Amino acid dipepetide frequency for Arthrobacter glacialis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.041AlaAla: 20.041 ± 0.181	0.709AlaCys: 0.709 ± 0.022	6.781AlaAsp: 6.781 ± 0.072	7.266AlaGlu: 7.266 ± 0.099	3.747AlaPhe: 3.747 ± 0.053	12.427AlaGly: 12.427 ± 0.136	2.495AlaHis: 2.495 ± 0.05	5.404AlaIle: 5.404 ± 0.074	4.155AlaLys: 4.155 ± 0.069	13.554AlaLeu: 13.554 ± 0.123	3.124AlaMet: 3.124 ± 0.053	3.263AlaAsn: 3.263 ± 0.052	6.263AlaPro: 6.263 ± 0.109	4.752AlaGln: 4.752 ± 0.08	6.755AlaArg: 6.755 ± 0.09	7.283AlaSer: 7.283 ± 0.088	7.773AlaThr: 7.773 ± 0.104	11.145AlaVal: 11.145 ± 0.11	1.612AlaTrp: 1.612 ± 0.04	2.215AlaTyr: 2.215 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.794CysAla: 0.794 ± 0.027	0.063CysCys: 0.063 ± 0.006	0.353CysAsp: 0.353 ± 0.019	0.306CysGlu: 0.306 ± 0.014	0.198CysPhe: 0.198 ± 0.011	0.679CysGly: 0.679 ± 0.025	0.147CysHis: 0.147 ± 0.011	0.261CysIle: 0.261 ± 0.013	0.124CysLys: 0.124 ± 0.01	0.534CysLeu: 0.534 ± 0.025	0.115CysMet: 0.115 ± 0.01	0.168CysAsn: 0.168 ± 0.011	0.32CysPro: 0.32 ± 0.017	0.194CysGln: 0.194 ± 0.012	0.344CysArg: 0.344 ± 0.017	0.408CysSer: 0.408 ± 0.017	0.418CysThr: 0.418 ± 0.018	0.443CysVal: 0.443 ± 0.02	0.095CysTrp: 0.095 ± 0.008	0.134CysTyr: 0.134 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.016AspAla: 7.016 ± 0.075	0.311AspCys: 0.311 ± 0.019	2.75AspAsp: 2.75 ± 0.05	2.96AspGlu: 2.96 ± 0.055	1.985AspPhe: 1.985 ± 0.04	5.384AspGly: 5.384 ± 0.077	1.193AspHis: 1.193 ± 0.036	2.423AspIle: 2.423 ± 0.052	1.433AspLys: 1.433 ± 0.036	5.302AspLeu: 5.302 ± 0.066	0.997AspMet: 0.997 ± 0.031	1.207AspAsn: 1.207 ± 0.029	3.545AspPro: 3.545 ± 0.052	1.634AspGln: 1.634 ± 0.035	2.729AspArg: 2.729 ± 0.057	3.056AspSer: 3.056 ± 0.051	2.71AspThr: 2.71 ± 0.044	4.63AspVal: 4.63 ± 0.066	0.863AspTrp: 0.863 ± 0.027	1.287AspTyr: 1.287 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	6.142GluAla: 6.142 ± 0.089	0.284GluCys: 0.284 ± 0.015	2.574GluAsp: 2.574 ± 0.056	2.723GluGlu: 2.723 ± 0.059	1.838GluPhe: 1.838 ± 0.043	3.533GluGly: 3.533 ± 0.056	1.418GluHis: 1.418 ± 0.038	2.622GluIle: 2.622 ± 0.055	1.786GluLys: 1.786 ± 0.047	6.766GluLeu: 6.766 ± 0.088	1.048GluMet: 1.048 ± 0.028	1.677GluAsn: 1.677 ± 0.037	2.599GluPro: 2.599 ± 0.044	2.265GluGln: 2.265 ± 0.049	3.515GluArg: 3.515 ± 0.053	3.179GluSer: 3.179 ± 0.054	2.885GluThr: 2.885 ± 0.044	4.048GluVal: 4.048 ± 0.065	0.704GluTrp: 0.704 ± 0.024	1.073GluTyr: 1.073 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.165PheAla: 4.165 ± 0.06	0.227PheCys: 0.227 ± 0.013	2.135PheAsp: 2.135 ± 0.04	1.69PheGlu: 1.69 ± 0.035	1.221PhePhe: 1.221 ± 0.036	3.183PheGly: 3.183 ± 0.065	0.668PheHis: 0.668 ± 0.024	1.505PheIle: 1.505 ± 0.039	0.864PheLys: 0.864 ± 0.03	3.107PheLeu: 3.107 ± 0.066	0.708PheMet: 0.708 ± 0.023	1.004PheAsn: 1.004 ± 0.033	1.501PhePro: 1.501 ± 0.034	0.837PheGln: 0.837 ± 0.028	1.603PheArg: 1.603 ± 0.04	2.289PheSer: 2.289 ± 0.044	2.353PheThr: 2.353 ± 0.048	2.587PheVal: 2.587 ± 0.055	0.501PheTrp: 0.501 ± 0.022	0.739PheTyr: 0.739 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	10.27GlyAla: 10.27 ± 0.107	0.599GlyCys: 0.599 ± 0.02	4.092GlyAsp: 4.092 ± 0.06	4.367GlyGlu: 4.367 ± 0.063	3.211GlyPhe: 3.211 ± 0.053	7.186GlyGly: 7.186 ± 0.106	1.963GlyHis: 1.963 ± 0.04	4.616GlyIle: 4.616 ± 0.06	3.102GlyLys: 3.102 ± 0.055	8.88GlyLeu: 8.88 ± 0.098	2.168GlyMet: 2.168 ± 0.043	2.484GlyAsn: 2.484 ± 0.053	3.838GlyPro: 3.838 ± 0.051	3.085GlyGln: 3.085 ± 0.051	5.002GlyArg: 5.002 ± 0.07	5.691GlySer: 5.691 ± 0.069	6.253GlyThr: 6.253 ± 0.102	7.291GlyVal: 7.291 ± 0.078	1.597GlyTrp: 1.597 ± 0.037	2.206GlyTyr: 2.206 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	2.305HisAla: 2.305 ± 0.051	0.168HisCys: 0.168 ± 0.011	1.221HisAsp: 1.221 ± 0.03	1.178HisGlu: 1.178 ± 0.032	0.686HisPhe: 0.686 ± 0.023	2.101HisGly: 2.101 ± 0.043	0.623HisHis: 0.623 ± 0.026	0.878HisIle: 0.878 ± 0.025	0.53HisLys: 0.53 ± 0.021	2.044HisLeu: 2.044 ± 0.041	0.426HisMet: 0.426 ± 0.019	0.535HisAsn: 0.535 ± 0.02	1.436HisPro: 1.436 ± 0.033	0.771HisGln: 0.771 ± 0.025	1.397HisArg: 1.397 ± 0.033	1.269HisSer: 1.269 ± 0.033	1.104HisThr: 1.104 ± 0.034	1.657HisVal: 1.657 ± 0.04	0.366HisTrp: 0.366 ± 0.019	0.516HisTyr: 0.516 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	6.147IleAla: 6.147 ± 0.074	0.345IleCys: 0.345 ± 0.018	2.805IleAsp: 2.805 ± 0.054	2.392IleGlu: 2.392 ± 0.049	1.587IlePhe: 1.587 ± 0.035	4.105IleGly: 4.105 ± 0.068	0.941IleHis: 0.941 ± 0.031	2.11IleIle: 2.11 ± 0.051	1.399IleLys: 1.399 ± 0.039	4.199IleLeu: 4.199 ± 0.064	0.967IleMet: 0.967 ± 0.03	1.468IleAsn: 1.468 ± 0.03	2.597IlePro: 2.597 ± 0.051	1.205IleGln: 1.205 ± 0.035	2.445IleArg: 2.445 ± 0.049	3.042IleSer: 3.042 ± 0.057	2.948IleThr: 2.948 ± 0.052	3.858IleVal: 3.858 ± 0.064	0.514IleTrp: 0.514 ± 0.023	0.925IleTyr: 0.925 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	3.775LysAla: 3.775 ± 0.064	0.118LysCys: 0.118 ± 0.01	1.764LysAsp: 1.764 ± 0.047	1.534LysGlu: 1.534 ± 0.041	0.989LysPhe: 0.989 ± 0.03	2.086LysGly: 2.086 ± 0.046	0.657LysHis: 0.657 ± 0.021	1.525LysIle: 1.525 ± 0.036	1.207LysLys: 1.207 ± 0.034	2.898LysLeu: 2.898 ± 0.051	0.755LysMet: 0.755 ± 0.027	1.042LysAsn: 1.042 ± 0.03	1.647LysPro: 1.647 ± 0.043	0.881LysGln: 0.881 ± 0.027	1.66LysArg: 1.66 ± 0.035	1.869LysSer: 1.869 ± 0.043	1.898LysThr: 1.898 ± 0.039	2.535LysVal: 2.535 ± 0.053	0.371LysTrp: 0.371 ± 0.016	0.76LysTyr: 0.76 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	14.901LeuAla: 14.901 ± 0.148	0.702LeuCys: 0.702 ± 0.027	5.837LeuAsp: 5.837 ± 0.078	5.191LeuGlu: 5.191 ± 0.068	3.067LeuPhe: 3.067 ± 0.056	9.245LeuGly: 9.245 ± 0.095	2.015LeuHis: 2.015 ± 0.042	4.581LeuIle: 4.581 ± 0.08	2.741LeuLys: 2.741 ± 0.052	10.523LeuLeu: 10.523 ± 0.129	2.141LeuMet: 2.141 ± 0.044	2.819LeuAsn: 2.819 ± 0.048	5.601LeuPro: 5.601 ± 0.063	2.805LeuGln: 2.805 ± 0.047	6.306LeuArg: 6.306 ± 0.082	6.516LeuSer: 6.516 ± 0.08	6.275LeuThr: 6.275 ± 0.067	8.421LeuVal: 8.421 ± 0.095	1.341LeuTrp: 1.341 ± 0.032	1.648LeuTyr: 1.648 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	2.949MetAla: 2.949 ± 0.047	0.129MetCys: 0.129 ± 0.01	1.207MetAsp: 1.207 ± 0.03	1.025MetGlu: 1.025 ± 0.035	0.641MetPhe: 0.641 ± 0.025	1.872MetGly: 1.872 ± 0.037	0.371MetHis: 0.371 ± 0.018	1.032MetIle: 1.032 ± 0.027	0.669MetLys: 0.669 ± 0.022	2.078MetLeu: 2.078 ± 0.044	0.471MetMet: 0.471 ± 0.02	0.738MetAsn: 0.738 ± 0.024	1.176MetPro: 1.176 ± 0.029	0.548MetGln: 0.548 ± 0.021	1.24MetArg: 1.24 ± 0.033	1.649MetSer: 1.649 ± 0.037	1.699MetThr: 1.699 ± 0.038	1.92MetVal: 1.92 ± 0.043	0.242MetTrp: 0.242 ± 0.014	0.359MetTyr: 0.359 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.254AsnAla: 3.254 ± 0.048	0.174AsnCys: 0.174 ± 0.013	1.52AsnAsp: 1.52 ± 0.036	1.27AsnGlu: 1.27 ± 0.031	0.984AsnPhe: 0.984 ± 0.028	2.667AsnGly: 2.667 ± 0.052	0.607AsnHis: 0.607 ± 0.02	1.306AsnIle: 1.306 ± 0.036	0.864AsnLys: 0.864 ± 0.029	2.547AsnLeu: 2.547 ± 0.044	0.582AsnMet: 0.582 ± 0.024	0.973AsnAsn: 0.973 ± 0.029	2.05AsnPro: 2.05 ± 0.04	0.903AsnGln: 0.903 ± 0.027	1.551AsnArg: 1.551 ± 0.032	1.764AsnSer: 1.764 ± 0.042	1.859AsnThr: 1.859 ± 0.077	2.265AsnVal: 2.265 ± 0.048	0.418AsnTrp: 0.418 ± 0.02	0.737AsnTyr: 0.737 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	7.748ProAla: 7.748 ± 0.106	0.232ProCys: 0.232 ± 0.013	3.111ProAsp: 3.111 ± 0.054	3.662ProGlu: 3.662 ± 0.059	1.648ProPhe: 1.648 ± 0.033	5.037ProGly: 5.037 ± 0.06	1.143ProHis: 1.143 ± 0.027	1.89ProIle: 1.89 ± 0.045	1.395ProLys: 1.395 ± 0.035	4.888ProLeu: 4.888 ± 0.055	1.102ProMet: 1.102 ± 0.028	1.34ProAsn: 1.34 ± 0.031	2.057ProPro: 2.057 ± 0.053	1.712ProGln: 1.712 ± 0.039	2.542ProArg: 2.542 ± 0.048	3.395ProSer: 3.395 ± 0.056	3.277ProThr: 3.277 ± 0.058	4.652ProVal: 4.652 ± 0.065	0.845ProTrp: 0.845 ± 0.025	1.026ProTyr: 1.026 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	4.14GlnAla: 4.14 ± 0.062	0.183GlnCys: 0.183 ± 0.012	1.581GlnAsp: 1.581 ± 0.04	1.753GlnGlu: 1.753 ± 0.039	0.997GlnPhe: 0.997 ± 0.026	2.588GlnGly: 2.588 ± 0.047	0.723GlnHis: 0.723 ± 0.023	1.572GlnIle: 1.572 ± 0.036	0.966GlnLys: 0.966 ± 0.031	3.855GlnLeu: 3.855 ± 0.058	0.731GlnMet: 0.731 ± 0.026	0.861GlnAsn: 0.861 ± 0.028	1.601GlnPro: 1.601 ± 0.038	1.42GlnGln: 1.42 ± 0.038	2.35GlnArg: 2.35 ± 0.048	1.811GlnSer: 1.811 ± 0.037	1.681GlnThr: 1.681 ± 0.039	2.535GlnVal: 2.535 ± 0.045	0.625GlnTrp: 0.625 ± 0.021	0.67GlnTyr: 0.67 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	6.282ArgAla: 6.282 ± 0.085	0.339ArgCys: 0.339 ± 0.017	2.976ArgAsp: 2.976 ± 0.051	3.378ArgGlu: 3.378 ± 0.055	1.874ArgPhe: 1.874 ± 0.039	4.313ArgGly: 4.313 ± 0.063	1.399ArgHis: 1.399 ± 0.037	2.979ArgIle: 2.979 ± 0.049	1.844ArgLys: 1.844 ± 0.042	5.89ArgLeu: 5.89 ± 0.083	1.403ArgMet: 1.403 ± 0.036	1.833ArgAsn: 1.833 ± 0.042	2.782ArgPro: 2.782 ± 0.049	2.035ArgGln: 2.035 ± 0.047	4.469ArgArg: 4.469 ± 0.071	3.557ArgSer: 3.557 ± 0.052	3.603ArgThr: 3.603 ± 0.055	4.197ArgVal: 4.197 ± 0.062	0.957ArgTrp: 0.957 ± 0.028	1.301ArgTyr: 1.301 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	7.852SerAla: 7.852 ± 0.087	0.399SerCys: 0.399 ± 0.019	2.965SerAsp: 2.965 ± 0.048	2.882SerGlu: 2.882 ± 0.048	2.058SerPhe: 2.058 ± 0.036	6.042SerGly: 6.042 ± 0.073	1.267SerHis: 1.267 ± 0.033	2.844SerIle: 2.844 ± 0.051	1.847SerLys: 1.847 ± 0.037	6.077SerLeu: 6.077 ± 0.075	1.547SerMet: 1.547 ± 0.034	1.839SerAsn: 1.839 ± 0.035	3.292SerPro: 3.292 ± 0.055	1.946SerGln: 1.946 ± 0.042	3.411SerArg: 3.411 ± 0.05	4.023SerSer: 4.023 ± 0.066	4.125SerThr: 4.125 ± 0.074	5.109SerVal: 5.109 ± 0.073	1.013SerTrp: 1.013 ± 0.026	1.541SerTyr: 1.541 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	8.343ThrAla: 8.343 ± 0.119	0.294ThrCys: 0.294 ± 0.016	3.11ThrAsp: 3.11 ± 0.052	2.991ThrGlu: 2.991 ± 0.052	2.115ThrPhe: 2.115 ± 0.043	5.872ThrGly: 5.872 ± 0.096	1.235ThrHis: 1.235 ± 0.029	2.942ThrIle: 2.942 ± 0.052	1.703ThrLys: 1.703 ± 0.046	6.35ThrLeu: 6.35 ± 0.065	1.257ThrMet: 1.257 ± 0.033	1.648ThrAsn: 1.648 ± 0.047	3.972ThrPro: 3.972 ± 0.069	1.824ThrGln: 1.824 ± 0.033	2.992ThrArg: 2.992 ± 0.052	3.801ThrSer: 3.801 ± 0.056	4.142ThrThr: 4.142 ± 0.09	5.865ThrVal: 5.865 ± 0.09	0.845ThrTrp: 0.845 ± 0.029	1.135ThrTyr: 1.135 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	10.839ValAla: 10.839 ± 0.099	0.574ValCys: 0.574 ± 0.024	4.741ValAsp: 4.741 ± 0.069	4.424ValGlu: 4.424 ± 0.058	2.626ValPhe: 2.626 ± 0.053	6.59ValGly: 6.59 ± 0.08	1.696ValHis: 1.696 ± 0.036	4.046ValIle: 4.046 ± 0.06	2.322ValLys: 2.322 ± 0.05	9.105ValLeu: 9.105 ± 0.103	1.754ValMet: 1.754 ± 0.042	2.322ValAsn: 2.322 ± 0.057	4.669ValPro: 4.669 ± 0.061	2.441ValGln: 2.441 ± 0.045	4.724ValArg: 4.724 ± 0.062	5.228ValSer: 5.228 ± 0.062	5.335ValThr: 5.335 ± 0.086	7.986ValVal: 7.986 ± 0.094	0.981ValTrp: 0.981 ± 0.033	1.399ValTyr: 1.399 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.536TrpAla: 1.536 ± 0.035	0.112TrpCys: 0.112 ± 0.009	0.768TrpAsp: 0.768 ± 0.027	0.663TrpGlu: 0.663 ± 0.021	0.581TrpPhe: 0.581 ± 0.024	1.033TrpGly: 1.033 ± 0.031	0.339TrpHis: 0.339 ± 0.014	0.723TrpIle: 0.723 ± 0.026	0.404TrpLys: 0.404 ± 0.017	1.815TrpLeu: 1.815 ± 0.043	0.353TrpMet: 0.353 ± 0.017	0.5TrpAsn: 0.5 ± 0.022	0.673TrpPro: 0.673 ± 0.024	0.639TrpGln: 0.639 ± 0.023	1.018TrpArg: 1.018 ± 0.032	0.881TrpSer: 0.881 ± 0.026	0.841TrpThr: 0.841 ± 0.027	1.077TrpVal: 1.077 ± 0.034	0.313TrpTrp: 0.313 ± 0.018	0.291TrpTyr: 0.291 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.264TyrAla: 2.264 ± 0.044	0.135TyrCys: 0.135 ± 0.01	1.123TyrAsp: 1.123 ± 0.033	1.026TyrGlu: 1.026 ± 0.029	0.834TyrPhe: 0.834 ± 0.023	1.96TyrGly: 1.96 ± 0.042	0.312TyrHis: 0.312 ± 0.015	0.741TyrIle: 0.741 ± 0.029	0.615TyrLys: 0.615 ± 0.024	2.263TyrLeu: 2.263 ± 0.049	0.366TyrMet: 0.366 ± 0.017	0.577TyrAsn: 0.577 ± 0.025	1.082TyrPro: 1.082 ± 0.031	0.747TyrGln: 0.747 ± 0.023	1.359TyrArg: 1.359 ± 0.034	1.368TyrSer: 1.368 ± 0.037	1.256TyrThr: 1.256 ± 0.04	1.582TyrVal: 1.582 ± 0.034	0.355TyrTrp: 0.355 ± 0.017	0.478TyrTyr: 0.478 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3921 proteins (1276308 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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