Amino acid dipepetide frequency for Anaerospora hongkongensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.023AlaAla: 12.023 ± 0.149	1.195AlaCys: 1.195 ± 0.036	4.8AlaAsp: 4.8 ± 0.076	6.058AlaGlu: 6.058 ± 0.078	3.386AlaPhe: 3.386 ± 0.059	8.453AlaGly: 8.453 ± 0.12	1.459AlaHis: 1.459 ± 0.041	6.864AlaIle: 6.864 ± 0.078	5.356AlaLys: 5.356 ± 0.067	9.126AlaLeu: 9.126 ± 0.103	2.717AlaMet: 2.717 ± 0.049	3.297AlaAsn: 3.297 ± 0.058	2.677AlaPro: 2.677 ± 0.054	3.454AlaGln: 3.454 ± 0.061	3.964AlaArg: 3.964 ± 0.06	4.738AlaSer: 4.738 ± 0.084	4.81AlaThr: 4.81 ± 0.204	8.536AlaVal: 8.536 ± 0.083	0.796AlaTrp: 0.796 ± 0.024	2.75AlaTyr: 2.75 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.885CysAla: 0.885 ± 0.022	0.254CysCys: 0.254 ± 0.022	0.541CysAsp: 0.541 ± 0.025	0.635CysGlu: 0.635 ± 0.026	0.464CysPhe: 0.464 ± 0.018	1.189CysGly: 1.189 ± 0.033	0.293CysHis: 0.293 ± 0.015	0.788CysIle: 0.788 ± 0.026	0.527CysLys: 0.527 ± 0.022	1.126CysLeu: 1.126 ± 0.031	0.269CysMet: 0.269 ± 0.014	0.452CysAsn: 0.452 ± 0.021	0.658CysPro: 0.658 ± 0.028	0.467CysGln: 0.467 ± 0.019	0.713CysArg: 0.713 ± 0.027	0.786CysSer: 0.786 ± 0.023	0.63CysThr: 0.63 ± 0.023	0.669CysVal: 0.669 ± 0.025	0.117CysTrp: 0.117 ± 0.009	0.398CysTyr: 0.398 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	3.823AspAla: 3.823 ± 0.067	0.627AspCys: 0.627 ± 0.025	2.082AspAsp: 2.082 ± 0.056	3.115AspGlu: 3.115 ± 0.052	2.014AspPhe: 2.014 ± 0.043	3.378AspGly: 3.378 ± 0.059	0.914AspHis: 0.914 ± 0.027	4.032AspIle: 4.032 ± 0.056	3.111AspLys: 3.111 ± 0.049	4.311AspLeu: 4.311 ± 0.063	1.308AspMet: 1.308 ± 0.031	1.964AspAsn: 1.964 ± 0.046	1.833AspPro: 1.833 ± 0.037	1.622AspGln: 1.622 ± 0.034	2.403AspArg: 2.403 ± 0.046	2.539AspSer: 2.539 ± 0.047	2.568AspThr: 2.568 ± 0.041	3.466AspVal: 3.466 ± 0.056	0.61AspTrp: 0.61 ± 0.023	1.883AspTyr: 1.883 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	5.74GluAla: 5.74 ± 0.078	0.593GluCys: 0.593 ± 0.029	2.673GluAsp: 2.673 ± 0.05	4.559GluGlu: 4.559 ± 0.067	2.185GluPhe: 2.185 ± 0.038	3.615GluGly: 3.615 ± 0.056	1.181GluHis: 1.181 ± 0.029	4.586GluIle: 4.586 ± 0.063	4.407GluLys: 4.407 ± 0.059	6.607GluLeu: 6.607 ± 0.078	1.882GluMet: 1.882 ± 0.035	2.462GluAsn: 2.462 ± 0.049	1.847GluPro: 1.847 ± 0.038	3.52GluGln: 3.52 ± 0.061	3.386GluArg: 3.386 ± 0.056	2.588GluSer: 2.588 ± 0.045	3.125GluThr: 3.125 ± 0.065	4.392GluVal: 4.392 ± 0.056	0.634GluTrp: 0.634 ± 0.025	1.948GluTyr: 1.948 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	3.554PheAla: 3.554 ± 0.057	0.532PheCys: 0.532 ± 0.023	1.965PheAsp: 1.965 ± 0.042	1.842PheGlu: 1.842 ± 0.04	1.714PhePhe: 1.714 ± 0.044	3.109PheGly: 3.109 ± 0.055	0.74PheHis: 0.74 ± 0.021	2.771PheIle: 2.771 ± 0.05	1.621PheLys: 1.621 ± 0.035	3.753PheLeu: 3.753 ± 0.066	0.982PheMet: 0.982 ± 0.03	1.396PheAsn: 1.396 ± 0.034	1.481PhePro: 1.481 ± 0.035	1.24PheGln: 1.24 ± 0.03	1.681PheArg: 1.681 ± 0.037	2.722PheSer: 2.722 ± 0.049	2.475PheThr: 2.475 ± 0.043	2.697PheVal: 2.697 ± 0.049	0.454PheTrp: 0.454 ± 0.021	1.396PheTyr: 1.396 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	7.122GlyAla: 7.122 ± 0.222	1.044GlyCys: 1.044 ± 0.03	3.4GlyAsp: 3.4 ± 0.06	4.224GlyGlu: 4.224 ± 0.065	3.093GlyPhe: 3.093 ± 0.054	5.549GlyGly: 5.549 ± 0.091	1.444GlyHis: 1.444 ± 0.032	6.316GlyIle: 6.316 ± 0.08	4.812GlyLys: 4.812 ± 0.074	7.496GlyLeu: 7.496 ± 0.084	2.27GlyMet: 2.27 ± 0.047	2.75GlyAsn: 2.75 ± 0.06	2.065GlyPro: 2.065 ± 0.049	2.969GlyGln: 2.969 ± 0.047	3.604GlyArg: 3.604 ± 0.058	4.366GlySer: 4.366 ± 0.07	4.394GlyThr: 4.394 ± 0.071	5.601GlyVal: 5.601 ± 0.075	0.821GlyTrp: 0.821 ± 0.025	2.853GlyTyr: 2.853 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	1.447HisAla: 1.447 ± 0.033	0.295HisCys: 0.295 ± 0.019	0.893HisAsp: 0.893 ± 0.027	0.963HisGlu: 0.963 ± 0.024	0.804HisPhe: 0.804 ± 0.023	1.369HisGly: 1.369 ± 0.032	0.535HisHis: 0.535 ± 0.026	1.405HisIle: 1.405 ± 0.035	0.923HisLys: 0.923 ± 0.027	1.746HisLeu: 1.746 ± 0.039	0.511HisMet: 0.511 ± 0.019	0.779HisAsn: 0.779 ± 0.024	0.973HisPro: 0.973 ± 0.027	0.764HisGln: 0.764 ± 0.023	0.926HisArg: 0.926 ± 0.029	1.148HisSer: 1.148 ± 0.029	1.098HisThr: 1.098 ± 0.028	1.222HisVal: 1.222 ± 0.028	0.217HisTrp: 0.217 ± 0.01	0.75HisTyr: 0.75 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	7.582IleAla: 7.582 ± 0.081	0.85IleCys: 0.85 ± 0.028	3.786IleAsp: 3.786 ± 0.06	4.215IleGlu: 4.215 ± 0.065	2.421IlePhe: 2.421 ± 0.05	5.75IleGly: 5.75 ± 0.088	1.364IleHis: 1.364 ± 0.034	5.269IleIle: 5.269 ± 0.072	3.713IleLys: 3.713 ± 0.058	6.439IleLeu: 6.439 ± 0.077	1.77IleMet: 1.77 ± 0.037	2.916IleAsn: 2.916 ± 0.051	3.345IlePro: 3.345 ± 0.05	2.41IleGln: 2.41 ± 0.041	3.486IleArg: 3.486 ± 0.054	4.454IleSer: 4.454 ± 0.066	4.674IleThr: 4.674 ± 0.061	5.351IleVal: 5.351 ± 0.076	0.562IleTrp: 0.562 ± 0.021	1.962IleTyr: 1.962 ± 0.04	0.0IleXaa: 0.0 ± 0.0
Lys	5.189LysAla: 5.189 ± 0.081	0.511LysCys: 0.511 ± 0.022	2.659LysAsp: 2.659 ± 0.052	4.117LysGlu: 4.117 ± 0.059	1.598LysPhe: 1.598 ± 0.036	3.411LysGly: 3.411 ± 0.052	0.913LysHis: 0.913 ± 0.025	3.844LysIle: 3.844 ± 0.056	3.589LysLys: 3.589 ± 0.065	5.422LysLeu: 5.422 ± 0.065	1.804LysMet: 1.804 ± 0.037	2.379LysAsn: 2.379 ± 0.045	2.175LysPro: 2.175 ± 0.043	2.648LysGln: 2.648 ± 0.042	2.557LysArg: 2.557 ± 0.051	2.744LysSer: 2.744 ± 0.05	3.092LysThr: 3.092 ± 0.044	4.076LysVal: 4.076 ± 0.057	0.578LysTrp: 0.578 ± 0.027	1.74LysTyr: 1.74 ± 0.039	0.0LysXaa: 0.0 ± 0.0
Leu	10.719LeuAla: 10.719 ± 0.111	1.098LeuCys: 1.098 ± 0.033	4.523LeuAsp: 4.523 ± 0.064	5.885LeuGlu: 5.885 ± 0.075	3.99LeuPhe: 3.99 ± 0.071	7.27LeuGly: 7.27 ± 0.086	1.775LeuHis: 1.775 ± 0.032	6.388LeuIle: 6.388 ± 0.08	5.136LeuLys: 5.136 ± 0.061	10.759LeuLeu: 10.759 ± 0.138	2.279LeuMet: 2.279 ± 0.041	3.676LeuAsn: 3.676 ± 0.057	4.653LeuPro: 4.653 ± 0.058	4.038LeuGln: 4.038 ± 0.054	4.48LeuArg: 4.48 ± 0.069	6.291LeuSer: 6.291 ± 0.074	6.197LeuThr: 6.197 ± 0.075	7.008LeuVal: 7.008 ± 0.072	0.934LeuTrp: 0.934 ± 0.034	2.822LeuTyr: 2.822 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	2.688MetAla: 2.688 ± 0.046	0.221MetCys: 0.221 ± 0.012	1.301MetAsp: 1.301 ± 0.032	1.671MetGlu: 1.671 ± 0.036	0.826MetPhe: 0.826 ± 0.023	1.942MetGly: 1.942 ± 0.043	0.45MetHis: 0.45 ± 0.019	1.782MetIle: 1.782 ± 0.037	1.672MetLys: 1.672 ± 0.035	2.871MetLeu: 2.871 ± 0.051	0.728MetMet: 0.728 ± 0.027	1.212MetAsn: 1.212 ± 0.031	1.204MetPro: 1.204 ± 0.035	1.114MetGln: 1.114 ± 0.03	1.209MetArg: 1.209 ± 0.028	1.579MetSer: 1.579 ± 0.032	1.564MetThr: 1.564 ± 0.035	1.984MetVal: 1.984 ± 0.036	0.187MetTrp: 0.187 ± 0.012	0.635MetTyr: 0.635 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.092AsnAla: 3.092 ± 0.054	0.521AsnCys: 0.521 ± 0.021	1.661AsnAsp: 1.661 ± 0.035	2.144AsnGlu: 2.144 ± 0.041	1.352AsnPhe: 1.352 ± 0.034	2.809AsnGly: 2.809 ± 0.048	0.794AsnHis: 0.794 ± 0.026	2.943AsnIle: 2.943 ± 0.057	2.183AsnLys: 2.183 ± 0.043	3.726AsnLeu: 3.726 ± 0.055	1.041AsnMet: 1.041 ± 0.025	1.576AsnAsn: 1.576 ± 0.036	2.055AsnPro: 2.055 ± 0.042	1.508AsnGln: 1.508 ± 0.035	1.988AsnArg: 1.988 ± 0.038	2.238AsnSer: 2.238 ± 0.054	2.17AsnThr: 2.17 ± 0.048	2.665AsnVal: 2.665 ± 0.047	0.48AsnTrp: 0.48 ± 0.021	1.314AsnTyr: 1.314 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	3.919ProAla: 3.919 ± 0.061	0.443ProCys: 0.443 ± 0.017	2.264ProAsp: 2.264 ± 0.042	3.111ProGlu: 3.111 ± 0.053	1.618ProPhe: 1.618 ± 0.033	3.321ProGly: 3.321 ± 0.05	0.794ProHis: 0.794 ± 0.025	2.351ProIle: 2.351 ± 0.044	1.653ProLys: 1.653 ± 0.036	3.964ProLeu: 3.964 ± 0.054	0.91ProMet: 0.91 ± 0.029	1.235ProAsn: 1.235 ± 0.029	1.353ProPro: 1.353 ± 0.036	1.581ProGln: 1.581 ± 0.036	1.454ProArg: 1.454 ± 0.035	1.882ProSer: 1.882 ± 0.037	1.85ProThr: 1.85 ± 0.04	3.815ProVal: 3.815 ± 0.055	0.445ProTrp: 0.445 ± 0.019	1.306ProTyr: 1.306 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	4.328GlnAla: 4.328 ± 0.067	0.387GlnCys: 0.387 ± 0.021	1.8GlnAsp: 1.8 ± 0.036	2.874GlnGlu: 2.874 ± 0.044	1.358GlnPhe: 1.358 ± 0.03	2.766GlnGly: 2.766 ± 0.048	0.798GlnHis: 0.798 ± 0.027	2.691GlnIle: 2.691 ± 0.044	2.217GlnLys: 2.217 ± 0.042	4.249GlnLeu: 4.249 ± 0.067	1.106GlnMet: 1.106 ± 0.029	1.513GlnAsn: 1.513 ± 0.034	1.627GlnPro: 1.627 ± 0.038	2.341GlnGln: 2.341 ± 0.058	1.794GlnArg: 1.794 ± 0.043	2.084GlnSer: 2.084 ± 0.047	2.146GlnThr: 2.146 ± 0.047	2.944GlnVal: 2.944 ± 0.05	0.371GlnTrp: 0.371 ± 0.017	1.343GlnTyr: 1.343 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	3.3ArgAla: 3.3 ± 0.048	0.505ArgCys: 0.505 ± 0.021	2.252ArgAsp: 2.252 ± 0.046	3.434ArgGlu: 3.434 ± 0.058	1.909ArgPhe: 1.909 ± 0.042	2.853ArgGly: 2.853 ± 0.056	1.005ArgHis: 1.005 ± 0.028	3.555ArgIle: 3.555 ± 0.061	2.685ArgLys: 2.685 ± 0.05	5.109ArgLeu: 5.109 ± 0.072	1.419ArgMet: 1.419 ± 0.035	1.843ArgAsn: 1.843 ± 0.04	1.75ArgPro: 1.75 ± 0.038	2.556ArgGln: 2.556 ± 0.051	2.516ArgArg: 2.516 ± 0.052	2.478ArgSer: 2.478 ± 0.047	2.416ArgThr: 2.416 ± 0.036	3.107ArgVal: 3.107 ± 0.053	0.476ArgTrp: 0.476 ± 0.019	1.764ArgTyr: 1.764 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	4.844SerAla: 4.844 ± 0.098	0.694SerCys: 0.694 ± 0.026	2.491SerAsp: 2.491 ± 0.045	3.102SerGlu: 3.102 ± 0.044	2.493SerPhe: 2.493 ± 0.042	5.0SerGly: 5.0 ± 0.074	1.106SerHis: 1.106 ± 0.031	4.068SerIle: 4.068 ± 0.059	2.689SerLys: 2.689 ± 0.048	5.892SerLeu: 5.892 ± 0.071	1.489SerMet: 1.489 ± 0.031	1.987SerAsn: 1.987 ± 0.043	2.216SerPro: 2.216 ± 0.045	2.169SerGln: 2.169 ± 0.041	2.845SerArg: 2.845 ± 0.043	3.463SerSer: 3.463 ± 0.065	2.999SerThr: 2.999 ± 0.064	4.017SerVal: 4.017 ± 0.079	0.602SerTrp: 0.602 ± 0.02	1.885SerTyr: 1.885 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	5.948ThrAla: 5.948 ± 0.096	0.568ThrCys: 0.568 ± 0.021	2.595ThrAsp: 2.595 ± 0.043	3.146ThrGlu: 3.146 ± 0.054	2.044ThrPhe: 2.044 ± 0.045	6.085ThrGly: 6.085 ± 0.315	0.974ThrHis: 0.974 ± 0.029	4.229ThrIle: 4.229 ± 0.06	2.632ThrLys: 2.632 ± 0.041	5.292ThrLeu: 5.292 ± 0.059	1.37ThrMet: 1.37 ± 0.03	2.052ThrAsn: 2.052 ± 0.04	2.542ThrPro: 2.542 ± 0.044	1.646ThrGln: 1.646 ± 0.039	2.143ThrArg: 2.143 ± 0.038	2.933ThrSer: 2.933 ± 0.066	3.263ThrThr: 3.263 ± 0.072	4.916ThrVal: 4.916 ± 0.064	0.512ThrTrp: 0.512 ± 0.023	1.599ThrTyr: 1.599 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	6.985ValAla: 6.985 ± 0.092	0.923ValCys: 0.923 ± 0.028	3.753ValAsp: 3.753 ± 0.059	4.453ValGlu: 4.453 ± 0.058	3.036ValPhe: 3.036 ± 0.051	5.009ValGly: 5.009 ± 0.071	1.271ValHis: 1.271 ± 0.031	5.803ValIle: 5.803 ± 0.07	4.106ValLys: 4.106 ± 0.058	7.52ValLeu: 7.52 ± 0.084	1.966ValMet: 1.966 ± 0.04	3.098ValAsn: 3.098 ± 0.057	3.02ValPro: 3.02 ± 0.048	2.561ValGln: 2.561 ± 0.051	3.408ValArg: 3.408 ± 0.05	4.497ValSer: 4.497 ± 0.062	4.751ValThr: 4.751 ± 0.07	5.936ValVal: 5.936 ± 0.086	0.655ValTrp: 0.655 ± 0.02	2.242ValTyr: 2.242 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.748TrpAla: 0.748 ± 0.024	0.124TrpCys: 0.124 ± 0.01	0.494TrpAsp: 0.494 ± 0.022	0.58TrpGlu: 0.58 ± 0.021	0.416TrpPhe: 0.416 ± 0.021	0.74TrpGly: 0.74 ± 0.026	0.238TrpHis: 0.238 ± 0.016	0.536TrpIle: 0.536 ± 0.021	0.503TrpLys: 0.503 ± 0.023	1.23TrpLeu: 1.23 ± 0.031	0.285TrpMet: 0.285 ± 0.015	0.422TrpAsn: 0.422 ± 0.018	0.39TrpPro: 0.39 ± 0.019	0.631TrpGln: 0.631 ± 0.025	0.536TrpArg: 0.536 ± 0.021	0.592TrpSer: 0.592 ± 0.022	0.465TrpThr: 0.465 ± 0.016	0.589TrpVal: 0.589 ± 0.024	0.173TrpTrp: 0.173 ± 0.011	0.336TrpTyr: 0.336 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.524TyrAla: 2.524 ± 0.037	0.476TyrCys: 0.476 ± 0.019	1.669TyrAsp: 1.669 ± 0.031	1.803TyrGlu: 1.803 ± 0.04	1.402TyrPhe: 1.402 ± 0.03	2.575TyrGly: 2.575 ± 0.045	0.721TyrHis: 0.721 ± 0.021	2.098TyrIle: 2.098 ± 0.042	1.515TyrLys: 1.515 ± 0.037	3.281TyrLeu: 3.281 ± 0.054	0.733TyrMet: 0.733 ± 0.023	1.249TyrAsn: 1.249 ± 0.034	1.405TyrPro: 1.405 ± 0.036	1.499TyrGln: 1.499 ± 0.034	1.837TyrArg: 1.837 ± 0.04	1.928TyrSer: 1.928 ± 0.042	1.804TyrThr: 1.804 ± 0.041	2.001TyrVal: 2.001 ± 0.048	0.407TyrTrp: 0.407 ± 0.02	1.253TyrTyr: 1.253 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4497 proteins (1371066 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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