Amino acid dipepetide frequency for Rotavirus D

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.57AlaAla: 2.57 ± 0.73
0.184AlaCys: 0.184 ± 0.151
3.672AlaAsp: 3.672 ± 0.373
2.203AlaGlu: 2.203 ± 0.907
1.652AlaPhe: 1.652 ± 0.562
2.203AlaGly: 2.203 ± 0.768
0.367AlaHis: 0.367 ± 0.235
4.773AlaIle: 4.773 ± 0.951
2.203AlaLys: 2.203 ± 0.877
3.855AlaLeu: 3.855 ± 0.756
1.652AlaMet: 1.652 ± 0.609
3.672AlaAsn: 3.672 ± 0.789
0.551AlaPro: 0.551 ± 0.279
1.285AlaGln: 1.285 ± 0.467
3.305AlaArg: 3.305 ± 0.849
5.508AlaSer: 5.508 ± 1.2
2.57AlaThr: 2.57 ± 1.019
4.039AlaVal: 4.039 ± 1.014
0.0AlaTrp: 0.0 ± 0.0
3.305AlaTyr: 3.305 ± 0.774
0.0AlaXaa: 0.0 ± 0.0
Cys
0.184CysAla: 0.184 ± 0.192
0.551CysCys: 0.551 ± 0.329
0.918CysAsp: 0.918 ± 0.363
0.918CysGlu: 0.918 ± 0.328
0.918CysPhe: 0.918 ± 0.48
0.918CysGly: 0.918 ± 0.61
0.0CysHis: 0.0 ± 0.043
0.734CysIle: 0.734 ± 0.525
1.102CysLys: 1.102 ± 0.636
1.102CysLeu: 1.102 ± 0.605
0.184CysMet: 0.184 ± 0.21
1.102CysAsn: 1.102 ± 0.527
0.734CysPro: 0.734 ± 0.435
0.551CysGln: 0.551 ± 0.245
0.918CysArg: 0.918 ± 0.6
0.551CysSer: 0.551 ± 0.311
0.184CysThr: 0.184 ± 0.18
0.551CysVal: 0.551 ± 0.3
0.0CysTrp: 0.0 ± 0.0
0.367CysTyr: 0.367 ± 0.214
0.0CysXaa: 0.0 ± 0.0
Asp
2.754AspAla: 2.754 ± 0.866
0.918AspCys: 0.918 ± 0.784
5.508AspAsp: 5.508 ± 0.95
4.59AspGlu: 4.59 ± 1.612
2.937AspPhe: 2.937 ± 0.652
1.836AspGly: 1.836 ± 0.488
0.551AspHis: 0.551 ± 0.324
6.426AspIle: 6.426 ± 0.916
5.508AspLys: 5.508 ± 0.859
5.875AspLeu: 5.875 ± 0.92
2.754AspMet: 2.754 ± 0.636
2.754AspAsn: 2.754 ± 0.622
0.734AspPro: 0.734 ± 0.255
2.754AspGln: 2.754 ± 0.547
2.57AspArg: 2.57 ± 0.504
3.488AspSer: 3.488 ± 1.153
3.672AspThr: 3.672 ± 0.661
4.773AspVal: 4.773 ± 0.805
0.367AspTrp: 0.367 ± 0.344
3.305AspTyr: 3.305 ± 0.741
0.0AspXaa: 0.0 ± 0.0
Glu
1.652GluAla: 1.652 ± 0.592
0.551GluCys: 0.551 ± 0.465
2.937GluAsp: 2.937 ± 1.103
3.672GluGlu: 3.672 ± 0.938
2.203GluPhe: 2.203 ± 0.761
1.469GluGly: 1.469 ± 0.495
0.918GluHis: 0.918 ± 0.399
4.957GluIle: 4.957 ± 0.861
4.773GluLys: 4.773 ± 0.998
6.976GluLeu: 6.976 ± 0.761
1.285GluMet: 1.285 ± 0.519
3.672GluAsn: 3.672 ± 0.626
0.551GluPro: 0.551 ± 0.421
1.102GluGln: 1.102 ± 0.525
2.387GluArg: 2.387 ± 0.806
5.691GluSer: 5.691 ± 0.796
2.754GluThr: 2.754 ± 0.622
2.203GluVal: 2.203 ± 0.678
0.918GluTrp: 0.918 ± 0.39
2.937GluTyr: 2.937 ± 0.738
0.0GluXaa: 0.0 ± 0.0
Phe
2.57PheAla: 2.57 ± 0.695
0.184PheCys: 0.184 ± 0.192
4.406PheAsp: 4.406 ± 0.656
2.937PheGlu: 2.937 ± 0.433
0.734PhePhe: 0.734 ± 0.403
2.57PheGly: 2.57 ± 0.671
0.918PheHis: 0.918 ± 0.398
2.754PheIle: 2.754 ± 0.833
2.754PheLys: 2.754 ± 0.906
2.387PheLeu: 2.387 ± 0.479
0.734PheMet: 0.734 ± 0.434
3.488PheAsn: 3.488 ± 0.677
1.652PhePro: 1.652 ± 0.601
1.102PheGln: 1.102 ± 0.444
2.387PheArg: 2.387 ± 0.659
3.121PheSer: 3.121 ± 0.418
2.387PheThr: 2.387 ± 0.525
2.754PheVal: 2.754 ± 0.49
0.0PheTrp: 0.0 ± 0.0
1.836PheTyr: 1.836 ± 0.473
0.0PheXaa: 0.0 ± 0.0
Gly
1.469GlyAla: 1.469 ± 0.37
0.734GlyCys: 0.734 ± 0.443
0.918GlyAsp: 0.918 ± 0.292
0.918GlyGlu: 0.918 ± 0.489
0.734GlyPhe: 0.734 ± 0.46
0.734GlyGly: 0.734 ± 0.355
0.551GlyHis: 0.551 ± 0.342
3.672GlyIle: 3.672 ± 0.797
2.57GlyLys: 2.57 ± 0.729
3.305GlyLeu: 3.305 ± 0.468
0.918GlyMet: 0.918 ± 0.456
2.754GlyAsn: 2.754 ± 0.706
1.652GlyPro: 1.652 ± 0.821
1.102GlyGln: 1.102 ± 0.585
1.836GlyArg: 1.836 ± 0.981
2.387GlySer: 2.387 ± 0.6
2.387GlyThr: 2.387 ± 1.001
2.203GlyVal: 2.203 ± 0.486
0.0GlyTrp: 0.0 ± 0.0
1.469GlyTyr: 1.469 ± 0.514
0.0GlyXaa: 0.0 ± 0.0
His
0.551HisAla: 0.551 ± 0.308
0.0HisCys: 0.0 ± 0.0
0.184HisAsp: 0.184 ± 0.161
1.469HisGlu: 1.469 ± 0.34
0.734HisPhe: 0.734 ± 0.338
0.367HisGly: 0.367 ± 0.275
0.0HisHis: 0.0 ± 0.0
1.102HisIle: 1.102 ± 0.441
0.184HisLys: 0.184 ± 0.151
1.469HisLeu: 1.469 ± 0.344
0.367HisMet: 0.367 ± 0.262
1.285HisAsn: 1.285 ± 0.371
0.551HisPro: 0.551 ± 0.308
0.734HisGln: 0.734 ± 0.403
0.367HisArg: 0.367 ± 0.262
0.734HisSer: 0.734 ± 0.261
1.285HisThr: 1.285 ± 0.399
2.203HisVal: 2.203 ± 0.548
0.0HisTrp: 0.0 ± 0.0
1.652HisTyr: 1.652 ± 0.738
0.0HisXaa: 0.0 ± 0.0
Ile
6.793IleAla: 6.793 ± 1.083
1.102IleCys: 1.102 ± 0.556
7.16IleAsp: 7.16 ± 1.104
4.223IleGlu: 4.223 ± 1.011
4.406IlePhe: 4.406 ± 0.635
2.57IleGly: 2.57 ± 0.608
1.836IleHis: 1.836 ± 0.752
6.609IleIle: 6.609 ± 1.559
3.305IleLys: 3.305 ± 0.875
6.976IleLeu: 6.976 ± 1.187
1.469IleMet: 1.469 ± 0.659
6.058IleAsn: 6.058 ± 1.045
3.488IlePro: 3.488 ± 0.862
2.019IleGln: 2.019 ± 0.62
4.223IleArg: 4.223 ± 0.764
5.875IleSer: 5.875 ± 1.112
6.058IleThr: 6.058 ± 1.365
4.957IleVal: 4.957 ± 0.938
0.367IleTrp: 0.367 ± 0.303
3.121IleTyr: 3.121 ± 1.078
0.0IleXaa: 0.0 ± 0.0
Lys
2.019LysAla: 2.019 ± 0.75
0.734LysCys: 0.734 ± 0.353
3.855LysAsp: 3.855 ± 0.937
2.754LysGlu: 2.754 ± 0.852
2.387LysPhe: 2.387 ± 0.794
1.285LysGly: 1.285 ± 0.458
1.102LysHis: 1.102 ± 0.327
6.058LysIle: 6.058 ± 1.169
4.59LysLys: 4.59 ± 0.81
7.894LysLeu: 7.894 ± 1.581
2.387LysMet: 2.387 ± 0.921
3.855LysAsn: 3.855 ± 0.916
1.836LysPro: 1.836 ± 0.442
2.019LysGln: 2.019 ± 0.71
2.019LysArg: 2.019 ± 0.707
4.59LysSer: 4.59 ± 1.185
3.855LysThr: 3.855 ± 1.029
4.039LysVal: 4.039 ± 1.294
0.918LysTrp: 0.918 ± 0.38
4.59LysTyr: 4.59 ± 0.876
0.0LysXaa: 0.0 ± 0.0
Leu
3.855LeuAla: 3.855 ± 0.465
1.469LeuCys: 1.469 ± 0.52
4.773LeuAsp: 4.773 ± 0.812
4.773LeuGlu: 4.773 ± 1.161
4.773LeuPhe: 4.773 ± 1.245
2.019LeuGly: 2.019 ± 0.841
0.551LeuHis: 0.551 ± 0.291
6.426LeuIle: 6.426 ± 0.828
5.324LeuLys: 5.324 ± 0.806
7.711LeuLeu: 7.711 ± 1.017
2.387LeuMet: 2.387 ± 0.711
8.812LeuAsn: 8.812 ± 1.267
3.121LeuPro: 3.121 ± 0.796
3.855LeuGln: 3.855 ± 0.732
6.793LeuArg: 6.793 ± 0.847
7.894LeuSer: 7.894 ± 1.03
6.426LeuThr: 6.426 ± 1.068
4.957LeuVal: 4.957 ± 1.221
1.469LeuTrp: 1.469 ± 0.637
6.793LeuTyr: 6.793 ± 0.883
0.0LeuXaa: 0.0 ± 0.0
Met
1.469MetAla: 1.469 ± 0.267
0.184MetCys: 0.184 ± 0.151
2.019MetAsp: 2.019 ± 0.552
0.918MetGlu: 0.918 ± 0.354
1.469MetPhe: 1.469 ± 0.362
0.184MetGly: 0.184 ± 0.186
0.551MetHis: 0.551 ± 0.301
1.652MetIle: 1.652 ± 0.544
1.285MetLys: 1.285 ± 0.616
5.324MetLeu: 5.324 ± 0.982
1.652MetMet: 1.652 ± 0.725
2.019MetAsn: 2.019 ± 0.628
0.734MetPro: 0.734 ± 0.284
0.918MetGln: 0.918 ± 0.384
1.285MetArg: 1.285 ± 0.398
2.57MetSer: 2.57 ± 0.759
2.387MetThr: 2.387 ± 0.855
1.285MetVal: 1.285 ± 0.569
0.0MetTrp: 0.0 ± 0.0
1.102MetTyr: 1.102 ± 0.48
0.0MetXaa: 0.0 ± 0.0
Asn
4.223AsnAla: 4.223 ± 0.812
1.285AsnCys: 1.285 ± 0.533
4.223AsnAsp: 4.223 ± 1.244
4.59AsnGlu: 4.59 ± 1.145
2.019AsnPhe: 2.019 ± 0.649
2.203AsnGly: 2.203 ± 0.606
1.836AsnHis: 1.836 ± 0.556
5.691AsnIle: 5.691 ± 0.982
3.855AsnLys: 3.855 ± 1.211
5.14AsnLeu: 5.14 ± 0.791
2.019AsnMet: 2.019 ± 0.459
5.324AsnAsn: 5.324 ± 1.011
2.203AsnPro: 2.203 ± 0.481
4.039AsnGln: 4.039 ± 0.633
3.672AsnArg: 3.672 ± 0.669
7.16AsnSer: 7.16 ± 1.154
4.039AsnThr: 4.039 ± 1.194
3.855AsnVal: 3.855 ± 0.685
0.551AsnTrp: 0.551 ± 0.324
5.691AsnTyr: 5.691 ± 0.763
0.0AsnXaa: 0.0 ± 0.0
Pro
2.203ProAla: 2.203 ± 0.682
0.367ProCys: 0.367 ± 0.249
2.019ProAsp: 2.019 ± 0.782
0.367ProGlu: 0.367 ± 0.219
1.469ProPhe: 1.469 ± 0.751
0.734ProGly: 0.734 ± 0.282
0.551ProHis: 0.551 ± 0.395
2.57ProIle: 2.57 ± 0.622
0.551ProLys: 0.551 ± 0.322
3.305ProLeu: 3.305 ± 0.595
0.734ProMet: 0.734 ± 0.369
1.102ProAsn: 1.102 ± 0.42
0.551ProPro: 0.551 ± 0.262
1.469ProGln: 1.469 ± 0.758
1.102ProArg: 1.102 ± 0.484
3.121ProSer: 3.121 ± 0.604
2.387ProThr: 2.387 ± 0.615
2.019ProVal: 2.019 ± 0.376
0.184ProTrp: 0.184 ± 0.161
1.836ProTyr: 1.836 ± 0.922
0.0ProXaa: 0.0 ± 0.0
Gln
1.285GlnAla: 1.285 ± 0.6
0.367GlnCys: 0.367 ± 0.338
1.836GlnAsp: 1.836 ± 0.843
1.102GlnGlu: 1.102 ± 0.433
2.387GlnPhe: 2.387 ± 0.513
0.734GlnGly: 0.734 ± 0.287
0.367GlnHis: 0.367 ± 0.192
3.855GlnIle: 3.855 ± 0.678
2.754GlnLys: 2.754 ± 1.04
5.508GlnLeu: 5.508 ± 1.159
1.469GlnMet: 1.469 ± 0.492
2.387GlnAsn: 2.387 ± 0.581
1.102GlnPro: 1.102 ± 0.32
2.937GlnGln: 2.937 ± 0.701
0.918GlnArg: 0.918 ± 0.485
3.121GlnSer: 3.121 ± 0.346
2.937GlnThr: 2.937 ± 0.739
1.102GlnVal: 1.102 ± 0.537
0.184GlnTrp: 0.184 ± 0.161
1.469GlnTyr: 1.469 ± 0.471
0.0GlnXaa: 0.0 ± 0.0
Arg
2.203ArgAla: 2.203 ± 0.571
0.551ArgCys: 0.551 ± 0.3
2.937ArgAsp: 2.937 ± 0.533
3.305ArgGlu: 3.305 ± 0.662
2.203ArgPhe: 2.203 ± 0.73
1.836ArgGly: 1.836 ± 0.453
1.102ArgHis: 1.102 ± 0.503
2.203ArgIle: 2.203 ± 0.46
3.672ArgLys: 3.672 ± 0.888
4.039ArgLeu: 4.039 ± 1.135
1.836ArgMet: 1.836 ± 0.493
3.672ArgAsn: 3.672 ± 0.899
0.734ArgPro: 0.734 ± 0.578
2.203ArgGln: 2.203 ± 0.632
3.488ArgArg: 3.488 ± 0.816
3.305ArgSer: 3.305 ± 0.701
4.039ArgThr: 4.039 ± 0.702
3.855ArgVal: 3.855 ± 0.767
0.551ArgTrp: 0.551 ± 0.244
2.937ArgTyr: 2.937 ± 0.537
0.0ArgXaa: 0.0 ± 0.0
Ser
4.406SerAla: 4.406 ± 1.147
1.285SerCys: 1.285 ± 0.577
3.855SerAsp: 3.855 ± 1.144
5.324SerGlu: 5.324 ± 0.853
3.121SerPhe: 3.121 ± 0.699
4.406SerGly: 4.406 ± 0.949
1.102SerHis: 1.102 ± 0.527
6.609SerIle: 6.609 ± 0.797
4.223SerLys: 4.223 ± 0.972
8.078SerLeu: 8.078 ± 2.006
2.57SerMet: 2.57 ± 0.627
6.609SerAsn: 6.609 ± 1.067
1.469SerPro: 1.469 ± 0.475
3.672SerGln: 3.672 ± 0.583
1.836SerArg: 1.836 ± 0.551
6.242SerSer: 6.242 ± 1.87
4.406SerThr: 4.406 ± 1.023
5.691SerVal: 5.691 ± 0.644
0.367SerTrp: 0.367 ± 0.262
4.039SerTyr: 4.039 ± 0.883
0.0SerXaa: 0.0 ± 0.0
Thr
3.488ThrAla: 3.488 ± 0.721
0.551ThrCys: 0.551 ± 0.576
3.305ThrAsp: 3.305 ± 0.888
4.406ThrGlu: 4.406 ± 0.524
3.305ThrPhe: 3.305 ± 0.591
2.203ThrGly: 2.203 ± 0.709
1.285ThrHis: 1.285 ± 0.482
5.691ThrIle: 5.691 ± 1.145
3.488ThrLys: 3.488 ± 0.846
5.875ThrLeu: 5.875 ± 0.617
1.652ThrMet: 1.652 ± 0.648
4.039ThrAsn: 4.039 ± 0.831
2.203ThrPro: 2.203 ± 0.582
2.387ThrGln: 2.387 ± 0.995
3.672ThrArg: 3.672 ± 0.504
4.59ThrSer: 4.59 ± 1.334
7.16ThrThr: 7.16 ± 1.445
4.773ThrVal: 4.773 ± 0.585
0.184ThrTrp: 0.184 ± 0.18
4.039ThrTyr: 4.039 ± 0.927
0.0ThrXaa: 0.0 ± 0.0
Val
2.203ValAla: 2.203 ± 0.611
0.918ValCys: 0.918 ± 0.611
4.223ValAsp: 4.223 ± 0.882
2.387ValGlu: 2.387 ± 0.568
2.57ValPhe: 2.57 ± 0.544
1.285ValGly: 1.285 ± 0.487
0.918ValHis: 0.918 ± 0.285
7.343ValIle: 7.343 ± 0.926
5.14ValLys: 5.14 ± 0.879
3.305ValLeu: 3.305 ± 0.655
1.469ValMet: 1.469 ± 0.435
5.324ValAsn: 5.324 ± 0.618
2.57ValPro: 2.57 ± 0.595
0.918ValGln: 0.918 ± 0.319
4.406ValArg: 4.406 ± 0.77
4.957ValSer: 4.957 ± 0.837
4.957ValThr: 4.957 ± 0.811
2.387ValVal: 2.387 ± 0.731
0.184ValTrp: 0.184 ± 0.163
3.305ValTyr: 3.305 ± 0.682
0.0ValXaa: 0.0 ± 0.0
Trp
0.367TrpAla: 0.367 ± 0.214
0.184TrpCys: 0.184 ± 0.151
0.734TrpAsp: 0.734 ± 0.334
0.551TrpGlu: 0.551 ± 0.342
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
0.184TrpHis: 0.184 ± 0.187
0.0TrpIle: 0.0 ± 0.0
0.734TrpLys: 0.734 ± 0.384
1.102TrpLeu: 1.102 ± 0.391
0.184TrpMet: 0.184 ± 0.151
0.184TrpAsn: 0.184 ± 0.192
0.367TrpPro: 0.367 ± 0.256
0.734TrpGln: 0.734 ± 0.293
0.367TrpArg: 0.367 ± 0.23
0.184TrpSer: 0.184 ± 0.18
0.551TrpThr: 0.551 ± 0.291
0.184TrpVal: 0.184 ± 0.163
0.184TrpTrp: 0.184 ± 0.185
0.184TrpTyr: 0.184 ± 0.192
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.305TyrAla: 3.305 ± 0.493
0.367TyrCys: 0.367 ± 0.214
4.59TyrAsp: 4.59 ± 0.725
2.203TyrGlu: 2.203 ± 0.515
1.652TyrPhe: 1.652 ± 0.429
2.754TyrGly: 2.754 ± 0.724
0.551TyrHis: 0.551 ± 0.319
3.488TyrIle: 3.488 ± 0.849
4.59TyrLys: 4.59 ± 1.116
4.957TyrLeu: 4.957 ± 1.003
1.285TyrMet: 1.285 ± 0.536
5.508TyrAsn: 5.508 ± 0.814
1.836TyrPro: 1.836 ± 0.36
2.019TyrGln: 2.019 ± 0.39
3.305TyrArg: 3.305 ± 0.836
4.223TyrSer: 4.223 ± 0.651
3.855TyrThr: 3.855 ± 0.746
2.937TyrVal: 2.937 ± 0.602
0.551TyrTrp: 0.551 ± 0.308
2.387TyrTyr: 2.387 ± 0.798
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 11 proteins (5448 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski