Amino acid dipepetide frequency for Corynebacterium spheniscorum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.841AlaAla: 14.841 ± 0.211	1.028AlaCys: 1.028 ± 0.043	6.379AlaAsp: 6.379 ± 0.107	8.495AlaGlu: 8.495 ± 0.146	3.371AlaPhe: 3.371 ± 0.081	9.446AlaGly: 9.446 ± 0.144	2.581AlaHis: 2.581 ± 0.058	5.77AlaIle: 5.77 ± 0.105	4.184AlaLys: 4.184 ± 0.1	12.026AlaLeu: 12.026 ± 0.183	2.732AlaMet: 2.732 ± 0.066	2.674AlaAsn: 2.674 ± 0.066	5.313AlaPro: 5.313 ± 0.111	4.28AlaGln: 4.28 ± 0.1	6.613AlaArg: 6.613 ± 0.116	5.771AlaSer: 5.771 ± 0.096	6.41AlaThr: 6.41 ± 0.093	8.605AlaVal: 8.605 ± 0.125	1.422AlaTrp: 1.422 ± 0.042	2.402AlaTyr: 2.402 ± 0.075	0.0AlaXaa: 0.0 ± 0.0
Cys	0.984CysAla: 0.984 ± 0.042	0.148CysCys: 0.148 ± 0.022	0.507CysAsp: 0.507 ± 0.033	0.567CysGlu: 0.567 ± 0.03	0.307CysPhe: 0.307 ± 0.023	0.908CysGly: 0.908 ± 0.039	0.226CysHis: 0.226 ± 0.018	0.382CysIle: 0.382 ± 0.024	0.162CysLys: 0.162 ± 0.015	0.719CysLeu: 0.719 ± 0.03	0.173CysMet: 0.173 ± 0.016	0.168CysAsn: 0.168 ± 0.016	0.457CysPro: 0.457 ± 0.027	0.254CysGln: 0.254 ± 0.02	0.484CysArg: 0.484 ± 0.029	0.565CysSer: 0.565 ± 0.034	0.517CysThr: 0.517 ± 0.03	0.633CysVal: 0.633 ± 0.031	0.125CysTrp: 0.125 ± 0.013	0.168CysTyr: 0.168 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	6.521AspAla: 6.521 ± 0.102	0.485AspCys: 0.485 ± 0.029	3.111AspAsp: 3.111 ± 0.086	4.105AspGlu: 4.105 ± 0.094	1.823AspPhe: 1.823 ± 0.047	4.387AspGly: 4.387 ± 0.081	1.29AspHis: 1.29 ± 0.04	3.217AspIle: 3.217 ± 0.081	1.785AspLys: 1.785 ± 0.055	5.585AspLeu: 5.585 ± 0.09	1.183AspMet: 1.183 ± 0.046	1.627AspAsn: 1.627 ± 0.046	4.099AspPro: 4.099 ± 0.091	1.747AspGln: 1.747 ± 0.051	3.393AspArg: 3.393 ± 0.091	3.091AspSer: 3.091 ± 0.074	3.145AspThr: 3.145 ± 0.071	4.029AspVal: 4.029 ± 0.081	0.664AspTrp: 0.664 ± 0.031	1.562AspTyr: 1.562 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	7.491GluAla: 7.491 ± 0.154	0.476GluCys: 0.476 ± 0.027	4.13GluAsp: 4.13 ± 0.094	5.629GluGlu: 5.629 ± 0.125	2.048GluPhe: 2.048 ± 0.063	4.88GluGly: 4.88 ± 0.101	1.876GluHis: 1.876 ± 0.051	3.645GluIle: 3.645 ± 0.084	2.936GluLys: 2.936 ± 0.077	7.436GluLeu: 7.436 ± 0.118	1.288GluMet: 1.288 ± 0.043	2.072GluAsn: 2.072 ± 0.054	2.929GluPro: 2.929 ± 0.086	2.408GluGln: 2.408 ± 0.06	4.011GluArg: 4.011 ± 0.079	3.031GluSer: 3.031 ± 0.064	3.204GluThr: 3.204 ± 0.078	5.219GluVal: 5.219 ± 0.097	0.767GluTrp: 0.767 ± 0.035	1.372GluTyr: 1.372 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	3.457PheAla: 3.457 ± 0.079	0.299PheCys: 0.299 ± 0.02	2.098PheAsp: 2.098 ± 0.06	1.819PheGlu: 1.819 ± 0.053	1.315PhePhe: 1.315 ± 0.052	3.324PheGly: 3.324 ± 0.077	0.743PheHis: 0.743 ± 0.036	1.921PheIle: 1.921 ± 0.057	0.88PheLys: 0.88 ± 0.034	3.338PheLeu: 3.338 ± 0.075	0.719PheMet: 0.719 ± 0.032	0.995PheAsn: 0.995 ± 0.033	1.527PhePro: 1.527 ± 0.047	0.89PheGln: 0.89 ± 0.036	1.721PheArg: 1.721 ± 0.047	2.115PheSer: 2.115 ± 0.058	1.778PheThr: 1.778 ± 0.052	2.112PheVal: 2.112 ± 0.062	0.416PheTrp: 0.416 ± 0.023	0.836PheTyr: 0.836 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	8.562GlyAla: 8.562 ± 0.143	0.782GlyCys: 0.782 ± 0.036	4.137GlyAsp: 4.137 ± 0.078	5.186GlyGlu: 5.186 ± 0.088	3.104GlyPhe: 3.104 ± 0.07	6.528GlyGly: 6.528 ± 0.129	1.892GlyHis: 1.892 ± 0.052	4.78GlyIle: 4.78 ± 0.076	3.113GlyLys: 3.113 ± 0.075	8.237GlyLeu: 8.237 ± 0.113	2.232GlyMet: 2.232 ± 0.062	2.069GlyAsn: 2.069 ± 0.056	3.33GlyPro: 3.33 ± 0.071	2.705GlyGln: 2.705 ± 0.061	4.878GlyArg: 4.878 ± 0.101	4.818GlySer: 4.818 ± 0.096	4.811GlyThr: 4.811 ± 0.094	7.081GlyVal: 7.081 ± 0.109	1.377GlyTrp: 1.377 ± 0.045	2.143GlyTyr: 2.143 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	2.332HisAla: 2.332 ± 0.058	0.231HisCys: 0.231 ± 0.02	1.376HisAsp: 1.376 ± 0.048	1.283HisGlu: 1.283 ± 0.041	0.736HisPhe: 0.736 ± 0.035	2.045HisGly: 2.045 ± 0.06	0.72HisHis: 0.72 ± 0.035	1.115HisIle: 1.115 ± 0.04	0.596HisLys: 0.596 ± 0.031	2.246HisLeu: 2.246 ± 0.056	0.523HisMet: 0.523 ± 0.028	0.761HisAsn: 0.761 ± 0.028	1.747HisPro: 1.747 ± 0.056	0.897HisGln: 0.897 ± 0.039	1.665HisArg: 1.665 ± 0.058	1.377HisSer: 1.377 ± 0.048	1.456HisThr: 1.456 ± 0.05	1.508HisVal: 1.508 ± 0.044	0.295HisTrp: 0.295 ± 0.021	0.643HisTyr: 0.643 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.741IleAla: 6.741 ± 0.105	0.484IleCys: 0.484 ± 0.025	3.437IleAsp: 3.437 ± 0.078	3.144IleGlu: 3.144 ± 0.068	1.882IlePhe: 1.882 ± 0.058	4.532IleGly: 4.532 ± 0.091	1.128IleHis: 1.128 ± 0.046	3.214IleIle: 3.214 ± 0.084	1.582IleLys: 1.582 ± 0.057	4.717IleLeu: 4.717 ± 0.101	1.136IleMet: 1.136 ± 0.041	1.682IleAsn: 1.682 ± 0.046	3.08IlePro: 3.08 ± 0.068	1.425IleGln: 1.425 ± 0.049	2.9IleArg: 2.9 ± 0.066	3.361IleSer: 3.361 ± 0.071	3.265IleThr: 3.265 ± 0.072	4.074IleVal: 4.074 ± 0.075	0.554IleTrp: 0.554 ± 0.028	1.119IleTyr: 1.119 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	3.956LysAla: 3.956 ± 0.091	0.142LysCys: 0.142 ± 0.015	2.24LysAsp: 2.24 ± 0.063	2.756LysGlu: 2.756 ± 0.077	0.808LysPhe: 0.808 ± 0.033	2.237LysGly: 2.237 ± 0.054	0.768LysHis: 0.768 ± 0.029	1.787LysIle: 1.787 ± 0.051	1.947LysLys: 1.947 ± 0.075	3.22LysLeu: 3.22 ± 0.068	0.785LysMet: 0.785 ± 0.037	1.252LysAsn: 1.252 ± 0.042	1.865LysPro: 1.865 ± 0.078	1.214LysGln: 1.214 ± 0.048	2.182LysArg: 2.182 ± 0.05	1.599LysSer: 1.599 ± 0.052	1.943LysThr: 1.943 ± 0.061	2.946LysVal: 2.946 ± 0.07	0.372LysTrp: 0.372 ± 0.024	0.668LysTyr: 0.668 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	12.379LeuAla: 12.379 ± 0.154	0.921LeuCys: 0.921 ± 0.042	5.678LeuAsp: 5.678 ± 0.094	5.327LeuGlu: 5.327 ± 0.088	2.932LeuPhe: 2.932 ± 0.074	8.992LeuGly: 8.992 ± 0.132	2.268LeuHis: 2.268 ± 0.053	5.542LeuIle: 5.542 ± 0.119	3.592LeuLys: 3.592 ± 0.074	9.448LeuLeu: 9.448 ± 0.166	2.227LeuMet: 2.227 ± 0.061	2.87LeuAsn: 2.87 ± 0.062	5.588LeuPro: 5.588 ± 0.096	2.666LeuGln: 2.666 ± 0.061	6.451LeuArg: 6.451 ± 0.096	6.648LeuSer: 6.648 ± 0.118	5.065LeuThr: 5.065 ± 0.082	7.794LeuVal: 7.794 ± 0.116	1.246LeuTrp: 1.246 ± 0.049	1.821LeuTyr: 1.821 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	2.619MetAla: 2.619 ± 0.06	0.186MetCys: 0.186 ± 0.017	1.128MetAsp: 1.128 ± 0.036	1.119MetGlu: 1.119 ± 0.041	0.665MetPhe: 0.665 ± 0.032	1.734MetGly: 1.734 ± 0.063	0.481MetHis: 0.481 ± 0.024	1.304MetIle: 1.304 ± 0.037	0.825MetLys: 0.825 ± 0.035	2.364MetLeu: 2.364 ± 0.055	0.564MetMet: 0.564 ± 0.027	0.764MetAsn: 0.764 ± 0.031	1.231MetPro: 1.231 ± 0.039	0.647MetGln: 0.647 ± 0.029	1.49MetArg: 1.49 ± 0.045	1.814MetSer: 1.814 ± 0.055	1.499MetThr: 1.499 ± 0.046	1.881MetVal: 1.881 ± 0.045	0.268MetTrp: 0.268 ± 0.019	0.347MetTyr: 0.347 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.032AsnAla: 3.032 ± 0.066	0.207AsnCys: 0.207 ± 0.016	1.36AsnAsp: 1.36 ± 0.044	1.504AsnGlu: 1.504 ± 0.053	0.935AsnPhe: 0.935 ± 0.038	1.998AsnGly: 1.998 ± 0.062	0.668AsnHis: 0.668 ± 0.032	1.436AsnIle: 1.436 ± 0.041	0.954AsnLys: 0.954 ± 0.037	2.879AsnLeu: 2.879 ± 0.067	0.634AsnMet: 0.634 ± 0.031	0.904AsnAsn: 0.904 ± 0.041	2.356AsnPro: 2.356 ± 0.059	1.015AsnGln: 1.015 ± 0.038	1.641AsnArg: 1.641 ± 0.052	1.586AsnSer: 1.586 ± 0.047	1.72AsnThr: 1.72 ± 0.047	1.852AsnVal: 1.852 ± 0.054	0.381AsnTrp: 0.381 ± 0.021	0.802AsnTyr: 0.802 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	5.962ProAla: 5.962 ± 0.124	0.326ProCys: 0.326 ± 0.02	3.29ProAsp: 3.29 ± 0.076	5.168ProGlu: 5.168 ± 0.104	1.604ProPhe: 1.604 ± 0.048	4.59ProGly: 4.59 ± 0.094	1.327ProHis: 1.327 ± 0.041	2.33ProIle: 2.33 ± 0.062	2.102ProLys: 2.102 ± 0.079	4.539ProLeu: 4.539 ± 0.08	1.197ProMet: 1.197 ± 0.038	1.535ProAsn: 1.535 ± 0.061	2.13ProPro: 2.13 ± 0.09	2.217ProGln: 2.217 ± 0.062	3.025ProArg: 3.025 ± 0.062	2.929ProSer: 2.929 ± 0.077	3.512ProThr: 3.512 ± 0.076	4.129ProVal: 4.129 ± 0.085	0.756ProTrp: 0.756 ± 0.029	1.201ProTyr: 1.201 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	3.987GlnAla: 3.987 ± 0.088	0.217GlnCys: 0.217 ± 0.02	1.642GlnAsp: 1.642 ± 0.049	2.337GlnGlu: 2.337 ± 0.062	0.815GlnPhe: 0.815 ± 0.032	2.377GlnGly: 2.377 ± 0.063	0.901GlnHis: 0.901 ± 0.037	1.67GlnIle: 1.67 ± 0.052	1.091GlnLys: 1.091 ± 0.041	3.651GlnLeu: 3.651 ± 0.068	0.698GlnMet: 0.698 ± 0.032	0.805GlnAsn: 0.805 ± 0.037	1.974GlnPro: 1.974 ± 0.064	1.491GlnGln: 1.491 ± 0.057	2.709GlnArg: 2.709 ± 0.06	1.562GlnSer: 1.562 ± 0.055	1.414GlnThr: 1.414 ± 0.039	2.724GlnVal: 2.724 ± 0.066	0.589GlnTrp: 0.589 ± 0.03	0.595GlnTyr: 0.595 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	6.266ArgAla: 6.266 ± 0.098	0.472ArgCys: 0.472 ± 0.027	3.486ArgAsp: 3.486 ± 0.074	4.48ArgGlu: 4.48 ± 0.084	2.105ArgPhe: 2.105 ± 0.056	4.786ArgGly: 4.786 ± 0.095	1.441ArgHis: 1.441 ± 0.04	3.482ArgIle: 3.482 ± 0.072	2.182ArgLys: 2.182 ± 0.058	5.674ArgLeu: 5.674 ± 0.089	1.647ArgMet: 1.647 ± 0.052	1.731ArgAsn: 1.731 ± 0.059	3.065ArgPro: 3.065 ± 0.074	2.191ArgGln: 2.191 ± 0.052	5.128ArgArg: 5.128 ± 0.124	3.548ArgSer: 3.548 ± 0.083	3.544ArgThr: 3.544 ± 0.078	4.422ArgVal: 4.422 ± 0.088	0.953ArgTrp: 0.953 ± 0.035	1.57ArgTyr: 1.57 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	6.516SerAla: 6.516 ± 0.109	0.419SerCys: 0.419 ± 0.025	2.928SerAsp: 2.928 ± 0.066	3.52SerGlu: 3.52 ± 0.075	2.013SerPhe: 2.013 ± 0.052	5.26SerGly: 5.26 ± 0.082	1.279SerHis: 1.279 ± 0.049	2.825SerIle: 2.825 ± 0.072	1.748SerLys: 1.748 ± 0.044	5.393SerLeu: 5.393 ± 0.099	1.511SerMet: 1.511 ± 0.049	1.427SerAsn: 1.427 ± 0.04	3.066SerPro: 3.066 ± 0.061	1.969SerGln: 1.969 ± 0.048	3.507SerArg: 3.507 ± 0.076	3.661SerSer: 3.661 ± 0.084	4.018SerThr: 4.018 ± 0.086	4.02SerVal: 4.02 ± 0.081	0.878SerTrp: 0.878 ± 0.043	1.398SerTyr: 1.398 ± 0.053	0.0SerXaa: 0.0 ± 0.0
Thr	6.169ThrAla: 6.169 ± 0.103	0.475ThrCys: 0.475 ± 0.03	2.883ThrAsp: 2.883 ± 0.062	3.248ThrGlu: 3.248 ± 0.075	1.861ThrPhe: 1.861 ± 0.057	4.645ThrGly: 4.645 ± 0.075	1.396ThrHis: 1.396 ± 0.045	3.022ThrIle: 3.022 ± 0.066	1.845ThrLys: 1.845 ± 0.054	5.778ThrLeu: 5.778 ± 0.1	1.208ThrMet: 1.208 ± 0.039	1.508ThrAsn: 1.508 ± 0.048	4.277ThrPro: 4.277 ± 0.1	1.875ThrGln: 1.875 ± 0.052	3.221ThrArg: 3.221 ± 0.075	3.242ThrSer: 3.242 ± 0.077	4.016ThrThr: 4.016 ± 0.083	4.7ThrVal: 4.7 ± 0.099	0.88ThrTrp: 0.88 ± 0.039	1.308ThrTyr: 1.308 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	8.691ValAla: 8.691 ± 0.123	0.795ValCys: 0.795 ± 0.031	5.136ValAsp: 5.136 ± 0.087	4.938ValGlu: 4.938 ± 0.095	2.536ValPhe: 2.536 ± 0.069	6.05ValGly: 6.05 ± 0.111	1.782ValHis: 1.782 ± 0.051	4.371ValIle: 4.371 ± 0.082	2.256ValLys: 2.256 ± 0.065	8.297ValLeu: 8.297 ± 0.124	1.725ValMet: 1.725 ± 0.055	2.065ValAsn: 2.065 ± 0.064	3.943ValPro: 3.943 ± 0.08	1.999ValGln: 1.999 ± 0.057	4.542ValArg: 4.542 ± 0.068	4.514ValSer: 4.514 ± 0.081	4.373ValThr: 4.373 ± 0.097	6.977ValVal: 6.977 ± 0.113	0.978ValTrp: 0.978 ± 0.041	1.473ValTyr: 1.473 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	1.466TrpAla: 1.466 ± 0.05	0.141TrpCys: 0.141 ± 0.014	0.679TrpAsp: 0.679 ± 0.032	0.785TrpGlu: 0.785 ± 0.033	0.56TrpPhe: 0.56 ± 0.03	0.988TrpGly: 0.988 ± 0.041	0.295TrpHis: 0.295 ± 0.017	0.713TrpIle: 0.713 ± 0.03	0.409TrpLys: 0.409 ± 0.024	1.514TrpLeu: 1.514 ± 0.057	0.381TrpMet: 0.381 ± 0.026	0.372TrpAsn: 0.372 ± 0.025	0.596TrpPro: 0.596 ± 0.029	0.5TrpGln: 0.5 ± 0.029	1.021TrpArg: 1.021 ± 0.045	0.76TrpSer: 0.76 ± 0.035	0.668TrpThr: 0.668 ± 0.029	1.162TrpVal: 1.162 ± 0.041	0.351TrpTrp: 0.351 ± 0.023	0.275TrpTyr: 0.275 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.373TyrAla: 2.373 ± 0.048	0.22TyrCys: 0.22 ± 0.018	1.222TyrAsp: 1.222 ± 0.048	1.441TyrGlu: 1.441 ± 0.048	0.881TyrPhe: 0.881 ± 0.039	2.058TyrGly: 2.058 ± 0.056	0.492TyrHis: 0.492 ± 0.026	0.926TyrIle: 0.926 ± 0.036	0.499TyrLys: 0.499 ± 0.027	2.394TyrLeu: 2.394 ± 0.062	0.364TyrMet: 0.364 ± 0.022	0.582TyrAsn: 0.582 ± 0.031	1.297TyrPro: 1.297 ± 0.046	0.86TyrGln: 0.86 ± 0.039	1.593TyrArg: 1.593 ± 0.049	1.363TyrSer: 1.363 ± 0.045	1.201TyrThr: 1.201 ± 0.041	1.575TyrVal: 1.575 ± 0.05	0.364TyrTrp: 0.364 ± 0.022	0.509TyrTyr: 0.509 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2153 proteins (709375 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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