Amino acid dipepetide frequency for Dissulfuribacter thermophilus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.71AlaAla: 4.71 ± 0.099	1.004AlaCys: 1.004 ± 0.042	2.792AlaAsp: 2.792 ± 0.069	3.877AlaGlu: 3.877 ± 0.083	3.385AlaPhe: 3.385 ± 0.073	4.99AlaGly: 4.99 ± 0.112	1.326AlaHis: 1.326 ± 0.047	6.126AlaIle: 6.126 ± 0.096	4.797AlaLys: 4.797 ± 0.089	8.255AlaLeu: 8.255 ± 0.125	1.942AlaMet: 1.942 ± 0.05	2.249AlaAsn: 2.249 ± 0.058	2.504AlaPro: 2.504 ± 0.053	2.432AlaGln: 2.432 ± 0.056	4.033AlaArg: 4.033 ± 0.078	4.011AlaSer: 4.011 ± 0.082	3.265AlaThr: 3.265 ± 0.083	4.585AlaVal: 4.585 ± 0.092	0.744AlaTrp: 0.744 ± 0.033	2.144AlaTyr: 2.144 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.928CysAla: 0.928 ± 0.035	0.2CysCys: 0.2 ± 0.016	0.541CysAsp: 0.541 ± 0.026	0.781CysGlu: 0.781 ± 0.03	0.632CysPhe: 0.632 ± 0.032	1.168CysGly: 1.168 ± 0.042	0.584CysHis: 0.584 ± 0.055	0.851CysIle: 0.851 ± 0.03	0.691CysLys: 0.691 ± 0.03	1.4CysLeu: 1.4 ± 0.051	0.28CysMet: 0.28 ± 0.02	0.439CysAsn: 0.439 ± 0.025	0.953CysPro: 0.953 ± 0.046	0.385CysGln: 0.385 ± 0.025	0.551CysArg: 0.551 ± 0.028	0.849CysSer: 0.849 ± 0.038	0.581CysThr: 0.581 ± 0.033	0.861CysVal: 0.861 ± 0.035	0.115CysTrp: 0.115 ± 0.014	0.375CysTyr: 0.375 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	3.561AspAla: 3.561 ± 0.065	0.857AspCys: 0.857 ± 0.036	2.436AspAsp: 2.436 ± 0.069	4.106AspGlu: 4.106 ± 0.08	2.749AspPhe: 2.749 ± 0.062	3.561AspGly: 3.561 ± 0.077	1.052AspHis: 1.052 ± 0.039	4.294AspIle: 4.294 ± 0.078	2.754AspLys: 2.754 ± 0.071	6.278AspLeu: 6.278 ± 0.089	1.145AspMet: 1.145 ± 0.04	1.476AspAsn: 1.476 ± 0.046	3.106AspPro: 3.106 ± 0.069	1.43AspGln: 1.43 ± 0.049	2.717AspArg: 2.717 ± 0.053	2.785AspSer: 2.785 ± 0.062	2.321AspThr: 2.321 ± 0.056	3.571AspVal: 3.571 ± 0.071	0.649AspTrp: 0.649 ± 0.034	1.79AspTyr: 1.79 ± 0.053	0.0AspXaa: 0.0 ± 0.0
Glu	6.123GluAla: 6.123 ± 0.101	0.672GluCys: 0.672 ± 0.032	4.002GluAsp: 4.002 ± 0.082	6.238GluGlu: 6.238 ± 0.114	2.838GluPhe: 2.838 ± 0.064	4.623GluGly: 4.623 ± 0.082	1.265GluHis: 1.265 ± 0.044	6.103GluIle: 6.103 ± 0.103	6.014GluLys: 6.014 ± 0.103	7.419GluLeu: 7.419 ± 0.114	1.664GluMet: 1.664 ± 0.044	2.601GluAsn: 2.601 ± 0.06	2.361GluPro: 2.361 ± 0.052	2.072GluGln: 2.072 ± 0.055	4.501GluArg: 4.501 ± 0.09	3.146GluSer: 3.146 ± 0.066	3.1GluThr: 3.1 ± 0.07	5.094GluVal: 5.094 ± 0.085	0.64GluTrp: 0.64 ± 0.031	1.79GluTyr: 1.79 ± 0.053	0.0GluXaa: 0.0 ± 0.0
Phe	2.48PheAla: 2.48 ± 0.064	0.68PheCys: 0.68 ± 0.033	2.532PheAsp: 2.532 ± 0.064	3.114PheGlu: 3.114 ± 0.068	2.64PhePhe: 2.64 ± 0.081	3.264PheGly: 3.264 ± 0.077	0.9PheHis: 0.9 ± 0.033	3.122PheIle: 3.122 ± 0.064	2.948PheLys: 2.948 ± 0.077	5.215PheLeu: 5.215 ± 0.1	1.043PheMet: 1.043 ± 0.04	1.706PheAsn: 1.706 ± 0.054	1.921PhePro: 1.921 ± 0.052	1.209PheGln: 1.209 ± 0.042	2.121PheArg: 2.121 ± 0.062	3.506PheSer: 3.506 ± 0.077	2.206PheThr: 2.206 ± 0.059	2.965PheVal: 2.965 ± 0.072	0.604PheTrp: 0.604 ± 0.024	1.505PheTyr: 1.505 ± 0.05	0.0PheXaa: 0.0 ± 0.0
Gly	5.341GlyAla: 5.341 ± 0.106	1.041GlyCys: 1.041 ± 0.044	3.662GlyAsp: 3.662 ± 0.074	4.557GlyGlu: 4.557 ± 0.081	3.354GlyPhe: 3.354 ± 0.071	5.197GlyGly: 5.197 ± 0.118	1.65GlyHis: 1.65 ± 0.051	6.51GlyIle: 6.51 ± 0.1	5.329GlyLys: 5.329 ± 0.097	8.189GlyLeu: 8.189 ± 0.125	1.732GlyMet: 1.732 ± 0.055	2.346GlyAsn: 2.346 ± 0.067	2.852GlyPro: 2.852 ± 0.066	2.102GlyGln: 2.102 ± 0.057	3.909GlyArg: 3.909 ± 0.087	3.879GlySer: 3.879 ± 0.082	4.003GlyThr: 4.003 ± 0.078	5.365GlyVal: 5.365 ± 0.094	0.787GlyTrp: 0.787 ± 0.031	2.394GlyTyr: 2.394 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	1.25HisAla: 1.25 ± 0.039	0.319HisCys: 0.319 ± 0.019	0.94HisAsp: 0.94 ± 0.033	1.31HisGlu: 1.31 ± 0.042	0.947HisPhe: 0.947 ± 0.037	1.638HisGly: 1.638 ± 0.05	0.516HisHis: 0.516 ± 0.027	1.48HisIle: 1.48 ± 0.046	0.992HisLys: 0.992 ± 0.036	2.17HisLeu: 2.17 ± 0.062	0.452HisMet: 0.452 ± 0.028	0.647HisAsn: 0.647 ± 0.028	1.246HisPro: 1.246 ± 0.039	0.565HisGln: 0.565 ± 0.027	1.028HisArg: 1.028 ± 0.04	1.147HisSer: 1.147 ± 0.038	0.881HisThr: 0.881 ± 0.033	1.221HisVal: 1.221 ± 0.043	0.263HisTrp: 0.263 ± 0.016	0.652HisTyr: 0.652 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	4.917IleAla: 4.917 ± 0.096	0.94IleCys: 0.94 ± 0.035	4.313IleAsp: 4.313 ± 0.079	5.988IleGlu: 5.988 ± 0.092	3.517IlePhe: 3.517 ± 0.069	5.683IleGly: 5.683 ± 0.094	1.582IleHis: 1.582 ± 0.051	5.194IleIle: 5.194 ± 0.097	5.425IleLys: 5.425 ± 0.091	7.736IleLeu: 7.736 ± 0.118	1.496IleMet: 1.496 ± 0.046	2.857IleAsn: 2.857 ± 0.063	3.89IlePro: 3.89 ± 0.074	2.181IleGln: 2.181 ± 0.06	4.13IleArg: 4.13 ± 0.066	5.061IleSer: 5.061 ± 0.088	3.81IleThr: 3.81 ± 0.078	5.195IleVal: 5.195 ± 0.101	0.704IleTrp: 0.704 ± 0.031	2.124IleTyr: 2.124 ± 0.051	0.0IleXaa: 0.0 ± 0.0
Lys	5.733LysAla: 5.733 ± 0.093	0.705LysCys: 0.705 ± 0.034	4.625LysAsp: 4.625 ± 0.082	6.77LysGlu: 6.77 ± 0.096	2.168LysPhe: 2.168 ± 0.052	5.844LysGly: 5.844 ± 0.105	1.028LysHis: 1.028 ± 0.041	5.503LysIle: 5.503 ± 0.094	6.507LysLys: 6.507 ± 0.118	4.983LysLeu: 4.983 ± 0.085	1.648LysMet: 1.648 ± 0.051	2.922LysAsn: 2.922 ± 0.075	2.073LysPro: 2.073 ± 0.054	1.732LysGln: 1.732 ± 0.047	4.801LysArg: 4.801 ± 0.099	3.274LysSer: 3.274 ± 0.078	3.377LysThr: 3.377 ± 0.068	4.781LysVal: 4.781 ± 0.077	0.692LysTrp: 0.692 ± 0.036	1.8LysTyr: 1.8 ± 0.06	0.0LysXaa: 0.0 ± 0.0
Leu	6.768LeuAla: 6.768 ± 0.124	1.273LeuCys: 1.273 ± 0.034	5.386LeuAsp: 5.386 ± 0.073	7.592LeuGlu: 7.592 ± 0.092	4.754LeuPhe: 4.754 ± 0.111	7.595LeuGly: 7.595 ± 0.122	1.689LeuHis: 1.689 ± 0.046	7.18LeuIle: 7.18 ± 0.099	8.909LeuLys: 8.909 ± 0.142	9.667LeuLeu: 9.667 ± 0.153	2.217LeuMet: 2.217 ± 0.057	4.055LeuAsn: 4.055 ± 0.074	4.518LeuPro: 4.518 ± 0.078	2.636LeuGln: 2.636 ± 0.062	5.875LeuArg: 5.875 ± 0.094	7.495LeuSer: 7.495 ± 0.109	4.85LeuThr: 4.85 ± 0.078	6.452LeuVal: 6.452 ± 0.1	1.036LeuTrp: 1.036 ± 0.035	2.956LeuTyr: 2.956 ± 0.067	0.0LeuXaa: 0.0 ± 0.0
Met	2.334MetAla: 2.334 ± 0.062	0.217MetCys: 0.217 ± 0.017	1.394MetAsp: 1.394 ± 0.046	1.716MetGlu: 1.716 ± 0.047	0.735MetPhe: 0.735 ± 0.032	1.814MetGly: 1.814 ± 0.05	0.375MetHis: 0.375 ± 0.024	1.336MetIle: 1.336 ± 0.047	1.734MetLys: 1.734 ± 0.041	1.957MetLeu: 1.957 ± 0.052	0.472MetMet: 0.472 ± 0.024	0.968MetAsn: 0.968 ± 0.039	1.123MetPro: 1.123 ± 0.038	0.539MetGln: 0.539 ± 0.027	1.244MetArg: 1.244 ± 0.04	1.232MetSer: 1.232 ± 0.039	1.111MetThr: 1.111 ± 0.035	1.582MetVal: 1.582 ± 0.049	0.189MetTrp: 0.189 ± 0.015	0.451MetTyr: 0.451 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	2.493AsnAla: 2.493 ± 0.065	0.581AsnCys: 0.581 ± 0.03	1.618AsnAsp: 1.618 ± 0.051	2.252AsnGlu: 2.252 ± 0.056	1.654AsnPhe: 1.654 ± 0.052	2.656AsnGly: 2.656 ± 0.07	0.683AsnHis: 0.683 ± 0.034	2.946AsnIle: 2.946 ± 0.063	2.132AsnLys: 2.132 ± 0.054	3.842AsnLeu: 3.842 ± 0.076	0.848AsnMet: 0.848 ± 0.034	1.216AsnAsn: 1.216 ± 0.045	2.254AsnPro: 2.254 ± 0.052	1.081AsnGln: 1.081 ± 0.034	1.997AsnArg: 1.997 ± 0.046	2.073AsnSer: 2.073 ± 0.062	1.696AsnThr: 1.696 ± 0.046	2.268AsnVal: 2.268 ± 0.059	0.457AsnTrp: 0.457 ± 0.024	1.088AsnTyr: 1.088 ± 0.046	0.0AsnXaa: 0.0 ± 0.0
Pro	2.238ProAla: 2.238 ± 0.065	0.549ProCys: 0.549 ± 0.03	2.74ProAsp: 2.74 ± 0.068	3.874ProGlu: 3.874 ± 0.078	2.261ProPhe: 2.261 ± 0.052	3.611ProGly: 3.611 ± 0.089	0.904ProHis: 0.904 ± 0.031	3.225ProIle: 3.225 ± 0.073	3.042ProLys: 3.042 ± 0.064	4.165ProLeu: 4.165 ± 0.083	0.948ProMet: 0.948 ± 0.035	1.761ProAsn: 1.761 ± 0.05	1.94ProPro: 1.94 ± 0.056	1.457ProGln: 1.457 ± 0.044	2.08ProArg: 2.08 ± 0.056	2.724ProSer: 2.724 ± 0.056	2.045ProThr: 2.045 ± 0.051	3.425ProVal: 3.425 ± 0.077	0.603ProTrp: 0.603 ± 0.031	1.582ProTyr: 1.582 ± 0.047	0.0ProXaa: 0.0 ± 0.0
Gln	2.321GlnAla: 2.321 ± 0.056	0.363GlnCys: 0.363 ± 0.027	1.616GlnAsp: 1.616 ± 0.037	2.43GlnGlu: 2.43 ± 0.057	1.059GlnPhe: 1.059 ± 0.036	2.296GlnGly: 2.296 ± 0.059	0.499GlnHis: 0.499 ± 0.028	2.048GlnIle: 2.048 ± 0.054	2.529GlnLys: 2.529 ± 0.068	2.349GlnLeu: 2.349 ± 0.057	0.753GlnMet: 0.753 ± 0.033	1.158GlnAsn: 1.158 ± 0.042	0.963GlnPro: 0.963 ± 0.034	0.755GlnGln: 0.755 ± 0.03	1.848GlnArg: 1.848 ± 0.05	1.44GlnSer: 1.44 ± 0.043	1.257GlnThr: 1.257 ± 0.046	1.982GlnVal: 1.982 ± 0.058	0.341GlnTrp: 0.341 ± 0.02	0.915GlnTyr: 0.915 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	3.939ArgAla: 3.939 ± 0.074	0.675ArgCys: 0.675 ± 0.034	2.981ArgAsp: 2.981 ± 0.068	4.153ArgGlu: 4.153 ± 0.091	2.7ArgPhe: 2.7 ± 0.062	3.577ArgGly: 3.577 ± 0.069	1.113ArgHis: 1.113 ± 0.041	4.317ArgIle: 4.317 ± 0.071	3.33ArgLys: 3.33 ± 0.079	6.619ArgLeu: 6.619 ± 0.098	1.232ArgMet: 1.232 ± 0.04	1.761ArgAsn: 1.761 ± 0.048	2.738ArgPro: 2.738 ± 0.059	1.836ArgGln: 1.836 ± 0.048	3.402ArgArg: 3.402 ± 0.081	2.897ArgSer: 2.897 ± 0.07	2.373ArgThr: 2.373 ± 0.051	3.466ArgVal: 3.466 ± 0.071	0.603ArgTrp: 0.603 ± 0.03	1.894ArgTyr: 1.894 ± 0.056	0.0ArgXaa: 0.0 ± 0.0
Ser	3.519SerAla: 3.519 ± 0.067	0.845SerCys: 0.845 ± 0.034	2.65SerAsp: 2.65 ± 0.059	3.338SerGlu: 3.338 ± 0.067	3.026SerPhe: 3.026 ± 0.065	4.749SerGly: 4.749 ± 0.088	1.278SerHis: 1.278 ± 0.042	4.751SerIle: 4.751 ± 0.088	3.861SerLys: 3.861 ± 0.077	6.164SerLeu: 6.164 ± 0.096	1.425SerMet: 1.425 ± 0.045	2.092SerAsn: 2.092 ± 0.06	2.93SerPro: 2.93 ± 0.068	1.889SerGln: 1.889 ± 0.057	3.192SerArg: 3.192 ± 0.066	3.879SerSer: 3.879 ± 0.087	2.752SerThr: 2.752 ± 0.065	3.843SerVal: 3.843 ± 0.077	0.733SerTrp: 0.733 ± 0.032	1.852SerTyr: 1.852 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	3.029ThrAla: 3.029 ± 0.065	0.656ThrCys: 0.656 ± 0.035	2.31ThrAsp: 2.31 ± 0.06	2.608ThrGlu: 2.608 ± 0.062	2.105ThrPhe: 2.105 ± 0.057	4.325ThrGly: 4.325 ± 0.084	0.961ThrHis: 0.961 ± 0.037	3.989ThrIle: 3.989 ± 0.076	2.753ThrLys: 2.753 ± 0.066	4.947ThrLeu: 4.947 ± 0.087	0.953ThrMet: 0.953 ± 0.035	1.682ThrAsn: 1.682 ± 0.049	2.657ThrPro: 2.657 ± 0.06	1.492ThrGln: 1.492 ± 0.05	2.27ThrArg: 2.27 ± 0.053	2.613ThrSer: 2.613 ± 0.065	2.324ThrThr: 2.324 ± 0.059	3.412ThrVal: 3.412 ± 0.068	0.496ThrTrp: 0.496 ± 0.029	1.489ThrTyr: 1.489 ± 0.047	0.0ThrXaa: 0.0 ± 0.0
Val	4.842ValAla: 4.842 ± 0.106	0.919ValCys: 0.919 ± 0.036	3.838ValAsp: 3.838 ± 0.081	4.806ValGlu: 4.806 ± 0.079	3.125ValPhe: 3.125 ± 0.077	4.513ValGly: 4.513 ± 0.096	1.338ValHis: 1.338 ± 0.046	4.99ValIle: 4.99 ± 0.092	4.733ValLys: 4.733 ± 0.083	7.038ValLeu: 7.038 ± 0.11	1.434ValMet: 1.434 ± 0.043	2.368ValAsn: 2.368 ± 0.06	3.153ValPro: 3.153 ± 0.068	1.886ValGln: 1.886 ± 0.044	3.571ValArg: 3.571 ± 0.069	4.225ValSer: 4.225 ± 0.068	3.386ValThr: 3.386 ± 0.075	5.249ValVal: 5.249 ± 0.098	0.607ValTrp: 0.607 ± 0.03	1.798ValTyr: 1.798 ± 0.055	0.0ValXaa: 0.0 ± 0.0
Trp	0.771TrpAla: 0.771 ± 0.032	0.133TrpCys: 0.133 ± 0.013	0.664TrpAsp: 0.664 ± 0.035	0.74TrpGlu: 0.74 ± 0.033	0.481TrpPhe: 0.481 ± 0.025	0.743TrpGly: 0.743 ± 0.032	0.264TrpHis: 0.264 ± 0.02	0.849TrpIle: 0.849 ± 0.04	0.687TrpLys: 0.687 ± 0.031	1.16TrpLeu: 1.16 ± 0.041	0.259TrpMet: 0.259 ± 0.017	0.441TrpAsn: 0.441 ± 0.029	0.448TrpPro: 0.448 ± 0.024	0.355TrpGln: 0.355 ± 0.022	0.637TrpArg: 0.637 ± 0.026	0.548TrpSer: 0.548 ± 0.029	0.472TrpThr: 0.472 ± 0.029	0.683TrpVal: 0.683 ± 0.029	0.192TrpTrp: 0.192 ± 0.016	0.356TrpTyr: 0.356 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.873TyrAla: 1.873 ± 0.06	0.535TyrCys: 0.535 ± 0.027	1.6TyrAsp: 1.6 ± 0.044	2.016TyrGlu: 2.016 ± 0.054	1.552TyrPhe: 1.552 ± 0.048	2.353TyrGly: 2.353 ± 0.061	0.656TyrHis: 0.656 ± 0.032	1.929TyrIle: 1.929 ± 0.051	1.8TyrLys: 1.8 ± 0.053	3.35TyrLeu: 3.35 ± 0.079	0.579TyrMet: 0.579 ± 0.029	1.089TyrAsn: 1.089 ± 0.039	1.544TyrPro: 1.544 ± 0.042	0.887TyrGln: 0.887 ± 0.038	1.7TyrArg: 1.7 ± 0.046	1.986TyrSer: 1.986 ± 0.048	1.261TyrThr: 1.261 ± 0.038	1.818TyrVal: 1.818 ± 0.046	0.428TyrTrp: 0.428 ± 0.024	1.061TyrTyr: 1.061 ± 0.042	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2462 proteins (750110 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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