Amino acid dipepetide frequency for Bacillus aquimaris

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.558AlaAla: 6.558 ± 0.103	0.543AlaCys: 0.543 ± 0.024	3.59AlaAsp: 3.59 ± 0.048	4.887AlaGlu: 4.887 ± 0.066	3.276AlaPhe: 3.276 ± 0.056	6.142AlaGly: 6.142 ± 0.083	1.309AlaHis: 1.309 ± 0.038	5.129AlaIle: 5.129 ± 0.066	4.215AlaLys: 4.215 ± 0.065	7.049AlaLeu: 7.049 ± 0.087	2.023AlaMet: 2.023 ± 0.044	2.275AlaAsn: 2.275 ± 0.047	2.137AlaPro: 2.137 ± 0.052	1.972AlaGln: 1.972 ± 0.043	2.709AlaArg: 2.709 ± 0.052	4.179AlaSer: 4.179 ± 0.062	2.75AlaThr: 2.75 ± 0.051	5.887AlaVal: 5.887 ± 0.077	0.627AlaTrp: 0.627 ± 0.025	2.267AlaTyr: 2.267 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	0.392CysAla: 0.392 ± 0.018	0.091CysCys: 0.091 ± 0.01	0.413CysAsp: 0.413 ± 0.019	0.466CysGlu: 0.466 ± 0.017	0.288CysPhe: 0.288 ± 0.016	0.646CysGly: 0.646 ± 0.025	0.199CysHis: 0.199 ± 0.013	0.54CysIle: 0.54 ± 0.021	0.332CysLys: 0.332 ± 0.016	0.675CysLeu: 0.675 ± 0.025	0.194CysMet: 0.194 ± 0.012	0.242CysAsn: 0.242 ± 0.014	0.359CysPro: 0.359 ± 0.018	0.208CysGln: 0.208 ± 0.012	0.35CysArg: 0.35 ± 0.017	0.521CysSer: 0.521 ± 0.021	0.402CysThr: 0.402 ± 0.017	0.406CysVal: 0.406 ± 0.017	0.069CysTrp: 0.069 ± 0.007	0.231CysTyr: 0.231 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.427AspAla: 3.427 ± 0.057	0.404AspCys: 0.404 ± 0.019	2.606AspAsp: 2.606 ± 0.052	4.738AspGlu: 4.738 ± 0.07	2.525AspPhe: 2.525 ± 0.051	3.827AspGly: 3.827 ± 0.066	1.211AspHis: 1.211 ± 0.034	4.084AspIle: 4.084 ± 0.056	3.273AspLys: 3.273 ± 0.064	5.156AspLeu: 5.156 ± 0.062	1.429AspMet: 1.429 ± 0.036	1.651AspAsn: 1.651 ± 0.045	2.184AspPro: 2.184 ± 0.047	1.902AspGln: 1.902 ± 0.04	2.5AspArg: 2.5 ± 0.044	2.956AspSer: 2.956 ± 0.051	2.555AspThr: 2.555 ± 0.051	3.696AspVal: 3.696 ± 0.051	0.734AspTrp: 0.734 ± 0.03	2.215AspTyr: 2.215 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	5.624GluAla: 5.624 ± 0.077	0.433GluCys: 0.433 ± 0.02	4.317GluAsp: 4.317 ± 0.071	8.103GluGlu: 8.103 ± 0.099	2.655GluPhe: 2.655 ± 0.055	5.077GluGly: 5.077 ± 0.076	1.487GluHis: 1.487 ± 0.037	5.375GluIle: 5.375 ± 0.076	6.928GluLys: 6.928 ± 0.1	7.419GluLeu: 7.419 ± 0.09	2.523GluMet: 2.523 ± 0.047	3.65GluAsn: 3.65 ± 0.052	1.971GluPro: 1.971 ± 0.047	2.804GluGln: 2.804 ± 0.05	3.645GluArg: 3.645 ± 0.063	3.866GluSer: 3.866 ± 0.062	3.874GluThr: 3.874 ± 0.056	5.433GluVal: 5.433 ± 0.065	0.91GluTrp: 0.91 ± 0.032	2.467GluTyr: 2.467 ± 0.051	0.0GluXaa: 0.0 ± 0.0
Phe	2.9PheAla: 2.9 ± 0.05	0.346PheCys: 0.346 ± 0.019	2.399PheAsp: 2.399 ± 0.042	2.838PheGlu: 2.838 ± 0.048	2.368PhePhe: 2.368 ± 0.052	3.336PheGly: 3.336 ± 0.058	1.097PheHis: 1.097 ± 0.034	3.898PheIle: 3.898 ± 0.072	2.493PheLys: 2.493 ± 0.044	4.719PheLeu: 4.719 ± 0.075	1.281PheMet: 1.281 ± 0.035	1.868PheAsn: 1.868 ± 0.04	1.689PhePro: 1.689 ± 0.042	1.549PheGln: 1.549 ± 0.036	1.643PheArg: 1.643 ± 0.035	3.346PheSer: 3.346 ± 0.055	2.687PheThr: 2.687 ± 0.053	2.944PheVal: 2.944 ± 0.054	0.505PheTrp: 0.505 ± 0.023	1.765PheTyr: 1.765 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	5.073GlyAla: 5.073 ± 0.086	0.634GlyCys: 0.634 ± 0.025	3.66GlyAsp: 3.66 ± 0.062	5.207GlyGlu: 5.207 ± 0.066	3.577GlyPhe: 3.577 ± 0.064	5.276GlyGly: 5.276 ± 0.086	1.398GlyHis: 1.398 ± 0.037	5.969GlyIle: 5.969 ± 0.071	5.414GlyLys: 5.414 ± 0.065	6.958GlyLeu: 6.958 ± 0.08	2.389GlyMet: 2.389 ± 0.043	2.743GlyAsn: 2.743 ± 0.05	1.818GlyPro: 1.818 ± 0.039	2.108GlyGln: 2.108 ± 0.047	3.021GlyArg: 3.021 ± 0.059	4.448GlySer: 4.448 ± 0.065	4.207GlyThr: 4.207 ± 0.067	5.462GlyVal: 5.462 ± 0.071	0.895GlyTrp: 0.895 ± 0.033	2.859GlyTyr: 2.859 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	1.279HisAla: 1.279 ± 0.034	0.218HisCys: 0.218 ± 0.014	1.056HisAsp: 1.056 ± 0.028	1.525HisGlu: 1.525 ± 0.039	1.128HisPhe: 1.128 ± 0.034	1.502HisGly: 1.502 ± 0.037	0.7HisHis: 0.7 ± 0.024	1.476HisIle: 1.476 ± 0.04	1.137HisLys: 1.137 ± 0.032	2.181HisLeu: 2.181 ± 0.044	0.542HisMet: 0.542 ± 0.023	0.76HisAsn: 0.76 ± 0.025	1.181HisPro: 1.181 ± 0.035	0.782HisGln: 0.782 ± 0.024	0.957HisArg: 0.957 ± 0.028	1.415HisSer: 1.415 ± 0.031	1.082HisThr: 1.082 ± 0.031	1.363HisVal: 1.363 ± 0.034	0.23HisTrp: 0.23 ± 0.014	0.964HisTyr: 0.964 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.397IleAla: 5.397 ± 0.082	0.591IleCys: 0.591 ± 0.024	4.2IleAsp: 4.2 ± 0.058	5.626IleGlu: 5.626 ± 0.084	3.136IlePhe: 3.136 ± 0.064	5.995IleGly: 5.995 ± 0.072	1.744IleHis: 1.744 ± 0.042	5.557IleIle: 5.557 ± 0.089	4.315IleLys: 4.315 ± 0.061	7.229IleLeu: 7.229 ± 0.085	1.802IleMet: 1.802 ± 0.042	2.815IleAsn: 2.815 ± 0.05	3.302IlePro: 3.302 ± 0.053	2.545IleGln: 2.545 ± 0.041	3.062IleArg: 3.062 ± 0.05	5.025IleSer: 5.025 ± 0.068	4.039IleThr: 4.039 ± 0.066	4.997IleVal: 4.997 ± 0.078	0.633IleTrp: 0.633 ± 0.024	2.301IleTyr: 2.301 ± 0.047	0.0IleXaa: 0.0 ± 0.0
Lys	4.843LysAla: 4.843 ± 0.073	0.314LysCys: 0.314 ± 0.016	4.117LysAsp: 4.117 ± 0.066	7.438LysGlu: 7.438 ± 0.108	1.907LysPhe: 1.907 ± 0.034	4.962LysGly: 4.962 ± 0.061	1.336LysHis: 1.336 ± 0.032	4.381LysIle: 4.381 ± 0.07	6.153LysLys: 6.153 ± 0.088	5.664LysLeu: 5.664 ± 0.066	2.205LysMet: 2.205 ± 0.041	3.051LysAsn: 3.051 ± 0.054	2.32LysPro: 2.32 ± 0.048	2.645LysGln: 2.645 ± 0.053	3.299LysArg: 3.299 ± 0.053	3.622LysSer: 3.622 ± 0.057	3.422LysThr: 3.422 ± 0.051	4.829LysVal: 4.829 ± 0.067	0.878LysTrp: 0.878 ± 0.026	1.973LysTyr: 1.973 ± 0.043	0.0LysXaa: 0.0 ± 0.0
Leu	7.117LeuAla: 7.117 ± 0.084	0.638LeuCys: 0.638 ± 0.023	4.927LeuAsp: 4.927 ± 0.066	6.714LeuGlu: 6.714 ± 0.078	4.956LeuPhe: 4.956 ± 0.079	6.438LeuGly: 6.438 ± 0.078	2.047LeuHis: 2.047 ± 0.045	7.153LeuIle: 7.153 ± 0.102	6.962LeuLys: 6.962 ± 0.089	10.012LeuLeu: 10.012 ± 0.125	2.609LeuMet: 2.609 ± 0.051	4.12LeuAsn: 4.12 ± 0.06	3.954LeuPro: 3.954 ± 0.06	3.389LeuGln: 3.389 ± 0.061	3.551LeuArg: 3.551 ± 0.054	7.011LeuSer: 7.011 ± 0.087	5.593LeuThr: 5.593 ± 0.071	6.235LeuVal: 6.235 ± 0.071	0.843LeuTrp: 0.843 ± 0.026	3.195LeuTyr: 3.195 ± 0.058	0.0LeuXaa: 0.0 ± 0.0
Met	2.026MetAla: 2.026 ± 0.046	0.177MetCys: 0.177 ± 0.012	1.581MetAsp: 1.581 ± 0.037	2.167MetGlu: 2.167 ± 0.042	1.121MetPhe: 1.121 ± 0.031	1.933MetGly: 1.933 ± 0.044	0.459MetHis: 0.459 ± 0.021	2.22MetIle: 2.22 ± 0.047	2.862MetLys: 2.862 ± 0.045	2.474MetLeu: 2.474 ± 0.041	0.939MetMet: 0.939 ± 0.033	1.709MetAsn: 1.709 ± 0.039	1.018MetPro: 1.018 ± 0.03	0.801MetGln: 0.801 ± 0.026	1.167MetArg: 1.167 ± 0.032	1.637MetSer: 1.637 ± 0.038	1.787MetThr: 1.787 ± 0.042	1.852MetVal: 1.852 ± 0.039	0.207MetTrp: 0.207 ± 0.015	0.713MetTyr: 0.713 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	2.522AsnAla: 2.522 ± 0.045	0.267AsnCys: 0.267 ± 0.015	2.075AsnAsp: 2.075 ± 0.043	3.364AsnGlu: 3.364 ± 0.064	1.44AsnPhe: 1.44 ± 0.038	3.356AsnGly: 3.356 ± 0.058	1.004AsnHis: 1.004 ± 0.029	2.96AsnIle: 2.96 ± 0.059	2.636AsnLys: 2.636 ± 0.047	3.593AsnLeu: 3.593 ± 0.055	1.116AsnMet: 1.116 ± 0.032	1.575AsnAsn: 1.575 ± 0.042	2.081AsnPro: 2.081 ± 0.047	1.572AsnGln: 1.572 ± 0.042	1.876AsnArg: 1.876 ± 0.041	2.13AsnSer: 2.13 ± 0.041	1.949AsnThr: 1.949 ± 0.041	2.816AsnVal: 2.816 ± 0.049	0.475AsnTrp: 0.475 ± 0.02	1.341AsnTyr: 1.341 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	2.638ProAla: 2.638 ± 0.05	0.222ProCys: 0.222 ± 0.015	2.258ProAsp: 2.258 ± 0.044	3.167ProGlu: 3.167 ± 0.06	2.067ProPhe: 2.067 ± 0.042	2.688ProGly: 2.688 ± 0.057	0.92ProHis: 0.92 ± 0.029	2.462ProIle: 2.462 ± 0.047	1.99ProLys: 1.99 ± 0.04	3.607ProLeu: 3.607 ± 0.062	0.9ProMet: 0.9 ± 0.032	1.3ProAsn: 1.3 ± 0.039	1.072ProPro: 1.072 ± 0.031	1.145ProGln: 1.145 ± 0.033	1.185ProArg: 1.185 ± 0.031	2.465ProSer: 2.465 ± 0.047	1.605ProThr: 1.605 ± 0.038	3.167ProVal: 3.167 ± 0.055	0.393ProTrp: 0.393 ± 0.018	1.428ProTyr: 1.428 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	2.363GlnAla: 2.363 ± 0.044	0.203GlnCys: 0.203 ± 0.012	1.609GlnAsp: 1.609 ± 0.033	2.694GlnGlu: 2.694 ± 0.052	1.452GlnPhe: 1.452 ± 0.036	2.224GlnGly: 2.224 ± 0.041	0.753GlnHis: 0.753 ± 0.025	2.07GlnIle: 2.07 ± 0.045	2.498GlnLys: 2.498 ± 0.055	3.501GlnLeu: 3.501 ± 0.069	1.007GlnMet: 1.007 ± 0.031	1.354GlnAsn: 1.354 ± 0.033	1.203GlnPro: 1.203 ± 0.036	1.455GlnGln: 1.455 ± 0.042	1.406GlnArg: 1.406 ± 0.037	2.13GlnSer: 2.13 ± 0.048	1.799GlnThr: 1.799 ± 0.038	2.06GlnVal: 2.06 ± 0.043	0.406GlnTrp: 0.406 ± 0.02	1.3GlnTyr: 1.3 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	2.367ArgAla: 2.367 ± 0.045	0.252ArgCys: 0.252 ± 0.014	2.332ArgAsp: 2.332 ± 0.041	3.469ArgGlu: 3.469 ± 0.068	2.027ArgPhe: 2.027 ± 0.042	2.558ArgGly: 2.558 ± 0.055	0.932ArgHis: 0.932 ± 0.027	3.06ArgIle: 3.06 ± 0.052	3.3ArgLys: 3.3 ± 0.058	4.017ArgLeu: 4.017 ± 0.062	1.407ArgMet: 1.407 ± 0.033	1.912ArgAsn: 1.912 ± 0.037	1.339ArgPro: 1.339 ± 0.035	1.486ArgGln: 1.486 ± 0.035	1.944ArgArg: 1.944 ± 0.047	2.414ArgSer: 2.414 ± 0.043	2.044ArgThr: 2.044 ± 0.036	2.683ArgVal: 2.683 ± 0.054	0.435ArgTrp: 0.435 ± 0.019	1.575ArgTyr: 1.575 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	4.003SerAla: 4.003 ± 0.068	0.413SerCys: 0.413 ± 0.019	3.012SerAsp: 3.012 ± 0.054	4.267SerGlu: 4.267 ± 0.059	3.471SerPhe: 3.471 ± 0.058	5.02SerGly: 5.02 ± 0.07	1.331SerHis: 1.331 ± 0.031	4.978SerIle: 4.978 ± 0.066	3.852SerLys: 3.852 ± 0.057	6.488SerLeu: 6.488 ± 0.079	1.864SerMet: 1.864 ± 0.033	2.201SerAsn: 2.201 ± 0.047	2.393SerPro: 2.393 ± 0.049	1.963SerGln: 1.963 ± 0.038	2.542SerArg: 2.542 ± 0.047	4.267SerSer: 4.267 ± 0.071	3.017SerThr: 3.017 ± 0.046	4.391SerVal: 4.391 ± 0.061	0.666SerTrp: 0.666 ± 0.022	2.242SerTyr: 2.242 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	4.054ThrAla: 4.054 ± 0.067	0.336ThrCys: 0.336 ± 0.018	2.711ThrAsp: 2.711 ± 0.049	3.463ThrGlu: 3.463 ± 0.055	2.555ThrPhe: 2.555 ± 0.042	4.46ThrGly: 4.46 ± 0.073	1.008ThrHis: 1.008 ± 0.03	4.159ThrIle: 4.159 ± 0.061	3.017ThrLys: 3.017 ± 0.05	5.161ThrLeu: 5.161 ± 0.066	1.241ThrMet: 1.241 ± 0.033	2.005ThrAsn: 2.005 ± 0.044	2.223ThrPro: 2.223 ± 0.046	1.267ThrGln: 1.267 ± 0.035	1.873ThrArg: 1.873 ± 0.039	3.149ThrSer: 3.149 ± 0.045	2.571ThrThr: 2.571 ± 0.062	4.157ThrVal: 4.157 ± 0.068	0.462ThrTrp: 0.462 ± 0.018	1.842ThrTyr: 1.842 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	4.354ValAla: 4.354 ± 0.074	0.563ValCys: 0.563 ± 0.023	3.719ValAsp: 3.719 ± 0.058	5.133ValGlu: 5.133 ± 0.07	3.317ValPhe: 3.317 ± 0.06	4.355ValGly: 4.355 ± 0.066	1.462ValHis: 1.462 ± 0.035	5.586ValIle: 5.586 ± 0.084	4.997ValLys: 4.997 ± 0.081	6.964ValLeu: 6.964 ± 0.081	2.102ValMet: 2.102 ± 0.039	2.991ValAsn: 2.991 ± 0.06	2.765ValPro: 2.765 ± 0.048	2.243ValGln: 2.243 ± 0.044	2.756ValArg: 2.756 ± 0.047	4.823ValSer: 4.823 ± 0.069	4.047ValThr: 4.047 ± 0.063	4.932ValVal: 4.932 ± 0.085	0.656ValTrp: 0.656 ± 0.026	2.383ValTyr: 2.383 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	0.625TrpAla: 0.625 ± 0.024	0.075TrpCys: 0.075 ± 0.008	0.578TrpAsp: 0.578 ± 0.025	0.68TrpGlu: 0.68 ± 0.024	0.547TrpPhe: 0.547 ± 0.021	0.756TrpGly: 0.756 ± 0.027	0.231TrpHis: 0.231 ± 0.013	0.85TrpIle: 0.85 ± 0.03	0.817TrpLys: 0.817 ± 0.024	1.127TrpLeu: 1.127 ± 0.032	0.354TrpMet: 0.354 ± 0.016	0.556TrpAsn: 0.556 ± 0.021	0.284TrpPro: 0.284 ± 0.016	0.329TrpGln: 0.329 ± 0.019	0.379TrpArg: 0.379 ± 0.019	0.657TrpSer: 0.657 ± 0.024	0.542TrpThr: 0.542 ± 0.023	0.678TrpVal: 0.678 ± 0.023	0.166TrpTrp: 0.166 ± 0.011	0.371TrpTyr: 0.371 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.961TyrAla: 1.961 ± 0.04	0.303TyrCys: 0.303 ± 0.015	1.912TyrAsp: 1.912 ± 0.046	2.614TyrGlu: 2.614 ± 0.05	1.86TyrPhe: 1.86 ± 0.041	2.564TyrGly: 2.564 ± 0.051	0.853TyrHis: 0.853 ± 0.032	2.401TyrIle: 2.401 ± 0.045	2.166TyrLys: 2.166 ± 0.04	3.469TyrLeu: 3.469 ± 0.056	0.925TyrMet: 0.925 ± 0.028	1.369TyrAsn: 1.369 ± 0.035	1.384TyrPro: 1.384 ± 0.035	1.326TyrGln: 1.326 ± 0.034	1.688TyrArg: 1.688 ± 0.038	2.32TyrSer: 2.32 ± 0.046	1.743TyrThr: 1.743 ± 0.039	2.158TyrVal: 2.158 ± 0.045	0.415TyrTrp: 0.415 ± 0.018	1.432TyrTyr: 1.432 ± 0.047	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4196 proteins (1192751 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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