Amino acid dipepetide frequency for Pelagicola sp. LXJ1103

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.152AlaAla: 17.152 ± 0.206	1.179AlaCys: 1.179 ± 0.04	6.941AlaAsp: 6.941 ± 0.095	8.486AlaGlu: 8.486 ± 0.124	4.273AlaPhe: 4.273 ± 0.083	10.78AlaGly: 10.78 ± 0.107	2.695AlaHis: 2.695 ± 0.058	5.765AlaIle: 5.765 ± 0.081	3.899AlaLys: 3.899 ± 0.076	14.686AlaLeu: 14.686 ± 0.175	4.025AlaMet: 4.025 ± 0.068	2.692AlaAsn: 2.692 ± 0.056	6.478AlaPro: 6.478 ± 0.105	4.982AlaGln: 4.982 ± 0.087	9.411AlaArg: 9.411 ± 0.13	5.59AlaSer: 5.59 ± 0.071	5.729AlaThr: 5.729 ± 0.083	8.199AlaVal: 8.199 ± 0.116	1.538AlaTrp: 1.538 ± 0.04	2.647AlaTyr: 2.647 ± 0.059	0.0AlaXaa: 0.0 ± 0.0
Cys	1.255CysAla: 1.255 ± 0.041	0.127CysCys: 0.127 ± 0.012	0.636CysAsp: 0.636 ± 0.029	0.473CysGlu: 0.473 ± 0.025	0.357CysPhe: 0.357 ± 0.018	0.992CysGly: 0.992 ± 0.035	0.265CysHis: 0.265 ± 0.019	0.464CysIle: 0.464 ± 0.023	0.223CysLys: 0.223 ± 0.013	0.849CysLeu: 0.849 ± 0.029	0.18CysMet: 0.18 ± 0.013	0.24CysAsn: 0.24 ± 0.017	0.493CysPro: 0.493 ± 0.024	0.236CysGln: 0.236 ± 0.015	0.528CysArg: 0.528 ± 0.023	0.412CysSer: 0.412 ± 0.02	0.54CysThr: 0.54 ± 0.024	0.701CysVal: 0.701 ± 0.027	0.118CysTrp: 0.118 ± 0.011	0.226CysTyr: 0.226 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	7.891AspAla: 7.891 ± 0.111	0.534AspCys: 0.534 ± 0.024	3.183AspAsp: 3.183 ± 0.079	3.4AspGlu: 3.4 ± 0.071	2.257AspPhe: 2.257 ± 0.056	5.286AspGly: 5.286 ± 0.099	1.356AspHis: 1.356 ± 0.047	3.35AspIle: 3.35 ± 0.068	1.691AspLys: 1.691 ± 0.043	6.254AspLeu: 6.254 ± 0.073	1.953AspMet: 1.953 ± 0.045	1.185AspAsn: 1.185 ± 0.04	3.446AspPro: 3.446 ± 0.066	1.787AspGln: 1.787 ± 0.051	3.759AspArg: 3.759 ± 0.06	1.945AspSer: 1.945 ± 0.045	3.169AspThr: 3.169 ± 0.073	4.494AspVal: 4.494 ± 0.082	1.134AspTrp: 1.134 ± 0.036	1.447AspTyr: 1.447 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	9.008GluAla: 9.008 ± 0.128	0.396GluCys: 0.396 ± 0.019	3.379GluAsp: 3.379 ± 0.069	3.495GluGlu: 3.495 ± 0.078	1.818GluPhe: 1.818 ± 0.041	5.397GluGly: 5.397 ± 0.091	1.169GluHis: 1.169 ± 0.039	3.628GluIle: 3.628 ± 0.068	1.915GluLys: 1.915 ± 0.056	4.72GluLeu: 4.72 ± 0.079	2.206GluMet: 2.206 ± 0.05	1.641GluAsn: 1.641 ± 0.04	2.414GluPro: 2.414 ± 0.057	1.769GluGln: 1.769 ± 0.045	4.302GluArg: 4.302 ± 0.076	2.0GluSer: 2.0 ± 0.051	3.739GluThr: 3.739 ± 0.065	4.497GluVal: 4.497 ± 0.077	0.758GluTrp: 0.758 ± 0.032	1.093GluTyr: 1.093 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.531PheAla: 4.531 ± 0.081	0.427PheCys: 0.427 ± 0.021	2.785PheAsp: 2.785 ± 0.056	2.366PheGlu: 2.366 ± 0.055	1.468PhePhe: 1.468 ± 0.049	3.707PheGly: 3.707 ± 0.068	0.748PheHis: 0.748 ± 0.031	1.717PheIle: 1.717 ± 0.041	0.936PheLys: 0.936 ± 0.033	3.23PheLeu: 3.23 ± 0.063	0.91PheMet: 0.91 ± 0.029	1.025PheAsn: 1.025 ± 0.03	1.468PhePro: 1.468 ± 0.037	1.075PheGln: 1.075 ± 0.037	1.962PheArg: 1.962 ± 0.052	1.998PheSer: 1.998 ± 0.046	2.153PheThr: 2.153 ± 0.058	2.562PheVal: 2.562 ± 0.058	0.528PheTrp: 0.528 ± 0.026	0.961PheTyr: 0.961 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	11.257GlyAla: 11.257 ± 0.129	0.871GlyCys: 0.871 ± 0.032	4.889GlyAsp: 4.889 ± 0.1	4.553GlyGlu: 4.553 ± 0.075	3.69GlyPhe: 3.69 ± 0.065	7.685GlyGly: 7.685 ± 0.119	2.035GlyHis: 2.035 ± 0.048	4.474GlyIle: 4.474 ± 0.079	3.022GlyLys: 3.022 ± 0.066	9.166GlyLeu: 9.166 ± 0.121	2.783GlyMet: 2.783 ± 0.054	1.925GlyAsn: 1.925 ± 0.053	3.888GlyPro: 3.888 ± 0.064	3.124GlyGln: 3.124 ± 0.058	5.772GlyArg: 5.772 ± 0.09	4.038GlySer: 4.038 ± 0.073	4.944GlyThr: 4.944 ± 0.088	6.399GlyVal: 6.399 ± 0.099	1.437GlyTrp: 1.437 ± 0.05	2.378GlyTyr: 2.378 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	2.624HisAla: 2.624 ± 0.056	0.265HisCys: 0.265 ± 0.016	1.279HisAsp: 1.279 ± 0.036	1.075HisGlu: 1.075 ± 0.035	0.849HisPhe: 0.849 ± 0.028	1.981HisGly: 1.981 ± 0.046	0.598HisHis: 0.598 ± 0.033	1.085HisIle: 1.085 ± 0.036	0.575HisLys: 0.575 ± 0.024	2.116HisLeu: 2.116 ± 0.05	0.683HisMet: 0.683 ± 0.029	0.508HisAsn: 0.508 ± 0.021	1.355HisPro: 1.355 ± 0.041	0.581HisGln: 0.581 ± 0.03	1.242HisArg: 1.242 ± 0.039	0.967HisSer: 0.967 ± 0.035	0.94HisThr: 0.94 ± 0.034	1.582HisVal: 1.582 ± 0.041	0.344HisTrp: 0.344 ± 0.021	0.574HisTyr: 0.574 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	7.133IleAla: 7.133 ± 0.083	0.671IleCys: 0.671 ± 0.031	3.394IleAsp: 3.394 ± 0.064	3.649IleGlu: 3.649 ± 0.066	1.847IlePhe: 1.847 ± 0.048	4.82IleGly: 4.82 ± 0.078	0.899IleHis: 0.899 ± 0.034	2.555IleIle: 2.555 ± 0.061	1.596IleLys: 1.596 ± 0.042	4.801IleLeu: 4.801 ± 0.084	1.251IleMet: 1.251 ± 0.036	1.457IleAsn: 1.457 ± 0.039	2.407IlePro: 2.407 ± 0.061	1.096IleGln: 1.096 ± 0.034	3.056IleArg: 3.056 ± 0.055	3.079IleSer: 3.079 ± 0.056	3.327IleThr: 3.327 ± 0.061	3.726IleVal: 3.726 ± 0.067	0.741IleTrp: 0.741 ± 0.032	1.239IleTyr: 1.239 ± 0.04	0.0IleXaa: 0.0 ± 0.0
Lys	3.895LysAla: 3.895 ± 0.077	0.187LysCys: 0.187 ± 0.015	1.762LysAsp: 1.762 ± 0.051	1.455LysGlu: 1.455 ± 0.043	0.945LysPhe: 0.945 ± 0.031	2.839LysGly: 2.839 ± 0.066	0.665LysHis: 0.665 ± 0.031	1.748LysIle: 1.748 ± 0.045	1.184LysLys: 1.184 ± 0.042	2.867LysLeu: 2.867 ± 0.056	0.946LysMet: 0.946 ± 0.03	0.783LysAsn: 0.783 ± 0.028	1.809LysPro: 1.809 ± 0.043	0.838LysGln: 0.838 ± 0.031	2.273LysArg: 2.273 ± 0.048	1.821LysSer: 1.821 ± 0.057	1.863LysThr: 1.863 ± 0.049	2.154LysVal: 2.154 ± 0.063	0.41LysTrp: 0.41 ± 0.025	0.647LysTyr: 0.647 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	12.306LeuAla: 12.306 ± 0.168	1.034LeuCys: 1.034 ± 0.033	5.738LeuAsp: 5.738 ± 0.083	5.762LeuGlu: 5.762 ± 0.082	3.294LeuPhe: 3.294 ± 0.065	8.497LeuGly: 8.497 ± 0.118	1.972LeuHis: 1.972 ± 0.045	5.478LeuIle: 5.478 ± 0.092	3.224LeuLys: 3.224 ± 0.062	8.556LeuLeu: 8.556 ± 0.126	2.883LeuMet: 2.883 ± 0.053	2.591LeuAsn: 2.591 ± 0.053	5.545LeuPro: 5.545 ± 0.085	2.505LeuGln: 2.505 ± 0.056	7.323LeuArg: 7.323 ± 0.101	6.77LeuSer: 6.77 ± 0.114	5.799LeuThr: 5.799 ± 0.082	6.38LeuVal: 6.38 ± 0.091	1.326LeuTrp: 1.326 ± 0.047	2.028LeuTyr: 2.028 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	3.806MetAla: 3.806 ± 0.069	0.219MetCys: 0.219 ± 0.014	1.69MetAsp: 1.69 ± 0.042	1.446MetGlu: 1.446 ± 0.036	0.83MetPhe: 0.83 ± 0.028	2.69MetGly: 2.69 ± 0.061	0.505MetHis: 0.505 ± 0.022	1.785MetIle: 1.785 ± 0.043	1.093MetLys: 1.093 ± 0.037	2.831MetLeu: 2.831 ± 0.06	0.884MetMet: 0.884 ± 0.035	0.839MetAsn: 0.839 ± 0.03	1.684MetPro: 1.684 ± 0.039	1.113MetGln: 1.113 ± 0.038	2.179MetArg: 2.179 ± 0.051	1.883MetSer: 1.883 ± 0.046	2.083MetThr: 2.083 ± 0.039	2.027MetVal: 2.027 ± 0.054	0.27MetTrp: 0.27 ± 0.018	0.362MetTyr: 0.362 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.104AsnAla: 3.104 ± 0.066	0.256AsnCys: 0.256 ± 0.015	1.381AsnAsp: 1.381 ± 0.04	1.175AsnGlu: 1.175 ± 0.036	0.949AsnPhe: 0.949 ± 0.032	2.254AsnGly: 2.254 ± 0.051	0.5AsnHis: 0.5 ± 0.024	1.387AsnIle: 1.387 ± 0.04	0.654AsnLys: 0.654 ± 0.027	2.456AsnLeu: 2.456 ± 0.057	0.72AsnMet: 0.72 ± 0.032	0.623AsnAsn: 0.623 ± 0.028	1.744AsnPro: 1.744 ± 0.043	0.65AsnGln: 0.65 ± 0.026	1.546AsnArg: 1.546 ± 0.04	1.099AsnSer: 1.099 ± 0.039	1.394AsnThr: 1.394 ± 0.043	1.818AsnVal: 1.818 ± 0.05	0.413AsnTrp: 0.413 ± 0.021	0.618AsnTyr: 0.618 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	5.664ProAla: 5.664 ± 0.091	0.372ProCys: 0.372 ± 0.021	3.728ProAsp: 3.728 ± 0.068	4.532ProGlu: 4.532 ± 0.078	1.993ProPhe: 1.993 ± 0.05	4.657ProGly: 4.657 ± 0.081	1.138ProHis: 1.138 ± 0.038	2.309ProIle: 2.309 ± 0.052	1.785ProLys: 1.785 ± 0.052	4.72ProLeu: 4.72 ± 0.075	1.473ProMet: 1.473 ± 0.042	1.335ProAsn: 1.335 ± 0.037	2.247ProPro: 2.247 ± 0.06	1.623ProGln: 1.623 ± 0.043	2.846ProArg: 2.846 ± 0.055	2.634ProSer: 2.634 ± 0.058	2.361ProThr: 2.361 ± 0.047	3.905ProVal: 3.905 ± 0.063	0.63ProTrp: 0.63 ± 0.028	1.175ProTyr: 1.175 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	3.768GlnAla: 3.768 ± 0.068	0.198GlnCys: 0.198 ± 0.015	1.698GlnAsp: 1.698 ± 0.039	1.497GlnGlu: 1.497 ± 0.036	1.089GlnPhe: 1.089 ± 0.032	2.66GlnGly: 2.66 ± 0.052	0.607GlnHis: 0.607 ± 0.026	2.151GlnIle: 2.151 ± 0.048	0.998GlnLys: 0.998 ± 0.033	2.799GlnLeu: 2.799 ± 0.053	1.184GlnMet: 1.184 ± 0.036	0.912GlnAsn: 0.912 ± 0.031	1.484GlnPro: 1.484 ± 0.044	0.911GlnGln: 0.911 ± 0.043	2.061GlnArg: 2.061 ± 0.049	1.913GlnSer: 1.913 ± 0.045	1.946GlnThr: 1.946 ± 0.047	2.301GlnVal: 2.301 ± 0.044	0.401GlnTrp: 0.401 ± 0.02	0.595GlnTyr: 0.595 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	9.012ArgAla: 9.012 ± 0.119	0.483ArgCys: 0.483 ± 0.024	4.178ArgAsp: 4.178 ± 0.065	3.709ArgGlu: 3.709 ± 0.068	2.552ArgPhe: 2.552 ± 0.062	4.87ArgGly: 4.87 ± 0.074	1.526ArgHis: 1.526 ± 0.04	3.807ArgIle: 3.807 ± 0.063	2.149ArgLys: 2.149 ± 0.052	6.955ArgLeu: 6.955 ± 0.096	2.099ArgMet: 2.099 ± 0.05	1.599ArgAsn: 1.599 ± 0.045	3.261ArgPro: 3.261 ± 0.07	2.091ArgGln: 2.091 ± 0.048	4.91ArgArg: 4.91 ± 0.085	3.14ArgSer: 3.14 ± 0.062	3.007ArgThr: 3.007 ± 0.059	4.731ArgVal: 4.731 ± 0.072	0.904ArgTrp: 0.904 ± 0.036	1.507ArgTyr: 1.507 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	6.038SerAla: 6.038 ± 0.094	0.469SerCys: 0.469 ± 0.026	3.199SerAsp: 3.199 ± 0.058	2.973SerGlu: 2.973 ± 0.051	2.142SerPhe: 2.142 ± 0.051	5.201SerGly: 5.201 ± 0.089	1.067SerHis: 1.067 ± 0.035	2.423SerIle: 2.423 ± 0.057	1.541SerLys: 1.541 ± 0.051	4.842SerLeu: 4.842 ± 0.079	1.382SerMet: 1.382 ± 0.04	1.359SerAsn: 1.359 ± 0.037	2.455SerPro: 2.455 ± 0.05	1.56SerGln: 1.56 ± 0.043	2.913SerArg: 2.913 ± 0.062	2.367SerSer: 2.367 ± 0.055	2.552SerThr: 2.552 ± 0.058	3.803SerVal: 3.803 ± 0.069	0.637SerTrp: 0.637 ± 0.023	1.285SerTyr: 1.285 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	6.305ThrAla: 6.305 ± 0.096	0.55ThrCys: 0.55 ± 0.027	3.152ThrAsp: 3.152 ± 0.064	2.975ThrGlu: 2.975 ± 0.067	1.967ThrPhe: 1.967 ± 0.042	5.424ThrGly: 5.424 ± 0.091	1.215ThrHis: 1.215 ± 0.037	2.598ThrIle: 2.598 ± 0.063	1.56ThrLys: 1.56 ± 0.051	6.161ThrLeu: 6.161 ± 0.083	1.354ThrMet: 1.354 ± 0.037	1.262ThrAsn: 1.262 ± 0.044	3.605ThrPro: 3.605 ± 0.076	1.76ThrGln: 1.76 ± 0.048	3.584ThrArg: 3.584 ± 0.062	2.654ThrSer: 2.654 ± 0.06	2.723ThrThr: 2.723 ± 0.059	3.936ThrVal: 3.936 ± 0.073	0.714ThrTrp: 0.714 ± 0.028	1.306ThrTyr: 1.306 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	8.283ValAla: 8.283 ± 0.102	0.7ValCys: 0.7 ± 0.03	4.091ValAsp: 4.091 ± 0.079	4.352ValGlu: 4.352 ± 0.068	2.778ValPhe: 2.778 ± 0.071	5.318ValGly: 5.318 ± 0.093	1.377ValHis: 1.377 ± 0.038	4.322ValIle: 4.322 ± 0.072	2.025ValLys: 2.025 ± 0.057	7.248ValLeu: 7.248 ± 0.105	2.324ValMet: 2.324 ± 0.056	1.803ValAsn: 1.803 ± 0.045	3.544ValPro: 3.544 ± 0.062	2.251ValGln: 2.251 ± 0.057	4.314ValArg: 4.314 ± 0.075	4.018ValSer: 4.018 ± 0.07	4.502ValThr: 4.502 ± 0.074	5.138ValVal: 5.138 ± 0.082	0.953ValTrp: 0.953 ± 0.035	1.427ValTyr: 1.427 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.453TrpAla: 1.453 ± 0.042	0.155TrpCys: 0.155 ± 0.014	0.815TrpAsp: 0.815 ± 0.03	0.719TrpGlu: 0.719 ± 0.028	0.542TrpPhe: 0.542 ± 0.025	1.065TrpGly: 1.065 ± 0.041	0.32TrpHis: 0.32 ± 0.02	0.68TrpIle: 0.68 ± 0.025	0.427TrpLys: 0.427 ± 0.024	1.533TrpLeu: 1.533 ± 0.044	0.433TrpMet: 0.433 ± 0.021	0.378TrpAsn: 0.378 ± 0.021	0.714TrpPro: 0.714 ± 0.029	0.569TrpGln: 0.569 ± 0.027	1.048TrpArg: 1.048 ± 0.039	0.789TrpSer: 0.789 ± 0.03	0.791TrpThr: 0.791 ± 0.03	0.892TrpVal: 0.892 ± 0.034	0.231TrpTrp: 0.231 ± 0.017	0.263TrpTyr: 0.263 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.66TyrAla: 2.66 ± 0.058	0.224TyrCys: 0.224 ± 0.016	1.601TyrAsp: 1.601 ± 0.042	1.254TyrGlu: 1.254 ± 0.042	0.919TyrPhe: 0.919 ± 0.033	2.207TyrGly: 2.207 ± 0.056	0.564TyrHis: 0.564 ± 0.024	1.02TyrIle: 1.02 ± 0.033	0.592TyrLys: 0.592 ± 0.024	2.222TyrLeu: 2.222 ± 0.054	0.545TyrMet: 0.545 ± 0.023	0.584TyrAsn: 0.584 ± 0.025	1.085TyrPro: 1.085 ± 0.035	0.654TyrGln: 0.654 ± 0.027	1.461TyrArg: 1.461 ± 0.049	1.094TyrSer: 1.094 ± 0.034	1.237TyrThr: 1.237 ± 0.035	1.519TyrVal: 1.519 ± 0.043	0.335TyrTrp: 0.335 ± 0.022	0.591TyrTyr: 0.591 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2960 proteins (927427 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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