Amino acid dipepetide frequency for Kangiella geojedonensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.504AlaAla: 6.504 ± 0.117
0.872AlaCys: 0.872 ± 0.047
4.782AlaAsp: 4.782 ± 0.214
5.987AlaGlu: 5.987 ± 0.101
3.318AlaPhe: 3.318 ± 0.082
5.829AlaGly: 5.829 ± 0.125
1.582AlaHis: 1.582 ± 0.047
5.572AlaIle: 5.572 ± 0.093
4.964AlaLys: 4.964 ± 0.103
8.406AlaLeu: 8.406 ± 0.118
2.154AlaMet: 2.154 ± 0.061
3.426AlaAsn: 3.426 ± 0.087
2.76AlaPro: 2.76 ± 0.104
3.306AlaGln: 3.306 ± 0.071
3.353AlaArg: 3.353 ± 0.073
5.095AlaSer: 5.095 ± 0.088
4.363AlaThr: 4.363 ± 0.253
5.651AlaVal: 5.651 ± 0.09
0.85AlaTrp: 0.85 ± 0.035
2.382AlaTyr: 2.382 ± 0.07
0.0AlaXaa: 0.0 ± 0.0
Cys
0.616CysAla: 0.616 ± 0.032
0.098CysCys: 0.098 ± 0.012
0.58CysAsp: 0.58 ± 0.046
0.504CysGlu: 0.504 ± 0.027
0.362CysPhe: 0.362 ± 0.022
0.784CysGly: 0.784 ± 0.042
0.258CysHis: 0.258 ± 0.017
0.473CysIle: 0.473 ± 0.027
0.373CysLys: 0.373 ± 0.022
0.873CysLeu: 0.873 ± 0.033
0.178CysMet: 0.178 ± 0.017
0.308CysAsn: 0.308 ± 0.021
0.419CysPro: 0.419 ± 0.041
0.42CysGln: 0.42 ± 0.027
0.399CysArg: 0.399 ± 0.025
0.686CysSer: 0.686 ± 0.029
0.411CysThr: 0.411 ± 0.027
0.578CysVal: 0.578 ± 0.033
0.102CysTrp: 0.102 ± 0.011
0.266CysTyr: 0.266 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
4.564AspAla: 4.564 ± 0.19
0.531AspCys: 0.531 ± 0.029
3.948AspAsp: 3.948 ± 0.163
4.194AspGlu: 4.194 ± 0.092
2.803AspPhe: 2.803 ± 0.063
4.496AspGly: 4.496 ± 0.222
1.127AspHis: 1.127 ± 0.036
4.396AspIle: 4.396 ± 0.079
3.806AspLys: 3.806 ± 0.084
5.48AspLeu: 5.48 ± 0.085
1.543AspMet: 1.543 ± 0.048
2.971AspAsn: 2.971 ± 0.125
2.137AspPro: 2.137 ± 0.055
2.073AspGln: 2.073 ± 0.07
2.331AspArg: 2.331 ± 0.058
3.944AspSer: 3.944 ± 0.1
3.063AspThr: 3.063 ± 0.138
3.89AspVal: 3.89 ± 0.115
0.945AspTrp: 0.945 ± 0.041
2.492AspTyr: 2.492 ± 0.076
0.0AspXaa: 0.0 ± 0.0
Glu
5.768GluAla: 5.768 ± 0.109
0.431GluCys: 0.431 ± 0.027
3.478GluAsp: 3.478 ± 0.085
4.939GluGlu: 4.939 ± 0.128
2.632GluPhe: 2.632 ± 0.06
4.084GluGly: 4.084 ± 0.078
1.75GluHis: 1.75 ± 0.058
3.701GluIle: 3.701 ± 0.071
4.469GluLys: 4.469 ± 0.093
7.675GluLeu: 7.675 ± 0.126
1.643GluMet: 1.643 ± 0.055
2.657GluAsn: 2.657 ± 0.067
2.405GluPro: 2.405 ± 0.061
4.154GluGln: 4.154 ± 0.093
3.604GluArg: 3.604 ± 0.085
4.095GluSer: 4.095 ± 0.095
3.536GluThr: 3.536 ± 0.121
4.85GluVal: 4.85 ± 0.079
0.841GluTrp: 0.841 ± 0.038
2.015GluTyr: 2.015 ± 0.058
0.0GluXaa: 0.0 ± 0.0
Phe
3.289PheAla: 3.289 ± 0.074
0.386PheCys: 0.386 ± 0.02
2.904PheAsp: 2.904 ± 0.072
2.878PheGlu: 2.878 ± 0.068
1.775PhePhe: 1.775 ± 0.06
3.059PheGly: 3.059 ± 0.086
0.757PheHis: 0.757 ± 0.031
2.708PheIle: 2.708 ± 0.074
2.321PheLys: 2.321 ± 0.056
3.474PheLeu: 3.474 ± 0.081
1.02PheMet: 1.02 ± 0.037
1.988PheAsn: 1.988 ± 0.047
1.41PhePro: 1.41 ± 0.044
1.144PheGln: 1.144 ± 0.043
1.426PheArg: 1.426 ± 0.039
3.087PheSer: 3.087 ± 0.068
2.378PheThr: 2.378 ± 0.128
2.712PheVal: 2.712 ± 0.067
0.506PheTrp: 0.506 ± 0.026
1.439PheTyr: 1.439 ± 0.041
0.0PheXaa: 0.0 ± 0.0
Gly
5.394GlyAla: 5.394 ± 0.113
0.735GlyCys: 0.735 ± 0.034
4.366GlyAsp: 4.366 ± 0.138
4.405GlyGlu: 4.405 ± 0.088
3.259GlyPhe: 3.259 ± 0.075
5.156GlyGly: 5.156 ± 0.121
1.578GlyHis: 1.578 ± 0.055
4.542GlyIle: 4.542 ± 0.098
4.209GlyLys: 4.209 ± 0.102
6.817GlyLeu: 6.817 ± 0.126
1.887GlyMet: 1.887 ± 0.065
2.697GlyAsn: 2.697 ± 0.083
1.809GlyPro: 1.809 ± 0.068
2.801GlyGln: 2.801 ± 0.071
2.981GlyArg: 2.981 ± 0.076
4.423GlySer: 4.423 ± 0.083
3.865GlyThr: 3.865 ± 0.289
5.331GlyVal: 5.331 ± 0.091
0.944GlyTrp: 0.944 ± 0.036
2.59GlyTyr: 2.59 ± 0.07
0.0GlyXaa: 0.0 ± 0.0
His
1.463HisAla: 1.463 ± 0.047
0.263HisCys: 0.263 ± 0.019
1.216HisAsp: 1.216 ± 0.04
1.269HisGlu: 1.269 ± 0.046
1.047HisPhe: 1.047 ± 0.038
1.521HisGly: 1.521 ± 0.06
0.654HisHis: 0.654 ± 0.036
1.468HisIle: 1.468 ± 0.05
1.228HisLys: 1.228 ± 0.045
2.186HisLeu: 2.186 ± 0.066
0.527HisMet: 0.527 ± 0.029
0.959HisAsn: 0.959 ± 0.034
1.162HisPro: 1.162 ± 0.042
1.166HisGln: 1.166 ± 0.051
0.998HisArg: 0.998 ± 0.037
1.397HisSer: 1.397 ± 0.051
1.002HisThr: 1.002 ± 0.041
1.254HisVal: 1.254 ± 0.045
0.331HisTrp: 0.331 ± 0.021
0.868HisTyr: 0.868 ± 0.041
0.0HisXaa: 0.0 ± 0.0
Ile
5.841IleAla: 5.841 ± 0.09
0.552IleCys: 0.552 ± 0.029
4.406IleAsp: 4.406 ± 0.084
4.867IleGlu: 4.867 ± 0.098
2.262IlePhe: 2.262 ± 0.063
4.546IleGly: 4.546 ± 0.087
1.265IleHis: 1.265 ± 0.044
3.929IleIle: 3.929 ± 0.089
3.833IleLys: 3.833 ± 0.08
5.345IleLeu: 5.345 ± 0.105
1.268IleMet: 1.268 ± 0.044
3.06IleAsn: 3.06 ± 0.088
2.754IlePro: 2.754 ± 0.061
2.313IleGln: 2.313 ± 0.056
2.531IleArg: 2.531 ± 0.074
4.348IleSer: 4.348 ± 0.086
3.731IleThr: 3.731 ± 0.129
3.954IleVal: 3.954 ± 0.079
0.618IleTrp: 0.618 ± 0.032
1.744IleTyr: 1.744 ± 0.053
0.0IleXaa: 0.0 ± 0.0
Lys
5.36LysAla: 5.36 ± 0.111
0.287LysCys: 0.287 ± 0.025
3.471LysAsp: 3.471 ± 0.09
4.351LysGlu: 4.351 ± 0.093
1.741LysPhe: 1.741 ± 0.047
3.738LysGly: 3.738 ± 0.099
1.373LysHis: 1.373 ± 0.047
3.118LysIle: 3.118 ± 0.065
3.96LysLys: 3.96 ± 0.103
5.688LysLeu: 5.688 ± 0.127
1.379LysMet: 1.379 ± 0.044
2.436LysAsn: 2.436 ± 0.064
2.685LysPro: 2.685 ± 0.071
2.948LysGln: 2.948 ± 0.071
2.956LysArg: 2.956 ± 0.074
3.634LysSer: 3.634 ± 0.087
3.192LysThr: 3.192 ± 0.079
4.465LysVal: 4.465 ± 0.099
0.559LysTrp: 0.559 ± 0.027
1.59LysTyr: 1.59 ± 0.052
0.0LysXaa: 0.0 ± 0.0
Leu
8.612LeuAla: 8.612 ± 0.13
0.883LeuCys: 0.883 ± 0.037
5.803LeuAsp: 5.803 ± 0.092
6.961LeuGlu: 6.961 ± 0.138
3.878LeuPhe: 3.878 ± 0.091
6.927LeuGly: 6.927 ± 0.117
1.954LeuHis: 1.954 ± 0.063
6.131LeuIle: 6.131 ± 0.125
6.044LeuLys: 6.044 ± 0.127
10.115LeuLeu: 10.115 ± 0.189
2.413LeuMet: 2.413 ± 0.068
4.142LeuAsn: 4.142 ± 0.082
4.141LeuPro: 4.141 ± 0.095
3.594LeuGln: 3.594 ± 0.084
4.223LeuArg: 4.223 ± 0.09
7.5LeuSer: 7.5 ± 0.117
5.422LeuThr: 5.422 ± 0.106
6.653LeuVal: 6.653 ± 0.109
1.078LeuTrp: 1.078 ± 0.048
2.693LeuTyr: 2.693 ± 0.08
0.0LeuXaa: 0.0 ± 0.0
Met
2.285MetAla: 2.285 ± 0.059
0.164MetCys: 0.164 ± 0.015
1.251MetAsp: 1.251 ± 0.04
1.344MetGlu: 1.344 ± 0.042
0.824MetPhe: 0.824 ± 0.035
1.699MetGly: 1.699 ± 0.06
0.438MetHis: 0.438 ± 0.029
1.443MetIle: 1.443 ± 0.048
1.594MetLys: 1.594 ± 0.053
2.371MetLeu: 2.371 ± 0.066
0.723MetMet: 0.723 ± 0.04
1.043MetAsn: 1.043 ± 0.033
1.148MetPro: 1.148 ± 0.041
1.011MetGln: 1.011 ± 0.044
1.109MetArg: 1.109 ± 0.038
2.022MetSer: 2.022 ± 0.056
1.531MetThr: 1.531 ± 0.048
1.746MetVal: 1.746 ± 0.049
0.23MetTrp: 0.23 ± 0.016
0.504MetTyr: 0.504 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
3.162AsnAla: 3.162 ± 0.062
0.397AsnCys: 0.397 ± 0.043
2.71AsnAsp: 2.71 ± 0.13
2.42AsnGlu: 2.42 ± 0.09
1.702AsnPhe: 1.702 ± 0.052
2.977AsnGly: 2.977 ± 0.084
0.998AsnHis: 0.998 ± 0.036
2.798AsnIle: 2.798 ± 0.065
2.404AsnLys: 2.404 ± 0.068
3.811AsnLeu: 3.811 ± 0.072
0.973AsnMet: 0.973 ± 0.038
2.103AsnAsn: 2.103 ± 0.06
2.187AsnPro: 2.187 ± 0.07
2.089AsnGln: 2.089 ± 0.065
1.986AsnArg: 1.986 ± 0.05
2.831AsnSer: 2.831 ± 0.064
2.474AsnThr: 2.474 ± 0.122
2.675AsnVal: 2.675 ± 0.069
0.636AsnTrp: 0.636 ± 0.031
1.491AsnTyr: 1.491 ± 0.045
0.0AsnXaa: 0.0 ± 0.0
Pro
2.923ProAla: 2.923 ± 0.089
0.274ProCys: 0.274 ± 0.018
2.461ProAsp: 2.461 ± 0.061
3.367ProGlu: 3.367 ± 0.074
1.662ProPhe: 1.662 ± 0.052
2.434ProGly: 2.434 ± 0.065
0.869ProHis: 0.869 ± 0.034
2.379ProIle: 2.379 ± 0.081
2.306ProLys: 2.306 ± 0.063
3.662ProLeu: 3.662 ± 0.079
0.982ProMet: 0.982 ± 0.037
1.749ProAsn: 1.749 ± 0.053
1.178ProPro: 1.178 ± 0.045
1.696ProGln: 1.696 ± 0.07
1.338ProArg: 1.338 ± 0.04
2.527ProSer: 2.527 ± 0.063
2.05ProThr: 2.05 ± 0.058
3.01ProVal: 3.01 ± 0.076
0.473ProTrp: 0.473 ± 0.027
1.33ProTyr: 1.33 ± 0.042
0.0ProXaa: 0.0 ± 0.0
Gln
3.792GlnAla: 3.792 ± 0.072
0.305GlnCys: 0.305 ± 0.022
2.256GlnAsp: 2.256 ± 0.062
2.915GlnGlu: 2.915 ± 0.091
1.668GlnPhe: 1.668 ± 0.051
2.838GlnGly: 2.838 ± 0.084
1.075GlnHis: 1.075 ± 0.047
2.267GlnIle: 2.267 ± 0.064
2.535GlnLys: 2.535 ± 0.073
4.87GlnLeu: 4.87 ± 0.121
1.014GlnMet: 1.014 ± 0.04
1.593GlnAsn: 1.593 ± 0.052
1.696GlnPro: 1.696 ± 0.052
2.823GlnGln: 2.823 ± 0.108
2.13GlnArg: 2.13 ± 0.063
2.956GlnSer: 2.956 ± 0.071
1.992GlnThr: 1.992 ± 0.061
2.887GlnVal: 2.887 ± 0.061
0.56GlnTrp: 0.56 ± 0.029
1.436GlnTyr: 1.436 ± 0.048
0.0GlnXaa: 0.0 ± 0.0
Arg
3.173ArgAla: 3.173 ± 0.081
0.366ArgCys: 0.366 ± 0.021
2.583ArgAsp: 2.583 ± 0.062
3.037ArgGlu: 3.037 ± 0.079
1.994ArgPhe: 1.994 ± 0.053
2.704ArgGly: 2.704 ± 0.067
1.127ArgHis: 1.127 ± 0.043
2.758ArgIle: 2.758 ± 0.062
2.506ArgLys: 2.506 ± 0.07
4.58ArgLeu: 4.58 ± 0.1
1.163ArgMet: 1.163 ± 0.033
1.801ArgAsn: 1.801 ± 0.059
1.563ArgPro: 1.563 ± 0.049
2.165ArgGln: 2.165 ± 0.059
2.21ArgArg: 2.21 ± 0.064
2.503ArgSer: 2.503 ± 0.063
1.905ArgThr: 1.905 ± 0.054
3.033ArgVal: 3.033 ± 0.076
0.597ArgTrp: 0.597 ± 0.027
1.765ArgTyr: 1.765 ± 0.055
0.0ArgXaa: 0.0 ± 0.0
Ser
5.045SerAla: 5.045 ± 0.09
0.599SerCys: 0.599 ± 0.032
4.244SerAsp: 4.244 ± 0.092
4.392SerGlu: 4.392 ± 0.07
2.869SerPhe: 2.869 ± 0.065
5.205SerGly: 5.205 ± 0.09
1.582SerHis: 1.582 ± 0.048
4.344SerIle: 4.344 ± 0.074
3.619SerLys: 3.619 ± 0.089
6.751SerLeu: 6.751 ± 0.13
1.68SerMet: 1.68 ± 0.052
2.998SerAsn: 2.998 ± 0.079
2.5SerPro: 2.5 ± 0.064
2.855SerGln: 2.855 ± 0.073
2.779SerArg: 2.779 ± 0.074
4.779SerSer: 4.779 ± 0.108
3.28SerThr: 3.28 ± 0.078
4.493SerVal: 4.493 ± 0.087
0.796SerTrp: 0.796 ± 0.036
2.169SerTyr: 2.169 ± 0.068
0.0SerXaa: 0.0 ± 0.0
Thr
4.484ThrAla: 4.484 ± 0.312
0.404ThrCys: 0.404 ± 0.028
3.281ThrAsp: 3.281 ± 0.274
3.326ThrGlu: 3.326 ± 0.07
2.123ThrPhe: 2.123 ± 0.099
4.062ThrGly: 4.062 ± 0.126
1.142ThrHis: 1.142 ± 0.048
3.72ThrIle: 3.72 ± 0.218
2.558ThrLys: 2.558 ± 0.067
5.743ThrLeu: 5.743 ± 0.117
1.124ThrMet: 1.124 ± 0.044
2.05ThrAsn: 2.05 ± 0.073
2.518ThrPro: 2.518 ± 0.079
2.184ThrGln: 2.184 ± 0.051
2.022ThrArg: 2.022 ± 0.054
3.238ThrSer: 3.238 ± 0.072
2.873ThrThr: 2.873 ± 0.183
4.339ThrVal: 4.339 ± 0.358
0.567ThrTrp: 0.567 ± 0.028
1.653ThrTyr: 1.653 ± 0.082
0.0ThrXaa: 0.0 ± 0.0
Val
5.826ValAla: 5.826 ± 0.101
0.647ValCys: 0.647 ± 0.03
4.411ValAsp: 4.411 ± 0.105
5.112ValGlu: 5.112 ± 0.092
2.613ValPhe: 2.613 ± 0.062
4.621ValGly: 4.621 ± 0.096
1.288ValHis: 1.288 ± 0.046
4.901ValIle: 4.901 ± 0.086
3.985ValLys: 3.985 ± 0.096
6.44ValLeu: 6.44 ± 0.113
1.837ValMet: 1.837 ± 0.059
3.144ValAsn: 3.144 ± 0.122
2.473ValPro: 2.473 ± 0.055
2.161ValGln: 2.161 ± 0.055
2.842ValArg: 2.842 ± 0.066
4.851ValSer: 4.851 ± 0.085
4.244ValThr: 4.244 ± 0.284
5.068ValVal: 5.068 ± 0.101
0.789ValTrp: 0.789 ± 0.038
2.017ValTyr: 2.017 ± 0.05
0.0ValXaa: 0.0 ± 0.0
Trp
0.843TrpAla: 0.843 ± 0.034
0.104TrpCys: 0.104 ± 0.013
0.639TrpAsp: 0.639 ± 0.032
0.599TrpGlu: 0.599 ± 0.032
0.629TrpPhe: 0.629 ± 0.032
0.758TrpGly: 0.758 ± 0.03
0.332TrpHis: 0.332 ± 0.019
0.742TrpIle: 0.742 ± 0.04
0.556TrpLys: 0.556 ± 0.03
1.654TrpLeu: 1.654 ± 0.053
0.308TrpMet: 0.308 ± 0.021
0.404TrpAsn: 0.404 ± 0.023
0.393TrpPro: 0.393 ± 0.021
0.785TrpGln: 0.785 ± 0.038
0.574TrpArg: 0.574 ± 0.027
0.847TrpSer: 0.847 ± 0.039
0.487TrpThr: 0.487 ± 0.032
0.875TrpVal: 0.875 ± 0.038
0.164TrpTrp: 0.164 ± 0.016
0.414TrpTyr: 0.414 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.215TyrAla: 2.215 ± 0.057
0.386TyrCys: 0.386 ± 0.024
1.942TyrAsp: 1.942 ± 0.069
1.86TyrGlu: 1.86 ± 0.05
1.501TyrPhe: 1.501 ± 0.047
2.354TyrGly: 2.354 ± 0.059
0.83TyrHis: 0.83 ± 0.033
1.775TyrIle: 1.775 ± 0.058
1.66TyrLys: 1.66 ± 0.05
3.226TyrLeu: 3.226 ± 0.083
0.663TyrMet: 0.663 ± 0.032
1.299TyrAsn: 1.299 ± 0.047
1.333TyrPro: 1.333 ± 0.044
1.917TyrGln: 1.917 ± 0.06
1.74TyrArg: 1.74 ± 0.062
2.217TyrSer: 2.217 ± 0.061
1.612TyrThr: 1.612 ± 0.08
1.807TyrVal: 1.807 ± 0.05
0.522TyrTrp: 0.522 ± 0.029
1.264TyrTyr: 1.264 ± 0.05
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2207 proteins (737553 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski