ± 0.065	4.311ValSer: 4.311 ± 0.047	5.781ValThr: 5.781 ± 0.061	8.004ValVal: 8.004 ± 0.07	1.123ValTrp: 1.123 ± 0.023	1.603ValTyr: 1.603 ± 0.027	0.0ValXaa: 0.0 ± 0.0
Trp	1.65TrpAla: 1.65 ± 0.029	0.162TrpCys: 0.162 ± 0.01	0.815TrpAsp: 0.815 ± 0.021	0.673TrpGlu: 0.673 ± 0.018	0.487TrpPhe: 0.487 ± 0.017	0.997TrpGly: 0.997 ± 0.025	0.396TrpHis: 0.396 ± 0.014	0.527TrpIle: 0.527 ± 0.017	0.372TrpLys: 0.372 ± 0.012	1.719TrpLeu: 1.719 ± 0.034	0.277TrpMet: 0.277 ± 0.012	0.399TrpAsn: 0.399 ± 0.014	0.765TrpPro: 0.765 ± 0.021	0.637TrpGln: 0.637 ± 0.02	1.332TrpArg: 1.332 ± 0.027	0.891TrpSer: 0.891 ± 0.019	1.04TrpThr: 1.04 ± 0.022	0.939TrpVal: 0.939 ± 0.022	0.314TrpTrp: 0.314 ± 0.013	0.38TrpTyr: 0.38 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.833TyrAla: 2.833 ± 0.037	0.187TyrCys: 0.187 ± 0.009	1.5TyrAsp: 1.5 ± 0.03	1.26TyrGlu: 1.26 ± 0.024	0.664TyrPhe: 0.664 ± 0.018	2.339TyrGly: 2.339 ± 0.034	0.397TyrHis: 0.397 ± 0.013	0.451TyrIle: 0.451 ± 0.015	0.394TyrLys: 0.394 ± 0.014	2.101TyrLeu: 2.101 ± 0.034	0.252TyrMet: 0.252 ± 0.012	0.41TyrAsn: 0.41 ± 0.015	1.038TyrPro: 1.038 ± 0.025	0.607TyrGln: 0.607 ± 0.018	1.877TyrArg: 1.877 ± 0.03	0.967TyrSer: 0.967 ± 0.024	1.241TyrThr: 1.241 ± 0.027	1.681TyrVal: 1.681 ± 0.032	0.347TyrTrp: 0.347 ± 0.014	0.466TyrTyr: 0.466 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6806 proteins (2096350 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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