Amino acid dipepetide frequency for Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.983AlaAla: 10.983 ± 0.132	1.169AlaCys: 1.169 ± 0.022	3.573AlaAsp: 3.573 ± 0.026	4.409AlaGlu: 4.409 ± 0.037	2.173AlaPhe: 2.173 ± 0.019	4.758AlaGly: 4.758 ± 0.038	1.801AlaHis: 1.801 ± 0.02	3.569AlaIle: 3.569 ± 0.025	4.016AlaLys: 4.016 ± 0.031	6.528AlaLeu: 6.528 ± 0.043	1.797AlaMet: 1.797 ± 0.016	3.535AlaAsn: 3.535 ± 0.024	4.008AlaPro: 4.008 ± 0.047	3.593AlaGln: 3.593 ± 0.031	3.295AlaArg: 3.295 ± 0.024	6.148AlaSer: 6.148 ± 0.044	5.849AlaThr: 5.849 ± 0.052	4.592AlaVal: 4.592 ± 0.03	0.591AlaTrp: 0.591 ± 0.011	1.84AlaTyr: 1.84 ± 0.016	0.0AlaXaa: 0.0 ± 0.0
Cys	1.305CysAla: 1.305 ± 0.021	0.547CysCys: 0.547 ± 0.009	1.103CysAsp: 1.103 ± 0.018	1.123CysGlu: 1.123 ± 0.019	0.722CysPhe: 0.722 ± 0.011	1.345CysGly: 1.345 ± 0.022	0.502CysHis: 0.502 ± 0.009	1.016CysIle: 1.016 ± 0.016	0.966CysLys: 0.966 ± 0.012	1.812CysLeu: 1.812 ± 0.022	0.442CysMet: 0.442 ± 0.009	0.99CysAsn: 0.99 ± 0.015	0.96CysPro: 0.96 ± 0.022	0.836CysGln: 0.836 ± 0.017	1.093CysArg: 1.093 ± 0.022	1.607CysSer: 1.607 ± 0.024	1.013CysThr: 1.013 ± 0.017	1.208CysVal: 1.208 ± 0.02	0.206CysTrp: 0.206 ± 0.006	0.598CysTyr: 0.598 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	4.0AspAla: 4.0 ± 0.025	1.034AspCys: 1.034 ± 0.019	4.205AspAsp: 4.205 ± 0.054	4.361AspGlu: 4.361 ± 0.035	2.074AspPhe: 2.074 ± 0.021	3.047AspGly: 3.047 ± 0.028	1.034AspHis: 1.034 ± 0.014	2.871AspIle: 2.871 ± 0.025	2.68AspLys: 2.68 ± 0.025	4.494AspLeu: 4.494 ± 0.035	1.327AspMet: 1.327 ± 0.013	2.524AspAsn: 2.524 ± 0.025	2.066AspPro: 2.066 ± 0.023	1.809AspGln: 1.809 ± 0.019	2.267AspArg: 2.267 ± 0.024	3.689AspSer: 3.689 ± 0.029	2.423AspThr: 2.423 ± 0.018	3.39AspVal: 3.39 ± 0.026	0.604AspTrp: 0.604 ± 0.008	1.885AspTyr: 1.885 ± 0.017	0.0AspXaa: 0.0 ± 0.0
Glu	4.258GluAla: 4.258 ± 0.035	1.132GluCys: 1.132 ± 0.023	3.5GluAsp: 3.5 ± 0.03	5.136GluGlu: 5.136 ± 0.055	2.039GluPhe: 2.039 ± 0.021	2.397GluGly: 2.397 ± 0.027	1.733GluHis: 1.733 ± 0.017	3.071GluIle: 3.071 ± 0.028	3.611GluLys: 3.611 ± 0.035	6.538GluLeu: 6.538 ± 0.053	1.572GluMet: 1.572 ± 0.018	2.689GluAsn: 2.689 ± 0.025	2.713GluPro: 2.713 ± 0.027	4.052GluGln: 4.052 ± 0.033	3.945GluArg: 3.945 ± 0.031	4.073GluSer: 4.073 ± 0.056	3.286GluThr: 3.286 ± 0.028	3.116GluVal: 3.116 ± 0.025	0.554GluTrp: 0.554 ± 0.009	1.732GluTyr: 1.732 ± 0.016	0.0GluXaa: 0.0 ± 0.0
Phe	2.342PheAla: 2.342 ± 0.02	0.732PheCys: 0.732 ± 0.013	2.046PheAsp: 2.046 ± 0.021	2.116PheGlu: 2.116 ± 0.02	1.376PhePhe: 1.376 ± 0.018	2.361PheGly: 2.361 ± 0.025	0.865PheHis: 0.865 ± 0.011	1.836PheIle: 1.836 ± 0.02	1.852PheLys: 1.852 ± 0.019	3.13PheLeu: 3.13 ± 0.033	0.916PheMet: 0.916 ± 0.013	1.769PheAsn: 1.769 ± 0.019	1.349PhePro: 1.349 ± 0.014	1.4PheGln: 1.4 ± 0.015	1.778PheArg: 1.778 ± 0.018	2.417PheSer: 2.417 ± 0.022	1.759PheThr: 1.759 ± 0.021	2.369PheVal: 2.369 ± 0.023	0.419PheTrp: 0.419 ± 0.009	1.296PheTyr: 1.296 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	4.406GlyAla: 4.406 ± 0.039	1.053GlyCys: 1.053 ± 0.016	2.871GlyAsp: 2.871 ± 0.021	2.861GlyGlu: 2.861 ± 0.03	2.044GlyPhe: 2.044 ± 0.021	6.073GlyGly: 6.073 ± 0.095	1.581GlyHis: 1.581 ± 0.023	2.971GlyIle: 2.971 ± 0.029	2.887GlyLys: 2.887 ± 0.025	4.459GlyLeu: 4.459 ± 0.033	1.272GlyMet: 1.272 ± 0.017	3.056GlyAsn: 3.056 ± 0.027	2.098GlyPro: 2.098 ± 0.033	2.332GlyGln: 2.332 ± 0.024	2.814GlyArg: 2.814 ± 0.026	5.16GlySer: 5.16 ± 0.043	3.016GlyThr: 3.016 ± 0.024	3.424GlyVal: 3.424 ± 0.026	0.597GlyTrp: 0.597 ± 0.01	2.051GlyTyr: 2.051 ± 0.024	0.0GlyXaa: 0.0 ± 0.0
His	1.709HisAla: 1.709 ± 0.02	0.613HisCys: 0.613 ± 0.012	1.14HisAsp: 1.14 ± 0.015	1.423HisGlu: 1.423 ± 0.017	1.054HisPhe: 1.054 ± 0.012	1.509HisGly: 1.509 ± 0.019	1.53HisHis: 1.53 ± 0.034	1.44HisIle: 1.44 ± 0.015	1.42HisLys: 1.42 ± 0.016	2.609HisLeu: 2.609 ± 0.019	0.755HisMet: 0.755 ± 0.011	1.389HisAsn: 1.389 ± 0.017	1.373HisPro: 1.373 ± 0.018	1.813HisGln: 1.813 ± 0.024	1.442HisArg: 1.442 ± 0.016	2.196HisSer: 2.196 ± 0.018	1.406HisThr: 1.406 ± 0.015	1.485HisVal: 1.485 ± 0.016	0.314HisTrp: 0.314 ± 0.007	0.927HisTyr: 0.927 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	3.636IleAla: 3.636 ± 0.032	1.26IleCys: 1.26 ± 0.021	2.824IleAsp: 2.824 ± 0.025	3.198IleGlu: 3.198 ± 0.029	2.119IlePhe: 2.119 ± 0.021	2.767IleGly: 2.767 ± 0.026	1.074IleHis: 1.074 ± 0.013	2.823IleIle: 2.823 ± 0.025	2.864IleLys: 2.864 ± 0.022	4.152IleLeu: 4.152 ± 0.034	1.189IleMet: 1.189 ± 0.014	2.556IleAsn: 2.556 ± 0.023	2.116IlePro: 2.116 ± 0.017	1.875IleGln: 1.875 ± 0.017	2.383IleArg: 2.383 ± 0.02	4.095IleSer: 4.095 ± 0.028	2.803IleThr: 2.803 ± 0.023	3.313IleVal: 3.313 ± 0.024	0.566IleTrp: 0.566 ± 0.01	1.808IleTyr: 1.808 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	3.346LysAla: 3.346 ± 0.027	1.128LysCys: 1.128 ± 0.019	2.712LysAsp: 2.712 ± 0.034	3.486LysGlu: 3.486 ± 0.033	1.835LysPhe: 1.835 ± 0.019	2.097LysGly: 2.097 ± 0.022	1.454LysHis: 1.454 ± 0.016	2.677LysIle: 2.677 ± 0.024	3.707LysLys: 3.707 ± 0.046	5.443LysLeu: 5.443 ± 0.039	1.424LysMet: 1.424 ± 0.016	2.268LysAsn: 2.268 ± 0.02	2.913LysPro: 2.913 ± 0.041	3.071LysGln: 3.071 ± 0.031	3.654LysArg: 3.654 ± 0.029	4.142LysSer: 4.142 ± 0.036	2.983LysThr: 2.983 ± 0.026	2.802LysVal: 2.802 ± 0.026	0.589LysTrp: 0.589 ± 0.01	1.797LysTyr: 1.797 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	6.795LeuAla: 6.795 ± 0.038	1.803LeuCys: 1.803 ± 0.02	4.858LeuAsp: 4.858 ± 0.031	5.866LeuGlu: 5.866 ± 0.043	2.967LeuPhe: 2.967 ± 0.026	4.751LeuGly: 4.751 ± 0.03	2.698LeuHis: 2.698 ± 0.024	4.442LeuIle: 4.442 ± 0.035	5.265LeuLys: 5.265 ± 0.034	9.839LeuLeu: 9.839 ± 0.071	2.222LeuMet: 2.222 ± 0.02	4.453LeuAsn: 4.453 ± 0.033	5.277LeuPro: 5.277 ± 0.031	5.69LeuGln: 5.69 ± 0.046	5.58LeuArg: 5.58 ± 0.041	6.941LeuSer: 6.941 ± 0.034	4.879LeuThr: 4.879 ± 0.031	4.939LeuVal: 4.939 ± 0.034	0.869LeuTrp: 0.869 ± 0.013	2.577LeuTyr: 2.577 ± 0.027	0.0LeuXaa: 0.0 ± 0.0
Met	1.838MetAla: 1.838 ± 0.018	0.456MetCys: 0.456 ± 0.008	1.398MetAsp: 1.398 ± 0.014	1.575MetGlu: 1.575 ± 0.016	0.793MetPhe: 0.793 ± 0.012	1.348MetGly: 1.348 ± 0.017	0.684MetHis: 0.684 ± 0.011	0.977MetIle: 0.977 ± 0.012	1.197MetLys: 1.197 ± 0.014	2.436MetLeu: 2.436 ± 0.022	0.636MetMet: 0.636 ± 0.009	1.009MetAsn: 1.009 ± 0.014	1.5MetPro: 1.5 ± 0.017	1.411MetGln: 1.411 ± 0.016	1.565MetArg: 1.565 ± 0.017	1.888MetSer: 1.888 ± 0.017	1.181MetThr: 1.181 ± 0.015	1.215MetVal: 1.215 ± 0.015	0.238MetTrp: 0.238 ± 0.005	0.647MetTyr: 0.647 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.72AsnAla: 3.72 ± 0.025	1.085AsnCys: 1.085 ± 0.017	2.49AsnAsp: 2.49 ± 0.024	2.923AsnGlu: 2.923 ± 0.022	1.783AsnPhe: 1.783 ± 0.017	3.422AsnGly: 3.422 ± 0.033	1.123AsnHis: 1.123 ± 0.015	2.638AsnIle: 2.638 ± 0.024	2.448AsnLys: 2.448 ± 0.021	4.081AsnLeu: 4.081 ± 0.03	1.265AsnMet: 1.265 ± 0.014	4.479AsnAsn: 4.479 ± 0.067	2.138AsnPro: 2.138 ± 0.02	1.874AsnGln: 1.874 ± 0.018	2.272AsnArg: 2.272 ± 0.02	4.617AsnSer: 4.617 ± 0.04	2.601AsnThr: 2.601 ± 0.022	3.038AsnVal: 3.038 ± 0.023	0.549AsnTrp: 0.549 ± 0.01	1.698AsnTyr: 1.698 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	4.314ProAla: 4.314 ± 0.046	0.715ProCys: 0.715 ± 0.021	2.318ProAsp: 2.318 ± 0.02	3.084ProGlu: 3.084 ± 0.037	1.549ProPhe: 1.549 ± 0.018	2.657ProGly: 2.657 ± 0.041	1.492ProHis: 1.492 ± 0.02	2.433ProIle: 2.433 ± 0.022	2.762ProLys: 2.762 ± 0.028	4.44ProLeu: 4.44 ± 0.027	1.155ProMet: 1.155 ± 0.016	2.434ProAsn: 2.434 ± 0.023	4.512ProPro: 4.512 ± 0.066	2.807ProGln: 2.807 ± 0.034	2.345ProArg: 2.345 ± 0.021	4.022ProSer: 4.022 ± 0.037	3.611ProThr: 3.611 ± 0.034	3.045ProVal: 3.045 ± 0.041	0.439ProTrp: 0.439 ± 0.009	1.384ProTyr: 1.384 ± 0.018	0.0ProXaa: 0.0 ± 0.0
Gln	3.3GlnAla: 3.3 ± 0.028	0.88GlnCys: 0.88 ± 0.018	1.798GlnAsp: 1.798 ± 0.017	2.773GlnGlu: 2.773 ± 0.026	1.587GlnPhe: 1.587 ± 0.018	1.762GlnGly: 1.762 ± 0.019	2.301GlnHis: 2.301 ± 0.028	2.206GlnIle: 2.206 ± 0.018	2.505GlnLys: 2.505 ± 0.024	6.575GlnLeu: 6.575 ± 0.058	1.347GlnMet: 1.347 ± 0.016	1.995GlnAsn: 1.995 ± 0.016	3.075GlnPro: 3.075 ± 0.039	11.731GlnGln: 11.731 ± 0.259	3.601GlnArg: 3.601 ± 0.028	3.547GlnSer: 3.547 ± 0.028	2.626GlnThr: 2.626 ± 0.019	2.403GlnVal: 2.403 ± 0.022	0.437GlnTrp: 0.437 ± 0.008	1.301GlnTyr: 1.301 ± 0.015	0.001GlnXaa: 0.001 ± 0.0
Arg	3.29ArgAla: 3.29 ± 0.023	1.14ArgCys: 1.14 ± 0.02	2.719ArgAsp: 2.719 ± 0.023	3.336ArgGlu: 3.336 ± 0.032	1.946ArgPhe: 1.946 ± 0.02	2.649ArgGly: 2.649 ± 0.026	1.653ArgHis: 1.653 ± 0.016	2.858ArgIle: 2.858 ± 0.024	3.359ArgLys: 3.359 ± 0.028	5.159ArgLeu: 5.159 ± 0.032	1.252ArgMet: 1.252 ± 0.013	2.814ArgAsn: 2.814 ± 0.022	2.557ArgPro: 2.557 ± 0.033	3.028ArgGln: 3.028 ± 0.028	4.392ArgArg: 4.392 ± 0.036	4.244ArgSer: 4.244 ± 0.037	2.734ArgThr: 2.734 ± 0.021	2.752ArgVal: 2.752 ± 0.02	0.563ArgTrp: 0.563 ± 0.01	1.715ArgTyr: 1.715 ± 0.016	0.001ArgXaa: 0.001 ± 0.0
Ser	6.08SerAla: 6.08 ± 0.045	1.545SerCys: 1.545 ± 0.022	4.012SerAsp: 4.012 ± 0.028	4.162SerGlu: 4.162 ± 0.032	2.572SerPhe: 2.572 ± 0.022	5.137SerGly: 5.137 ± 0.038	1.923SerHis: 1.923 ± 0.018	3.804SerIle: 3.804 ± 0.027	4.027SerLys: 4.027 ± 0.034	6.609SerLeu: 6.609 ± 0.04	1.814SerMet: 1.814 ± 0.02	4.851SerAsn: 4.851 ± 0.041	4.135SerPro: 4.135 ± 0.036	3.262SerGln: 3.262 ± 0.027	3.697SerArg: 3.697 ± 0.037	10.481SerSer: 10.481 ± 0.121	5.329SerThr: 5.329 ± 0.047	4.45SerVal: 4.45 ± 0.047	0.739SerTrp: 0.739 ± 0.01	2.326SerTyr: 2.326 ± 0.026	0.001SerXaa: 0.001 ± 0.0
Thr	5.287ThrAla: 5.287 ± 0.046	0.996ThrCys: 0.996 ± 0.015	2.741ThrAsp: 2.741 ± 0.03	3.228ThrGlu: 3.228 ± 0.029	1.82ThrPhe: 1.82 ± 0.017	3.235ThrGly: 3.235 ± 0.026	1.456ThrHis: 1.456 ± 0.015	2.917ThrIle: 2.917 ± 0.022	2.788ThrLys: 2.788 ± 0.023	5.191ThrLeu: 5.191 ± 0.034	1.251ThrMet: 1.251 ± 0.013	2.701ThrAsn: 2.701 ± 0.021	3.906ThrPro: 3.906 ± 0.037	2.55ThrGln: 2.55 ± 0.021	2.593ThrArg: 2.593 ± 0.017	4.768ThrSer: 4.768 ± 0.038	5.943ThrThr: 5.943 ± 0.089	3.396ThrVal: 3.396 ± 0.029	0.494ThrTrp: 0.494 ± 0.008	1.503ThrTyr: 1.503 ± 0.016	0.001ThrXaa: 0.001 ± 0.0
Val	4.941ValAla: 4.941 ± 0.038	1.206ValCys: 1.206 ± 0.017	3.216ValAsp: 3.216 ± 0.025	3.706ValGlu: 3.706 ± 0.034	1.997ValPhe: 1.997 ± 0.021	3.324ValGly: 3.324 ± 0.026	1.515ValHis: 1.515 ± 0.017	2.847ValIle: 2.847 ± 0.025	3.021ValLys: 3.021 ± 0.029	5.339ValLeu: 5.339 ± 0.033	1.264ValMet: 1.264 ± 0.014	2.643ValAsn: 2.643 ± 0.019	3.085ValPro: 3.085 ± 0.025	2.676ValGln: 2.676 ± 0.021	3.052ValArg: 3.052 ± 0.026	4.016ValSer: 4.016 ± 0.032	3.157ValThr: 3.157 ± 0.028	3.82ValVal: 3.82 ± 0.032	0.583ValTrp: 0.583 ± 0.01	1.698ValTyr: 1.698 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	0.526TrpAla: 0.526 ± 0.009	0.206TrpCys: 0.206 ± 0.005	0.488TrpAsp: 0.488 ± 0.009	0.506TrpGlu: 0.506 ± 0.008	0.381TrpPhe: 0.381 ± 0.008	0.5TrpGly: 0.5 ± 0.009	0.312TrpHis: 0.312 ± 0.007	0.529TrpIle: 0.529 ± 0.01	0.541TrpLys: 0.541 ± 0.01	1.132TrpLeu: 1.132 ± 0.016	0.273TrpMet: 0.273 ± 0.007	0.484TrpAsn: 0.484 ± 0.01	0.422TrpPro: 0.422 ± 0.008	0.587TrpGln: 0.587 ± 0.01	0.698TrpArg: 0.698 ± 0.011	0.774TrpSer: 0.774 ± 0.012	0.561TrpThr: 0.561 ± 0.009	0.483TrpVal: 0.483 ± 0.009	0.161TrpTrp: 0.161 ± 0.005	0.316TrpTyr: 0.316 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.151TyrAla: 2.151 ± 0.019	0.695TyrCys: 0.695 ± 0.012	1.771TyrAsp: 1.771 ± 0.016	1.878TyrGlu: 1.878 ± 0.015	1.296TyrPhe: 1.296 ± 0.015	1.885TyrGly: 1.885 ± 0.022	0.815TyrHis: 0.815 ± 0.012	1.496TyrIle: 1.496 ± 0.017	1.614TyrLys: 1.614 ± 0.015	2.743TyrLeu: 2.743 ± 0.026	0.819TyrMet: 0.819 ± 0.012	1.603TyrAsn: 1.603 ± 0.018	1.315TyrPro: 1.315 ± 0.019	1.357TyrGln: 1.357 ± 0.016	1.699TyrArg: 1.699 ± 0.017	2.127TyrSer: 2.127 ± 0.023	1.603TyrThr: 1.603 ± 0.019	1.864TyrVal: 1.864 ± 0.018	0.368TyrTrp: 0.368 ± 0.009	1.23TyrTyr: 1.23 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.001XaaPhe: 0.001 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.373XaaXaa: 0.373 ± 0.112

Statistics based on 14754 proteins (7386485 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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