Amino acid dipepetide frequency for Aeromicrobium sp. IC_218

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.272AlaAla: 19.272 ± 0.218	0.971AlaCys: 0.971 ± 0.029	8.841AlaAsp: 8.841 ± 0.101	8.241AlaGlu: 8.241 ± 0.112	3.541AlaPhe: 3.541 ± 0.059	12.446AlaGly: 12.446 ± 0.132	2.525AlaHis: 2.525 ± 0.055	4.064AlaIle: 4.064 ± 0.079	2.574AlaLys: 2.574 ± 0.073	14.209AlaLeu: 14.209 ± 0.154	2.804AlaMet: 2.804 ± 0.052	1.902AlaAsn: 1.902 ± 0.045	5.936AlaPro: 5.936 ± 0.103	3.778AlaGln: 3.778 ± 0.068	9.619AlaArg: 9.619 ± 0.114	6.737AlaSer: 6.737 ± 0.098	7.805AlaThr: 7.805 ± 0.112	12.443AlaVal: 12.443 ± 0.132	2.076AlaTrp: 2.076 ± 0.046	2.625AlaTyr: 2.625 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.802CysAla: 0.802 ± 0.029	0.062CysCys: 0.062 ± 0.008	0.425CysAsp: 0.425 ± 0.019	0.367CysGlu: 0.367 ± 0.021	0.205CysPhe: 0.205 ± 0.015	0.733CysGly: 0.733 ± 0.029	0.166CysHis: 0.166 ± 0.011	0.146CysIle: 0.146 ± 0.012	0.084CysLys: 0.084 ± 0.009	0.623CysLeu: 0.623 ± 0.023	0.078CysMet: 0.078 ± 0.009	0.113CysAsn: 0.113 ± 0.009	0.361CysPro: 0.361 ± 0.018	0.14CysGln: 0.14 ± 0.01	0.457CysArg: 0.457 ± 0.022	0.389CysSer: 0.389 ± 0.021	0.399CysThr: 0.399 ± 0.022	0.538CysVal: 0.538 ± 0.024	0.091CysTrp: 0.091 ± 0.009	0.101CysTyr: 0.101 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	9.389AspAla: 9.389 ± 0.109	0.294AspCys: 0.294 ± 0.016	5.125AspAsp: 5.125 ± 0.092	5.007AspGlu: 5.007 ± 0.073	1.59AspPhe: 1.59 ± 0.044	6.547AspGly: 6.547 ± 0.092	1.498AspHis: 1.498 ± 0.035	1.395AspIle: 1.395 ± 0.036	1.038AspLys: 1.038 ± 0.038	7.143AspLeu: 7.143 ± 0.102	0.84AspMet: 0.84 ± 0.031	0.816AspAsn: 0.816 ± 0.028	4.472AspPro: 4.472 ± 0.071	1.66AspGln: 1.66 ± 0.042	4.903AspArg: 4.903 ± 0.072	2.317AspSer: 2.317 ± 0.053	2.83AspThr: 2.83 ± 0.065	7.681AspVal: 7.681 ± 0.086	0.924AspTrp: 0.924 ± 0.028	1.083AspTyr: 1.083 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	7.394GluAla: 7.394 ± 0.114	0.283GluCys: 0.283 ± 0.02	3.101GluAsp: 3.101 ± 0.061	2.717GluGlu: 2.717 ± 0.062	1.178GluPhe: 1.178 ± 0.037	4.324GluGly: 4.324 ± 0.068	1.839GluHis: 1.839 ± 0.043	2.045GluIle: 2.045 ± 0.053	1.376GluLys: 1.376 ± 0.053	6.616GluLeu: 6.616 ± 0.092	0.996GluMet: 0.996 ± 0.036	0.982GluAsn: 0.982 ± 0.035	3.576GluPro: 3.576 ± 0.065	2.63GluGln: 2.63 ± 0.06	5.759GluArg: 5.759 ± 0.09	2.751GluSer: 2.751 ± 0.046	3.003GluThr: 3.003 ± 0.058	5.408GluVal: 5.408 ± 0.076	0.704GluTrp: 0.704 ± 0.028	0.956GluTyr: 0.956 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	3.563PheAla: 3.563 ± 0.059	0.251PheCys: 0.251 ± 0.015	2.091PheAsp: 2.091 ± 0.047	1.511PheGlu: 1.511 ± 0.042	0.905PhePhe: 0.905 ± 0.034	2.916PheGly: 2.916 ± 0.065	0.514PheHis: 0.514 ± 0.024	0.702PheIle: 0.702 ± 0.03	0.481PheLys: 0.481 ± 0.024	2.462PheLeu: 2.462 ± 0.054	0.442PheMet: 0.442 ± 0.023	0.493PheAsn: 0.493 ± 0.021	1.142PhePro: 1.142 ± 0.036	0.635PheGln: 0.635 ± 0.025	1.63PheArg: 1.63 ± 0.042	1.458PheSer: 1.458 ± 0.035	1.803PheThr: 1.803 ± 0.043	2.82PheVal: 2.82 ± 0.057	0.429PheTrp: 0.429 ± 0.019	0.621PheTyr: 0.621 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	10.354GlyAla: 10.354 ± 0.116	0.68GlyCys: 0.68 ± 0.029	5.601GlyAsp: 5.601 ± 0.079	4.964GlyGlu: 4.964 ± 0.069	2.959GlyPhe: 2.959 ± 0.061	7.902GlyGly: 7.902 ± 0.121	2.016GlyHis: 2.016 ± 0.043	3.146GlyIle: 3.146 ± 0.057	2.041GlyLys: 2.041 ± 0.055	9.772GlyLeu: 9.772 ± 0.122	1.8GlyMet: 1.8 ± 0.042	1.416GlyAsn: 1.416 ± 0.044	4.371GlyPro: 4.371 ± 0.068	2.486GlyGln: 2.486 ± 0.055	7.69GlyArg: 7.69 ± 0.099	5.262GlySer: 5.262 ± 0.08	6.233GlyThr: 6.233 ± 0.105	8.57GlyVal: 8.57 ± 0.097	1.628GlyTrp: 1.628 ± 0.046	2.145GlyTyr: 2.145 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	2.717HisAla: 2.717 ± 0.06	0.145HisCys: 0.145 ± 0.012	1.688HisAsp: 1.688 ± 0.044	1.366HisGlu: 1.366 ± 0.039	0.496HisPhe: 0.496 ± 0.022	2.232HisGly: 2.232 ± 0.048	0.691HisHis: 0.691 ± 0.029	0.358HisIle: 0.358 ± 0.02	0.305HisLys: 0.305 ± 0.019	2.413HisLeu: 2.413 ± 0.057	0.301HisMet: 0.301 ± 0.019	0.296HisAsn: 0.296 ± 0.016	1.476HisPro: 1.476 ± 0.04	0.601HisGln: 0.601 ± 0.025	1.758HisArg: 1.758 ± 0.05	0.77HisSer: 0.77 ± 0.027	0.998HisThr: 0.998 ± 0.032	2.439HisVal: 2.439 ± 0.051	0.27HisTrp: 0.27 ± 0.016	0.359HisTyr: 0.359 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	4.33IleAla: 4.33 ± 0.087	0.21IleCys: 0.21 ± 0.015	2.345IleAsp: 2.345 ± 0.047	2.073IleGlu: 2.073 ± 0.061	0.751IlePhe: 0.751 ± 0.029	3.307IleGly: 3.307 ± 0.066	0.503IleHis: 0.503 ± 0.019	0.978IleIle: 0.978 ± 0.038	0.69IleLys: 0.69 ± 0.027	2.235IleLeu: 2.235 ± 0.054	0.465IleMet: 0.465 ± 0.026	0.671IleAsn: 0.671 ± 0.027	1.405IlePro: 1.405 ± 0.035	0.674IleGln: 0.674 ± 0.029	1.707IleArg: 1.707 ± 0.042	1.576IleSer: 1.576 ± 0.041	1.946IleThr: 1.946 ± 0.048	3.09IleVal: 3.09 ± 0.06	0.318IleTrp: 0.318 ± 0.023	0.493IleTyr: 0.493 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	2.756LysAla: 2.756 ± 0.074	0.071LysCys: 0.071 ± 0.009	1.169LysAsp: 1.169 ± 0.039	0.87LysGlu: 0.87 ± 0.031	0.412LysPhe: 0.412 ± 0.021	1.688LysGly: 1.688 ± 0.051	0.469LysHis: 0.469 ± 0.022	0.827LysIle: 0.827 ± 0.035	0.789LysLys: 0.789 ± 0.047	1.657LysLeu: 1.657 ± 0.046	0.31LysMet: 0.31 ± 0.018	0.482LysAsn: 0.482 ± 0.027	1.189LysPro: 1.189 ± 0.037	0.761LysGln: 0.761 ± 0.028	1.46LysArg: 1.46 ± 0.044	0.984LysSer: 0.984 ± 0.038	1.216LysThr: 1.216 ± 0.049	2.025LysVal: 2.025 ± 0.057	0.16LysTrp: 0.16 ± 0.014	0.375LysTyr: 0.375 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	15.383LeuAla: 15.383 ± 0.167	0.645LeuCys: 0.645 ± 0.024	7.803LeuAsp: 7.803 ± 0.106	5.777LeuGlu: 5.777 ± 0.079	2.398LeuPhe: 2.398 ± 0.058	10.059LeuGly: 10.059 ± 0.13	2.068LeuHis: 2.068 ± 0.045	2.324LeuIle: 2.324 ± 0.063	1.795LeuLys: 1.795 ± 0.05	10.933LeuLeu: 10.933 ± 0.161	1.641LeuMet: 1.641 ± 0.041	1.492LeuAsn: 1.492 ± 0.041	5.589LeuPro: 5.589 ± 0.08	2.437LeuGln: 2.437 ± 0.056	7.884LeuArg: 7.884 ± 0.106	5.264LeuSer: 5.264 ± 0.07	6.409LeuThr: 6.409 ± 0.077	11.992LeuVal: 11.992 ± 0.156	1.204LeuTrp: 1.204 ± 0.04	1.491LeuTyr: 1.491 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	2.259MetAla: 2.259 ± 0.051	0.108MetCys: 0.108 ± 0.01	0.99MetAsp: 0.99 ± 0.028	0.692MetGlu: 0.692 ± 0.028	0.454MetPhe: 0.454 ± 0.023	1.384MetGly: 1.384 ± 0.041	0.35MetHis: 0.35 ± 0.022	0.635MetIle: 0.635 ± 0.028	0.419MetLys: 0.419 ± 0.02	1.842MetLeu: 1.842 ± 0.048	0.307MetMet: 0.307 ± 0.019	0.404MetAsn: 0.404 ± 0.021	0.991MetPro: 0.991 ± 0.029	0.466MetGln: 0.466 ± 0.02	1.445MetArg: 1.445 ± 0.034	1.442MetSer: 1.442 ± 0.035	1.787MetThr: 1.787 ± 0.04	1.371MetVal: 1.371 ± 0.039	0.167MetTrp: 0.167 ± 0.013	0.254MetTyr: 0.254 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.094AsnAla: 2.094 ± 0.042	0.088AsnCys: 0.088 ± 0.01	0.963AsnAsp: 0.963 ± 0.035	0.811AsnGlu: 0.811 ± 0.032	0.43AsnPhe: 0.43 ± 0.019	1.568AsnGly: 1.568 ± 0.042	0.325AsnHis: 0.325 ± 0.021	0.574AsnIle: 0.574 ± 0.027	0.32AsnLys: 0.32 ± 0.018	1.75AsnLeu: 1.75 ± 0.041	0.226AsnMet: 0.226 ± 0.015	0.392AsnAsn: 0.392 ± 0.019	1.241AsnPro: 1.241 ± 0.038	0.447AsnGln: 0.447 ± 0.024	1.167AsnArg: 1.167 ± 0.036	0.635AsnSer: 0.635 ± 0.025	0.887AsnThr: 0.887 ± 0.034	1.618AsnVal: 1.618 ± 0.043	0.197AsnTrp: 0.197 ± 0.015	0.327AsnTyr: 0.327 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	7.349ProAla: 7.349 ± 0.109	0.244ProCys: 0.244 ± 0.013	4.466ProAsp: 4.466 ± 0.073	3.77ProGlu: 3.77 ± 0.065	1.609ProPhe: 1.609 ± 0.04	5.371ProGly: 5.371 ± 0.095	1.194ProHis: 1.194 ± 0.031	1.408ProIle: 1.408 ± 0.037	0.958ProLys: 0.958 ± 0.036	4.718ProLeu: 4.718 ± 0.077	0.898ProMet: 0.898 ± 0.032	0.775ProAsn: 0.775 ± 0.029	2.4ProPro: 2.4 ± 0.064	1.54ProGln: 1.54 ± 0.042	3.841ProArg: 3.841 ± 0.067	2.988ProSer: 2.988 ± 0.058	3.361ProThr: 3.361 ± 0.057	5.448ProVal: 5.448 ± 0.081	0.935ProTrp: 0.935 ± 0.033	1.119ProTyr: 1.119 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	3.871GlnAla: 3.871 ± 0.074	0.126GlnCys: 0.126 ± 0.011	1.534GlnAsp: 1.534 ± 0.038	1.328GlnGlu: 1.328 ± 0.038	0.614GlnPhe: 0.614 ± 0.026	2.099GlnGly: 2.099 ± 0.047	0.775GlnHis: 0.775 ± 0.029	0.942GlnIle: 0.942 ± 0.034	0.646GlnLys: 0.646 ± 0.031	3.009GlnLeu: 3.009 ± 0.058	0.527GlnMet: 0.527 ± 0.024	0.47GlnAsn: 0.47 ± 0.023	1.508GlnPro: 1.508 ± 0.037	1.189GlnGln: 1.189 ± 0.038	2.54GlnArg: 2.54 ± 0.057	1.208GlnSer: 1.208 ± 0.034	1.395GlnThr: 1.395 ± 0.042	3.239GlnVal: 3.239 ± 0.058	0.473GlnTrp: 0.473 ± 0.023	0.518GlnTyr: 0.518 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	8.931ArgAla: 8.931 ± 0.112	0.432ArgCys: 0.432 ± 0.02	4.811ArgAsp: 4.811 ± 0.076	4.727ArgGlu: 4.727 ± 0.082	2.224ArgPhe: 2.224 ± 0.045	5.862ArgGly: 5.862 ± 0.08	1.844ArgHis: 1.844 ± 0.052	2.556ArgIle: 2.556 ± 0.053	1.452ArgLys: 1.452 ± 0.039	8.803ArgLeu: 8.803 ± 0.103	1.774ArgMet: 1.774 ± 0.043	1.093ArgAsn: 1.093 ± 0.035	4.604ArgPro: 4.604 ± 0.078	2.128ArgGln: 2.128 ± 0.051	7.706ArgArg: 7.706 ± 0.118	4.028ArgSer: 4.028 ± 0.061	5.308ArgThr: 5.308 ± 0.071	6.916ArgVal: 6.916 ± 0.085	1.41ArgTrp: 1.41 ± 0.038	1.532ArgTyr: 1.532 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	6.28SerAla: 6.28 ± 0.088	0.325SerCys: 0.325 ± 0.018	2.965SerAsp: 2.965 ± 0.053	2.414SerGlu: 2.414 ± 0.06	1.672SerPhe: 1.672 ± 0.047	5.467SerGly: 5.467 ± 0.084	0.938SerHis: 0.938 ± 0.031	1.839SerIle: 1.839 ± 0.049	0.996SerLys: 0.996 ± 0.039	5.188SerLeu: 5.188 ± 0.064	1.149SerMet: 1.149 ± 0.036	0.895SerAsn: 0.895 ± 0.03	2.886SerPro: 2.886 ± 0.06	1.309SerGln: 1.309 ± 0.037	3.789SerArg: 3.789 ± 0.064	3.203SerSer: 3.203 ± 0.058	3.401SerThr: 3.401 ± 0.067	4.702SerVal: 4.702 ± 0.08	0.921SerTrp: 0.921 ± 0.031	1.193SerTyr: 1.193 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	7.533ThrAla: 7.533 ± 0.099	0.397ThrCys: 0.397 ± 0.022	3.611ThrAsp: 3.611 ± 0.065	2.992ThrGlu: 2.992 ± 0.056	1.937ThrPhe: 1.937 ± 0.042	5.903ThrGly: 5.903 ± 0.088	1.169ThrHis: 1.169 ± 0.03	2.34ThrIle: 2.34 ± 0.048	1.207ThrLys: 1.207 ± 0.045	6.114ThrLeu: 6.114 ± 0.076	1.003ThrMet: 1.003 ± 0.033	1.077ThrAsn: 1.077 ± 0.033	3.705ThrPro: 3.705 ± 0.071	1.51ThrGln: 1.51 ± 0.04	4.105ThrArg: 4.105 ± 0.067	3.768ThrSer: 3.768 ± 0.069	4.281ThrThr: 4.281 ± 0.087	6.381ThrVal: 6.381 ± 0.118	1.071ThrTrp: 1.071 ± 0.041	1.477ThrTyr: 1.477 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	13.941ValAla: 13.941 ± 0.14	0.678ValCys: 0.678 ± 0.025	6.757ValAsp: 6.757 ± 0.09	6.246ValGlu: 6.246 ± 0.084	2.32ValPhe: 2.32 ± 0.052	8.31ValGly: 8.31 ± 0.095	2.137ValHis: 2.137 ± 0.043	2.631ValIle: 2.631 ± 0.059	1.87ValLys: 1.87 ± 0.047	11.421ValLeu: 11.421 ± 0.16	1.669ValMet: 1.669 ± 0.037	1.643ValAsn: 1.643 ± 0.042	5.883ValPro: 5.883 ± 0.075	2.56ValGln: 2.56 ± 0.045	7.861ValArg: 7.861 ± 0.093	4.808ValSer: 4.808 ± 0.069	6.421ValThr: 6.421 ± 0.108	12.484ValVal: 12.484 ± 0.126	1.149ValTrp: 1.149 ± 0.039	1.544ValTyr: 1.544 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	1.596TrpAla: 1.596 ± 0.045	0.144TrpCys: 0.144 ± 0.012	0.886TrpAsp: 0.886 ± 0.032	0.606TrpGlu: 0.606 ± 0.024	0.547TrpPhe: 0.547 ± 0.021	1.051TrpGly: 1.051 ± 0.03	0.367TrpHis: 0.367 ± 0.02	0.491TrpIle: 0.491 ± 0.025	0.295TrpLys: 0.295 ± 0.02	1.703TrpLeu: 1.703 ± 0.048	0.319TrpMet: 0.319 ± 0.018	0.318TrpAsn: 0.318 ± 0.018	0.753TrpPro: 0.753 ± 0.026	0.53TrpGln: 0.53 ± 0.026	1.281TrpArg: 1.281 ± 0.039	0.989TrpSer: 0.989 ± 0.034	1.102TrpThr: 1.102 ± 0.037	1.149TrpVal: 1.149 ± 0.032	0.374TrpTrp: 0.374 ± 0.021	0.287TrpTyr: 0.287 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.597TyrAla: 2.597 ± 0.052	0.126TyrCys: 0.126 ± 0.011	1.381TyrAsp: 1.381 ± 0.041	1.161TyrGlu: 1.161 ± 0.035	0.627TyrPhe: 0.627 ± 0.022	1.869TyrGly: 1.869 ± 0.041	0.293TyrHis: 0.293 ± 0.019	0.37TyrIle: 0.37 ± 0.02	0.336TyrLys: 0.336 ± 0.019	1.976TyrLeu: 1.976 ± 0.049	0.216TyrMet: 0.216 ± 0.017	0.329TyrAsn: 0.329 ± 0.016	0.906TyrPro: 0.906 ± 0.032	0.527TyrGln: 0.527 ± 0.025	1.54TyrArg: 1.54 ± 0.039	0.949TyrSer: 0.949 ± 0.033	0.995TyrThr: 0.995 ± 0.036	2.018TyrVal: 2.018 ± 0.038	0.286TyrTrp: 0.286 ± 0.016	0.399TyrTyr: 0.399 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3175 proteins (1021998 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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