Amino acid dipepetide frequency for Methanosarcina virus MetMV

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.524AlaAla: 9.524 ± 1.785
0.997AlaCys: 0.997 ± 0.263
4.319AlaAsp: 4.319 ± 0.784
6.368AlaGlu: 6.368 ± 0.886
2.602AlaPhe: 2.602 ± 0.406
5.759AlaGly: 5.759 ± 0.562
1.218AlaHis: 1.218 ± 0.278
5.426AlaIle: 5.426 ± 0.649
5.925AlaLys: 5.925 ± 0.648
5.703AlaLeu: 5.703 ± 0.623
1.495AlaMet: 1.495 ± 0.303
4.817AlaAsn: 4.817 ± 0.645
2.547AlaPro: 2.547 ± 0.48
2.436AlaGln: 2.436 ± 0.351
4.43AlaArg: 4.43 ± 0.723
4.153AlaSer: 4.153 ± 0.577
5.26AlaThr: 5.26 ± 0.688
3.765AlaVal: 3.765 ± 0.708
0.775AlaTrp: 0.775 ± 0.252
3.322AlaTyr: 3.322 ± 0.475
0.0AlaXaa: 0.0 ± 0.0
Cys
0.72CysAla: 0.72 ± 0.289
0.388CysCys: 0.388 ± 0.179
0.831CysAsp: 0.831 ± 0.235
0.997CysGlu: 0.997 ± 0.291
0.72CysPhe: 0.72 ± 0.223
0.997CysGly: 0.997 ± 0.311
0.498CysHis: 0.498 ± 0.177
0.775CysIle: 0.775 ± 0.227
1.218CysLys: 1.218 ± 0.362
0.997CysLeu: 0.997 ± 0.259
0.166CysMet: 0.166 ± 0.142
0.498CysAsn: 0.498 ± 0.157
1.274CysPro: 1.274 ± 0.449
0.166CysGln: 0.166 ± 0.1
0.498CysArg: 0.498 ± 0.212
0.664CysSer: 0.664 ± 0.214
1.274CysThr: 1.274 ± 0.299
0.609CysVal: 0.609 ± 0.21
0.332CysTrp: 0.332 ± 0.15
0.775CysTyr: 0.775 ± 0.235
0.0CysXaa: 0.0 ± 0.0
Asp
5.15AspAla: 5.15 ± 0.894
0.941AspCys: 0.941 ± 0.262
3.931AspAsp: 3.931 ± 0.526
4.264AspGlu: 4.264 ± 0.476
3.212AspPhe: 3.212 ± 0.434
4.374AspGly: 4.374 ± 0.61
0.997AspHis: 0.997 ± 0.287
4.208AspIle: 4.208 ± 0.422
3.987AspLys: 3.987 ± 0.555
4.097AspLeu: 4.097 ± 0.523
1.052AspMet: 1.052 ± 0.228
2.935AspAsn: 2.935 ± 0.333
1.938AspPro: 1.938 ± 0.41
1.329AspGln: 1.329 ± 0.205
2.381AspArg: 2.381 ± 0.372
3.156AspSer: 3.156 ± 0.37
3.378AspThr: 3.378 ± 0.491
3.931AspVal: 3.931 ± 0.417
0.997AspTrp: 0.997 ± 0.262
2.935AspTyr: 2.935 ± 0.373
0.0AspXaa: 0.0 ± 0.0
Glu
5.039GluAla: 5.039 ± 0.707
0.886GluCys: 0.886 ± 0.315
3.765GluAsp: 3.765 ± 0.594
5.371GluGlu: 5.371 ± 0.685
2.713GluPhe: 2.713 ± 0.377
3.599GluGly: 3.599 ± 0.475
0.997GluHis: 0.997 ± 0.255
5.426GluIle: 5.426 ± 0.629
7.198GluLys: 7.198 ± 0.916
6.257GluLeu: 6.257 ± 0.726
1.883GluMet: 1.883 ± 0.433
3.156GluAsn: 3.156 ± 0.498
1.495GluPro: 1.495 ± 0.342
3.322GluGln: 3.322 ± 0.481
3.821GluArg: 3.821 ± 0.574
4.54GluSer: 4.54 ± 0.61
4.928GluThr: 4.928 ± 0.594
3.654GluVal: 3.654 ± 0.575
0.609GluTrp: 0.609 ± 0.212
2.602GluTyr: 2.602 ± 0.324
0.0GluXaa: 0.0 ± 0.0
Phe
2.27PheAla: 2.27 ± 0.403
0.609PheCys: 0.609 ± 0.2
2.436PheAsp: 2.436 ± 0.286
1.883PheGlu: 1.883 ± 0.305
1.274PhePhe: 1.274 ± 0.214
2.27PheGly: 2.27 ± 0.347
0.609PheHis: 0.609 ± 0.17
1.606PheIle: 1.606 ± 0.314
2.381PheLys: 2.381 ± 0.401
2.713PheLeu: 2.713 ± 0.402
0.72PheMet: 0.72 ± 0.185
2.769PheAsn: 2.769 ± 0.427
1.384PhePro: 1.384 ± 0.296
1.329PheGln: 1.329 ± 0.284
1.218PheArg: 1.218 ± 0.23
2.547PheSer: 2.547 ± 0.367
1.993PheThr: 1.993 ± 0.381
2.215PheVal: 2.215 ± 0.419
0.609PheTrp: 0.609 ± 0.203
1.717PheTyr: 1.717 ± 0.286
0.0PheXaa: 0.0 ± 0.0
Gly
4.264GlyAla: 4.264 ± 0.571
1.052GlyCys: 1.052 ± 0.311
3.987GlyAsp: 3.987 ± 0.531
4.707GlyGlu: 4.707 ± 0.602
2.602GlyPhe: 2.602 ± 0.338
5.426GlyGly: 5.426 ± 0.656
0.886GlyHis: 0.886 ± 0.185
5.869GlyIle: 5.869 ± 0.545
4.596GlyLys: 4.596 ± 0.493
5.759GlyLeu: 5.759 ± 0.531
1.827GlyMet: 1.827 ± 0.25
3.654GlyAsn: 3.654 ± 0.461
0.941GlyPro: 0.941 ± 0.298
2.492GlyGln: 2.492 ± 0.384
3.488GlyArg: 3.488 ± 0.384
3.821GlySer: 3.821 ± 0.504
5.592GlyThr: 5.592 ± 0.657
4.817GlyVal: 4.817 ± 0.629
1.107GlyTrp: 1.107 ± 0.305
3.378GlyTyr: 3.378 ± 0.385
0.0GlyXaa: 0.0 ± 0.0
His
1.384HisAla: 1.384 ± 0.305
0.277HisCys: 0.277 ± 0.136
0.831HisAsp: 0.831 ± 0.183
1.052HisGlu: 1.052 ± 0.187
0.443HisPhe: 0.443 ± 0.175
1.384HisGly: 1.384 ± 0.273
0.609HisHis: 0.609 ± 0.216
0.831HisIle: 0.831 ± 0.241
1.717HisLys: 1.717 ± 0.37
1.384HisLeu: 1.384 ± 0.27
0.055HisMet: 0.055 ± 0.062
0.997HisAsn: 0.997 ± 0.224
0.664HisPro: 0.664 ± 0.222
0.388HisGln: 0.388 ± 0.161
0.498HisArg: 0.498 ± 0.194
0.554HisSer: 0.554 ± 0.169
0.775HisThr: 0.775 ± 0.188
0.664HisVal: 0.664 ± 0.187
0.166HisTrp: 0.166 ± 0.082
0.831HisTyr: 0.831 ± 0.245
0.0HisXaa: 0.0 ± 0.0
Ile
6.368IleAla: 6.368 ± 0.606
0.775IleCys: 0.775 ± 0.232
5.15IleAsp: 5.15 ± 0.484
4.873IleGlu: 4.873 ± 0.6
2.492IlePhe: 2.492 ± 0.475
4.097IleGly: 4.097 ± 0.672
0.941IleHis: 0.941 ± 0.212
4.928IleIle: 4.928 ± 0.784
5.482IleLys: 5.482 ± 0.573
3.987IleLeu: 3.987 ± 0.414
1.218IleMet: 1.218 ± 0.258
4.651IleAsn: 4.651 ± 0.645
3.101IlePro: 3.101 ± 0.366
2.049IleGln: 2.049 ± 0.378
3.267IleArg: 3.267 ± 0.403
4.153IleSer: 4.153 ± 0.626
5.759IleThr: 5.759 ± 0.654
3.71IleVal: 3.71 ± 0.544
0.554IleTrp: 0.554 ± 0.17
2.713IleTyr: 2.713 ± 0.373
0.0IleXaa: 0.0 ± 0.0
Lys
5.869LysAla: 5.869 ± 0.7
1.163LysCys: 1.163 ± 0.403
4.319LysAsp: 4.319 ± 0.765
6.423LysGlu: 6.423 ± 0.786
1.661LysPhe: 1.661 ± 0.275
5.094LysGly: 5.094 ± 0.661
1.44LysHis: 1.44 ± 0.352
5.482LysIle: 5.482 ± 0.609
6.755LysLys: 6.755 ± 1.019
6.534LysLeu: 6.534 ± 0.713
1.938LysMet: 1.938 ± 0.304
5.15LysAsn: 5.15 ± 0.733
2.436LysPro: 2.436 ± 0.519
3.212LysGln: 3.212 ± 0.519
3.267LysArg: 3.267 ± 0.59
3.488LysSer: 3.488 ± 0.483
4.153LysThr: 4.153 ± 0.478
3.821LysVal: 3.821 ± 0.446
1.163LysTrp: 1.163 ± 0.259
3.544LysTyr: 3.544 ± 0.476
0.0LysXaa: 0.0 ± 0.0
Leu
7.087LeuAla: 7.087 ± 0.806
1.218LeuCys: 1.218 ± 0.341
4.707LeuAsp: 4.707 ± 0.492
5.482LeuGlu: 5.482 ± 0.554
2.492LeuPhe: 2.492 ± 0.329
4.43LeuGly: 4.43 ± 0.592
1.052LeuHis: 1.052 ± 0.231
6.202LeuIle: 6.202 ± 0.714
5.703LeuLys: 5.703 ± 0.607
5.316LeuLeu: 5.316 ± 0.733
1.55LeuMet: 1.55 ± 0.304
4.042LeuAsn: 4.042 ± 0.538
3.267LeuPro: 3.267 ± 0.434
3.101LeuGln: 3.101 ± 0.467
2.879LeuArg: 2.879 ± 0.362
5.814LeuSer: 5.814 ± 0.585
4.817LeuThr: 4.817 ± 0.6
3.654LeuVal: 3.654 ± 0.568
0.941LeuTrp: 0.941 ± 0.326
2.879LeuTyr: 2.879 ± 0.466
0.0LeuXaa: 0.0 ± 0.0
Met
1.993MetAla: 1.993 ± 0.342
0.111MetCys: 0.111 ± 0.084
1.052MetAsp: 1.052 ± 0.162
1.661MetGlu: 1.661 ± 0.309
0.72MetPhe: 0.72 ± 0.242
1.661MetGly: 1.661 ± 0.29
0.443MetHis: 0.443 ± 0.16
1.772MetIle: 1.772 ± 0.341
1.938MetLys: 1.938 ± 0.367
1.274MetLeu: 1.274 ± 0.351
0.388MetMet: 0.388 ± 0.15
1.107MetAsn: 1.107 ± 0.246
0.886MetPro: 0.886 ± 0.241
0.609MetGln: 0.609 ± 0.185
1.107MetArg: 1.107 ± 0.204
2.159MetSer: 2.159 ± 0.343
1.107MetThr: 1.107 ± 0.264
1.107MetVal: 1.107 ± 0.331
0.388MetTrp: 0.388 ± 0.131
0.664MetTyr: 0.664 ± 0.165
0.0MetXaa: 0.0 ± 0.0
Asn
3.987AsnAla: 3.987 ± 0.593
0.609AsnCys: 0.609 ± 0.177
2.99AsnAsp: 2.99 ± 0.456
3.101AsnGlu: 3.101 ± 0.41
2.27AsnPhe: 2.27 ± 0.367
3.931AsnGly: 3.931 ± 0.619
1.107AsnHis: 1.107 ± 0.269
3.987AsnIle: 3.987 ± 0.464
3.654AsnLys: 3.654 ± 0.517
4.817AsnLeu: 4.817 ± 0.559
0.72AsnMet: 0.72 ± 0.256
3.876AsnAsn: 3.876 ± 1.265
2.879AsnPro: 2.879 ± 0.427
2.159AsnGln: 2.159 ± 0.333
2.159AsnArg: 2.159 ± 0.307
3.599AsnSer: 3.599 ± 0.801
2.658AsnThr: 2.658 ± 0.344
3.544AsnVal: 3.544 ± 0.547
0.997AsnTrp: 0.997 ± 0.31
2.159AsnTyr: 2.159 ± 0.346
0.0AsnXaa: 0.0 ± 0.0
Pro
3.045ProAla: 3.045 ± 0.544
0.554ProCys: 0.554 ± 0.176
3.045ProAsp: 3.045 ± 0.442
3.267ProGlu: 3.267 ± 0.613
1.717ProPhe: 1.717 ± 0.273
2.99ProGly: 2.99 ± 0.324
0.664ProHis: 0.664 ± 0.178
1.993ProIle: 1.993 ± 0.405
2.049ProLys: 2.049 ± 0.443
2.326ProLeu: 2.326 ± 0.352
0.72ProMet: 0.72 ± 0.189
1.218ProAsn: 1.218 ± 0.349
1.384ProPro: 1.384 ± 0.315
1.218ProGln: 1.218 ± 0.285
0.941ProArg: 0.941 ± 0.209
2.326ProSer: 2.326 ± 0.355
2.713ProThr: 2.713 ± 0.386
3.156ProVal: 3.156 ± 0.375
0.775ProTrp: 0.775 ± 0.252
1.44ProTyr: 1.44 ± 0.299
0.0ProXaa: 0.0 ± 0.0
Gln
3.156GlnAla: 3.156 ± 0.45
0.388GlnCys: 0.388 ± 0.154
1.163GlnAsp: 1.163 ± 0.301
2.602GlnGlu: 2.602 ± 0.385
0.775GlnPhe: 0.775 ± 0.203
2.713GlnGly: 2.713 ± 0.311
0.388GlnHis: 0.388 ± 0.127
2.436GlnIle: 2.436 ± 0.419
2.713GlnLys: 2.713 ± 0.343
2.547GlnLeu: 2.547 ± 0.372
1.107GlnMet: 1.107 ± 0.208
1.44GlnAsn: 1.44 ± 0.249
1.993GlnPro: 1.993 ± 0.342
1.107GlnGln: 1.107 ± 0.259
1.772GlnArg: 1.772 ± 0.368
2.27GlnSer: 2.27 ± 0.392
2.547GlnThr: 2.547 ± 0.463
2.104GlnVal: 2.104 ± 0.343
0.443GlnTrp: 0.443 ± 0.163
1.218GlnTyr: 1.218 ± 0.277
0.0GlnXaa: 0.0 ± 0.0
Arg
3.101ArgAla: 3.101 ± 0.425
0.498ArgCys: 0.498 ± 0.183
2.658ArgAsp: 2.658 ± 0.36
3.378ArgGlu: 3.378 ± 0.507
1.329ArgPhe: 1.329 ± 0.277
2.879ArgGly: 2.879 ± 0.348
0.554ArgHis: 0.554 ± 0.137
3.156ArgIle: 3.156 ± 0.402
4.097ArgLys: 4.097 ± 0.668
3.544ArgLeu: 3.544 ± 0.425
0.997ArgMet: 0.997 ± 0.22
2.436ArgAsn: 2.436 ± 0.311
1.274ArgPro: 1.274 ± 0.303
1.717ArgGln: 1.717 ± 0.353
2.381ArgArg: 2.381 ± 0.436
2.159ArgSer: 2.159 ± 0.355
2.049ArgThr: 2.049 ± 0.296
2.436ArgVal: 2.436 ± 0.393
0.997ArgTrp: 0.997 ± 0.288
1.55ArgTyr: 1.55 ± 0.24
0.0ArgXaa: 0.0 ± 0.0
Ser
5.039SerAla: 5.039 ± 0.535
0.886SerCys: 0.886 ± 0.259
3.71SerAsp: 3.71 ± 0.417
3.654SerGlu: 3.654 ± 0.524
2.049SerPhe: 2.049 ± 0.325
5.814SerGly: 5.814 ± 0.629
0.609SerHis: 0.609 ± 0.187
4.54SerIle: 4.54 ± 0.656
4.485SerLys: 4.485 ± 0.422
4.762SerLeu: 4.762 ± 0.545
1.329SerMet: 1.329 ± 0.254
3.212SerAsn: 3.212 ± 0.607
2.27SerPro: 2.27 ± 0.373
2.27SerGln: 2.27 ± 0.304
1.938SerArg: 1.938 ± 0.318
3.544SerSer: 3.544 ± 0.676
2.769SerThr: 2.769 ± 0.518
3.987SerVal: 3.987 ± 0.605
1.495SerTrp: 1.495 ± 0.368
1.938SerTyr: 1.938 ± 0.342
0.0SerXaa: 0.0 ± 0.0
Thr
4.596ThrAla: 4.596 ± 0.614
0.72ThrCys: 0.72 ± 0.234
3.987ThrAsp: 3.987 ± 0.62
4.596ThrGlu: 4.596 ± 0.628
1.606ThrPhe: 1.606 ± 0.377
5.482ThrGly: 5.482 ± 0.764
0.886ThrHis: 0.886 ± 0.21
4.817ThrIle: 4.817 ± 0.63
3.821ThrLys: 3.821 ± 0.459
5.482ThrLeu: 5.482 ± 1.005
1.883ThrMet: 1.883 ± 0.342
3.101ThrAsn: 3.101 ± 0.493
2.935ThrPro: 2.935 ± 0.481
1.827ThrGln: 1.827 ± 0.246
2.159ThrArg: 2.159 ± 0.324
3.544ThrSer: 3.544 ± 0.68
4.208ThrThr: 4.208 ± 0.84
4.374ThrVal: 4.374 ± 0.636
0.664ThrTrp: 0.664 ± 0.183
1.938ThrTyr: 1.938 ± 0.374
0.0ThrXaa: 0.0 ± 0.0
Val
3.876ValAla: 3.876 ± 0.503
1.163ValCys: 1.163 ± 0.322
3.433ValAsp: 3.433 ± 0.534
3.599ValGlu: 3.599 ± 0.421
2.326ValPhe: 2.326 ± 0.34
2.879ValGly: 2.879 ± 0.478
0.609ValHis: 0.609 ± 0.243
4.097ValIle: 4.097 ± 0.58
4.485ValLys: 4.485 ± 0.696
4.707ValLeu: 4.707 ± 0.566
1.772ValMet: 1.772 ± 0.329
3.267ValAsn: 3.267 ± 0.432
2.935ValPro: 2.935 ± 0.423
2.215ValGln: 2.215 ± 0.378
2.159ValArg: 2.159 ± 0.348
4.153ValSer: 4.153 ± 0.629
3.599ValThr: 3.599 ± 0.699
3.821ValVal: 3.821 ± 0.412
0.997ValTrp: 0.997 ± 0.236
2.159ValTyr: 2.159 ± 0.509
0.0ValXaa: 0.0 ± 0.0
Trp
1.606TrpAla: 1.606 ± 0.261
0.111TrpCys: 0.111 ± 0.079
0.886TrpAsp: 0.886 ± 0.217
1.329TrpGlu: 1.329 ± 0.264
0.498TrpPhe: 0.498 ± 0.149
0.941TrpGly: 0.941 ± 0.24
0.221TrpHis: 0.221 ± 0.097
0.609TrpIle: 0.609 ± 0.191
1.384TrpLys: 1.384 ± 0.255
1.218TrpLeu: 1.218 ± 0.274
0.388TrpMet: 0.388 ± 0.175
0.831TrpAsn: 0.831 ± 0.201
0.388TrpPro: 0.388 ± 0.156
0.554TrpGln: 0.554 ± 0.152
0.775TrpArg: 0.775 ± 0.247
0.775TrpSer: 0.775 ± 0.204
1.052TrpThr: 1.052 ± 0.257
0.443TrpVal: 0.443 ± 0.162
0.609TrpTrp: 0.609 ± 0.165
0.664TrpTyr: 0.664 ± 0.155
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.769TyrAla: 2.769 ± 0.511
1.052TyrCys: 1.052 ± 0.342
1.993TyrAsp: 1.993 ± 0.31
2.713TyrGlu: 2.713 ± 0.396
1.052TyrPhe: 1.052 ± 0.243
3.544TyrGly: 3.544 ± 0.66
0.775TyrHis: 0.775 ± 0.219
2.104TyrIle: 2.104 ± 0.424
3.322TyrLys: 3.322 ± 0.384
3.212TyrLeu: 3.212 ± 0.453
0.886TyrMet: 0.886 ± 0.205
2.049TyrAsn: 2.049 ± 0.341
1.55TyrPro: 1.55 ± 0.309
1.384TyrGln: 1.384 ± 0.245
2.049TyrArg: 2.049 ± 0.362
2.879TyrSer: 2.879 ± 0.403
1.993TyrThr: 1.993 ± 0.384
2.436TyrVal: 2.436 ± 0.436
0.664TyrTrp: 0.664 ± 0.167
2.326TyrTyr: 2.326 ± 0.549
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 79 proteins (18061 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski