Amino acid dipepetide frequency for Candidatus Kryptobacter tengchongensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	1.971AlaAla: 1.971 ± 0.076	0.55AlaCys: 0.55 ± 0.03	2.831AlaAsp: 2.831 ± 0.074	4.218AlaGlu: 4.218 ± 0.09	2.994AlaPhe: 2.994 ± 0.078	5.007AlaGly: 5.007 ± 0.107	0.892AlaHis: 0.892 ± 0.043	5.614AlaIle: 5.614 ± 0.116	4.595AlaLys: 4.595 ± 0.098	5.627AlaLeu: 5.627 ± 0.118	1.453AlaMet: 1.453 ± 0.057	2.349AlaAsn: 2.349 ± 0.064	1.627AlaPro: 1.627 ± 0.062	2.115AlaGln: 2.115 ± 0.066	2.919AlaArg: 2.919 ± 0.077	3.433AlaSer: 3.433 ± 0.082	2.756AlaThr: 2.756 ± 0.075	4.433AlaVal: 4.433 ± 0.09	0.6AlaTrp: 0.6 ± 0.034	2.215AlaTyr: 2.215 ± 0.063	0.005AlaXaa: 0.005 ± 0.003
Cys	0.523CysAla: 0.523 ± 0.028	0.068CysCys: 0.068 ± 0.012	0.423CysAsp: 0.423 ± 0.029	0.505CysGlu: 0.505 ± 0.033	0.366CysPhe: 0.366 ± 0.026	0.722CysGly: 0.722 ± 0.043	0.348CysHis: 0.348 ± 0.062	0.457CysIle: 0.457 ± 0.032	0.491CysLys: 0.491 ± 0.03	0.496CysLeu: 0.496 ± 0.027	0.127CysMet: 0.127 ± 0.016	0.276CysAsn: 0.276 ± 0.021	0.369CysPro: 0.369 ± 0.027	0.17CysGln: 0.17 ± 0.017	0.292CysArg: 0.292 ± 0.022	0.412CysSer: 0.412 ± 0.03	0.254CysThr: 0.254 ± 0.02	0.48CysVal: 0.48 ± 0.028	0.086CysTrp: 0.086 ± 0.016	0.319CysTyr: 0.319 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	2.752AspAla: 2.752 ± 0.066	0.319AspCys: 0.319 ± 0.026	2.575AspAsp: 2.575 ± 0.072	4.937AspGlu: 4.937 ± 0.121	3.143AspPhe: 3.143 ± 0.08	3.699AspGly: 3.699 ± 0.102	0.538AspHis: 0.538 ± 0.033	4.69AspIle: 4.69 ± 0.092	4.012AspLys: 4.012 ± 0.088	4.383AspLeu: 4.383 ± 0.085	0.962AspMet: 0.962 ± 0.041	1.822AspAsn: 1.822 ± 0.07	2.052AspPro: 2.052 ± 0.061	0.876AspGln: 0.876 ± 0.043	2.023AspArg: 2.023 ± 0.066	2.806AspSer: 2.806 ± 0.09	2.236AspThr: 2.236 ± 0.075	4.191AspVal: 4.191 ± 0.098	0.577AspTrp: 0.577 ± 0.037	2.251AspTyr: 2.251 ± 0.057	0.0AspXaa: 0.0 ± 0.0
Glu	4.027GluAla: 4.027 ± 0.097	0.421GluCys: 0.421 ± 0.028	2.964GluAsp: 2.964 ± 0.083	5.399GluGlu: 5.399 ± 0.145	4.147GluPhe: 4.147 ± 0.092	3.561GluGly: 3.561 ± 0.084	1.047GluHis: 1.047 ± 0.045	8.741GluIle: 8.741 ± 0.167	7.463GluLys: 7.463 ± 0.148	7.166GluLeu: 7.166 ± 0.129	1.625GluMet: 1.625 ± 0.055	4.066GluAsn: 4.066 ± 0.091	2.115GluPro: 2.115 ± 0.056	2.027GluGln: 2.027 ± 0.072	3.926GluArg: 3.926 ± 0.099	3.347GluSer: 3.347 ± 0.09	3.134GluThr: 3.134 ± 0.071	5.141GluVal: 5.141 ± 0.103	0.627GluTrp: 0.627 ± 0.038	2.57GluTyr: 2.57 ± 0.082	0.0GluXaa: 0.0 ± 0.0
Phe	3.455PheAla: 3.455 ± 0.078	0.382PheCys: 0.382 ± 0.023	3.356PheAsp: 3.356 ± 0.076	4.302PheGlu: 4.302 ± 0.095	2.887PhePhe: 2.887 ± 0.082	4.113PheGly: 4.113 ± 0.096	0.745PheHis: 0.745 ± 0.04	4.862PheIle: 4.862 ± 0.117	4.482PheLys: 4.482 ± 0.103	5.304PheLeu: 5.304 ± 0.131	1.009PheMet: 1.009 ± 0.038	2.835PheAsn: 2.835 ± 0.083	2.059PhePro: 2.059 ± 0.07	1.314PheGln: 1.314 ± 0.045	2.032PheArg: 2.032 ± 0.062	3.919PheSer: 3.919 ± 0.102	2.64PheThr: 2.64 ± 0.065	4.209PheVal: 4.209 ± 0.1	0.6PheTrp: 0.6 ± 0.034	2.665PheTyr: 2.665 ± 0.075	0.0PheXaa: 0.0 ± 0.0
Gly	3.926GlyAla: 3.926 ± 0.092	0.613GlyCys: 0.613 ± 0.04	3.381GlyAsp: 3.381 ± 0.1	4.607GlyGlu: 4.607 ± 0.098	4.186GlyPhe: 4.186 ± 0.115	4.831GlyGly: 4.831 ± 0.122	1.038GlyHis: 1.038 ± 0.047	6.474GlyIle: 6.474 ± 0.127	5.824GlyLys: 5.824 ± 0.106	5.93GlyLeu: 5.93 ± 0.11	1.457GlyMet: 1.457 ± 0.056	2.998GlyAsn: 2.998 ± 0.089	1.496GlyPro: 1.496 ± 0.061	1.598GlyGln: 1.598 ± 0.059	3.088GlyArg: 3.088 ± 0.07	3.457GlySer: 3.457 ± 0.094	3.213GlyThr: 3.213 ± 0.092	5.489GlyVal: 5.489 ± 0.121	0.79GlyTrp: 0.79 ± 0.038	2.959GlyTyr: 2.959 ± 0.072	0.004GlyXaa: 0.004 ± 0.003
His	0.744HisAla: 0.744 ± 0.041	0.138HisCys: 0.138 ± 0.017	0.629HisAsp: 0.629 ± 0.034	0.866HisGlu: 0.866 ± 0.046	0.849HisPhe: 0.849 ± 0.04	1.12HisGly: 1.12 ± 0.048	0.324HisHis: 0.324 ± 0.026	1.306HisIle: 1.306 ± 0.05	0.891HisLys: 0.891 ± 0.037	1.482HisLeu: 1.482 ± 0.049	0.217HisMet: 0.217 ± 0.02	0.627HisAsn: 0.627 ± 0.035	1.038HisPro: 1.038 ± 0.045	0.452HisGln: 0.452 ± 0.03	0.763HisArg: 0.763 ± 0.038	0.876HisSer: 0.876 ± 0.043	0.674HisThr: 0.674 ± 0.03	0.781HisVal: 0.781 ± 0.038	0.163HisTrp: 0.163 ± 0.016	0.595HisTyr: 0.595 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.356IleAla: 6.356 ± 0.104	0.659IleCys: 0.659 ± 0.037	5.279IleAsp: 5.279 ± 0.113	7.277IleGlu: 7.277 ± 0.131	5.369IlePhe: 5.369 ± 0.126	5.89IleGly: 5.89 ± 0.125	1.267IleHis: 1.267 ± 0.054	7.166IleIle: 7.166 ± 0.132	7.098IleLys: 7.098 ± 0.126	8.807IleLeu: 8.807 ± 0.14	1.486IleMet: 1.486 ± 0.046	3.937IleAsn: 3.937 ± 0.091	3.937IlePro: 3.937 ± 0.106	2.459IleGln: 2.459 ± 0.067	3.469IleArg: 3.469 ± 0.093	6.544IleSer: 6.544 ± 0.112	4.259IleThr: 4.259 ± 0.079	6.157IleVal: 6.157 ± 0.112	0.889IleTrp: 0.889 ± 0.041	3.944IleTyr: 3.944 ± 0.099	0.004IleXaa: 0.004 ± 0.003
Lys	4.405LysAla: 4.405 ± 0.094	0.466LysCys: 0.466 ± 0.031	3.74LysAsp: 3.74 ± 0.082	5.646LysGlu: 5.646 ± 0.113	5.284LysPhe: 5.284 ± 0.104	3.987LysGly: 3.987 ± 0.087	1.059LysHis: 1.059 ± 0.044	9.569LysIle: 9.569 ± 0.162	6.435LysLys: 6.435 ± 0.126	7.67LysLeu: 7.67 ± 0.137	1.939LysMet: 1.939 ± 0.065	4.609LysAsn: 4.609 ± 0.085	3.127LysPro: 3.127 ± 0.072	2.023LysGln: 2.023 ± 0.062	3.792LysArg: 3.792 ± 0.096	4.195LysSer: 4.195 ± 0.096	3.831LysThr: 3.831 ± 0.097	5.913LysVal: 5.913 ± 0.095	0.754LysTrp: 0.754 ± 0.035	3.019LysTyr: 3.019 ± 0.094	0.004LysXaa: 0.004 ± 0.002
Leu	5.851LeuAla: 5.851 ± 0.116	0.661LeuCys: 0.661 ± 0.031	4.118LeuAsp: 4.118 ± 0.092	5.749LeuGlu: 5.749 ± 0.111	4.664LeuPhe: 4.664 ± 0.122	6.48LeuGly: 6.48 ± 0.113	1.233LeuHis: 1.233 ± 0.045	8.831LeuIle: 8.831 ± 0.158	9.012LeuLys: 9.012 ± 0.12	7.903LeuLeu: 7.903 ± 0.129	1.873LeuMet: 1.873 ± 0.066	5.218LeuAsn: 5.218 ± 0.103	3.91LeuPro: 3.91 ± 0.08	2.113LeuGln: 2.113 ± 0.065	4.548LeuArg: 4.548 ± 0.084	6.292LeuSer: 6.292 ± 0.122	5.173LeuThr: 5.173 ± 0.105	5.752LeuVal: 5.752 ± 0.119	0.878LeuTrp: 0.878 ± 0.046	3.12LeuTyr: 3.12 ± 0.075	0.0LeuXaa: 0.0 ± 0.0
Met	1.281MetAla: 1.281 ± 0.05	0.127MetCys: 0.127 ± 0.015	0.783MetAsp: 0.783 ± 0.038	1.165MetGlu: 1.165 ± 0.048	0.96MetPhe: 0.96 ± 0.044	1.262MetGly: 1.262 ± 0.057	0.292MetHis: 0.292 ± 0.025	1.729MetIle: 1.729 ± 0.06	2.156MetLys: 2.156 ± 0.063	2.064MetLeu: 2.064 ± 0.062	0.525MetMet: 0.525 ± 0.032	0.914MetAsn: 0.914 ± 0.042	0.86MetPro: 0.86 ± 0.041	0.573MetGln: 0.573 ± 0.035	1.346MetArg: 1.346 ± 0.041	1.224MetSer: 1.224 ± 0.05	0.957MetThr: 0.957 ± 0.047	1.15MetVal: 1.15 ± 0.05	0.168MetTrp: 0.168 ± 0.017	0.493MetTyr: 0.493 ± 0.031	0.002MetXaa: 0.002 ± 0.002
Asn	2.683AsnAla: 2.683 ± 0.074	0.389AsnCys: 0.389 ± 0.03	2.079AsnAsp: 2.079 ± 0.067	3.243AsnGlu: 3.243 ± 0.079	3.616AsnPhe: 3.616 ± 0.089	2.966AsnGly: 2.966 ± 0.08	0.595AsnHis: 0.595 ± 0.041	3.697AsnIle: 3.697 ± 0.083	2.853AsnLys: 2.853 ± 0.071	5.652AsnLeu: 5.652 ± 0.123	0.876AsnMet: 0.876 ± 0.038	1.813AsnAsn: 1.813 ± 0.071	2.847AsnPro: 2.847 ± 0.08	1.364AsnGln: 1.364 ± 0.055	1.971AsnArg: 1.971 ± 0.06	2.892AsnSer: 2.892 ± 0.076	1.65AsnThr: 1.65 ± 0.063	3.109AsnVal: 3.109 ± 0.076	0.638AsnTrp: 0.638 ± 0.042	2.514AsnTyr: 2.514 ± 0.073	0.0AsnXaa: 0.0 ± 0.0
Pro	2.131ProAla: 2.131 ± 0.069	0.229ProCys: 0.229 ± 0.022	2.776ProAsp: 2.776 ± 0.069	3.831ProGlu: 3.831 ± 0.095	2.082ProPhe: 2.082 ± 0.059	2.435ProGly: 2.435 ± 0.078	0.6ProHis: 0.6 ± 0.031	2.876ProIle: 2.876 ± 0.071	2.48ProLys: 2.48 ± 0.067	2.962ProLeu: 2.962 ± 0.08	0.667ProMet: 0.667 ± 0.037	1.842ProAsn: 1.842 ± 0.062	1.444ProPro: 1.444 ± 0.056	1.025ProGln: 1.025 ± 0.043	1.527ProArg: 1.527 ± 0.051	2.215ProSer: 2.215 ± 0.063	1.787ProThr: 1.787 ± 0.055	2.993ProVal: 2.993 ± 0.078	0.407ProTrp: 0.407 ± 0.031	1.577ProTyr: 1.577 ± 0.061	0.002ProXaa: 0.002 ± 0.002
Gln	1.568GlnAla: 1.568 ± 0.054	0.136GlnCys: 0.136 ± 0.014	1.088GlnAsp: 1.088 ± 0.043	1.616GlnGlu: 1.616 ± 0.055	1.224GlnPhe: 1.224 ± 0.047	1.512GlnGly: 1.512 ± 0.063	0.364GlnHis: 0.364 ± 0.029	2.878GlnIle: 2.878 ± 0.07	2.321GlnLys: 2.321 ± 0.067	2.346GlnLeu: 2.346 ± 0.074	0.654GlnMet: 0.654 ± 0.036	1.588GlnAsn: 1.588 ± 0.053	0.971GlnPro: 0.971 ± 0.042	0.78GlnGln: 0.78 ± 0.042	1.57GlnArg: 1.57 ± 0.057	1.374GlnSer: 1.374 ± 0.05	1.333GlnThr: 1.333 ± 0.05	1.792GlnVal: 1.792 ± 0.057	0.251GlnTrp: 0.251 ± 0.025	0.876GlnTyr: 0.876 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	2.675ArgAla: 2.675 ± 0.065	0.328ArgCys: 0.328 ± 0.025	2.394ArgAsp: 2.394 ± 0.067	3.896ArgGlu: 3.896 ± 0.103	2.643ArgPhe: 2.643 ± 0.069	2.883ArgGly: 2.883 ± 0.084	0.64ArgHis: 0.64 ± 0.038	4.018ArgIle: 4.018 ± 0.092	4.113ArgLys: 4.113 ± 0.097	3.996ArgLeu: 3.996 ± 0.098	1.041ArgMet: 1.041 ± 0.041	2.27ArgAsn: 2.27 ± 0.068	1.299ArgPro: 1.299 ± 0.052	1.116ArgGln: 1.116 ± 0.047	2.342ArgArg: 2.342 ± 0.072	2.15ArgSer: 2.15 ± 0.064	2.046ArgThr: 2.046 ± 0.062	3.132ArgVal: 3.132 ± 0.082	0.591ArgTrp: 0.591 ± 0.034	2.109ArgTyr: 2.109 ± 0.067	0.002ArgXaa: 0.002 ± 0.002
Ser	3.765SerAla: 3.765 ± 0.083	0.457SerCys: 0.457 ± 0.037	3.148SerAsp: 3.148 ± 0.082	4.211SerGlu: 4.211 ± 0.085	3.544SerPhe: 3.544 ± 0.092	4.822SerGly: 4.822 ± 0.115	0.882SerHis: 0.882 ± 0.038	4.928SerIle: 4.928 ± 0.1	4.363SerLys: 4.363 ± 0.102	5.842SerLeu: 5.842 ± 0.115	1.041SerMet: 1.041 ± 0.042	2.519SerAsn: 2.519 ± 0.074	2.206SerPro: 2.206 ± 0.074	1.729SerGln: 1.729 ± 0.056	2.36SerArg: 2.36 ± 0.062	3.686SerSer: 3.686 ± 0.086	2.736SerThr: 2.736 ± 0.074	3.964SerVal: 3.964 ± 0.101	0.579SerTrp: 0.579 ± 0.035	2.312SerTyr: 2.312 ± 0.068	0.002SerXaa: 0.002 ± 0.002
Thr	2.921ThrAla: 2.921 ± 0.077	0.319ThrCys: 0.319 ± 0.026	2.245ThrAsp: 2.245 ± 0.069	2.797ThrGlu: 2.797 ± 0.092	2.451ThrPhe: 2.451 ± 0.068	3.957ThrGly: 3.957 ± 0.109	0.844ThrHis: 0.844 ± 0.038	4.1ThrIle: 4.1 ± 0.088	3.002ThrLys: 3.002 ± 0.08	4.729ThrLeu: 4.729 ± 0.1	0.783ThrMet: 0.783 ± 0.04	1.804ThrAsn: 1.804 ± 0.064	2.177ThrPro: 2.177 ± 0.061	1.297ThrGln: 1.297 ± 0.059	1.962ThrArg: 1.962 ± 0.07	2.846ThrSer: 2.846 ± 0.085	2.382ThrThr: 2.382 ± 0.075	3.186ThrVal: 3.186 ± 0.08	0.466ThrTrp: 0.466 ± 0.032	1.765ThrTyr: 1.765 ± 0.054	0.0ThrXaa: 0.0 ± 0.0
Val	4.229ValAla: 4.229 ± 0.1	0.543ValCys: 0.543 ± 0.029	4.125ValAsp: 4.125 ± 0.093	5.523ValGlu: 5.523 ± 0.116	3.645ValPhe: 3.645 ± 0.094	4.453ValGly: 4.453 ± 0.109	0.93ValHis: 0.93 ± 0.042	6.096ValIle: 6.096 ± 0.106	6.327ValLys: 6.327 ± 0.107	6.22ValLeu: 6.22 ± 0.103	1.457ValMet: 1.457 ± 0.055	3.412ValAsn: 3.412 ± 0.079	2.36ValPro: 2.36 ± 0.07	1.749ValGln: 1.749 ± 0.067	3.331ValArg: 3.331 ± 0.079	4.351ValSer: 4.351 ± 0.101	2.756ValThr: 2.756 ± 0.083	5.209ValVal: 5.209 ± 0.112	0.699ValTrp: 0.699 ± 0.036	3.062ValTyr: 3.062 ± 0.084	0.0ValXaa: 0.0 ± 0.0
Trp	0.638TrpAla: 0.638 ± 0.037	0.075TrpCys: 0.075 ± 0.013	0.658TrpAsp: 0.658 ± 0.038	0.756TrpGlu: 0.756 ± 0.041	0.582TrpPhe: 0.582 ± 0.028	0.778TrpGly: 0.778 ± 0.044	0.177TrpHis: 0.177 ± 0.018	0.874TrpIle: 0.874 ± 0.041	0.787TrpLys: 0.787 ± 0.042	0.957TrpLeu: 0.957 ± 0.047	0.22TrpMet: 0.22 ± 0.022	0.607TrpAsn: 0.607 ± 0.035	0.204TrpPro: 0.204 ± 0.021	0.269TrpGln: 0.269 ± 0.02	0.579TrpArg: 0.579 ± 0.033	0.484TrpSer: 0.484 ± 0.034	0.448TrpThr: 0.448 ± 0.029	0.722TrpVal: 0.722 ± 0.038	0.177TrpTrp: 0.177 ± 0.022	0.412TrpTyr: 0.412 ± 0.028	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.306TyrAla: 2.306 ± 0.058	0.305TyrCys: 0.305 ± 0.021	2.252TyrAsp: 2.252 ± 0.068	2.967TyrGlu: 2.967 ± 0.076	2.53TyrPhe: 2.53 ± 0.071	2.881TyrGly: 2.881 ± 0.077	0.72TyrHis: 0.72 ± 0.039	3.347TyrIle: 3.347 ± 0.08	2.763TyrLys: 2.763 ± 0.066	3.842TyrLeu: 3.842 ± 0.089	0.616TyrMet: 0.616 ± 0.038	1.934TyrAsn: 1.934 ± 0.061	1.787TyrPro: 1.787 ± 0.065	1.192TyrGln: 1.192 ± 0.045	1.844TyrArg: 1.844 ± 0.06	2.588TyrSer: 2.588 ± 0.088	1.767TyrThr: 1.767 ± 0.064	2.672TyrVal: 2.672 ± 0.07	0.461TyrTrp: 0.461 ± 0.028	1.839TyrTyr: 1.839 ± 0.077	0.002TyrXaa: 0.002 ± 0.002
Xaa	0.002XaaAla: 0.002 ± 0.002	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.002XaaLys: 0.002 ± 0.002	0.0XaaLeu: 0.0 ± 0.0	0.002XaaMet: 0.002 ± 0.002	0.005XaaAsn: 0.005 ± 0.004	0.002XaaPro: 0.002 ± 0.002	0.002XaaGln: 0.002 ± 0.002	0.002XaaArg: 0.002 ± 0.002	0.005XaaSer: 0.005 ± 0.003	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.004XaaTrp: 0.004 ± 0.003	0.0XaaTyr: 0.0 ± 0.0	0.143XaaXaa: 0.143 ± 0.052

Statistics based on 1795 proteins (558051 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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