Amino acid dipepetide frequency for Pan paniscus (Pygmy chimpanzee) (Bonobo)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.43AlaAla: 6.43 ± 0.035	1.377AlaCys: 1.377 ± 0.01	2.884AlaAsp: 2.884 ± 0.012	4.761AlaGlu: 4.761 ± 0.024	2.642AlaPhe: 2.642 ± 0.014	4.578AlaGly: 4.578 ± 0.022	1.561AlaHis: 1.561 ± 0.01	2.81AlaIle: 2.81 ± 0.012	3.436AlaLys: 3.436 ± 0.018	7.032AlaLeu: 7.032 ± 0.027	1.507AlaMet: 1.507 ± 0.009	2.036AlaAsn: 2.036 ± 0.01	3.996AlaPro: 3.996 ± 0.022	3.255AlaGln: 3.255 ± 0.017	3.546AlaArg: 3.546 ± 0.018	5.649AlaSer: 5.649 ± 0.022	3.589AlaThr: 3.589 ± 0.016	4.65AlaVal: 4.65 ± 0.021	0.809AlaTrp: 0.809 ± 0.007	1.521AlaTyr: 1.521 ± 0.01	0.004AlaXaa: 0.004 ± 0.0
Cys	1.224CysAla: 1.224 ± 0.01	0.654CysCys: 0.654 ± 0.008	1.026CysAsp: 1.026 ± 0.011	1.306CysGlu: 1.306 ± 0.014	0.849CysPhe: 0.849 ± 0.007	1.753CysGly: 1.753 ± 0.017	0.684CysHis: 0.684 ± 0.007	0.967CysIle: 0.967 ± 0.009	1.18CysLys: 1.18 ± 0.011	2.21CysLeu: 2.21 ± 0.013	0.427CysMet: 0.427 ± 0.005	0.838CysAsn: 0.838 ± 0.009	1.386CysPro: 1.386 ± 0.013	1.085CysGln: 1.085 ± 0.011	1.292CysArg: 1.292 ± 0.011	2.002CysSer: 2.002 ± 0.014	1.113CysThr: 1.113 ± 0.01	1.304CysVal: 1.304 ± 0.01	0.305CysTrp: 0.305 ± 0.004	0.575CysTyr: 0.575 ± 0.006	0.001CysXaa: 0.001 ± 0.0
Asp	2.881AspAla: 2.881 ± 0.013	1.067AspCys: 1.067 ± 0.01	2.644AspAsp: 2.644 ± 0.016	3.467AspGlu: 3.467 ± 0.017	2.124AspPhe: 2.124 ± 0.012	3.313AspGly: 3.313 ± 0.022	1.14AspHis: 1.14 ± 0.007	2.639AspIle: 2.639 ± 0.013	2.568AspLys: 2.568 ± 0.015	5.039AspLeu: 5.039 ± 0.019	1.119AspMet: 1.119 ± 0.008	1.702AspAsn: 1.702 ± 0.011	2.893AspPro: 2.893 ± 0.013	1.839AspGln: 1.839 ± 0.01	2.419AspArg: 2.419 ± 0.014	4.181AspSer: 4.181 ± 0.018	2.48AspThr: 2.48 ± 0.012	3.096AspVal: 3.096 ± 0.017	0.628AspTrp: 0.628 ± 0.006	1.502AspTyr: 1.502 ± 0.009	0.001AspXaa: 0.001 ± 0.0
Glu	5.258GluAla: 5.258 ± 0.027	1.488GluCys: 1.488 ± 0.019	4.493GluAsp: 4.493 ± 0.021	8.039GluGlu: 8.039 ± 0.037	2.078GluPhe: 2.078 ± 0.011	4.195GluGly: 4.195 ± 0.021	1.534GluHis: 1.534 ± 0.009	3.242GluIle: 3.242 ± 0.016	5.495GluLys: 5.495 ± 0.03	6.534GluLeu: 6.534 ± 0.027	1.705GluMet: 1.705 ± 0.01	3.238GluAsn: 3.238 ± 0.013	3.187GluPro: 3.187 ± 0.018	3.179GluGln: 3.179 ± 0.016	3.998GluArg: 3.998 ± 0.02	4.4GluSer: 4.4 ± 0.019	3.439GluThr: 3.439 ± 0.017	4.207GluVal: 4.207 ± 0.018	0.717GluTrp: 0.717 ± 0.006	1.625GluTyr: 1.625 ± 0.012	0.001GluXaa: 0.001 ± 0.0
Phe	1.961PheAla: 1.961 ± 0.01	0.934PheCys: 0.934 ± 0.008	1.695PheAsp: 1.695 ± 0.009	2.033PheGlu: 2.033 ± 0.011	1.588PhePhe: 1.588 ± 0.011	2.198PheGly: 2.198 ± 0.012	1.062PheHis: 1.062 ± 0.008	1.838PheIle: 1.838 ± 0.011	1.832PheLys: 1.832 ± 0.01	4.082PheLeu: 4.082 ± 0.019	0.78PheMet: 0.78 ± 0.007	1.361PheAsn: 1.361 ± 0.011	2.019PhePro: 2.019 ± 0.01	1.814PheGln: 1.814 ± 0.011	1.973PheArg: 1.973 ± 0.013	3.427PheSer: 3.427 ± 0.017	2.055PheThr: 2.055 ± 0.011	2.135PheVal: 2.135 ± 0.011	0.497PheTrp: 0.497 ± 0.005	1.177PheTyr: 1.177 ± 0.008	0.001PheXaa: 0.001 ± 0.0
Gly	4.332GlyAla: 4.332 ± 0.022	1.288GlyCys: 1.288 ± 0.011	3.145GlyAsp: 3.145 ± 0.015	4.171GlyGlu: 4.171 ± 0.023	2.415GlyPhe: 2.415 ± 0.013	4.849GlyGly: 4.849 ± 0.029	1.683GlyHis: 1.683 ± 0.011	2.799GlyIle: 2.799 ± 0.014	3.871GlyLys: 3.871 ± 0.016	5.855GlyLeu: 5.855 ± 0.02	1.335GlyMet: 1.335 ± 0.009	2.39GlyAsn: 2.39 ± 0.013	4.135GlyPro: 4.135 ± 0.032	2.777GlyGln: 2.777 ± 0.014	3.707GlyArg: 3.707 ± 0.018	5.719GlySer: 5.719 ± 0.021	3.56GlyThr: 3.56 ± 0.015	3.542GlyVal: 3.542 ± 0.019	0.802GlyTrp: 0.802 ± 0.008	1.727GlyTyr: 1.727 ± 0.012	0.003GlyXaa: 0.003 ± 0.0
His	1.32HisAla: 1.32 ± 0.009	0.747HisCys: 0.747 ± 0.007	0.903HisAsp: 0.903 ± 0.007	1.345HisGlu: 1.345 ± 0.009	1.088HisPhe: 1.088 ± 0.006	1.561HisGly: 1.561 ± 0.009	0.901HisHis: 0.901 ± 0.009	1.278HisIle: 1.278 ± 0.008	1.298HisLys: 1.298 ± 0.009	2.972HisLeu: 2.972 ± 0.014	0.596HisMet: 0.596 ± 0.006	0.88HisAsn: 0.88 ± 0.007	1.661HisPro: 1.661 ± 0.01	1.38HisGln: 1.38 ± 0.01	1.597HisArg: 1.597 ± 0.01	2.32HisSer: 2.32 ± 0.013	1.562HisThr: 1.562 ± 0.012	1.486HisVal: 1.486 ± 0.01	0.35HisTrp: 0.35 ± 0.004	0.808HisTyr: 0.808 ± 0.007	0.001HisXaa: 0.001 ± 0.0
Ile	2.601IleAla: 2.601 ± 0.013	1.102IleCys: 1.102 ± 0.009	2.052IleAsp: 2.052 ± 0.012	2.635IleGlu: 2.635 ± 0.016	1.918IlePhe: 1.918 ± 0.013	2.227IleGly: 2.227 ± 0.013	1.403IleHis: 1.403 ± 0.01	2.436IleIle: 2.436 ± 0.014	2.692IleLys: 2.692 ± 0.014	4.629IleLeu: 4.629 ± 0.019	1.008IleMet: 1.008 ± 0.006	1.885IleAsn: 1.885 ± 0.011	2.629IlePro: 2.629 ± 0.013	2.351IleGln: 2.351 ± 0.014	2.399IleArg: 2.399 ± 0.013	3.755IleSer: 3.755 ± 0.016	2.599IleThr: 2.599 ± 0.016	2.517IleVal: 2.517 ± 0.016	0.522IleTrp: 0.522 ± 0.005	1.404IleTyr: 1.404 ± 0.01	0.001IleXaa: 0.001 ± 0.0
Lys	4.039LysAla: 4.039 ± 0.02	1.194LysCys: 1.194 ± 0.012	3.204LysAsp: 3.204 ± 0.017	5.211LysGlu: 5.211 ± 0.03	1.758LysPhe: 1.758 ± 0.01	3.273LysGly: 3.273 ± 0.019	1.423LysHis: 1.423 ± 0.01	2.855LysIle: 2.855 ± 0.014	4.727LysLys: 4.727 ± 0.029	5.263LysLeu: 5.263 ± 0.02	1.469LysMet: 1.469 ± 0.01	2.446LysAsn: 2.446 ± 0.012	3.144LysPro: 3.144 ± 0.018	2.658LysGln: 2.658 ± 0.014	3.321LysArg: 3.321 ± 0.017	3.925LysSer: 3.925 ± 0.02	3.149LysThr: 3.149 ± 0.013	3.496LysVal: 3.496 ± 0.018	0.62LysTrp: 0.62 ± 0.006	1.589LysTyr: 1.589 ± 0.009	0.001LysXaa: 0.001 ± 0.0
Leu	6.709LeuAla: 6.709 ± 0.026	2.211LeuCys: 2.211 ± 0.013	4.738LeuAsp: 4.738 ± 0.016	7.286LeuGlu: 7.286 ± 0.032	3.388LeuPhe: 3.388 ± 0.018	5.847LeuGly: 5.847 ± 0.022	2.761LeuHis: 2.761 ± 0.015	3.942LeuIle: 3.942 ± 0.017	5.899LeuLys: 5.899 ± 0.024	10.759LeuLeu: 10.759 ± 0.041	2.024LeuMet: 2.024 ± 0.011	3.541LeuAsn: 3.541 ± 0.018	5.972LeuPro: 5.972 ± 0.021	5.861LeuGln: 5.861 ± 0.028	5.865LeuArg: 5.865 ± 0.021	7.939LeuSer: 7.939 ± 0.027	5.121LeuThr: 5.121 ± 0.018	5.491LeuVal: 5.491 ± 0.021	1.148LeuTrp: 1.148 ± 0.009	2.546LeuTyr: 2.546 ± 0.011	0.003LeuXaa: 0.003 ± 0.0
Met	1.908MetAla: 1.908 ± 0.01	0.408MetCys: 0.408 ± 0.005	1.264MetAsp: 1.264 ± 0.007	1.912MetGlu: 1.912 ± 0.009	0.736MetPhe: 0.736 ± 0.006	1.322MetGly: 1.322 ± 0.01	0.479MetHis: 0.479 ± 0.005	0.862MetIle: 0.862 ± 0.007	1.477MetLys: 1.477 ± 0.009	1.995MetLeu: 1.995 ± 0.011	0.574MetMet: 0.574 ± 0.005	0.923MetAsn: 0.923 ± 0.008	1.104MetPro: 1.104 ± 0.011	0.931MetGln: 0.931 ± 0.008	1.059MetArg: 1.059 ± 0.007	1.573MetSer: 1.573 ± 0.01	1.135MetThr: 1.135 ± 0.007	1.39MetVal: 1.39 ± 0.009	0.247MetTrp: 0.247 ± 0.004	0.57MetTyr: 0.57 ± 0.005	0.001MetXaa: 0.001 ± 0.0
Asn	2.064AsnAla: 2.064 ± 0.011	0.855AsnCys: 0.855 ± 0.008	1.553AsnAsp: 1.553 ± 0.01	2.295AsnGlu: 2.295 ± 0.012	1.502AsnPhe: 1.502 ± 0.009	2.468AsnGly: 2.468 ± 0.014	0.978AsnHis: 0.978 ± 0.007	2.173AsnIle: 2.173 ± 0.012	2.26AsnLys: 2.26 ± 0.013	3.808AsnLeu: 3.808 ± 0.016	0.924AsnMet: 0.924 ± 0.007	1.562AsnAsn: 1.562 ± 0.012	2.193AsnPro: 2.193 ± 0.012	1.673AsnGln: 1.673 ± 0.012	1.862AsnArg: 1.862 ± 0.009	3.171AsnSer: 3.171 ± 0.014	1.971AsnThr: 1.971 ± 0.011	2.211AsnVal: 2.211 ± 0.011	0.46AsnTrp: 0.46 ± 0.005	1.144AsnTyr: 1.144 ± 0.008	0.0AsnXaa: 0.0 ± 0.0
Pro	4.677ProAla: 4.677 ± 0.024	1.138ProCys: 1.138 ± 0.011	2.773ProAsp: 2.773 ± 0.014	4.416ProGlu: 4.416 ± 0.02	1.914ProPhe: 1.914 ± 0.012	5.143ProGly: 5.143 ± 0.037	1.457ProHis: 1.457 ± 0.01	1.926ProIle: 1.926 ± 0.011	2.774ProLys: 2.774 ± 0.018	5.189ProLeu: 5.189 ± 0.019	1.062ProMet: 1.062 ± 0.009	1.839ProAsn: 1.839 ± 0.011	5.808ProPro: 5.808 ± 0.038	2.82ProGln: 2.82 ± 0.015	3.289ProArg: 3.289 ± 0.018	5.627ProSer: 5.627 ± 0.023	3.091ProThr: 3.091 ± 0.017	3.763ProVal: 3.763 ± 0.017	0.71ProTrp: 0.71 ± 0.007	1.538ProTyr: 1.538 ± 0.012	0.004ProXaa: 0.004 ± 0.0
Gln	3.544GlnAla: 3.544 ± 0.019	0.965GlnCys: 0.965 ± 0.01	2.356GlnAsp: 2.356 ± 0.013	3.994GlnGlu: 3.994 ± 0.02	1.386GlnPhe: 1.386 ± 0.008	2.88GlnGly: 2.88 ± 0.014	1.308GlnHis: 1.308 ± 0.01	2.026GlnIle: 2.026 ± 0.011	3.023GlnLys: 3.023 ± 0.016	4.762GlnLeu: 4.762 ± 0.024	1.137GlnMet: 1.137 ± 0.008	1.891GlnAsn: 1.891 ± 0.012	2.791GlnPro: 2.791 ± 0.016	3.144GlnGln: 3.144 ± 0.029	2.982GlnArg: 2.982 ± 0.017	3.13GlnSer: 3.13 ± 0.016	2.295GlnThr: 2.295 ± 0.013	2.834GlnVal: 2.834 ± 0.012	0.564GlnTrp: 0.564 ± 0.005	1.166GlnTyr: 1.166 ± 0.008	0.001GlnXaa: 0.001 ± 0.0
Arg	3.748ArgAla: 3.748 ± 0.017	1.222ArgCys: 1.222 ± 0.012	2.748ArgAsp: 2.748 ± 0.012	3.964ArgGlu: 3.964 ± 0.019	1.842ArgPhe: 1.842 ± 0.008	3.58ArgGly: 3.58 ± 0.02	1.541ArgHis: 1.541 ± 0.01	2.477ArgIle: 2.477 ± 0.012	3.685ArgLys: 3.685 ± 0.017	5.377ArgLeu: 5.377 ± 0.021	1.212ArgMet: 1.212 ± 0.009	2.16ArgAsn: 2.16 ± 0.011	3.169ArgPro: 3.169 ± 0.017	2.625ArgGln: 2.625 ± 0.014	4.223ArgArg: 4.223 ± 0.025	4.215ArgSer: 4.215 ± 0.024	2.811ArgThr: 2.811 ± 0.013	3.143ArgVal: 3.143 ± 0.019	0.715ArgTrp: 0.715 ± 0.007	1.45ArgTyr: 1.45 ± 0.009	0.002ArgXaa: 0.002 ± 0.0
Ser	5.209SerAla: 5.209 ± 0.02	1.866SerCys: 1.866 ± 0.013	3.873SerAsp: 3.873 ± 0.017	5.211SerGlu: 5.211 ± 0.021	3.064SerPhe: 3.064 ± 0.014	5.549SerGly: 5.549 ± 0.021	2.15SerHis: 2.15 ± 0.012	3.214SerIle: 3.214 ± 0.015	4.105SerLys: 4.105 ± 0.021	8.22SerLeu: 8.22 ± 0.029	1.608SerMet: 1.608 ± 0.009	2.731SerAsn: 2.731 ± 0.016	5.885SerPro: 5.885 ± 0.03	3.891SerGln: 3.891 ± 0.017	4.521SerArg: 4.521 ± 0.023	9.217SerSer: 9.217 ± 0.046	4.44SerThr: 4.44 ± 0.021	4.823SerVal: 4.823 ± 0.019	1.104SerTrp: 1.104 ± 0.008	2.09SerTyr: 2.09 ± 0.01	0.003SerXaa: 0.003 ± 0.0
Thr	3.741ThrAla: 3.741 ± 0.018	1.303ThrCys: 1.303 ± 0.012	2.469ThrAsp: 2.469 ± 0.012	3.557ThrGlu: 3.557 ± 0.017	2.102ThrPhe: 2.102 ± 0.012	3.57ThrGly: 3.57 ± 0.019	1.348ThrHis: 1.348 ± 0.009	2.41ThrIle: 2.41 ± 0.014	2.691ThrLys: 2.691 ± 0.013	5.288ThrLeu: 5.288 ± 0.018	1.127ThrMet: 1.127 ± 0.008	1.77ThrAsn: 1.77 ± 0.01	3.557ThrPro: 3.557 ± 0.02	2.312ThrGln: 2.312 ± 0.012	2.47ThrArg: 2.47 ± 0.011	4.613ThrSer: 4.613 ± 0.024	3.017ThrThr: 3.017 ± 0.023	3.839ThrVal: 3.839 ± 0.02	0.712ThrTrp: 0.712 ± 0.008	1.438ThrTyr: 1.438 ± 0.01	0.002ThrXaa: 0.002 ± 0.0
Val	4.235ValAla: 4.235 ± 0.016	1.431ValCys: 1.431 ± 0.01	2.958ValAsp: 2.958 ± 0.015	3.883ValGlu: 3.883 ± 0.019	2.403ValPhe: 2.403 ± 0.012	3.379ValGly: 3.379 ± 0.015	1.566ValHis: 1.566 ± 0.009	2.921ValIle: 2.921 ± 0.014	3.41ValLys: 3.41 ± 0.019	6.144ValLeu: 6.144 ± 0.021	1.326ValMet: 1.326 ± 0.009	2.272ValAsn: 2.272 ± 0.013	3.587ValPro: 3.587 ± 0.017	2.742ValGln: 2.742 ± 0.013	3.018ValArg: 3.018 ± 0.012	4.826ValSer: 4.826 ± 0.02	3.763ValThr: 3.763 ± 0.026	3.961ValVal: 3.961 ± 0.02	0.722ValTrp: 0.722 ± 0.006	1.623ValTyr: 1.623 ± 0.01	0.001ValXaa: 0.001 ± 0.0
Trp	0.797TrpAla: 0.797 ± 0.006	0.253TrpCys: 0.253 ± 0.004	0.664TrpAsp: 0.664 ± 0.006	0.838TrpGlu: 0.838 ± 0.007	0.442TrpPhe: 0.442 ± 0.005	0.75TrpGly: 0.75 ± 0.008	0.318TrpHis: 0.318 ± 0.004	0.556TrpIle: 0.556 ± 0.006	0.821TrpLys: 0.821 ± 0.006	1.232TrpLeu: 1.232 ± 0.009	0.322TrpMet: 0.322 ± 0.004	0.551TrpAsn: 0.551 ± 0.006	0.543TrpPro: 0.543 ± 0.005	0.552TrpGln: 0.552 ± 0.005	0.745TrpArg: 0.745 ± 0.006	0.894TrpSer: 0.894 ± 0.008	0.678TrpThr: 0.678 ± 0.008	0.707TrpVal: 0.707 ± 0.006	0.203TrpTrp: 0.203 ± 0.003	0.335TrpTyr: 0.335 ± 0.004	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.391TyrAla: 1.391 ± 0.009	0.679TyrCys: 0.679 ± 0.006	1.298TyrAsp: 1.298 ± 0.011	1.728TyrGlu: 1.728 ± 0.011	1.221TyrPhe: 1.221 ± 0.009	1.665TyrGly: 1.665 ± 0.011	0.757TyrHis: 0.757 ± 0.006	1.392TyrIle: 1.392 ± 0.009	1.518TyrLys: 1.518 ± 0.012	2.663TyrLeu: 2.663 ± 0.011	0.608TyrMet: 0.608 ± 0.006	1.11TyrAsn: 1.11 ± 0.009	1.296TyrPro: 1.296 ± 0.01	1.29TyrGln: 1.29 ± 0.008	1.621TyrArg: 1.621 ± 0.009	2.186TyrSer: 2.186 ± 0.011	1.464TyrThr: 1.464 ± 0.011	1.573TyrVal: 1.573 ± 0.009	0.367TyrTrp: 0.367 ± 0.006	0.949TyrTyr: 0.949 ± 0.007	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.004XaaAla: 0.004 ± 0.0	0.001XaaCys: 0.001 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.002XaaGlu: 0.002 ± 0.0	0.001XaaPhe: 0.001 ± 0.0	0.004XaaGly: 0.004 ± 0.0	0.001XaaHis: 0.001 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.001XaaLys: 0.001 ± 0.0	0.003XaaLeu: 0.003 ± 0.0	0.001XaaMet: 0.001 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.003XaaPro: 0.003 ± 0.0	0.001XaaGln: 0.001 ± 0.0	0.003XaaArg: 0.003 ± 0.0	0.002XaaSer: 0.002 ± 0.0	0.001XaaThr: 0.001 ± 0.0	0.001XaaVal: 0.001 ± 0.0	0.001XaaTrp: 0.001 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.419XaaXaa: 0.419 ± 0.034

Statistics based on 42998 proteins (22681937 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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