Amino acid dipepetide frequency for Propionicimonas paludicola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.56AlaAla: 20.56 ± 0.235
0.936AlaCys: 0.936 ± 0.033
8.324AlaAsp: 8.324 ± 0.102
8.957AlaGlu: 8.957 ± 0.141
3.519AlaPhe: 3.519 ± 0.073
12.656AlaGly: 12.656 ± 0.147
2.187AlaHis: 2.187 ± 0.052
5.71AlaIle: 5.71 ± 0.082
3.762AlaLys: 3.762 ± 0.067
13.369AlaLeu: 13.369 ± 0.15
2.775AlaMet: 2.775 ± 0.06
2.889AlaAsn: 2.889 ± 0.063
5.727AlaPro: 5.727 ± 0.092
4.43AlaGln: 4.43 ± 0.079
8.038AlaArg: 8.038 ± 0.113
7.519AlaSer: 7.519 ± 0.101
7.717AlaThr: 7.717 ± 0.132
11.009AlaVal: 11.009 ± 0.132
1.992AlaTrp: 1.992 ± 0.049
2.358AlaTyr: 2.358 ± 0.052
0.0AlaXaa: 0.0 ± 0.0
Cys
0.894CysAla: 0.894 ± 0.03
0.097CysCys: 0.097 ± 0.011
0.438CysAsp: 0.438 ± 0.023
0.312CysGlu: 0.312 ± 0.018
0.236CysPhe: 0.236 ± 0.016
0.802CysGly: 0.802 ± 0.035
0.187CysHis: 0.187 ± 0.013
0.214CysIle: 0.214 ± 0.014
0.111CysLys: 0.111 ± 0.01
0.695CysLeu: 0.695 ± 0.03
0.102CysMet: 0.102 ± 0.012
0.151CysAsn: 0.151 ± 0.012
0.45CysPro: 0.45 ± 0.024
0.22CysGln: 0.22 ± 0.016
0.508CysArg: 0.508 ± 0.025
0.445CysSer: 0.445 ± 0.02
0.489CysThr: 0.489 ± 0.051
0.525CysVal: 0.525 ± 0.023
0.14CysTrp: 0.14 ± 0.012
0.183CysTyr: 0.183 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
7.204AspAla: 7.204 ± 0.093
0.372AspCys: 0.372 ± 0.02
3.157AspAsp: 3.157 ± 0.078
3.587AspGlu: 3.587 ± 0.075
1.711AspPhe: 1.711 ± 0.04
5.605AspGly: 5.605 ± 0.09
1.172AspHis: 1.172 ± 0.031
1.668AspIle: 1.668 ± 0.046
1.123AspLys: 1.123 ± 0.04
6.345AspLeu: 6.345 ± 0.09
0.696AspMet: 0.696 ± 0.029
1.027AspAsn: 1.027 ± 0.035
4.35AspPro: 4.35 ± 0.08
2.276AspGln: 2.276 ± 0.049
3.889AspArg: 3.889 ± 0.067
2.601AspSer: 2.601 ± 0.057
2.425AspThr: 2.425 ± 0.052
4.273AspVal: 4.273 ± 0.074
0.971AspTrp: 0.971 ± 0.034
1.389AspTyr: 1.389 ± 0.045
0.0AspXaa: 0.0 ± 0.0
Glu
7.129GluAla: 7.129 ± 0.13
0.317GluCys: 0.317 ± 0.018
2.205GluAsp: 2.205 ± 0.061
2.331GluGlu: 2.331 ± 0.062
1.749GluPhe: 1.749 ± 0.045
3.159GluGly: 3.159 ± 0.054
1.244GluHis: 1.244 ± 0.04
2.331GluIle: 2.331 ± 0.065
1.099GluLys: 1.099 ± 0.039
7.919GluLeu: 7.919 ± 0.124
0.844GluMet: 0.844 ± 0.036
0.949GluAsn: 0.949 ± 0.033
3.315GluPro: 3.315 ± 0.074
2.32GluGln: 2.32 ± 0.058
4.078GluArg: 4.078 ± 0.088
2.583GluSer: 2.583 ± 0.055
2.331GluThr: 2.331 ± 0.056
4.985GluVal: 4.985 ± 0.083
0.802GluTrp: 0.802 ± 0.03
1.003GluTyr: 1.003 ± 0.038
0.0GluXaa: 0.0 ± 0.0
Phe
4.195PheAla: 4.195 ± 0.072
0.267PheCys: 0.267 ± 0.016
2.109PheAsp: 2.109 ± 0.053
1.488PheGlu: 1.488 ± 0.039
0.998PhePhe: 0.998 ± 0.042
3.351PheGly: 3.351 ± 0.068
0.526PheHis: 0.526 ± 0.025
1.087PheIle: 1.087 ± 0.031
0.485PheLys: 0.485 ± 0.025
2.624PheLeu: 2.624 ± 0.056
0.406PheMet: 0.406 ± 0.022
0.704PheAsn: 0.704 ± 0.026
1.364PhePro: 1.364 ± 0.038
0.723PheGln: 0.723 ± 0.03
1.682PheArg: 1.682 ± 0.038
1.89PheSer: 1.89 ± 0.047
2.218PheThr: 2.218 ± 0.076
2.586PheVal: 2.586 ± 0.058
0.454PheTrp: 0.454 ± 0.023
0.569PheTyr: 0.569 ± 0.027
0.0PheXaa: 0.0 ± 0.0
Gly
9.524GlyAla: 9.524 ± 0.139
0.854GlyCys: 0.854 ± 0.034
4.25GlyAsp: 4.25 ± 0.082
4.416GlyGlu: 4.416 ± 0.061
3.215GlyPhe: 3.215 ± 0.059
6.968GlyGly: 6.968 ± 0.106
1.805GlyHis: 1.805 ± 0.043
3.994GlyIle: 3.994 ± 0.062
2.6GlyLys: 2.6 ± 0.065
10.205GlyLeu: 10.205 ± 0.144
1.967GlyMet: 1.967 ± 0.049
1.816GlyAsn: 1.816 ± 0.058
3.953GlyPro: 3.953 ± 0.073
3.035GlyGln: 3.035 ± 0.055
6.31GlyArg: 6.31 ± 0.103
5.587GlySer: 5.587 ± 0.098
5.334GlyThr: 5.334 ± 0.12
7.657GlyVal: 7.657 ± 0.114
1.941GlyTrp: 1.941 ± 0.047
2.62GlyTyr: 2.62 ± 0.055
0.0GlyXaa: 0.0 ± 0.0
His
2.02HisAla: 2.02 ± 0.045
0.19HisCys: 0.19 ± 0.014
1.047HisAsp: 1.047 ± 0.032
0.928HisGlu: 0.928 ± 0.034
0.51HisPhe: 0.51 ± 0.026
1.714HisGly: 1.714 ± 0.044
0.545HisHis: 0.545 ± 0.025
0.552HisIle: 0.552 ± 0.023
0.358HisLys: 0.358 ± 0.018
2.192HisLeu: 2.192 ± 0.053
0.239HisMet: 0.239 ± 0.016
0.39HisAsn: 0.39 ± 0.021
1.482HisPro: 1.482 ± 0.038
0.699HisGln: 0.699 ± 0.029
1.549HisArg: 1.549 ± 0.042
1.052HisSer: 1.052 ± 0.037
1.001HisThr: 1.001 ± 0.032
1.233HisVal: 1.233 ± 0.037
0.337HisTrp: 0.337 ± 0.019
0.515HisTyr: 0.515 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
6.116IleAla: 6.116 ± 0.086
0.385IleCys: 0.385 ± 0.02
2.87IleAsp: 2.87 ± 0.056
2.636IleGlu: 2.636 ± 0.064
1.163IlePhe: 1.163 ± 0.037
4.67IleGly: 4.67 ± 0.083
0.649IleHis: 0.649 ± 0.027
1.548IleIle: 1.548 ± 0.047
0.958IleLys: 0.958 ± 0.035
3.425IleLeu: 3.425 ± 0.066
0.545IleMet: 0.545 ± 0.024
1.012IleAsn: 1.012 ± 0.034
2.059IlePro: 2.059 ± 0.049
1.016IleGln: 1.016 ± 0.033
2.404IleArg: 2.404 ± 0.062
2.79IleSer: 2.79 ± 0.057
3.086IleThr: 3.086 ± 0.074
3.528IleVal: 3.528 ± 0.066
0.608IleTrp: 0.608 ± 0.027
0.878IleTyr: 0.878 ± 0.032
0.0IleXaa: 0.0 ± 0.0
Lys
3.398LysAla: 3.398 ± 0.075
0.124LysCys: 0.124 ± 0.011
1.129LysAsp: 1.129 ± 0.036
0.953LysGlu: 0.953 ± 0.037
0.613LysPhe: 0.613 ± 0.028
1.69LysGly: 1.69 ± 0.053
0.419LysHis: 0.419 ± 0.018
1.044LysIle: 1.044 ± 0.035
0.891LysLys: 0.891 ± 0.042
2.631LysLeu: 2.631 ± 0.059
0.5LysMet: 0.5 ± 0.026
0.56LysAsn: 0.56 ± 0.025
1.408LysPro: 1.408 ± 0.048
0.758LysGln: 0.758 ± 0.027
1.479LysArg: 1.479 ± 0.04
1.3LysSer: 1.3 ± 0.04
1.58LysThr: 1.58 ± 0.05
2.443LysVal: 2.443 ± 0.061
0.294LysTrp: 0.294 ± 0.017
0.516LysTyr: 0.516 ± 0.027
0.0LysXaa: 0.0 ± 0.0
Leu
16.871LeuAla: 16.871 ± 0.179
0.685LeuCys: 0.685 ± 0.027
6.526LeuAsp: 6.526 ± 0.084
4.796LeuGlu: 4.796 ± 0.085
2.699LeuPhe: 2.699 ± 0.067
9.867LeuGly: 9.867 ± 0.121
1.849LeuHis: 1.849 ± 0.046
4.93LeuIle: 4.93 ± 0.094
2.218LeuLys: 2.218 ± 0.052
10.969LeuLeu: 10.969 ± 0.162
1.713LeuMet: 1.713 ± 0.047
2.375LeuAsn: 2.375 ± 0.055
6.329LeuPro: 6.329 ± 0.076
2.635LeuGln: 2.635 ± 0.056
7.491LeuArg: 7.491 ± 0.104
6.657LeuSer: 6.657 ± 0.093
6.823LeuThr: 6.823 ± 0.095
9.898LeuVal: 9.898 ± 0.125
1.293LeuTrp: 1.293 ± 0.042
1.709LeuTyr: 1.709 ± 0.038
0.0LeuXaa: 0.0 ± 0.0
Met
2.416MetAla: 2.416 ± 0.048
0.108MetCys: 0.108 ± 0.01
0.88MetAsp: 0.88 ± 0.038
0.657MetGlu: 0.657 ± 0.028
0.494MetPhe: 0.494 ± 0.023
1.218MetGly: 1.218 ± 0.037
0.277MetHis: 0.277 ± 0.018
0.956MetIle: 0.956 ± 0.035
0.524MetLys: 0.524 ± 0.026
1.897MetLeu: 1.897 ± 0.049
0.359MetMet: 0.359 ± 0.02
0.472MetAsn: 0.472 ± 0.023
1.032MetPro: 1.032 ± 0.035
0.456MetGln: 0.456 ± 0.025
1.159MetArg: 1.159 ± 0.035
1.464MetSer: 1.464 ± 0.039
1.432MetThr: 1.432 ± 0.038
1.572MetVal: 1.572 ± 0.046
0.22MetTrp: 0.22 ± 0.014
0.267MetTyr: 0.267 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
2.53AsnAla: 2.53 ± 0.064
0.167AsnCys: 0.167 ± 0.014
1.153AsnAsp: 1.153 ± 0.052
0.97AsnGlu: 0.97 ± 0.029
0.701AsnPhe: 0.701 ± 0.031
1.945AsnGly: 1.945 ± 0.057
0.417AsnHis: 0.417 ± 0.023
0.799AsnIle: 0.799 ± 0.028
0.489AsnLys: 0.489 ± 0.023
2.424AsnLeu: 2.424 ± 0.047
0.346AsnMet: 0.346 ± 0.019
0.554AsnAsn: 0.554 ± 0.027
1.861AsnPro: 1.861 ± 0.049
0.795AsnGln: 0.795 ± 0.031
1.416AsnArg: 1.416 ± 0.038
1.243AsnSer: 1.243 ± 0.037
1.216AsnThr: 1.216 ± 0.049
1.495AsnVal: 1.495 ± 0.042
0.4AsnTrp: 0.4 ± 0.021
0.56AsnTyr: 0.56 ± 0.025
0.0AsnXaa: 0.0 ± 0.0
Pro
7.418ProAla: 7.418 ± 0.119
0.276ProCys: 0.276 ± 0.016
3.914ProAsp: 3.914 ± 0.067
3.73ProGlu: 3.73 ± 0.072
1.508ProPhe: 1.508 ± 0.044
5.257ProGly: 5.257 ± 0.087
0.944ProHis: 0.944 ± 0.031
2.252ProIle: 2.252 ± 0.053
1.406ProLys: 1.406 ± 0.042
5.053ProLeu: 5.053 ± 0.074
0.932ProMet: 0.932 ± 0.028
1.229ProAsn: 1.229 ± 0.04
2.377ProPro: 2.377 ± 0.07
1.778ProGln: 1.778 ± 0.048
3.016ProArg: 3.016 ± 0.067
3.97ProSer: 3.97 ± 0.08
3.759ProThr: 3.759 ± 0.091
4.99ProVal: 4.99 ± 0.08
0.937ProTrp: 0.937 ± 0.035
1.117ProTyr: 1.117 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
4.645GlnAla: 4.645 ± 0.083
0.165GlnCys: 0.165 ± 0.014
1.103GlnAsp: 1.103 ± 0.033
1.223GlnGlu: 1.223 ± 0.035
0.879GlnPhe: 0.879 ± 0.03
2.024GlnGly: 2.024 ± 0.052
0.574GlnHis: 0.574 ± 0.027
1.547GlnIle: 1.547 ± 0.037
0.578GlnLys: 0.578 ± 0.028
4.467GlnLeu: 4.467 ± 0.074
0.536GlnMet: 0.536 ± 0.023
0.593GlnAsn: 0.593 ± 0.025
2.109GlnPro: 2.109 ± 0.059
1.314GlnGln: 1.314 ± 0.039
2.659GlnArg: 2.659 ± 0.065
1.538GlnSer: 1.538 ± 0.041
1.624GlnThr: 1.624 ± 0.046
3.51GlnVal: 3.51 ± 0.069
0.547GlnTrp: 0.547 ± 0.027
0.638GlnTyr: 0.638 ± 0.024
0.0GlnXaa: 0.0 ± 0.0
Arg
7.703ArgAla: 7.703 ± 0.117
0.428ArgCys: 0.428 ± 0.02
3.304ArgAsp: 3.304 ± 0.067
3.501ArgGlu: 3.501 ± 0.067
2.202ArgPhe: 2.202 ± 0.057
4.789ArgGly: 4.789 ± 0.077
1.426ArgHis: 1.426 ± 0.043
3.159ArgIle: 3.159 ± 0.055
1.528ArgLys: 1.528 ± 0.047
8.046ArgLeu: 8.046 ± 0.126
1.578ArgMet: 1.578 ± 0.045
1.464ArgAsn: 1.464 ± 0.041
3.931ArgPro: 3.931 ± 0.07
2.409ArgGln: 2.409 ± 0.054
6.091ArgArg: 6.091 ± 0.118
3.955ArgSer: 3.955 ± 0.065
3.854ArgThr: 3.854 ± 0.073
5.454ArgVal: 5.454 ± 0.083
1.251ArgTrp: 1.251 ± 0.034
1.624ArgTyr: 1.624 ± 0.047
0.0ArgXaa: 0.0 ± 0.0
Ser
7.833SerAla: 7.833 ± 0.117
0.436SerCys: 0.436 ± 0.038
3.1SerAsp: 3.1 ± 0.061
2.793SerGlu: 2.793 ± 0.059
1.897SerPhe: 1.897 ± 0.061
6.285SerGly: 6.285 ± 0.096
1.056SerHis: 1.056 ± 0.03
2.435SerIle: 2.435 ± 0.058
1.347SerLys: 1.347 ± 0.04
5.962SerLeu: 5.962 ± 0.087
1.288SerMet: 1.288 ± 0.036
1.179SerAsn: 1.179 ± 0.037
3.339SerPro: 3.339 ± 0.066
1.783SerGln: 1.783 ± 0.048
3.721SerArg: 3.721 ± 0.071
3.816SerSer: 3.816 ± 0.088
3.612SerThr: 3.612 ± 0.082
4.969SerVal: 4.969 ± 0.101
1.223SerTrp: 1.223 ± 0.04
1.559SerTyr: 1.559 ± 0.049
0.0SerXaa: 0.0 ± 0.0
Thr
7.612ThrAla: 7.612 ± 0.14
0.428ThrCys: 0.428 ± 0.026
3.432ThrAsp: 3.432 ± 0.07
3.221ThrGlu: 3.221 ± 0.065
1.75ThrPhe: 1.75 ± 0.059
5.886ThrGly: 5.886 ± 0.117
0.998ThrHis: 0.998 ± 0.031
2.637ThrIle: 2.637 ± 0.06
1.667ThrLys: 1.667 ± 0.054
5.668ThrLeu: 5.668 ± 0.084
0.998ThrMet: 0.998 ± 0.034
1.386ThrAsn: 1.386 ± 0.068
3.79ThrPro: 3.79 ± 0.08
1.717ThrGln: 1.717 ± 0.041
3.385ThrArg: 3.385 ± 0.059
3.857ThrSer: 3.857 ± 0.086
3.824ThrThr: 3.824 ± 0.09
5.493ThrVal: 5.493 ± 0.133
0.995ThrTrp: 0.995 ± 0.032
1.285ThrTyr: 1.285 ± 0.036
0.0ThrXaa: 0.0 ± 0.0
Val
12.093ValAla: 12.093 ± 0.134
0.64ValCys: 0.64 ± 0.024
4.885ValAsp: 4.885 ± 0.078
4.656ValGlu: 4.656 ± 0.084
2.535ValPhe: 2.535 ± 0.06
7.243ValGly: 7.243 ± 0.104
1.536ValHis: 1.536 ± 0.042
4.328ValIle: 4.328 ± 0.074
1.847ValLys: 1.847 ± 0.05
9.401ValLeu: 9.401 ± 0.124
1.529ValMet: 1.529 ± 0.042
1.89ValAsn: 1.89 ± 0.041
4.825ValPro: 4.825 ± 0.079
2.264ValGln: 2.264 ± 0.046
5.724ValArg: 5.724 ± 0.077
5.123ValSer: 5.123 ± 0.082
5.441ValThr: 5.441 ± 0.129
8.396ValVal: 8.396 ± 0.119
1.094ValTrp: 1.094 ± 0.036
1.41ValTyr: 1.41 ± 0.037
0.0ValXaa: 0.0 ± 0.0
Trp
1.803TrpAla: 1.803 ± 0.054
0.142TrpCys: 0.142 ± 0.012
0.744TrpAsp: 0.744 ± 0.024
0.599TrpGlu: 0.599 ± 0.026
0.572TrpPhe: 0.572 ± 0.026
1.061TrpGly: 1.061 ± 0.038
0.336TrpHis: 0.336 ± 0.018
0.624TrpIle: 0.624 ± 0.027
0.376TrpLys: 0.376 ± 0.02
2.334TrpLeu: 2.334 ± 0.06
0.3TrpMet: 0.3 ± 0.017
0.375TrpAsn: 0.375 ± 0.02
0.875TrpPro: 0.875 ± 0.028
0.713TrpGln: 0.713 ± 0.029
1.296TrpArg: 1.296 ± 0.038
1.008TrpSer: 1.008 ± 0.033
1.07TrpThr: 1.07 ± 0.036
1.301TrpVal: 1.301 ± 0.041
0.447TrpTrp: 0.447 ± 0.023
0.334TrpTyr: 0.334 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.473TyrAla: 2.473 ± 0.045
0.183TyrCys: 0.183 ± 0.014
1.271TyrAsp: 1.271 ± 0.037
0.937TyrGlu: 0.937 ± 0.036
0.775TyrPhe: 0.775 ± 0.028
1.861TyrGly: 1.861 ± 0.042
0.407TyrHis: 0.407 ± 0.02
0.534TyrIle: 0.534 ± 0.025
0.364TyrLys: 0.364 ± 0.02
2.704TyrLeu: 2.704 ± 0.054
0.206TyrMet: 0.206 ± 0.016
0.468TyrAsn: 0.468 ± 0.025
1.289TyrPro: 1.289 ± 0.042
0.929TyrGln: 0.929 ± 0.032
1.8TyrArg: 1.8 ± 0.047
1.235TyrSer: 1.235 ± 0.041
1.19TyrThr: 1.19 ± 0.038
1.544TyrVal: 1.544 ± 0.042
0.364TyrTrp: 0.364 ± 0.02
0.553TyrTyr: 0.553 ± 0.026
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2964 proteins (985853 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski