Amino acid dipepetide frequency for Gordonia Terrae phage RoadKill

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.497AlaAla: 18.497 ± 1.483
0.611AlaCys: 0.611 ± 0.183
10.109AlaAsp: 10.109 ± 1.021
8.887AlaGlu: 8.887 ± 0.975
2.777AlaPhe: 2.777 ± 0.581
13.053AlaGly: 13.053 ± 1.16
2.444AlaHis: 2.444 ± 0.414
6.11AlaIle: 6.11 ± 0.887
4.666AlaLys: 4.666 ± 0.599
9.054AlaLeu: 9.054 ± 0.648
2.0AlaMet: 2.0 ± 0.351
3.0AlaAsn: 3.0 ± 0.421
5.055AlaPro: 5.055 ± 0.585
4.555AlaGln: 4.555 ± 0.533
7.332AlaArg: 7.332 ± 0.882
6.61AlaSer: 6.61 ± 0.53
8.221AlaThr: 8.221 ± 0.671
8.332AlaVal: 8.332 ± 1.249
2.444AlaTrp: 2.444 ± 0.336
2.611AlaTyr: 2.611 ± 0.459
0.0AlaXaa: 0.0 ± 0.0
Cys
0.833CysAla: 0.833 ± 0.243
0.0CysCys: 0.0 ± 0.0
0.333CysAsp: 0.333 ± 0.139
0.667CysGlu: 0.667 ± 0.168
0.278CysPhe: 0.278 ± 0.12
0.833CysGly: 0.833 ± 0.292
0.167CysHis: 0.167 ± 0.1
0.056CysIle: 0.056 ± 0.062
0.222CysLys: 0.222 ± 0.098
0.444CysLeu: 0.444 ± 0.172
0.111CysMet: 0.111 ± 0.073
0.333CysAsn: 0.333 ± 0.146
0.778CysPro: 0.778 ± 0.223
0.167CysGln: 0.167 ± 0.107
0.944CysArg: 0.944 ± 0.246
0.444CysSer: 0.444 ± 0.169
0.611CysThr: 0.611 ± 0.196
0.389CysVal: 0.389 ± 0.135
0.111CysTrp: 0.111 ± 0.087
0.222CysTyr: 0.222 ± 0.116
0.0CysXaa: 0.0 ± 0.0
Asp
7.832AspAla: 7.832 ± 0.804
0.555AspCys: 0.555 ± 0.168
7.943AspAsp: 7.943 ± 1.212
5.332AspGlu: 5.332 ± 0.924
1.222AspPhe: 1.222 ± 0.249
7.61AspGly: 7.61 ± 0.673
1.555AspHis: 1.555 ± 0.301
1.5AspIle: 1.5 ± 0.282
2.0AspLys: 2.0 ± 0.374
6.388AspLeu: 6.388 ± 0.852
1.0AspMet: 1.0 ± 0.233
1.278AspAsn: 1.278 ± 0.28
5.999AspPro: 5.999 ± 0.647
3.277AspGln: 3.277 ± 0.422
5.999AspArg: 5.999 ± 0.805
3.111AspSer: 3.111 ± 0.436
4.277AspThr: 4.277 ± 0.571
4.666AspVal: 4.666 ± 0.559
1.777AspTrp: 1.777 ± 0.346
1.722AspTyr: 1.722 ± 0.354
0.0AspXaa: 0.0 ± 0.0
Glu
6.943GluAla: 6.943 ± 0.6
0.444GluCys: 0.444 ± 0.156
2.777GluAsp: 2.777 ± 0.509
1.389GluGlu: 1.389 ± 0.3
1.889GluPhe: 1.889 ± 0.37
3.499GluGly: 3.499 ± 0.479
1.278GluHis: 1.278 ± 0.23
3.166GluIle: 3.166 ± 0.44
1.0GluLys: 1.0 ± 0.234
5.166GluLeu: 5.166 ± 0.726
1.111GluMet: 1.111 ± 0.287
1.611GluAsn: 1.611 ± 0.299
3.166GluPro: 3.166 ± 0.484
3.888GluGln: 3.888 ± 0.644
4.499GluArg: 4.499 ± 0.608
3.0GluSer: 3.0 ± 0.46
2.833GluThr: 2.833 ± 0.346
4.388GluVal: 4.388 ± 0.501
1.833GluTrp: 1.833 ± 0.393
2.222GluTyr: 2.222 ± 0.388
0.0GluXaa: 0.0 ± 0.0
Phe
3.277PheAla: 3.277 ± 0.533
0.389PheCys: 0.389 ± 0.174
2.111PheAsp: 2.111 ± 0.366
1.389PheGlu: 1.389 ± 0.24
0.944PhePhe: 0.944 ± 0.401
2.833PheGly: 2.833 ± 0.385
0.278PheHis: 0.278 ± 0.134
0.667PheIle: 0.667 ± 0.192
0.722PheLys: 0.722 ± 0.443
1.555PheLeu: 1.555 ± 0.289
0.333PheMet: 0.333 ± 0.133
0.667PheAsn: 0.667 ± 0.318
1.222PhePro: 1.222 ± 0.296
1.0PheGln: 1.0 ± 0.225
1.333PheArg: 1.333 ± 0.276
1.5PheSer: 1.5 ± 0.358
2.166PheThr: 2.166 ± 0.431
1.555PheVal: 1.555 ± 0.292
0.722PheTrp: 0.722 ± 0.195
0.389PheTyr: 0.389 ± 0.145
0.0PheXaa: 0.0 ± 0.0
Gly
9.332GlyAla: 9.332 ± 1.163
0.611GlyCys: 0.611 ± 0.209
5.388GlyAsp: 5.388 ± 0.599
5.666GlyGlu: 5.666 ± 0.613
2.166GlyPhe: 2.166 ± 0.432
8.221GlyGly: 8.221 ± 0.903
1.666GlyHis: 1.666 ± 0.382
5.166GlyIle: 5.166 ± 0.71
3.111GlyLys: 3.111 ± 0.633
6.388GlyLeu: 6.388 ± 0.831
1.889GlyMet: 1.889 ± 0.336
3.166GlyAsn: 3.166 ± 0.511
3.611GlyPro: 3.611 ± 0.495
3.111GlyGln: 3.111 ± 0.378
5.943GlyArg: 5.943 ± 0.676
6.055GlySer: 6.055 ± 0.768
6.221GlyThr: 6.221 ± 0.891
6.166GlyVal: 6.166 ± 0.478
1.944GlyTrp: 1.944 ± 0.358
2.555GlyTyr: 2.555 ± 0.387
0.0GlyXaa: 0.0 ± 0.0
His
2.222HisAla: 2.222 ± 0.377
0.111HisCys: 0.111 ± 0.138
1.111HisAsp: 1.111 ± 0.254
1.166HisGlu: 1.166 ± 0.323
0.167HisPhe: 0.167 ± 0.087
1.5HisGly: 1.5 ± 0.319
0.5HisHis: 0.5 ± 0.189
0.778HisIle: 0.778 ± 0.17
0.167HisLys: 0.167 ± 0.108
2.111HisLeu: 2.111 ± 0.303
0.389HisMet: 0.389 ± 0.152
0.222HisAsn: 0.222 ± 0.119
1.722HisPro: 1.722 ± 0.35
0.722HisGln: 0.722 ± 0.221
1.777HisArg: 1.777 ± 0.34
0.833HisSer: 0.833 ± 0.303
1.166HisThr: 1.166 ± 0.241
1.389HisVal: 1.389 ± 0.303
0.333HisTrp: 0.333 ± 0.106
0.444HisTyr: 0.444 ± 0.137
0.0HisXaa: 0.0 ± 0.0
Ile
6.999IleAla: 6.999 ± 0.72
0.278IleCys: 0.278 ± 0.139
3.555IleAsp: 3.555 ± 0.438
3.833IleGlu: 3.833 ± 0.397
0.778IlePhe: 0.778 ± 0.197
4.721IleGly: 4.721 ± 0.741
0.611IleHis: 0.611 ± 0.207
1.722IleIle: 1.722 ± 0.417
1.444IleLys: 1.444 ± 0.278
2.277IleLeu: 2.277 ± 0.379
0.389IleMet: 0.389 ± 0.162
1.166IleAsn: 1.166 ± 0.206
2.833IlePro: 2.833 ± 0.287
0.889IleGln: 0.889 ± 0.306
2.833IleArg: 2.833 ± 0.335
2.0IleSer: 2.0 ± 0.387
3.277IleThr: 3.277 ± 0.436
3.444IleVal: 3.444 ± 0.495
0.778IleTrp: 0.778 ± 0.197
0.889IleTyr: 0.889 ± 0.182
0.0IleXaa: 0.0 ± 0.0
Lys
4.388LysAla: 4.388 ± 0.558
0.333LysCys: 0.333 ± 0.141
1.5LysAsp: 1.5 ± 0.289
0.444LysGlu: 0.444 ± 0.165
0.833LysPhe: 0.833 ± 0.287
2.555LysGly: 2.555 ± 0.406
0.611LysHis: 0.611 ± 0.167
2.0LysIle: 2.0 ± 0.389
0.833LysLys: 0.833 ± 0.23
3.555LysLeu: 3.555 ± 0.458
0.667LysMet: 0.667 ± 0.21
0.5LysAsn: 0.5 ± 0.182
1.5LysPro: 1.5 ± 0.301
0.778LysGln: 0.778 ± 0.218
2.388LysArg: 2.388 ± 0.378
1.389LysSer: 1.389 ± 0.358
1.333LysThr: 1.333 ± 0.283
2.277LysVal: 2.277 ± 0.293
0.389LysTrp: 0.389 ± 0.147
0.889LysTyr: 0.889 ± 0.205
0.0LysXaa: 0.0 ± 0.0
Leu
9.887LeuAla: 9.887 ± 0.777
0.611LeuCys: 0.611 ± 0.245
7.665LeuAsp: 7.665 ± 1.082
2.888LeuGlu: 2.888 ± 0.402
1.833LeuPhe: 1.833 ± 0.345
8.221LeuGly: 8.221 ± 0.948
1.278LeuHis: 1.278 ± 0.278
3.499LeuIle: 3.499 ± 0.348
1.444LeuLys: 1.444 ± 0.236
6.055LeuLeu: 6.055 ± 0.653
1.111LeuMet: 1.111 ± 0.263
2.222LeuAsn: 2.222 ± 0.385
4.999LeuPro: 4.999 ± 0.507
2.944LeuGln: 2.944 ± 0.585
4.388LeuArg: 4.388 ± 0.511
2.944LeuSer: 2.944 ± 0.366
6.055LeuThr: 6.055 ± 0.666
7.277LeuVal: 7.277 ± 0.581
1.444LeuTrp: 1.444 ± 0.31
1.278LeuTyr: 1.278 ± 0.252
0.0LeuXaa: 0.0 ± 0.0
Met
2.055MetAla: 2.055 ± 0.398
0.111MetCys: 0.111 ± 0.081
0.833MetAsp: 0.833 ± 0.186
0.333MetGlu: 0.333 ± 0.12
0.333MetPhe: 0.333 ± 0.147
1.055MetGly: 1.055 ± 0.21
0.278MetHis: 0.278 ± 0.104
0.889MetIle: 0.889 ± 0.235
0.555MetLys: 0.555 ± 0.224
1.666MetLeu: 1.666 ± 0.246
0.444MetMet: 0.444 ± 0.135
0.611MetAsn: 0.611 ± 0.188
1.889MetPro: 1.889 ± 0.319
0.111MetGln: 0.111 ± 0.067
1.444MetArg: 1.444 ± 0.311
1.389MetSer: 1.389 ± 0.257
3.888MetThr: 3.888 ± 0.415
0.722MetVal: 0.722 ± 0.225
0.333MetTrp: 0.333 ± 0.151
0.111MetTyr: 0.111 ± 0.093
0.0MetXaa: 0.0 ± 0.0
Asn
3.166AsnAla: 3.166 ± 0.488
0.333AsnCys: 0.333 ± 0.131
2.388AsnAsp: 2.388 ± 0.361
1.555AsnGlu: 1.555 ± 0.319
0.778AsnPhe: 0.778 ± 0.257
2.666AsnGly: 2.666 ± 0.414
0.278AsnHis: 0.278 ± 0.119
0.444AsnIle: 0.444 ± 0.184
0.778AsnLys: 0.778 ± 0.188
2.166AsnLeu: 2.166 ± 0.337
0.555AsnMet: 0.555 ± 0.207
0.722AsnAsn: 0.722 ± 0.203
2.111AsnPro: 2.111 ± 0.376
0.5AsnGln: 0.5 ± 0.192
1.889AsnArg: 1.889 ± 0.4
1.278AsnSer: 1.278 ± 0.371
2.166AsnThr: 2.166 ± 0.343
2.388AsnVal: 2.388 ± 0.446
0.5AsnTrp: 0.5 ± 0.121
0.5AsnTyr: 0.5 ± 0.171
0.0AsnXaa: 0.0 ± 0.0
Pro
7.832ProAla: 7.832 ± 0.806
0.389ProCys: 0.389 ± 0.156
4.944ProAsp: 4.944 ± 0.628
3.888ProGlu: 3.888 ± 0.576
1.722ProPhe: 1.722 ± 0.318
4.388ProGly: 4.388 ± 0.44
1.111ProHis: 1.111 ± 0.242
3.333ProIle: 3.333 ± 0.409
1.666ProLys: 1.666 ± 0.298
3.333ProLeu: 3.333 ± 0.447
1.0ProMet: 1.0 ± 0.218
1.611ProAsn: 1.611 ± 0.259
3.499ProPro: 3.499 ± 0.525
1.944ProGln: 1.944 ± 0.363
3.333ProArg: 3.333 ± 0.588
2.388ProSer: 2.388 ± 0.362
4.555ProThr: 4.555 ± 0.446
4.999ProVal: 4.999 ± 0.544
1.444ProTrp: 1.444 ± 0.305
1.222ProTyr: 1.222 ± 0.24
0.0ProXaa: 0.0 ± 0.0
Gln
5.11GlnAla: 5.11 ± 0.552
0.389GlnCys: 0.389 ± 0.157
1.444GlnAsp: 1.444 ± 0.265
1.278GlnGlu: 1.278 ± 0.252
1.5GlnPhe: 1.5 ± 0.205
2.666GlnGly: 2.666 ± 0.455
0.944GlnHis: 0.944 ± 0.224
2.277GlnIle: 2.277 ± 0.327
0.889GlnLys: 0.889 ± 0.153
3.166GlnLeu: 3.166 ± 0.444
1.389GlnMet: 1.389 ± 0.277
1.278GlnAsn: 1.278 ± 0.294
2.055GlnPro: 2.055 ± 0.324
2.777GlnGln: 2.777 ± 0.428
2.388GlnArg: 2.388 ± 0.351
1.222GlnSer: 1.222 ± 0.255
2.277GlnThr: 2.277 ± 0.278
3.166GlnVal: 3.166 ± 0.365
0.778GlnTrp: 0.778 ± 0.177
0.889GlnTyr: 0.889 ± 0.192
0.0GlnXaa: 0.0 ± 0.0
Arg
8.387ArgAla: 8.387 ± 0.774
0.611ArgCys: 0.611 ± 0.175
4.555ArgAsp: 4.555 ± 0.666
4.11ArgGlu: 4.11 ± 0.565
1.555ArgPhe: 1.555 ± 0.284
4.222ArgGly: 4.222 ± 0.517
1.5ArgHis: 1.5 ± 0.315
3.499ArgIle: 3.499 ± 0.52
2.555ArgLys: 2.555 ± 0.326
4.944ArgLeu: 4.944 ± 0.561
2.277ArgMet: 2.277 ± 0.322
1.833ArgAsn: 1.833 ± 0.367
3.277ArgPro: 3.277 ± 0.589
2.444ArgGln: 2.444 ± 0.378
7.277ArgArg: 7.277 ± 0.983
3.444ArgSer: 3.444 ± 0.382
4.888ArgThr: 4.888 ± 0.476
5.221ArgVal: 5.221 ± 0.706
1.333ArgTrp: 1.333 ± 0.316
1.889ArgTyr: 1.889 ± 0.361
0.0ArgXaa: 0.0 ± 0.0
Ser
6.832SerAla: 6.832 ± 0.927
0.278SerCys: 0.278 ± 0.125
2.666SerAsp: 2.666 ± 0.348
1.944SerGlu: 1.944 ± 0.404
1.166SerPhe: 1.166 ± 0.261
4.61SerGly: 4.61 ± 0.885
0.555SerHis: 0.555 ± 0.212
2.388SerIle: 2.388 ± 0.266
2.055SerLys: 2.055 ± 0.388
4.721SerLeu: 4.721 ± 0.494
1.055SerMet: 1.055 ± 0.192
1.278SerAsn: 1.278 ± 0.267
2.722SerPro: 2.722 ± 0.367
2.055SerGln: 2.055 ± 0.342
3.111SerArg: 3.111 ± 0.465
2.611SerSer: 2.611 ± 0.48
3.666SerThr: 3.666 ± 0.624
3.222SerVal: 3.222 ± 0.42
1.389SerTrp: 1.389 ± 0.271
0.889SerTyr: 0.889 ± 0.228
0.0SerXaa: 0.0 ± 0.0
Thr
9.11ThrAla: 9.11 ± 0.708
0.778ThrCys: 0.778 ± 0.24
6.11ThrAsp: 6.11 ± 0.576
4.388ThrGlu: 4.388 ± 0.483
1.833ThrPhe: 1.833 ± 0.401
7.11ThrGly: 7.11 ± 0.756
1.389ThrHis: 1.389 ± 0.258
3.277ThrIle: 3.277 ± 0.393
1.889ThrLys: 1.889 ± 0.322
5.666ThrLeu: 5.666 ± 0.525
1.444ThrMet: 1.444 ± 0.28
2.722ThrAsn: 2.722 ± 0.381
5.11ThrPro: 5.11 ± 0.712
1.555ThrGln: 1.555 ± 0.239
4.277ThrArg: 4.277 ± 0.616
3.499ThrSer: 3.499 ± 0.594
5.499ThrThr: 5.499 ± 1.227
5.055ThrVal: 5.055 ± 0.834
0.833ThrTrp: 0.833 ± 0.203
1.111ThrTyr: 1.111 ± 0.226
0.0ThrXaa: 0.0 ± 0.0
Val
8.61ValAla: 8.61 ± 0.699
0.389ValCys: 0.389 ± 0.163
6.277ValAsp: 6.277 ± 0.642
5.11ValGlu: 5.11 ± 0.481
2.055ValPhe: 2.055 ± 0.36
5.499ValGly: 5.499 ± 0.646
1.777ValHis: 1.777 ± 0.344
2.555ValIle: 2.555 ± 0.353
2.277ValLys: 2.277 ± 0.356
5.055ValLeu: 5.055 ± 0.499
1.111ValMet: 1.111 ± 0.244
1.777ValAsn: 1.777 ± 0.341
4.166ValPro: 4.166 ± 0.54
2.944ValGln: 2.944 ± 0.457
4.555ValArg: 4.555 ± 0.477
3.166ValSer: 3.166 ± 0.519
6.832ValThr: 6.832 ± 0.661
4.555ValVal: 4.555 ± 0.623
1.611ValTrp: 1.611 ± 0.271
1.944ValTyr: 1.944 ± 0.337
0.0ValXaa: 0.0 ± 0.0
Trp
2.611TrpAla: 2.611 ± 0.361
0.389TrpCys: 0.389 ± 0.136
1.222TrpAsp: 1.222 ± 0.241
0.667TrpGlu: 0.667 ± 0.186
0.889TrpPhe: 0.889 ± 0.207
1.222TrpGly: 1.222 ± 0.376
0.333TrpHis: 0.333 ± 0.158
0.611TrpIle: 0.611 ± 0.197
0.555TrpLys: 0.555 ± 0.182
2.388TrpLeu: 2.388 ± 0.358
0.389TrpMet: 0.389 ± 0.129
0.667TrpAsn: 0.667 ± 0.305
1.611TrpPro: 1.611 ± 0.283
1.555TrpGln: 1.555 ± 0.268
1.333TrpArg: 1.333 ± 0.298
1.0TrpSer: 1.0 ± 0.317
1.333TrpThr: 1.333 ± 0.324
1.444TrpVal: 1.444 ± 0.257
0.555TrpTrp: 0.555 ± 0.195
0.333TrpTyr: 0.333 ± 0.132
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.444TyrAla: 2.444 ± 0.618
0.333TyrCys: 0.333 ± 0.151
2.111TyrAsp: 2.111 ± 0.417
1.222TyrGlu: 1.222 ± 0.26
0.333TyrPhe: 0.333 ± 0.128
1.889TyrGly: 1.889 ± 0.257
0.278TyrHis: 0.278 ± 0.119
0.778TyrIle: 0.778 ± 0.237
0.333TyrLys: 0.333 ± 0.131
1.944TyrLeu: 1.944 ± 0.399
0.333TyrMet: 0.333 ± 0.151
0.5TyrAsn: 0.5 ± 0.21
1.278TyrPro: 1.278 ± 0.268
0.667TyrGln: 0.667 ± 0.201
2.777TyrArg: 2.777 ± 0.514
1.333TyrSer: 1.333 ± 0.268
1.389TyrThr: 1.389 ± 0.339
1.611TyrVal: 1.611 ± 0.326
0.555TyrTrp: 0.555 ± 0.175
0.5TyrTyr: 0.5 ± 0.203
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 84 proteins (18004 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski