Amino acid dipepetide frequency for Methylocystis heyeri

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.668AlaAla: 18.668 ± 0.178	1.29AlaCys: 1.29 ± 0.033	6.162AlaAsp: 6.162 ± 0.072	7.911AlaGlu: 7.911 ± 0.085	4.787AlaPhe: 4.787 ± 0.068	10.718AlaGly: 10.718 ± 0.087	2.436AlaHis: 2.436 ± 0.043	6.144AlaIle: 6.144 ± 0.069	4.489AlaLys: 4.489 ± 0.08	14.667AlaLeu: 14.667 ± 0.148	3.022AlaMet: 3.022 ± 0.051	3.131AlaAsn: 3.131 ± 0.046	7.699AlaPro: 7.699 ± 0.1	4.698AlaGln: 4.698 ± 0.071	9.924AlaArg: 9.924 ± 0.118	7.275AlaSer: 7.275 ± 0.069	5.695AlaThr: 5.695 ± 0.072	8.052AlaVal: 8.052 ± 0.091	1.379AlaTrp: 1.379 ± 0.035	2.82AlaTyr: 2.82 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	1.373CysAla: 1.373 ± 0.034	0.139CysCys: 0.139 ± 0.011	0.601CysAsp: 0.601 ± 0.022	0.561CysGlu: 0.561 ± 0.02	0.394CysPhe: 0.394 ± 0.018	1.086CysGly: 1.086 ± 0.033	0.243CysHis: 0.243 ± 0.018	0.373CysIle: 0.373 ± 0.018	0.235CysLys: 0.235 ± 0.014	0.898CysLeu: 0.898 ± 0.027	0.149CysMet: 0.149 ± 0.01	0.262CysAsn: 0.262 ± 0.013	0.523CysPro: 0.523 ± 0.02	0.215CysGln: 0.215 ± 0.011	0.676CysArg: 0.676 ± 0.029	0.59CysSer: 0.59 ± 0.022	0.343CysThr: 0.343 ± 0.018	0.775CysVal: 0.775 ± 0.026	0.139CysTrp: 0.139 ± 0.01	0.221CysTyr: 0.221 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.974AspAla: 6.974 ± 0.087	0.584AspCys: 0.584 ± 0.022	2.788AspAsp: 2.788 ± 0.046	3.427AspGlu: 3.427 ± 0.054	2.378AspPhe: 2.378 ± 0.047	4.523AspGly: 4.523 ± 0.074	1.154AspHis: 1.154 ± 0.029	2.795AspIle: 2.795 ± 0.049	1.765AspLys: 1.765 ± 0.05	5.53AspLeu: 5.53 ± 0.061	1.107AspMet: 1.107 ± 0.03	1.349AspAsn: 1.349 ± 0.033	3.39AspPro: 3.39 ± 0.055	1.563AspGln: 1.563 ± 0.041	3.928AspArg: 3.928 ± 0.065	2.375AspSer: 2.375 ± 0.043	1.833AspThr: 1.833 ± 0.037	3.65AspVal: 3.65 ± 0.054	0.894AspTrp: 0.894 ± 0.03	1.536AspTyr: 1.536 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	8.429GluAla: 8.429 ± 0.112	0.415GluCys: 0.415 ± 0.02	2.8GluAsp: 2.8 ± 0.048	3.753GluGlu: 3.753 ± 0.069	2.017GluPhe: 2.017 ± 0.046	4.318GluGly: 4.318 ± 0.067	1.158GluHis: 1.158 ± 0.033	3.825GluIle: 3.825 ± 0.063	2.816GluLys: 2.816 ± 0.053	5.679GluLeu: 5.679 ± 0.085	1.306GluMet: 1.306 ± 0.034	1.843GluAsn: 1.843 ± 0.04	3.018GluPro: 3.018 ± 0.064	2.03GluGln: 2.03 ± 0.043	5.3GluArg: 5.3 ± 0.091	2.929GluSer: 2.929 ± 0.051	3.621GluThr: 3.621 ± 0.064	3.391GluVal: 3.391 ± 0.051	0.728GluTrp: 0.728 ± 0.024	1.033GluTyr: 1.033 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.993PheAla: 4.993 ± 0.066	0.509PheCys: 0.509 ± 0.021	2.785PheAsp: 2.785 ± 0.05	2.45PheGlu: 2.45 ± 0.044	1.666PhePhe: 1.666 ± 0.041	3.869PheGly: 3.869 ± 0.063	0.809PheHis: 0.809 ± 0.03	1.665PheIle: 1.665 ± 0.036	1.179PheLys: 1.179 ± 0.034	3.759PheLeu: 3.759 ± 0.061	0.794PheMet: 0.794 ± 0.026	1.122PheAsn: 1.122 ± 0.033	1.753PhePro: 1.753 ± 0.042	1.055PheGln: 1.055 ± 0.026	2.413PheArg: 2.413 ± 0.047	2.778PheSer: 2.778 ± 0.05	1.832PheThr: 1.832 ± 0.044	2.942PheVal: 2.942 ± 0.05	0.587PheTrp: 0.587 ± 0.02	1.001PheTyr: 1.001 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	11.505GlyAla: 11.505 ± 0.13	0.913GlyCys: 0.913 ± 0.028	4.344GlyAsp: 4.344 ± 0.065	5.175GlyGlu: 5.175 ± 0.084	3.772GlyPhe: 3.772 ± 0.059	7.98GlyGly: 7.98 ± 0.134	1.622GlyHis: 1.622 ± 0.04	2.938GlyIle: 2.938 ± 0.046	3.274GlyLys: 3.274 ± 0.057	8.694GlyLeu: 8.694 ± 0.08	1.748GlyMet: 1.748 ± 0.04	1.939GlyAsn: 1.939 ± 0.05	3.608GlyPro: 3.608 ± 0.062	2.483GlyGln: 2.483 ± 0.048	6.017GlyArg: 6.017 ± 0.071	4.755GlySer: 4.755 ± 0.074	3.192GlyThr: 3.192 ± 0.067	7.078GlyVal: 7.078 ± 0.094	1.356GlyTrp: 1.356 ± 0.038	2.278GlyTyr: 2.278 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.211HisAla: 2.211 ± 0.043	0.238HisCys: 0.238 ± 0.014	1.069HisAsp: 1.069 ± 0.027	1.166HisGlu: 1.166 ± 0.031	0.898HisPhe: 0.898 ± 0.027	1.895HisGly: 1.895 ± 0.044	0.545HisHis: 0.545 ± 0.035	0.996HisIle: 0.996 ± 0.03	0.547HisLys: 0.547 ± 0.023	1.771HisLeu: 1.771 ± 0.039	0.478HisMet: 0.478 ± 0.02	0.524HisAsn: 0.524 ± 0.022	1.251HisPro: 1.251 ± 0.03	0.464HisGln: 0.464 ± 0.018	1.319HisArg: 1.319 ± 0.034	1.069HisSer: 1.069 ± 0.034	0.661HisThr: 0.661 ± 0.023	1.448HisVal: 1.448 ± 0.036	0.324HisTrp: 0.324 ± 0.016	0.625HisTyr: 0.625 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	6.818IleAla: 6.818 ± 0.074	0.556IleCys: 0.556 ± 0.022	3.369IleAsp: 3.369 ± 0.052	3.82IleGlu: 3.82 ± 0.058	1.796IlePhe: 1.796 ± 0.035	4.617IleGly: 4.617 ± 0.06	0.855IleHis: 0.855 ± 0.027	1.874IleIle: 1.874 ± 0.043	1.473IleLys: 1.473 ± 0.039	4.2IleLeu: 4.2 ± 0.067	0.823IleMet: 0.823 ± 0.026	1.245IleAsn: 1.245 ± 0.031	2.117IlePro: 2.117 ± 0.033	1.104IleGln: 1.104 ± 0.025	2.856IleArg: 2.856 ± 0.046	2.914IleSer: 2.914 ± 0.047	1.953IleThr: 1.953 ± 0.041	4.041IleVal: 4.041 ± 0.066	0.549IleTrp: 0.549 ± 0.024	1.256IleTyr: 1.256 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	4.284LysAla: 4.284 ± 0.074	0.223LysCys: 0.223 ± 0.013	1.748LysAsp: 1.748 ± 0.04	1.937LysGlu: 1.937 ± 0.041	1.136LysPhe: 1.136 ± 0.029	2.79LysGly: 2.79 ± 0.052	0.575LysHis: 0.575 ± 0.024	2.128LysIle: 2.128 ± 0.044	1.544LysLys: 1.544 ± 0.041	3.49LysLeu: 3.49 ± 0.062	0.778LysMet: 0.778 ± 0.026	1.069LysAsn: 1.069 ± 0.031	2.156LysPro: 2.156 ± 0.053	0.969LysGln: 0.969 ± 0.029	2.502LysArg: 2.502 ± 0.049	2.133LysSer: 2.133 ± 0.041	2.091LysThr: 2.091 ± 0.047	2.081LysVal: 2.081 ± 0.04	0.396LysTrp: 0.396 ± 0.016	0.743LysTyr: 0.743 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	14.383LeuAla: 14.383 ± 0.127	1.029LeuCys: 1.029 ± 0.033	5.964LeuAsp: 5.964 ± 0.075	5.819LeuGlu: 5.819 ± 0.083	3.878LeuPhe: 3.878 ± 0.059	8.279LeuGly: 8.279 ± 0.088	1.886LeuHis: 1.886 ± 0.039	4.632LeuIle: 4.632 ± 0.069	3.402LeuLys: 3.402 ± 0.055	9.67LeuLeu: 9.67 ± 0.097	1.957LeuMet: 1.957 ± 0.04	2.554LeuAsn: 2.554 ± 0.052	5.347LeuPro: 5.347 ± 0.07	2.91LeuGln: 2.91 ± 0.054	7.485LeuArg: 7.485 ± 0.099	6.732LeuSer: 6.732 ± 0.087	5.139LeuThr: 5.139 ± 0.071	6.683LeuVal: 6.683 ± 0.077	1.185LeuTrp: 1.185 ± 0.033	2.29LeuTyr: 2.29 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	2.5MetAla: 2.5 ± 0.045	0.153MetCys: 0.153 ± 0.011	0.897MetAsp: 0.897 ± 0.025	1.067MetGlu: 1.067 ± 0.03	0.658MetPhe: 0.658 ± 0.024	1.464MetGly: 1.464 ± 0.038	0.359MetHis: 0.359 ± 0.017	1.128MetIle: 1.128 ± 0.029	0.887MetLys: 0.887 ± 0.027	2.102MetLeu: 2.102 ± 0.042	0.477MetMet: 0.477 ± 0.019	0.713MetAsn: 0.713 ± 0.021	1.125MetPro: 1.125 ± 0.031	0.737MetGln: 0.737 ± 0.027	1.754MetArg: 1.754 ± 0.034	1.551MetSer: 1.551 ± 0.035	1.498MetThr: 1.498 ± 0.036	1.153MetVal: 1.153 ± 0.029	0.184MetTrp: 0.184 ± 0.01	0.243MetTyr: 0.243 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	3.287AsnAla: 3.287 ± 0.053	0.333AsnCys: 0.333 ± 0.018	1.338AsnAsp: 1.338 ± 0.035	1.394AsnGlu: 1.394 ± 0.033	1.177AsnPhe: 1.177 ± 0.03	2.456AsnGly: 2.456 ± 0.046	0.512AsnHis: 0.512 ± 0.023	1.494AsnIle: 1.494 ± 0.038	0.737AsnLys: 0.737 ± 0.03	2.703AsnLeu: 2.703 ± 0.047	0.508AsnMet: 0.508 ± 0.018	0.793AsnAsn: 0.793 ± 0.033	1.925AsnPro: 1.925 ± 0.038	0.798AsnGln: 0.798 ± 0.027	1.761AsnArg: 1.761 ± 0.041	1.449AsnSer: 1.449 ± 0.038	1.085AsnThr: 1.085 ± 0.033	1.949AsnVal: 1.949 ± 0.044	0.464AsnTrp: 0.464 ± 0.019	0.84AsnTyr: 0.84 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	6.994ProAla: 6.994 ± 0.1	0.418ProCys: 0.418 ± 0.018	3.218ProAsp: 3.218 ± 0.053	3.705ProGlu: 3.705 ± 0.055	2.175ProPhe: 2.175 ± 0.04	4.742ProGly: 4.742 ± 0.067	1.143ProHis: 1.143 ± 0.031	2.325ProIle: 2.325 ± 0.042	1.849ProLys: 1.849 ± 0.041	5.069ProLeu: 5.069 ± 0.068	1.007ProMet: 1.007 ± 0.026	1.495ProAsn: 1.495 ± 0.037	3.402ProPro: 3.402 ± 0.065	1.995ProGln: 1.995 ± 0.04	3.441ProArg: 3.441 ± 0.053	3.188ProSer: 3.188 ± 0.058	2.557ProThr: 2.557 ± 0.048	3.693ProVal: 3.693 ± 0.061	0.738ProTrp: 0.738 ± 0.021	1.229ProTyr: 1.229 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	3.982GlnAla: 3.982 ± 0.06	0.258GlnCys: 0.258 ± 0.016	1.417GlnAsp: 1.417 ± 0.035	1.671GlnGlu: 1.671 ± 0.043	1.111GlnPhe: 1.111 ± 0.032	2.363GlnGly: 2.363 ± 0.043	0.54GlnHis: 0.54 ± 0.019	1.806GlnIle: 1.806 ± 0.035	1.278GlnLys: 1.278 ± 0.033	2.783GlnLeu: 2.783 ± 0.047	0.708GlnMet: 0.708 ± 0.023	0.993GlnAsn: 0.993 ± 0.031	1.695GlnPro: 1.695 ± 0.04	1.154GlnGln: 1.154 ± 0.032	2.286GlnArg: 2.286 ± 0.042	1.934GlnSer: 1.934 ± 0.041	1.766GlnThr: 1.766 ± 0.035	1.73GlnVal: 1.73 ± 0.039	0.49GlnTrp: 0.49 ± 0.019	0.694GlnTyr: 0.694 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	8.787ArgAla: 8.787 ± 0.107	0.591ArgCys: 0.591 ± 0.023	3.849ArgAsp: 3.849 ± 0.067	4.856ArgGlu: 4.856 ± 0.069	3.151ArgPhe: 3.151 ± 0.05	4.904ArgGly: 4.904 ± 0.072	1.617ArgHis: 1.617 ± 0.04	3.975ArgIle: 3.975 ± 0.067	2.633ArgLys: 2.633 ± 0.052	8.674ArgLeu: 8.674 ± 0.114	1.592ArgMet: 1.592 ± 0.035	1.964ArgAsn: 1.964 ± 0.035	3.786ArgPro: 3.786 ± 0.063	2.255ArgGln: 2.255 ± 0.04	6.55ArgArg: 6.55 ± 0.099	3.981ArgSer: 3.981 ± 0.06	2.766ArgThr: 2.766 ± 0.042	4.558ArgVal: 4.558 ± 0.066	0.967ArgTrp: 0.967 ± 0.028	1.758ArgTyr: 1.758 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	7.141SerAla: 7.141 ± 0.079	0.62SerCys: 0.62 ± 0.021	2.911SerAsp: 2.911 ± 0.046	3.105SerGlu: 3.105 ± 0.052	2.713SerPhe: 2.713 ± 0.054	5.803SerGly: 5.803 ± 0.085	1.141SerHis: 1.141 ± 0.028	2.763SerIle: 2.763 ± 0.049	1.739SerLys: 1.739 ± 0.041	6.084SerLeu: 6.084 ± 0.071	1.197SerMet: 1.197 ± 0.032	1.554SerAsn: 1.554 ± 0.036	3.389SerPro: 3.389 ± 0.052	1.772SerGln: 1.772 ± 0.042	4.214SerArg: 4.214 ± 0.057	3.59SerSer: 3.59 ± 0.063	2.516SerThr: 2.516 ± 0.05	3.989SerVal: 3.989 ± 0.054	0.841SerTrp: 0.841 ± 0.026	1.513SerTyr: 1.513 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	5.437ThrAla: 5.437 ± 0.071	0.394ThrCys: 0.394 ± 0.019	2.165ThrAsp: 2.165 ± 0.044	2.179ThrGlu: 2.179 ± 0.036	1.721ThrPhe: 1.721 ± 0.041	4.375ThrGly: 4.375 ± 0.066	0.916ThrHis: 0.916 ± 0.027	2.505ThrIle: 2.505 ± 0.048	1.45ThrLys: 1.45 ± 0.036	5.315ThrLeu: 5.315 ± 0.085	0.851ThrMet: 0.851 ± 0.031	1.226ThrAsn: 1.226 ± 0.039	3.514ThrPro: 3.514 ± 0.067	1.562ThrGln: 1.562 ± 0.038	3.151ThrArg: 3.151 ± 0.055	2.557ThrSer: 2.557 ± 0.052	2.528ThrThr: 2.528 ± 0.057	3.341ThrVal: 3.341 ± 0.062	0.496ThrTrp: 0.496 ± 0.021	1.085ThrTyr: 1.085 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	9.226ValAla: 9.226 ± 0.094	0.701ValCys: 0.701 ± 0.024	3.97ValAsp: 3.97 ± 0.055	4.597ValGlu: 4.597 ± 0.062	2.921ValPhe: 2.921 ± 0.049	5.217ValGly: 5.217 ± 0.07	1.273ValHis: 1.273 ± 0.032	3.328ValIle: 3.328 ± 0.057	2.318ValLys: 2.318 ± 0.043	6.194ValLeu: 6.194 ± 0.08	1.434ValMet: 1.434 ± 0.038	2.011ValAsn: 2.011 ± 0.042	2.849ValPro: 2.849 ± 0.052	1.777ValGln: 1.777 ± 0.032	4.351ValArg: 4.351 ± 0.058	4.413ValSer: 4.413 ± 0.065	3.888ValThr: 3.888 ± 0.059	5.754ValVal: 5.754 ± 0.084	0.869ValTrp: 0.869 ± 0.031	1.626ValTyr: 1.626 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.213TrpAla: 1.213 ± 0.029	0.158TrpCys: 0.158 ± 0.011	0.587TrpAsp: 0.587 ± 0.023	0.537TrpGlu: 0.537 ± 0.02	0.54TrpPhe: 0.54 ± 0.019	0.952TrpGly: 0.952 ± 0.031	0.246TrpHis: 0.246 ± 0.017	0.647TrpIle: 0.647 ± 0.025	0.474TrpLys: 0.474 ± 0.02	1.593TrpLeu: 1.593 ± 0.04	0.29TrpMet: 0.29 ± 0.014	0.437TrpAsn: 0.437 ± 0.019	0.703TrpPro: 0.703 ± 0.023	0.374TrpGln: 0.374 ± 0.018	1.512TrpArg: 1.512 ± 0.036	0.973TrpSer: 0.973 ± 0.029	0.809TrpThr: 0.809 ± 0.028	0.69TrpVal: 0.69 ± 0.023	0.183TrpTrp: 0.183 ± 0.014	0.26TrpTyr: 0.26 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.762TyrAla: 2.762 ± 0.051	0.277TyrCys: 0.277 ± 0.015	1.562TyrAsp: 1.562 ± 0.046	1.276TyrGlu: 1.276 ± 0.028	1.074TyrPhe: 1.074 ± 0.027	2.318TyrGly: 2.318 ± 0.062	0.47TyrHis: 0.47 ± 0.021	0.894TyrIle: 0.894 ± 0.029	0.682TyrLys: 0.682 ± 0.026	2.349TyrLeu: 2.349 ± 0.047	0.425TyrMet: 0.425 ± 0.017	0.779TyrAsn: 0.779 ± 0.03	1.133TyrPro: 1.133 ± 0.031	0.745TyrGln: 0.745 ± 0.025	1.774TyrArg: 1.774 ± 0.037	1.408TyrSer: 1.408 ± 0.038	0.991TyrThr: 0.991 ± 0.029	1.721TyrVal: 1.721 ± 0.037	0.41TyrTrp: 0.41 ± 0.019	0.712TyrTyr: 0.712 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4086 proteins (1319365 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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