Amino acid dipepetide frequency for Ahniella affigens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.914AlaAla: 14.914 ± 0.142
1.216AlaCys: 1.216 ± 0.031
7.033AlaAsp: 7.033 ± 0.069
7.104AlaGlu: 7.104 ± 0.093
4.064AlaPhe: 4.064 ± 0.053
9.308AlaGly: 9.308 ± 0.095
2.345AlaHis: 2.345 ± 0.043
5.65AlaIle: 5.65 ± 0.063
3.661AlaLys: 3.661 ± 0.05
13.632AlaLeu: 13.632 ± 0.141
2.978AlaMet: 2.978 ± 0.044
3.941AlaAsn: 3.941 ± 0.07
5.75AlaPro: 5.75 ± 0.081
4.565AlaGln: 4.565 ± 0.059
8.146AlaArg: 8.146 ± 0.089
7.122AlaSer: 7.122 ± 0.079
6.554AlaThr: 6.554 ± 0.1
7.682AlaVal: 7.682 ± 0.078
1.705AlaTrp: 1.705 ± 0.037
2.495AlaTyr: 2.495 ± 0.04
0.0AlaXaa: 0.0 ± 0.0
Cys
1.092CysAla: 1.092 ± 0.029
0.132CysCys: 0.132 ± 0.009
0.582CysAsp: 0.582 ± 0.023
0.48CysGlu: 0.48 ± 0.018
0.336CysPhe: 0.336 ± 0.015
0.877CysGly: 0.877 ± 0.028
0.271CysHis: 0.271 ± 0.017
0.306CysIle: 0.306 ± 0.013
0.237CysLys: 0.237 ± 0.012
1.057CysLeu: 1.057 ± 0.024
0.155CysMet: 0.155 ± 0.009
0.29CysAsn: 0.29 ± 0.014
0.542CysPro: 0.542 ± 0.022
0.399CysGln: 0.399 ± 0.016
0.673CysArg: 0.673 ± 0.021
0.593CysSer: 0.593 ± 0.019
0.586CysThr: 0.586 ± 0.028
0.694CysVal: 0.694 ± 0.022
0.162CysTrp: 0.162 ± 0.011
0.23CysTyr: 0.23 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
7.559AspAla: 7.559 ± 0.07
0.543AspCys: 0.543 ± 0.018
3.223AspAsp: 3.223 ± 0.054
2.836AspGlu: 2.836 ± 0.049
2.181AspPhe: 2.181 ± 0.036
5.27AspGly: 5.27 ± 0.088
1.251AspHis: 1.251 ± 0.028
2.277AspIle: 2.277 ± 0.037
1.266AspLys: 1.266 ± 0.03
6.422AspLeu: 6.422 ± 0.071
0.929AspMet: 0.929 ± 0.023
1.472AspAsn: 1.472 ± 0.038
3.621AspPro: 3.621 ± 0.049
2.703AspGln: 2.703 ± 0.04
4.195AspArg: 4.195 ± 0.059
3.024AspSer: 3.024 ± 0.047
2.862AspThr: 2.862 ± 0.044
4.008AspVal: 4.008 ± 0.053
1.102AspTrp: 1.102 ± 0.026
1.495AspTyr: 1.495 ± 0.03
0.0AspXaa: 0.0 ± 0.0
Glu
6.295GluAla: 6.295 ± 0.096
0.427GluCys: 0.427 ± 0.017
2.192GluAsp: 2.192 ± 0.037
1.83GluGlu: 1.83 ± 0.048
1.969GluPhe: 1.969 ± 0.036
3.118GluGly: 3.118 ± 0.046
1.352GluHis: 1.352 ± 0.03
2.644GluIle: 2.644 ± 0.043
1.31GluLys: 1.31 ± 0.028
5.988GluLeu: 5.988 ± 0.067
1.058GluMet: 1.058 ± 0.024
1.222GluAsn: 1.222 ± 0.026
2.796GluPro: 2.796 ± 0.051
2.918GluGln: 2.918 ± 0.054
4.743GluArg: 4.743 ± 0.068
3.305GluSer: 3.305 ± 0.049
2.788GluThr: 2.788 ± 0.042
3.389GluVal: 3.389 ± 0.053
0.754GluTrp: 0.754 ± 0.02
1.041GluTyr: 1.041 ± 0.026
0.0GluXaa: 0.0 ± 0.0
Phe
4.579PheAla: 4.579 ± 0.054
0.36PheCys: 0.36 ± 0.016
2.814PheAsp: 2.814 ± 0.046
2.386PheGlu: 2.386 ± 0.034
1.21PhePhe: 1.21 ± 0.031
3.613PheGly: 3.613 ± 0.046
0.67PheHis: 0.67 ± 0.02
1.152PheIle: 1.152 ± 0.03
0.98PheLys: 0.98 ± 0.027
3.155PheLeu: 3.155 ± 0.048
0.674PheMet: 0.674 ± 0.02
1.312PheAsn: 1.312 ± 0.031
1.551PhePro: 1.551 ± 0.029
1.374PheGln: 1.374 ± 0.026
2.317PheArg: 2.317 ± 0.039
2.438PheSer: 2.438 ± 0.036
1.861PheThr: 1.861 ± 0.045
2.833PheVal: 2.833 ± 0.038
0.569PheTrp: 0.569 ± 0.021
0.851PheTyr: 0.851 ± 0.025
0.0PheXaa: 0.0 ± 0.0
Gly
8.333GlyAla: 8.333 ± 0.104
0.772GlyCys: 0.772 ± 0.021
4.566GlyAsp: 4.566 ± 0.065
3.797GlyGlu: 3.797 ± 0.053
3.323GlyPhe: 3.323 ± 0.049
6.396GlyGly: 6.396 ± 0.1
1.684GlyHis: 1.684 ± 0.029
3.725GlyIle: 3.725 ± 0.052
2.707GlyLys: 2.707 ± 0.049
8.29GlyLeu: 8.29 ± 0.083
1.899GlyMet: 1.899 ± 0.036
3.014GlyAsn: 3.014 ± 0.076
3.208GlyPro: 3.208 ± 0.049
3.565GlyGln: 3.565 ± 0.05
5.0GlyArg: 5.0 ± 0.059
5.414GlySer: 5.414 ± 0.087
5.033GlyThr: 5.033 ± 0.11
5.658GlyVal: 5.658 ± 0.073
1.235GlyTrp: 1.235 ± 0.027
1.978GlyTyr: 1.978 ± 0.034
0.0GlyXaa: 0.0 ± 0.0
His
2.581HisAla: 2.581 ± 0.039
0.316HisCys: 0.316 ± 0.013
1.196HisAsp: 1.196 ± 0.03
1.125HisGlu: 1.125 ± 0.026
0.868HisPhe: 0.868 ± 0.022
1.877HisGly: 1.877 ± 0.035
0.574HisHis: 0.574 ± 0.021
0.757HisIle: 0.757 ± 0.018
0.407HisLys: 0.407 ± 0.016
2.195HisLeu: 2.195 ± 0.041
0.355HisMet: 0.355 ± 0.013
0.461HisAsn: 0.461 ± 0.016
1.397HisPro: 1.397 ± 0.032
0.938HisGln: 0.938 ± 0.024
1.632HisArg: 1.632 ± 0.034
1.054HisSer: 1.054 ± 0.023
0.861HisThr: 0.861 ± 0.024
1.489HisVal: 1.489 ± 0.032
0.499HisTrp: 0.499 ± 0.019
0.641HisTyr: 0.641 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
6.147IleAla: 6.147 ± 0.075
0.432IleCys: 0.432 ± 0.017
3.611IleAsp: 3.611 ± 0.048
3.186IleGlu: 3.186 ± 0.044
1.122IlePhe: 1.122 ± 0.026
4.295IleGly: 4.295 ± 0.058
0.89IleHis: 0.89 ± 0.025
1.467IleIle: 1.467 ± 0.03
1.372IleLys: 1.372 ± 0.029
3.67IleLeu: 3.67 ± 0.045
0.659IleMet: 0.659 ± 0.02
1.593IleAsn: 1.593 ± 0.04
2.061IlePro: 2.061 ± 0.034
1.703IleGln: 1.703 ± 0.032
3.218IleArg: 3.218 ± 0.046
2.857IleSer: 2.857 ± 0.048
2.486IleThr: 2.486 ± 0.055
3.339IleVal: 3.339 ± 0.046
0.654IleTrp: 0.654 ± 0.019
0.92IleTyr: 0.92 ± 0.024
0.0IleXaa: 0.0 ± 0.0
Lys
3.371LysAla: 3.371 ± 0.053
0.176LysCys: 0.176 ± 0.012
1.332LysAsp: 1.332 ± 0.03
1.23LysGlu: 1.23 ± 0.032
0.795LysPhe: 0.795 ± 0.024
1.763LysGly: 1.763 ± 0.035
0.69LysHis: 0.69 ± 0.019
1.321LysIle: 1.321 ± 0.032
0.966LysLys: 0.966 ± 0.029
3.098LysLeu: 3.098 ± 0.051
0.519LysMet: 0.519 ± 0.019
0.721LysAsn: 0.721 ± 0.024
1.921LysPro: 1.921 ± 0.041
1.352LysGln: 1.352 ± 0.03
2.395LysArg: 2.395 ± 0.042
1.792LysSer: 1.792 ± 0.036
1.693LysThr: 1.693 ± 0.036
1.982LysVal: 1.982 ± 0.037
0.296LysTrp: 0.296 ± 0.014
0.523LysTyr: 0.523 ± 0.02
0.0LysXaa: 0.0 ± 0.0
Leu
13.939LeuAla: 13.939 ± 0.149
1.029LeuCys: 1.029 ± 0.028
6.374LeuAsp: 6.374 ± 0.075
4.91LeuGlu: 4.91 ± 0.075
3.465LeuPhe: 3.465 ± 0.054
8.228LeuGly: 8.228 ± 0.09
2.112LeuHis: 2.112 ± 0.043
5.234LeuIle: 5.234 ± 0.076
3.515LeuLys: 3.515 ± 0.051
11.055LeuLeu: 11.055 ± 0.138
2.09LeuMet: 2.09 ± 0.036
3.457LeuAsn: 3.457 ± 0.051
6.215LeuPro: 6.215 ± 0.073
3.993LeuGln: 3.993 ± 0.059
7.564LeuArg: 7.564 ± 0.081
7.137LeuSer: 7.137 ± 0.07
5.632LeuThr: 5.632 ± 0.062
7.28LeuVal: 7.28 ± 0.065
1.332LeuTrp: 1.332 ± 0.032
2.115LeuTyr: 2.115 ± 0.035
0.0LeuXaa: 0.0 ± 0.0
Met
2.427MetAla: 2.427 ± 0.039
0.143MetCys: 0.143 ± 0.01
0.897MetAsp: 0.897 ± 0.021
0.691MetGlu: 0.691 ± 0.018
0.662MetPhe: 0.662 ± 0.021
1.348MetGly: 1.348 ± 0.031
0.465MetHis: 0.465 ± 0.017
1.008MetIle: 1.008 ± 0.026
0.699MetLys: 0.699 ± 0.023
2.432MetLeu: 2.432 ± 0.042
0.448MetMet: 0.448 ± 0.017
0.764MetAsn: 0.764 ± 0.019
1.308MetPro: 1.308 ± 0.029
0.955MetGln: 0.955 ± 0.026
1.624MetArg: 1.624 ± 0.032
1.556MetSer: 1.556 ± 0.029
1.275MetThr: 1.275 ± 0.024
1.367MetVal: 1.367 ± 0.027
0.176MetTrp: 0.176 ± 0.01
0.327MetTyr: 0.327 ± 0.014
0.0MetXaa: 0.0 ± 0.0
Asn
3.829AsnAla: 3.829 ± 0.055
0.338AsnCys: 0.338 ± 0.017
1.822AsnAsp: 1.822 ± 0.045
1.457AsnGlu: 1.457 ± 0.031
1.145AsnPhe: 1.145 ± 0.033
3.072AsnGly: 3.072 ± 0.08
0.582AsnHis: 0.582 ± 0.017
1.206AsnIle: 1.206 ± 0.033
0.664AsnLys: 0.664 ± 0.022
3.3AsnLeu: 3.3 ± 0.046
0.53AsnMet: 0.53 ± 0.018
1.134AsnAsn: 1.134 ± 0.043
2.047AsnPro: 2.047 ± 0.04
1.484AsnGln: 1.484 ± 0.031
2.152AsnArg: 2.152 ± 0.038
1.76AsnSer: 1.76 ± 0.045
1.917AsnThr: 1.917 ± 0.046
2.288AsnVal: 2.288 ± 0.049
0.55AsnTrp: 0.55 ± 0.018
0.72AsnTyr: 0.72 ± 0.021
0.0AsnXaa: 0.0 ± 0.0
Pro
6.169ProAla: 6.169 ± 0.082
0.37ProCys: 0.37 ± 0.014
3.633ProAsp: 3.633 ± 0.052
3.66ProGlu: 3.66 ± 0.062
1.809ProPhe: 1.809 ± 0.034
4.488ProGly: 4.488 ± 0.062
0.907ProHis: 0.907 ± 0.024
2.719ProIle: 2.719 ± 0.04
1.789ProLys: 1.789 ± 0.034
4.631ProLeu: 4.631 ± 0.072
1.382ProMet: 1.382 ± 0.032
2.069ProAsn: 2.069 ± 0.035
2.58ProPro: 2.58 ± 0.056
1.544ProGln: 1.544 ± 0.032
2.603ProArg: 2.603 ± 0.042
3.296ProSer: 3.296 ± 0.045
3.097ProThr: 3.097 ± 0.048
4.025ProVal: 4.025 ± 0.055
0.792ProTrp: 0.792 ± 0.021
1.082ProTyr: 1.082 ± 0.028
0.0ProXaa: 0.0 ± 0.0
Gln
5.25GlnAla: 5.25 ± 0.072
0.354GlnCys: 0.354 ± 0.015
1.962GlnAsp: 1.962 ± 0.034
1.641GlnGlu: 1.641 ± 0.033
1.698GlnPhe: 1.698 ± 0.032
2.895GlnGly: 2.895 ± 0.042
1.058GlnHis: 1.058 ± 0.027
2.224GlnIle: 2.224 ± 0.03
1.061GlnLys: 1.061 ± 0.027
4.248GlnLeu: 4.248 ± 0.06
0.862GlnMet: 0.862 ± 0.023
1.232GlnAsn: 1.232 ± 0.03
2.172GlnPro: 2.172 ± 0.038
2.043GlnGln: 2.043 ± 0.046
3.311GlnArg: 3.311 ± 0.057
2.759GlnSer: 2.759 ± 0.038
2.444GlnThr: 2.444 ± 0.043
3.15GlnVal: 3.15 ± 0.046
0.675GlnTrp: 0.675 ± 0.02
0.902GlnTyr: 0.902 ± 0.023
0.0GlnXaa: 0.0 ± 0.0
Arg
7.862ArgAla: 7.862 ± 0.096
0.672ArgCys: 0.672 ± 0.023
4.127ArgAsp: 4.127 ± 0.055
3.909ArgGlu: 3.909 ± 0.057
3.313ArgPhe: 3.313 ± 0.042
4.372ArgGly: 4.372 ± 0.052
1.713ArgHis: 1.713 ± 0.037
3.736ArgIle: 3.736 ± 0.04
1.856ArgLys: 1.856 ± 0.037
8.132ArgLeu: 8.132 ± 0.099
1.596ArgMet: 1.596 ± 0.027
1.991ArgAsn: 1.991 ± 0.034
3.141ArgPro: 3.141 ± 0.046
3.202ArgGln: 3.202 ± 0.047
4.939ArgArg: 4.939 ± 0.072
3.855ArgSer: 3.855 ± 0.05
3.268ArgThr: 3.268 ± 0.045
5.087ArgVal: 5.087 ± 0.057
1.277ArgTrp: 1.277 ± 0.025
2.005ArgTyr: 2.005 ± 0.037
0.0ArgXaa: 0.0 ± 0.0
Ser
7.397SerAla: 7.397 ± 0.075
0.619SerCys: 0.619 ± 0.022
3.522SerAsp: 3.522 ± 0.047
3.069SerGlu: 3.069 ± 0.048
2.345SerPhe: 2.345 ± 0.039
6.055SerGly: 6.055 ± 0.085
1.152SerHis: 1.152 ± 0.026
2.772SerIle: 2.772 ± 0.046
1.713SerLys: 1.713 ± 0.036
6.394SerLeu: 6.394 ± 0.066
1.309SerMet: 1.309 ± 0.026
2.267SerAsn: 2.267 ± 0.053
3.185SerPro: 3.185 ± 0.047
2.184SerGln: 2.184 ± 0.036
3.815SerArg: 3.815 ± 0.052
3.694SerSer: 3.694 ± 0.065
3.333SerThr: 3.333 ± 0.062
4.671SerVal: 4.671 ± 0.059
0.999SerTrp: 0.999 ± 0.027
1.363SerTyr: 1.363 ± 0.03
0.0SerXaa: 0.0 ± 0.0
Thr
6.135ThrAla: 6.135 ± 0.094
0.615ThrCys: 0.615 ± 0.03
3.17ThrAsp: 3.17 ± 0.055
2.776ThrGlu: 2.776 ± 0.042
1.952ThrPhe: 1.952 ± 0.053
4.797ThrGly: 4.797 ± 0.077
1.12ThrHis: 1.12 ± 0.026
2.851ThrIle: 2.851 ± 0.073
1.234ThrLys: 1.234 ± 0.029
6.085ThrLeu: 6.085 ± 0.073
0.996ThrMet: 0.996 ± 0.026
1.811ThrAsn: 1.811 ± 0.049
3.37ThrPro: 3.37 ± 0.053
1.986ThrGln: 1.986 ± 0.038
3.429ThrArg: 3.429 ± 0.043
3.101ThrSer: 3.101 ± 0.064
3.167ThrThr: 3.167 ± 0.084
4.289ThrVal: 4.289 ± 0.09
0.905ThrTrp: 0.905 ± 0.026
1.255ThrTyr: 1.255 ± 0.036
0.0ThrXaa: 0.0 ± 0.0
Val
8.277ValAla: 8.277 ± 0.079
0.739ValCys: 0.739 ± 0.022
4.306ValAsp: 4.306 ± 0.057
3.438ValGlu: 3.438 ± 0.048
2.749ValPhe: 2.749 ± 0.041
5.317ValGly: 5.317 ± 0.063
1.475ValHis: 1.475 ± 0.031
3.256ValIle: 3.256 ± 0.047
1.705ValLys: 1.705 ± 0.037
8.184ValLeu: 8.184 ± 0.087
1.436ValMet: 1.436 ± 0.028
2.161ValAsn: 2.161 ± 0.053
3.832ValPro: 3.832 ± 0.057
2.821ValGln: 2.821 ± 0.04
4.862ValArg: 4.862 ± 0.066
4.784ValSer: 4.784 ± 0.073
4.078ValThr: 4.078 ± 0.086
5.322ValVal: 5.322 ± 0.072
0.942ValTrp: 0.942 ± 0.024
1.597ValTyr: 1.597 ± 0.035
0.0ValXaa: 0.0 ± 0.0
Trp
1.157TrpAla: 1.157 ± 0.031
0.19TrpCys: 0.19 ± 0.011
0.602TrpAsp: 0.602 ± 0.018
0.471TrpGlu: 0.471 ± 0.014
0.712TrpPhe: 0.712 ± 0.023
0.695TrpGly: 0.695 ± 0.024
0.431TrpHis: 0.431 ± 0.015
0.721TrpIle: 0.721 ± 0.019
0.334TrpLys: 0.334 ± 0.014
2.277TrpLeu: 2.277 ± 0.046
0.363TrpMet: 0.363 ± 0.015
0.488TrpAsn: 0.488 ± 0.017
0.85TrpPro: 0.85 ± 0.023
1.041TrpGln: 1.041 ± 0.027
1.366TrpArg: 1.366 ± 0.026
1.032TrpSer: 1.032 ± 0.026
0.9TrpThr: 0.9 ± 0.027
1.026TrpVal: 1.026 ± 0.026
0.307TrpTrp: 0.307 ± 0.017
0.395TrpTyr: 0.395 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.553TyrAla: 2.553 ± 0.041
0.252TyrCys: 0.252 ± 0.013
1.276TyrAsp: 1.276 ± 0.032
1.14TyrGlu: 1.14 ± 0.025
0.98TyrPhe: 0.98 ± 0.028
1.813TyrGly: 1.813 ± 0.031
0.48TyrHis: 0.48 ± 0.016
0.655TyrIle: 0.655 ± 0.021
0.46TyrLys: 0.46 ± 0.019
2.432TyrLeu: 2.432 ± 0.039
0.331TyrMet: 0.331 ± 0.014
0.595TyrAsn: 0.595 ± 0.021
1.1TyrPro: 1.1 ± 0.025
1.171TyrGln: 1.171 ± 0.027
2.071TyrArg: 2.071 ± 0.032
1.283TyrSer: 1.283 ± 0.031
1.21TyrThr: 1.21 ± 0.039
1.702TyrVal: 1.702 ± 0.033
0.429TyrTrp: 0.429 ± 0.016
0.581TyrTyr: 0.581 ± 0.019
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4694 proteins (1753483 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski