Amino acid dipepetide frequency for Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.139AlaAla: 11.139 ± 0.102	0.961AlaCys: 0.961 ± 0.019	4.17AlaAsp: 4.17 ± 0.039	5.77AlaGlu: 5.77 ± 0.092	2.888AlaPhe: 2.888 ± 0.031	6.07AlaGly: 6.07 ± 0.05	1.752AlaHis: 1.752 ± 0.023	3.993AlaIle: 3.993 ± 0.037	4.383AlaLys: 4.383 ± 0.052	7.841AlaLeu: 7.841 ± 0.057	1.868AlaMet: 1.868 ± 0.025	2.964AlaAsn: 2.964 ± 0.028	5.781AlaPro: 5.781 ± 0.088	3.845AlaGln: 3.845 ± 0.042	5.582AlaArg: 5.582 ± 0.047	7.147AlaSer: 7.147 ± 0.058	5.446AlaThr: 5.446 ± 0.048	5.62AlaVal: 5.62 ± 0.044	1.118AlaTrp: 1.118 ± 0.017	2.047AlaTyr: 2.047 ± 0.026	0.0AlaXaa: 0.0 ± 0.0
Cys	0.861CysAla: 0.861 ± 0.015	0.206CysCys: 0.206 ± 0.008	0.569CysAsp: 0.569 ± 0.013	0.583CysGlu: 0.583 ± 0.013	0.455CysPhe: 0.455 ± 0.013	0.829CysGly: 0.829 ± 0.02	0.277CysHis: 0.277 ± 0.009	0.588CysIle: 0.588 ± 0.012	0.474CysLys: 0.474 ± 0.011	1.091CysLeu: 1.091 ± 0.02	0.232CysMet: 0.232 ± 0.009	0.37CysAsn: 0.37 ± 0.01	0.659CysPro: 0.659 ± 0.014	0.393CysGln: 0.393 ± 0.01	0.714CysArg: 0.714 ± 0.014	0.777CysSer: 0.777 ± 0.017	0.581CysThr: 0.581 ± 0.013	0.702CysVal: 0.702 ± 0.014	0.186CysTrp: 0.186 ± 0.007	0.308CysTyr: 0.308 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.466AspAla: 4.466 ± 0.039	0.556AspCys: 0.556 ± 0.012	4.494AspAsp: 4.494 ± 0.054	4.726AspGlu: 4.726 ± 0.052	1.983AspPhe: 1.983 ± 0.023	3.977AspGly: 3.977 ± 0.035	1.125AspHis: 1.125 ± 0.021	2.704AspIle: 2.704 ± 0.033	2.457AspLys: 2.457 ± 0.032	4.715AspLeu: 4.715 ± 0.039	1.182AspMet: 1.182 ± 0.019	1.822AspAsn: 1.822 ± 0.024	3.667AspPro: 3.667 ± 0.034	1.707AspGln: 1.707 ± 0.023	3.143AspArg: 3.143 ± 0.046	3.759AspSer: 3.759 ± 0.037	2.571AspThr: 2.571 ± 0.026	3.54AspVal: 3.54 ± 0.034	0.825AspTrp: 0.825 ± 0.016	1.468AspTyr: 1.468 ± 0.02	0.0AspXaa: 0.0 ± 0.0
Glu	5.764GluAla: 5.764 ± 0.08	0.593GluCys: 0.593 ± 0.015	4.321GluAsp: 4.321 ± 0.049	7.356GluGlu: 7.356 ± 0.13	1.93GluPhe: 1.93 ± 0.024	4.383GluGly: 4.383 ± 0.047	1.362GluHis: 1.362 ± 0.018	2.965GluIle: 2.965 ± 0.033	4.325GluLys: 4.325 ± 0.052	5.5GluLeu: 5.5 ± 0.05	1.529GluMet: 1.529 ± 0.021	2.173GluAsn: 2.173 ± 0.024	3.309GluPro: 3.309 ± 0.089	2.864GluGln: 2.864 ± 0.036	4.67GluArg: 4.67 ± 0.058	4.055GluSer: 4.055 ± 0.043	3.394GluThr: 3.394 ± 0.048	3.894GluVal: 3.894 ± 0.048	0.937GluTrp: 0.937 ± 0.017	1.634GluTyr: 1.634 ± 0.022	0.001GluXaa: 0.001 ± 0.0
Phe	2.836PheAla: 2.836 ± 0.028	0.467PheCys: 0.467 ± 0.011	2.094PheAsp: 2.094 ± 0.022	2.026PheGlu: 2.026 ± 0.025	1.406PhePhe: 1.406 ± 0.02	2.609PheGly: 2.609 ± 0.037	0.794PheHis: 0.794 ± 0.014	1.564PheIle: 1.564 ± 0.02	1.387PheLys: 1.387 ± 0.02	3.162PheLeu: 3.162 ± 0.034	0.672PheMet: 0.672 ± 0.013	1.252PheAsn: 1.252 ± 0.02	1.909PhePro: 1.909 ± 0.021	1.208PheGln: 1.208 ± 0.022	1.95PheArg: 1.95 ± 0.026	2.624PheSer: 2.624 ± 0.031	1.947PheThr: 1.947 ± 0.021	2.195PheVal: 2.195 ± 0.024	0.56PheTrp: 0.56 ± 0.013	0.985PheTyr: 0.985 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	5.366GlyAla: 5.366 ± 0.039	0.798GlyCys: 0.798 ± 0.017	3.489GlyAsp: 3.489 ± 0.035	4.166GlyGlu: 4.166 ± 0.042	2.538GlyPhe: 2.538 ± 0.029	6.032GlyGly: 6.032 ± 0.063	1.594GlyHis: 1.594 ± 0.024	3.214GlyIle: 3.214 ± 0.035	3.587GlyLys: 3.587 ± 0.033	5.746GlyLeu: 5.746 ± 0.051	1.535GlyMet: 1.535 ± 0.025	2.496GlyAsn: 2.496 ± 0.033	3.678GlyPro: 3.678 ± 0.041	2.599GlyGln: 2.599 ± 0.028	4.403GlyArg: 4.403 ± 0.044	5.728GlySer: 5.728 ± 0.056	3.95GlyThr: 3.95 ± 0.039	4.464GlyVal: 4.464 ± 0.037	1.135GlyTrp: 1.135 ± 0.02	2.012GlyTyr: 2.012 ± 0.03	0.001GlyXaa: 0.001 ± 0.0
His	1.807HisAla: 1.807 ± 0.02	0.271HisCys: 0.271 ± 0.009	1.222HisAsp: 1.222 ± 0.018	1.24HisGlu: 1.24 ± 0.018	0.821HisPhe: 0.821 ± 0.016	1.612HisGly: 1.612 ± 0.024	1.081HisHis: 1.081 ± 0.028	1.113HisIle: 1.113 ± 0.016	0.906HisLys: 0.906 ± 0.017	2.103HisLeu: 2.103 ± 0.024	0.441HisMet: 0.441 ± 0.01	0.817HisAsn: 0.817 ± 0.017	1.804HisPro: 1.804 ± 0.027	1.033HisGln: 1.033 ± 0.019	1.527HisArg: 1.527 ± 0.023	1.696HisSer: 1.696 ± 0.024	1.187HisThr: 1.187 ± 0.019	1.315HisVal: 1.315 ± 0.019	0.315HisTrp: 0.315 ± 0.009	0.687HisTyr: 0.687 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	3.887IleAla: 3.887 ± 0.036	0.632IleCys: 0.632 ± 0.013	2.623IleAsp: 2.623 ± 0.028	2.861IleGlu: 2.861 ± 0.033	1.662IlePhe: 1.662 ± 0.025	2.772IleGly: 2.772 ± 0.029	1.045IleHis: 1.045 ± 0.018	2.273IleIle: 2.273 ± 0.03	2.198IleLys: 2.198 ± 0.028	4.146IleLeu: 4.146 ± 0.043	0.909IleMet: 0.909 ± 0.015	1.652IleAsn: 1.652 ± 0.022	3.142IlePro: 3.142 ± 0.03	1.665IleGln: 1.665 ± 0.022	2.816IleArg: 2.816 ± 0.03	3.257IleSer: 3.257 ± 0.028	2.731IleThr: 2.731 ± 0.028	2.98IleVal: 2.98 ± 0.032	0.63IleTrp: 0.63 ± 0.012	1.242IleTyr: 1.242 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	4.51LysAla: 4.51 ± 0.051	0.437LysCys: 0.437 ± 0.01	2.71LysAsp: 2.71 ± 0.031	4.007LysGlu: 4.007 ± 0.054	1.39LysPhe: 1.39 ± 0.018	3.137LysGly: 3.137 ± 0.034	1.147LysHis: 1.147 ± 0.021	2.184LysIle: 2.184 ± 0.026	4.024LysLys: 4.024 ± 0.057	4.187LysLeu: 4.187 ± 0.036	0.986LysMet: 0.986 ± 0.018	1.671LysAsn: 1.671 ± 0.022	3.166LysPro: 3.166 ± 0.041	2.012LysGln: 2.012 ± 0.025	3.693LysArg: 3.693 ± 0.04	3.131LysSer: 3.131 ± 0.033	2.81LysThr: 2.81 ± 0.034	2.915LysVal: 2.915 ± 0.037	0.647LysTrp: 0.647 ± 0.012	1.304LysTyr: 1.304 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	8.117LeuAla: 8.117 ± 0.061	1.072LeuCys: 1.072 ± 0.016	4.865LeuAsp: 4.865 ± 0.043	5.593LeuGlu: 5.593 ± 0.05	3.052LeuPhe: 3.052 ± 0.036	5.583LeuGly: 5.583 ± 0.051	2.057LeuHis: 2.057 ± 0.026	3.649LeuIle: 3.649 ± 0.037	4.211LeuLys: 4.211 ± 0.041	8.128LeuLeu: 8.128 ± 0.071	1.636LeuMet: 1.636 ± 0.023	2.951LeuAsn: 2.951 ± 0.035	5.899LeuPro: 5.899 ± 0.048	3.538LeuGln: 3.538 ± 0.034	6.176LeuArg: 6.176 ± 0.046	6.853LeuSer: 6.853 ± 0.048	4.827LeuThr: 4.827 ± 0.041	5.199LeuVal: 5.199 ± 0.044	1.121LeuTrp: 1.121 ± 0.021	2.117LeuTyr: 2.117 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	2.151MetAla: 2.151 ± 0.025	0.209MetCys: 0.209 ± 0.008	1.129MetAsp: 1.129 ± 0.017	1.249MetGlu: 1.249 ± 0.018	0.64MetPhe: 0.64 ± 0.014	1.395MetGly: 1.395 ± 0.019	0.405MetHis: 0.405 ± 0.011	0.875MetIle: 0.875 ± 0.018	0.926MetLys: 0.926 ± 0.015	1.767MetLeu: 1.767 ± 0.021	0.541MetMet: 0.541 ± 0.014	0.635MetAsn: 0.635 ± 0.015	1.291MetPro: 1.291 ± 0.022	0.776MetGln: 0.776 ± 0.014	1.321MetArg: 1.321 ± 0.019	1.676MetSer: 1.676 ± 0.022	1.225MetThr: 1.225 ± 0.019	1.258MetVal: 1.258 ± 0.02	0.243MetTrp: 0.243 ± 0.008	0.481MetTyr: 0.481 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.958AsnAla: 2.958 ± 0.027	0.379AsnCys: 0.379 ± 0.012	1.838AsnAsp: 1.838 ± 0.025	1.919AsnGlu: 1.919 ± 0.024	1.196AsnPhe: 1.196 ± 0.019	3.03AsnGly: 3.03 ± 0.034	0.813AsnHis: 0.813 ± 0.015	1.799AsnIle: 1.799 ± 0.024	1.604AsnLys: 1.604 ± 0.021	2.998AsnLeu: 2.998 ± 0.032	0.737AsnMet: 0.737 ± 0.014	1.797AsnAsn: 1.797 ± 0.046	2.662AsnPro: 2.662 ± 0.028	1.252AsnGln: 1.252 ± 0.021	1.918AsnArg: 1.918 ± 0.028	2.493AsnSer: 2.493 ± 0.028	2.015AsnThr: 2.015 ± 0.022	2.078AsnVal: 2.078 ± 0.022	0.51AsnTrp: 0.51 ± 0.012	0.944AsnTyr: 0.944 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	6.548ProAla: 6.548 ± 0.108	0.508ProCys: 0.508 ± 0.013	3.457ProAsp: 3.457 ± 0.032	4.37ProGlu: 4.37 ± 0.069	2.017ProPhe: 2.017 ± 0.023	4.444ProGly: 4.444 ± 0.049	1.434ProHis: 1.434 ± 0.022	2.671ProIle: 2.671 ± 0.028	2.999ProLys: 2.999 ± 0.034	5.071ProLeu: 5.071 ± 0.039	1.049ProMet: 1.049 ± 0.018	2.411ProAsn: 2.411 ± 0.028	7.155ProPro: 7.155 ± 0.106	2.956ProGln: 2.956 ± 0.046	3.801ProArg: 3.801 ± 0.037	6.824ProSer: 6.824 ± 0.072	4.568ProThr: 4.568 ± 0.052	4.077ProVal: 4.077 ± 0.06	0.723ProTrp: 0.723 ± 0.014	1.582ProTyr: 1.582 ± 0.02	0.001ProXaa: 0.001 ± 0.0
Gln	3.915GlnAla: 3.915 ± 0.043	0.386GlnCys: 0.386 ± 0.01	1.848GlnAsp: 1.848 ± 0.023	2.586GlnGlu: 2.586 ± 0.028	1.158GlnPhe: 1.158 ± 0.02	2.346GlnGly: 2.346 ± 0.027	1.175GlnHis: 1.175 ± 0.019	1.724GlnIle: 1.724 ± 0.024	1.997GlnLys: 1.997 ± 0.026	3.472GlnLeu: 3.472 ± 0.034	0.828GlnMet: 0.828 ± 0.017	1.374GlnAsn: 1.374 ± 0.022	3.335GlnPro: 3.335 ± 0.053	4.103GlnGln: 4.103 ± 0.109	2.789GlnArg: 2.789 ± 0.028	2.876GlnSer: 2.876 ± 0.031	2.317GlnThr: 2.317 ± 0.029	2.147GlnVal: 2.147 ± 0.026	0.504GlnTrp: 0.504 ± 0.011	1.054GlnTyr: 1.054 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	5.29ArgAla: 5.29 ± 0.043	0.686ArgCys: 0.686 ± 0.014	3.596ArgAsp: 3.596 ± 0.05	4.783ArgGlu: 4.783 ± 0.059	2.106ArgPhe: 2.106 ± 0.024	4.029ArgGly: 4.029 ± 0.044	1.616ArgHis: 1.616 ± 0.021	2.894ArgIle: 2.894 ± 0.033	3.707ArgLys: 3.707 ± 0.037	5.72ArgLeu: 5.72 ± 0.045	1.376ArgMet: 1.376 ± 0.021	2.163ArgAsn: 2.163 ± 0.024	4.056ArgPro: 4.056 ± 0.042	2.758ArgGln: 2.758 ± 0.031	5.929ArgArg: 5.929 ± 0.057	4.864ArgSer: 4.864 ± 0.046	3.272ArgThr: 3.272 ± 0.031	3.571ArgVal: 3.571 ± 0.034	0.968ArgTrp: 0.968 ± 0.018	1.663ArgTyr: 1.663 ± 0.02	0.0ArgXaa: 0.0 ± 0.0
Ser	6.793SerAla: 6.793 ± 0.057	0.739SerCys: 0.739 ± 0.015	3.917SerAsp: 3.917 ± 0.035	4.04SerGlu: 4.04 ± 0.039	2.579SerPhe: 2.579 ± 0.029	5.447SerGly: 5.447 ± 0.051	1.81SerHis: 1.81 ± 0.024	3.351SerIle: 3.351 ± 0.032	3.492SerLys: 3.492 ± 0.033	6.731SerLeu: 6.731 ± 0.045	1.483SerMet: 1.483 ± 0.019	2.724SerAsn: 2.724 ± 0.032	6.083SerPro: 6.083 ± 0.072	3.323SerGln: 3.323 ± 0.041	5.106SerArg: 5.106 ± 0.05	9.788SerSer: 9.788 ± 0.121	5.452SerThr: 5.452 ± 0.057	4.363SerVal: 4.363 ± 0.041	0.954SerTrp: 0.954 ± 0.016	1.756SerTyr: 1.756 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	5.549ThrAla: 5.549 ± 0.042	0.641ThrCys: 0.641 ± 0.011	2.614ThrAsp: 2.614 ± 0.028	3.073ThrGlu: 3.073 ± 0.044	2.027ThrPhe: 2.027 ± 0.024	4.102ThrGly: 4.102 ± 0.04	1.169ThrHis: 1.169 ± 0.016	2.883ThrIle: 2.883 ± 0.033	2.571ThrLys: 2.571 ± 0.028	5.043ThrLeu: 5.043 ± 0.04	1.064ThrMet: 1.064 ± 0.016	2.016ThrAsn: 2.016 ± 0.022	4.94ThrPro: 4.94 ± 0.049	2.104ThrGln: 2.104 ± 0.025	3.185ThrArg: 3.185 ± 0.029	5.345ThrSer: 5.345 ± 0.055	4.845ThrThr: 4.845 ± 0.058	3.681ThrVal: 3.681 ± 0.041	0.74ThrTrp: 0.74 ± 0.015	1.421ThrTyr: 1.421 ± 0.024	0.0ThrXaa: 0.0 ± 0.0
Val	5.333ValAla: 5.333 ± 0.047	0.762ValCys: 0.762 ± 0.012	3.524ValAsp: 3.524 ± 0.036	4.156ValGlu: 4.156 ± 0.074	2.235ValPhe: 2.235 ± 0.029	3.89ValGly: 3.89 ± 0.038	1.294ValHis: 1.294 ± 0.019	2.793ValIle: 2.793 ± 0.031	3.015ValLys: 3.015 ± 0.034	5.447ValLeu: 5.447 ± 0.046	1.252ValMet: 1.252 ± 0.02	2.107ValAsn: 2.107 ± 0.029	4.039ValPro: 4.039 ± 0.041	2.287ValGln: 2.287 ± 0.026	3.724ValArg: 3.724 ± 0.037	4.391ValSer: 4.391 ± 0.037	3.584ValThr: 3.584 ± 0.034	4.441ValVal: 4.441 ± 0.043	0.893ValTrp: 0.893 ± 0.016	1.648ValTyr: 1.648 ± 0.022	0.0ValXaa: 0.0 ± 0.0
Trp	1.092TrpAla: 1.092 ± 0.016	0.198TrpCys: 0.198 ± 0.007	0.848TrpAsp: 0.848 ± 0.017	0.933TrpGlu: 0.933 ± 0.017	0.503TrpPhe: 0.503 ± 0.012	0.91TrpGly: 0.91 ± 0.017	0.328TrpHis: 0.328 ± 0.01	0.641TrpIle: 0.641 ± 0.014	0.745TrpLys: 0.745 ± 0.015	1.304TrpLeu: 1.304 ± 0.017	0.331TrpMet: 0.331 ± 0.009	0.517TrpAsn: 0.517 ± 0.012	0.597TrpPro: 0.597 ± 0.014	0.519TrpGln: 0.519 ± 0.012	0.978TrpArg: 0.978 ± 0.016	0.895TrpSer: 0.895 ± 0.018	0.832TrpThr: 0.832 ± 0.014	0.851TrpVal: 0.851 ± 0.017	0.269TrpTrp: 0.269 ± 0.009	0.388TrpTyr: 0.388 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.004TyrAla: 2.004 ± 0.023	0.354TyrCys: 0.354 ± 0.01	1.559TyrAsp: 1.559 ± 0.023	1.523TyrGlu: 1.523 ± 0.024	1.061TyrPhe: 1.061 ± 0.015	1.931TyrGly: 1.931 ± 0.029	0.72TyrHis: 0.72 ± 0.014	1.245TyrIle: 1.245 ± 0.021	1.06TyrLys: 1.06 ± 0.02	2.471TyrLeu: 2.471 ± 0.029	0.54TyrMet: 0.54 ± 0.012	1.026TyrAsn: 1.026 ± 0.022	1.495TyrPro: 1.495 ± 0.023	0.993TyrGln: 0.993 ± 0.015	1.624TyrArg: 1.624 ± 0.019	1.751TyrSer: 1.751 ± 0.02	1.457TyrThr: 1.457 ± 0.021	1.527TyrVal: 1.527 ± 0.021	0.4TyrTrp: 0.4 ± 0.009	0.891TyrTyr: 0.891 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.046XaaXaa: 0.046 ± 0.021

Statistics based on 7185 proteins (3924665 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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