Amino acid dipepetide frequency for Bifidobacterium callitrichos DSM 23973

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.735AlaAla: 13.735 ± 0.162	1.118AlaCys: 1.118 ± 0.041	7.957AlaAsp: 7.957 ± 0.126	6.032AlaGlu: 6.032 ± 0.111	3.638AlaPhe: 3.638 ± 0.071	9.5AlaGly: 9.5 ± 0.134	2.164AlaHis: 2.164 ± 0.055	5.951AlaIle: 5.951 ± 0.099	4.642AlaLys: 4.642 ± 0.088	10.33AlaLeu: 10.33 ± 0.126	3.228AlaMet: 3.228 ± 0.067	3.382AlaAsn: 3.382 ± 0.072	4.096AlaPro: 4.096 ± 0.083	3.627AlaGln: 3.627 ± 0.081	6.629AlaArg: 6.629 ± 0.118	6.641AlaSer: 6.641 ± 0.122	6.043AlaThr: 6.043 ± 0.094	8.466AlaVal: 8.466 ± 0.113	1.553AlaTrp: 1.553 ± 0.042	2.721AlaTyr: 2.721 ± 0.061	0.0AlaXaa: 0.0 ± 0.0
Cys	1.061CysAla: 1.061 ± 0.034	0.119CysCys: 0.119 ± 0.011	0.525CysAsp: 0.525 ± 0.025	0.485CysGlu: 0.485 ± 0.025	0.315CysPhe: 0.315 ± 0.019	0.938CysGly: 0.938 ± 0.036	0.185CysHis: 0.185 ± 0.017	0.404CysIle: 0.404 ± 0.024	0.208CysLys: 0.208 ± 0.016	0.767CysLeu: 0.767 ± 0.031	0.244CysMet: 0.244 ± 0.019	0.219CysAsn: 0.219 ± 0.016	0.425CysPro: 0.425 ± 0.027	0.186CysGln: 0.186 ± 0.015	0.609CysArg: 0.609 ± 0.03	0.52CysSer: 0.52 ± 0.023	0.465CysThr: 0.465 ± 0.025	0.746CysVal: 0.746 ± 0.03	0.136CysTrp: 0.136 ± 0.013	0.206CysTyr: 0.206 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	7.742AspAla: 7.742 ± 0.117	0.487AspCys: 0.487 ± 0.028	5.146AspAsp: 5.146 ± 0.116	5.029AspGlu: 5.029 ± 0.097	2.242AspPhe: 2.242 ± 0.061	6.397AspGly: 6.397 ± 0.094	1.443AspHis: 1.443 ± 0.044	3.18AspIle: 3.18 ± 0.066	2.361AspLys: 2.361 ± 0.058	5.592AspLeu: 5.592 ± 0.101	1.734AspMet: 1.734 ± 0.047	1.687AspAsn: 1.687 ± 0.044	3.923AspPro: 3.923 ± 0.08	1.869AspGln: 1.869 ± 0.05	4.05AspArg: 4.05 ± 0.077	3.417AspSer: 3.417 ± 0.075	3.423AspThr: 3.423 ± 0.071	5.26AspVal: 5.26 ± 0.087	1.06AspTrp: 1.06 ± 0.035	2.015AspTyr: 2.015 ± 0.053	0.0AspXaa: 0.0 ± 0.0
Glu	5.97GluAla: 5.97 ± 0.11	0.442GluCys: 0.442 ± 0.025	3.152GluAsp: 3.152 ± 0.072	3.169GluGlu: 3.169 ± 0.08	1.778GluPhe: 1.778 ± 0.046	3.992GluGly: 3.992 ± 0.069	1.684GluHis: 1.684 ± 0.048	2.793GluIle: 2.793 ± 0.066	1.963GluLys: 1.963 ± 0.063	5.075GluLeu: 5.075 ± 0.098	1.288GluMet: 1.288 ± 0.043	1.732GluAsn: 1.732 ± 0.045	2.76GluPro: 2.76 ± 0.059	2.31GluGln: 2.31 ± 0.056	4.583GluArg: 4.583 ± 0.096	3.366GluSer: 3.366 ± 0.075	3.411GluThr: 3.411 ± 0.063	3.406GluVal: 3.406 ± 0.069	0.72GluTrp: 0.72 ± 0.029	1.699GluTyr: 1.699 ± 0.055	0.0GluXaa: 0.0 ± 0.0
Phe	3.917PheAla: 3.917 ± 0.078	0.329PheCys: 0.329 ± 0.022	2.79PheAsp: 2.79 ± 0.065	1.746PheGlu: 1.746 ± 0.05	1.147PhePhe: 1.147 ± 0.04	3.326PheGly: 3.326 ± 0.07	0.772PheHis: 0.772 ± 0.029	1.69PheIle: 1.69 ± 0.054	1.009PheLys: 1.009 ± 0.042	2.855PheLeu: 2.855 ± 0.074	0.783PheMet: 0.783 ± 0.028	1.237PheAsn: 1.237 ± 0.039	1.427PhePro: 1.427 ± 0.044	0.879PheGln: 0.879 ± 0.036	1.852PheArg: 1.852 ± 0.045	2.07PheSer: 2.07 ± 0.052	2.386PheThr: 2.386 ± 0.062	2.576PheVal: 2.576 ± 0.055	0.468PheTrp: 0.468 ± 0.024	0.914PheTyr: 0.914 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	7.929GlyAla: 7.929 ± 0.128	0.758GlyCys: 0.758 ± 0.03	5.146GlyAsp: 5.146 ± 0.091	4.777GlyGlu: 4.777 ± 0.089	3.274GlyPhe: 3.274 ± 0.07	6.332GlyGly: 6.332 ± 0.12	1.733GlyHis: 1.733 ± 0.048	4.605GlyIle: 4.605 ± 0.082	3.553GlyLys: 3.553 ± 0.069	7.328GlyLeu: 7.328 ± 0.102	2.258GlyMet: 2.258 ± 0.064	2.68GlyAsn: 2.68 ± 0.073	2.762GlyPro: 2.762 ± 0.065	2.459GlyGln: 2.459 ± 0.06	5.409GlyArg: 5.409 ± 0.113	5.392GlySer: 5.392 ± 0.095	5.121GlyThr: 5.121 ± 0.078	6.91GlyVal: 6.91 ± 0.091	1.374GlyTrp: 1.374 ± 0.049	2.716GlyTyr: 2.716 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	2.369HisAla: 2.369 ± 0.055	0.191HisCys: 0.191 ± 0.014	1.593HisAsp: 1.593 ± 0.043	1.161HisGlu: 1.161 ± 0.04	0.602HisPhe: 0.602 ± 0.032	2.065HisGly: 2.065 ± 0.059	0.604HisHis: 0.604 ± 0.029	1.163HisIle: 1.163 ± 0.035	0.562HisLys: 0.562 ± 0.028	1.671HisLeu: 1.671 ± 0.045	0.598HisMet: 0.598 ± 0.024	0.579HisAsn: 0.579 ± 0.026	1.345HisPro: 1.345 ± 0.043	0.549HisGln: 0.549 ± 0.024	1.513HisArg: 1.513 ± 0.044	0.955HisSer: 0.955 ± 0.035	1.184HisThr: 1.184 ± 0.041	1.84HisVal: 1.84 ± 0.048	0.335HisTrp: 0.335 ± 0.022	0.632HisTyr: 0.632 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	7.129IleAla: 7.129 ± 0.102	0.542IleCys: 0.542 ± 0.025	4.183IleAsp: 4.183 ± 0.082	3.202IleGlu: 3.202 ± 0.07	1.383IlePhe: 1.383 ± 0.047	4.796IleGly: 4.796 ± 0.094	0.974IleHis: 0.974 ± 0.035	2.81IleIle: 2.81 ± 0.066	1.624IleLys: 1.624 ± 0.054	4.026IleLeu: 4.026 ± 0.084	1.15IleMet: 1.15 ± 0.044	1.696IleAsn: 1.696 ± 0.044	2.71IlePro: 2.71 ± 0.061	1.297IleGln: 1.297 ± 0.047	3.132IleArg: 3.132 ± 0.07	2.883IleSer: 2.883 ± 0.075	3.43IleThr: 3.43 ± 0.076	4.811IleVal: 4.811 ± 0.087	0.599IleTrp: 0.599 ± 0.027	1.173IleTyr: 1.173 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	4.617LysAla: 4.617 ± 0.091	0.166LysCys: 0.166 ± 0.016	2.425LysAsp: 2.425 ± 0.07	2.043LysGlu: 2.043 ± 0.06	0.91LysPhe: 0.91 ± 0.033	2.709LysGly: 2.709 ± 0.068	0.775LysHis: 0.775 ± 0.03	1.593LysIle: 1.593 ± 0.047	1.422LysLys: 1.422 ± 0.051	3.109LysLeu: 3.109 ± 0.062	0.777LysMet: 0.777 ± 0.03	1.147LysAsn: 1.147 ± 0.038	2.162LysPro: 2.162 ± 0.053	1.325LysGln: 1.325 ± 0.043	2.377LysArg: 2.377 ± 0.061	2.13LysSer: 2.13 ± 0.054	2.501LysThr: 2.501 ± 0.068	2.692LysVal: 2.692 ± 0.068	0.489LysTrp: 0.489 ± 0.024	1.051LysTyr: 1.051 ± 0.037	0.0LysXaa: 0.0 ± 0.0
Leu	10.335LeuAla: 10.335 ± 0.13	0.893LeuCys: 0.893 ± 0.035	6.447LeuAsp: 6.447 ± 0.097	4.377LeuGlu: 4.377 ± 0.093	3.216LeuPhe: 3.216 ± 0.075	6.945LeuGly: 6.945 ± 0.108	1.797LeuHis: 1.797 ± 0.047	4.922LeuIle: 4.922 ± 0.093	3.627LeuLys: 3.627 ± 0.071	7.774LeuLeu: 7.774 ± 0.134	2.249LeuMet: 2.249 ± 0.065	2.804LeuAsn: 2.804 ± 0.06	4.449LeuPro: 4.449 ± 0.07	2.093LeuGln: 2.093 ± 0.049	5.272LeuArg: 5.272 ± 0.089	5.33LeuSer: 5.33 ± 0.087	5.679LeuThr: 5.679 ± 0.088	6.584LeuVal: 6.584 ± 0.101	1.048LeuTrp: 1.048 ± 0.036	2.136LeuTyr: 2.136 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	2.833MetAla: 2.833 ± 0.06	0.238MetCys: 0.238 ± 0.019	1.4MetAsp: 1.4 ± 0.046	1.043MetGlu: 1.043 ± 0.038	0.85MetPhe: 0.85 ± 0.035	1.851MetGly: 1.851 ± 0.055	0.541MetHis: 0.541 ± 0.026	1.412MetIle: 1.412 ± 0.042	0.893MetLys: 0.893 ± 0.032	2.609MetLeu: 2.609 ± 0.059	0.732MetMet: 0.732 ± 0.038	0.94MetAsn: 0.94 ± 0.031	1.479MetPro: 1.479 ± 0.044	0.777MetGln: 0.777 ± 0.033	1.863MetArg: 1.863 ± 0.052	1.779MetSer: 1.779 ± 0.056	2.169MetThr: 2.169 ± 0.053	1.755MetVal: 1.755 ± 0.049	0.32MetTrp: 0.32 ± 0.018	0.566MetTyr: 0.566 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.591AsnAla: 3.591 ± 0.068	0.224AsnCys: 0.224 ± 0.016	2.131AsnAsp: 2.131 ± 0.056	1.665AsnGlu: 1.665 ± 0.048	0.836AsnPhe: 0.836 ± 0.032	3.374AsnGly: 3.374 ± 0.079	0.645AsnHis: 0.645 ± 0.029	1.588AsnIle: 1.588 ± 0.051	1.082AsnLys: 1.082 ± 0.044	2.544AsnLeu: 2.544 ± 0.061	0.775AsnMet: 0.775 ± 0.029	0.986AsnAsn: 0.986 ± 0.039	2.226AsnPro: 2.226 ± 0.062	0.948AsnGln: 0.948 ± 0.039	1.937AsnArg: 1.937 ± 0.059	1.501AsnSer: 1.501 ± 0.054	2.013AsnThr: 2.013 ± 0.057	2.29AsnVal: 2.29 ± 0.05	0.439AsnTrp: 0.439 ± 0.024	0.844AsnTyr: 0.844 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	5.224ProAla: 5.224 ± 0.106	0.324ProCys: 0.324 ± 0.018	3.786ProAsp: 3.786 ± 0.077	3.241ProGlu: 3.241 ± 0.066	1.736ProPhe: 1.736 ± 0.048	3.677ProGly: 3.677 ± 0.08	0.974ProHis: 0.974 ± 0.03	2.308ProIle: 2.308 ± 0.058	1.785ProLys: 1.785 ± 0.048	3.897ProLeu: 3.897 ± 0.079	1.124ProMet: 1.124 ± 0.038	1.714ProAsn: 1.714 ± 0.061	1.402ProPro: 1.402 ± 0.05	1.664ProGln: 1.664 ± 0.049	2.585ProArg: 2.585 ± 0.067	3.022ProSer: 3.022 ± 0.069	2.977ProThr: 2.977 ± 0.062	3.936ProVal: 3.936 ± 0.061	0.714ProTrp: 0.714 ± 0.031	1.432ProTyr: 1.432 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	3.287GlnAla: 3.287 ± 0.072	0.257GlnCys: 0.257 ± 0.018	1.458GlnAsp: 1.458 ± 0.043	1.325GlnGlu: 1.325 ± 0.04	0.978GlnPhe: 0.978 ± 0.031	2.083GlnGly: 2.083 ± 0.05	0.662GlnHis: 0.662 ± 0.03	1.808GlnIle: 1.808 ± 0.05	0.928GlnLys: 0.928 ± 0.033	3.086GlnLeu: 3.086 ± 0.066	0.923GlnMet: 0.923 ± 0.037	0.959GlnAsn: 0.959 ± 0.038	1.531GlnPro: 1.531 ± 0.063	1.377GlnGln: 1.377 ± 0.05	2.15GlnArg: 2.15 ± 0.052	2.009GlnSer: 2.009 ± 0.06	1.725GlnThr: 1.725 ± 0.045	2.284GlnVal: 2.284 ± 0.055	0.582GlnTrp: 0.582 ± 0.028	0.965GlnTyr: 0.965 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	5.853ArgAla: 5.853 ± 0.096	0.489ArgCys: 0.489 ± 0.026	3.952ArgAsp: 3.952 ± 0.077	4.012ArgGlu: 4.012 ± 0.088	2.455ArgPhe: 2.455 ± 0.061	4.176ArgGly: 4.176 ± 0.084	1.733ArgHis: 1.733 ± 0.053	4.039ArgIle: 4.039 ± 0.07	2.375ArgLys: 2.375 ± 0.063	5.96ArgLeu: 5.96 ± 0.096	2.042ArgMet: 2.042 ± 0.051	2.102ArgAsn: 2.102 ± 0.052	2.845ArgPro: 2.845 ± 0.061	2.13ArgGln: 2.13 ± 0.055	5.536ArgArg: 5.536 ± 0.116	3.332ArgSer: 3.332 ± 0.066	3.802ArgThr: 3.802 ± 0.071	4.576ArgVal: 4.576 ± 0.073	0.933ArgTrp: 0.933 ± 0.032	1.974ArgTyr: 1.974 ± 0.054	0.0ArgXaa: 0.0 ± 0.0
Ser	6.343SerAla: 6.343 ± 0.114	0.47SerCys: 0.47 ± 0.029	3.925SerAsp: 3.925 ± 0.072	2.783SerGlu: 2.783 ± 0.059	2.128SerPhe: 2.128 ± 0.055	5.881SerGly: 5.881 ± 0.108	1.232SerHis: 1.232 ± 0.031	3.305SerIle: 3.305 ± 0.067	2.152SerLys: 2.152 ± 0.059	5.169SerLeu: 5.169 ± 0.078	1.576SerMet: 1.576 ± 0.044	1.943SerAsn: 1.943 ± 0.062	2.572SerPro: 2.572 ± 0.056	1.851SerGln: 1.851 ± 0.048	3.575SerArg: 3.575 ± 0.071	4.185SerSer: 4.185 ± 0.105	3.806SerThr: 3.806 ± 0.086	4.368SerVal: 4.368 ± 0.079	0.857SerTrp: 0.857 ± 0.033	1.553SerTyr: 1.553 ± 0.044	0.001SerXaa: 0.001 ± 0.001
Thr	6.697ThrAla: 6.697 ± 0.087	0.484ThrCys: 0.484 ± 0.023	3.989ThrAsp: 3.989 ± 0.085	2.703ThrGlu: 2.703 ± 0.061	2.147ThrPhe: 2.147 ± 0.059	5.528ThrGly: 5.528 ± 0.085	1.221ThrHis: 1.221 ± 0.036	3.534ThrIle: 3.534 ± 0.08	2.015ThrLys: 2.015 ± 0.053	5.826ThrLeu: 5.826 ± 0.092	1.504ThrMet: 1.504 ± 0.041	1.907ThrAsn: 1.907 ± 0.059	3.629ThrPro: 3.629 ± 0.068	1.732ThrGln: 1.732 ± 0.047	3.527ThrArg: 3.527 ± 0.07	3.705ThrSer: 3.705 ± 0.074	3.888ThrThr: 3.888 ± 0.083	5.482ThrVal: 5.482 ± 0.094	0.79ThrTrp: 0.79 ± 0.032	1.559ThrTyr: 1.559 ± 0.047	0.0ThrXaa: 0.0 ± 0.0
Val	8.498ValAla: 8.498 ± 0.118	0.816ValCys: 0.816 ± 0.036	5.221ValAsp: 5.221 ± 0.084	4.277ValGlu: 4.277 ± 0.083	2.96ValPhe: 2.96 ± 0.066	5.406ValGly: 5.406 ± 0.091	1.515ValHis: 1.515 ± 0.05	4.565ValIle: 4.565 ± 0.081	2.855ValLys: 2.855 ± 0.07	6.561ValLeu: 6.561 ± 0.112	1.982ValMet: 1.982 ± 0.047	2.458ValAsn: 2.458 ± 0.052	3.894ValPro: 3.894 ± 0.074	1.845ValGln: 1.845 ± 0.048	4.711ValArg: 4.711 ± 0.084	5.063ValSer: 5.063 ± 0.082	5.296ValThr: 5.296 ± 0.089	6.461ValVal: 6.461 ± 0.104	1.047ValTrp: 1.047 ± 0.042	1.898ValTyr: 1.898 ± 0.054	0.0ValXaa: 0.0 ± 0.0
Trp	1.235TrpAla: 1.235 ± 0.035	0.157TrpCys: 0.157 ± 0.013	0.871TrpAsp: 0.871 ± 0.034	0.546TrpGlu: 0.546 ± 0.028	0.577TrpPhe: 0.577 ± 0.03	0.927TrpGly: 0.927 ± 0.032	0.37TrpHis: 0.37 ± 0.021	0.737TrpIle: 0.737 ± 0.031	0.566TrpLys: 0.566 ± 0.028	1.408TrpLeu: 1.408 ± 0.045	0.451TrpMet: 0.451 ± 0.024	0.638TrpAsn: 0.638 ± 0.031	0.577TrpPro: 0.577 ± 0.029	0.605TrpGln: 0.605 ± 0.024	1.113TrpArg: 1.113 ± 0.042	0.871TrpSer: 0.871 ± 0.033	0.913TrpThr: 0.913 ± 0.036	0.899TrpVal: 0.899 ± 0.033	0.287TrpTrp: 0.287 ± 0.019	0.444TrpTyr: 0.444 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.088TyrAla: 3.088 ± 0.068	0.26TyrCys: 0.26 ± 0.02	1.956TyrAsp: 1.956 ± 0.054	1.675TyrGlu: 1.675 ± 0.043	1.001TyrPhe: 1.001 ± 0.037	2.615TyrGly: 2.615 ± 0.073	0.483TyrHis: 0.483 ± 0.026	1.143TyrIle: 1.143 ± 0.044	0.795TyrLys: 0.795 ± 0.035	2.389TyrLeu: 2.389 ± 0.063	0.631TyrMet: 0.631 ± 0.028	0.829TyrAsn: 0.829 ± 0.039	1.311TyrPro: 1.311 ± 0.038	0.853TyrGln: 0.853 ± 0.035	1.894TyrArg: 1.894 ± 0.051	1.503TyrSer: 1.503 ± 0.04	1.638TyrThr: 1.638 ± 0.052	1.99TyrVal: 1.99 ± 0.048	0.443TyrTrp: 0.443 ± 0.024	0.821TyrTyr: 0.821 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2362 proteins (826231 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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