Amino acid dipepetide frequency for Vavraia culicis (isolate floridensis) (Microsporidian parasite)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	2.701AlaAla: 2.701 ± 0.137	1.081AlaCys: 1.081 ± 0.033	2.736AlaAsp: 2.736 ± 0.054	3.113AlaGlu: 3.113 ± 0.08	2.248AlaPhe: 2.248 ± 0.049	2.465AlaGly: 2.465 ± 0.071	1.325AlaHis: 1.325 ± 0.043	3.141AlaIle: 3.141 ± 0.062	3.336AlaLys: 3.336 ± 0.068	4.889AlaLeu: 4.889 ± 0.07	1.384AlaMet: 1.384 ± 0.046	2.587AlaAsn: 2.587 ± 0.053	1.456AlaPro: 1.456 ± 0.04	1.743AlaGln: 1.743 ± 0.053	2.51AlaArg: 2.51 ± 0.06	3.013AlaSer: 3.013 ± 0.061	2.099AlaThr: 2.099 ± 0.047	3.497AlaVal: 3.497 ± 0.058	0.256AlaTrp: 0.256 ± 0.016	1.865AlaTyr: 1.865 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	1.388CysAla: 1.388 ± 0.037	0.544CysCys: 0.544 ± 0.028	1.44CysAsp: 1.44 ± 0.042	1.366CysGlu: 1.366 ± 0.04	1.127CysPhe: 1.127 ± 0.036	1.337CysGly: 1.337 ± 0.048	0.415CysHis: 0.415 ± 0.023	1.482CysIle: 1.482 ± 0.044	1.536CysLys: 1.536 ± 0.047	1.84CysLeu: 1.84 ± 0.044	0.572CysMet: 0.572 ± 0.023	1.126CysAsn: 1.126 ± 0.035	0.559CysPro: 0.559 ± 0.027	0.508CysGln: 0.508 ± 0.024	1.141CysArg: 1.141 ± 0.037	1.709CysSer: 1.709 ± 0.05	1.469CysThr: 1.469 ± 0.044	1.683CysVal: 1.683 ± 0.045	0.152CysTrp: 0.152 ± 0.013	0.983CysTyr: 0.983 ± 0.036	0.0CysXaa: 0.0 ± 0.0
Asp	2.841AspAla: 2.841 ± 0.059	1.009AspCys: 1.009 ± 0.029	3.92AspAsp: 3.92 ± 0.079	5.86AspGlu: 5.86 ± 0.093	2.532AspPhe: 2.532 ± 0.065	3.634AspGly: 3.634 ± 0.085	1.071AspHis: 1.071 ± 0.035	3.821AspIle: 3.821 ± 0.067	4.417AspLys: 4.417 ± 0.085	4.922AspLeu: 4.922 ± 0.082	1.549AspMet: 1.549 ± 0.043	3.027AspAsn: 3.027 ± 0.061	1.368AspPro: 1.368 ± 0.041	1.539AspGln: 1.539 ± 0.042	3.267AspArg: 3.267 ± 0.068	3.594AspSer: 3.594 ± 0.061	2.892AspThr: 2.892 ± 0.056	4.514AspVal: 4.514 ± 0.071	0.355AspTrp: 0.355 ± 0.019	2.062AspTyr: 2.062 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	2.495GluAla: 2.495 ± 0.067	1.816GluCys: 1.816 ± 0.052	3.819GluAsp: 3.819 ± 0.075	6.327GluGlu: 6.327 ± 0.154	2.553GluPhe: 2.553 ± 0.054	3.144GluGly: 3.144 ± 0.069	1.932GluHis: 1.932 ± 0.052	5.269GluIle: 5.269 ± 0.079	6.859GluLys: 6.859 ± 0.124	6.022GluLeu: 6.022 ± 0.097	2.651GluMet: 2.651 ± 0.066	5.183GluAsn: 5.183 ± 0.094	1.519GluPro: 1.519 ± 0.043	2.762GluGln: 2.762 ± 0.067	4.579GluArg: 4.579 ± 0.088	4.55GluSer: 4.55 ± 0.08	3.017GluThr: 3.017 ± 0.063	3.729GluVal: 3.729 ± 0.074	0.55GluTrp: 0.55 ± 0.026	3.098GluTyr: 3.098 ± 0.054	0.0GluXaa: 0.0 ± 0.0
Phe	1.97PheAla: 1.97 ± 0.046	1.184PheCys: 1.184 ± 0.037	2.891PheAsp: 2.891 ± 0.052	2.836PheGlu: 2.836 ± 0.063	2.866PhePhe: 2.866 ± 0.072	2.194PheGly: 2.194 ± 0.047	0.921PheHis: 0.921 ± 0.034	3.697PheIle: 3.697 ± 0.073	3.375PheLys: 3.375 ± 0.057	5.436PheLeu: 5.436 ± 0.099	1.301PheMet: 1.301 ± 0.047	2.753PheAsn: 2.753 ± 0.054	1.153PhePro: 1.153 ± 0.035	0.967PheGln: 0.967 ± 0.034	2.014PheArg: 2.014 ± 0.048	3.465PheSer: 3.465 ± 0.057	2.495PheThr: 2.495 ± 0.062	3.879PheVal: 3.879 ± 0.067	0.258PheTrp: 0.258 ± 0.017	2.744PheTyr: 2.744 ± 0.064	0.0PheXaa: 0.0 ± 0.0
Gly	2.605GlyAla: 2.605 ± 0.081	1.294GlyCys: 1.294 ± 0.042	3.016GlyAsp: 3.016 ± 0.07	3.475GlyGlu: 3.475 ± 0.087	1.767GlyPhe: 1.767 ± 0.04	2.938GlyGly: 2.938 ± 0.13	1.112GlyHis: 1.112 ± 0.036	3.385GlyIle: 3.385 ± 0.065	4.111GlyLys: 4.111 ± 0.084	3.822GlyLeu: 3.822 ± 0.073	1.737GlyMet: 1.737 ± 0.054	3.039GlyAsn: 3.039 ± 0.073	1.004GlyPro: 1.004 ± 0.035	1.384GlyGln: 1.384 ± 0.043	2.855GlyArg: 2.855 ± 0.064	3.644GlySer: 3.644 ± 0.079	3.178GlyThr: 3.178 ± 0.074	3.441GlyVal: 3.441 ± 0.073	0.355GlyTrp: 0.355 ± 0.019	1.828GlyTyr: 1.828 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	1.162HisAla: 1.162 ± 0.042	0.469HisCys: 0.469 ± 0.025	1.147HisAsp: 1.147 ± 0.036	1.396HisGlu: 1.396 ± 0.042	1.229HisPhe: 1.229 ± 0.034	1.377HisGly: 1.377 ± 0.04	0.611HisHis: 0.611 ± 0.032	1.535HisIle: 1.535 ± 0.042	1.686HisLys: 1.686 ± 0.046	2.125HisLeu: 2.125 ± 0.057	0.531HisMet: 0.531 ± 0.024	1.232HisAsn: 1.232 ± 0.04	0.837HisPro: 0.837 ± 0.029	0.621HisGln: 0.621 ± 0.029	1.251HisArg: 1.251 ± 0.036	1.839HisSer: 1.839 ± 0.048	1.368HisThr: 1.368 ± 0.042	1.65HisVal: 1.65 ± 0.042	0.112HisTrp: 0.112 ± 0.011	0.734HisTyr: 0.734 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	3.472IleAla: 3.472 ± 0.065	1.473IleCys: 1.473 ± 0.047	4.386IleAsp: 4.386 ± 0.073	4.753IleGlu: 4.753 ± 0.071	3.781IlePhe: 3.781 ± 0.079	3.326IleGly: 3.326 ± 0.055	1.401IleHis: 1.401 ± 0.039	4.451IleIle: 4.451 ± 0.078	5.715IleLys: 5.715 ± 0.084	6.785IleLeu: 6.785 ± 0.093	1.525IleMet: 1.525 ± 0.036	4.303IleAsn: 4.303 ± 0.073	2.051IlePro: 2.051 ± 0.048	1.72IleGln: 1.72 ± 0.042	3.723IleArg: 3.723 ± 0.069	4.906IleSer: 4.906 ± 0.077	3.644IleThr: 3.644 ± 0.073	4.66IleVal: 4.66 ± 0.068	0.309IleTrp: 0.309 ± 0.017	2.715IleTyr: 2.715 ± 0.059	0.0IleXaa: 0.0 ± 0.0
Lys	3.148LysAla: 3.148 ± 0.077	1.659LysCys: 1.659 ± 0.042	4.894LysAsp: 4.894 ± 0.093	6.832LysGlu: 6.832 ± 0.114	2.743LysPhe: 2.743 ± 0.051	3.467LysGly: 3.467 ± 0.062	1.858LysHis: 1.858 ± 0.048	6.145LysIle: 6.145 ± 0.094	8.188LysLys: 8.188 ± 0.136	6.364LysLeu: 6.364 ± 0.102	2.975LysMet: 2.975 ± 0.062	6.069LysAsn: 6.069 ± 0.089	1.812LysPro: 1.812 ± 0.072	2.431LysGln: 2.431 ± 0.055	5.12LysArg: 5.12 ± 0.078	5.214LysSer: 5.214 ± 0.095	4.078LysThr: 4.078 ± 0.07	4.332LysVal: 4.332 ± 0.073	0.482LysTrp: 0.482 ± 0.023	3.335LysTyr: 3.335 ± 0.072	0.0LysXaa: 0.0 ± 0.0
Leu	4.064LeuAla: 4.064 ± 0.07	2.274LeuCys: 2.274 ± 0.056	4.455LeuAsp: 4.455 ± 0.077	5.982LeuGlu: 5.982 ± 0.096	5.364LeuPhe: 5.364 ± 0.089	3.791LeuGly: 3.791 ± 0.066	2.174LeuHis: 2.174 ± 0.05	6.109LeuIle: 6.109 ± 0.094	8.012LeuLys: 8.012 ± 0.106	9.153LeuLeu: 9.153 ± 0.134	2.311LeuMet: 2.311 ± 0.049	5.383LeuAsn: 5.383 ± 0.072	2.792LeuPro: 2.792 ± 0.061	2.627LeuGln: 2.627 ± 0.059	5.33LeuArg: 5.33 ± 0.08	7.327LeuSer: 7.327 ± 0.098	4.281LeuThr: 4.281 ± 0.073	6.087LeuVal: 6.087 ± 0.088	0.552LeuTrp: 0.552 ± 0.024	3.642LeuTyr: 3.642 ± 0.07	0.0LeuXaa: 0.0 ± 0.0
Met	1.513MetAla: 1.513 ± 0.043	0.685MetCys: 0.685 ± 0.027	1.697MetAsp: 1.697 ± 0.046	1.859MetGlu: 1.859 ± 0.047	1.261MetPhe: 1.261 ± 0.037	1.313MetGly: 1.313 ± 0.049	0.853MetHis: 0.853 ± 0.028	1.735MetIle: 1.735 ± 0.038	2.425MetLys: 2.425 ± 0.052	2.77MetLeu: 2.77 ± 0.053	0.767MetMet: 0.767 ± 0.029	1.851MetAsn: 1.851 ± 0.046	0.971MetPro: 0.971 ± 0.042	0.865MetGln: 0.865 ± 0.032	1.576MetArg: 1.576 ± 0.047	2.047MetSer: 2.047 ± 0.054	1.116MetThr: 1.116 ± 0.038	1.999MetVal: 1.999 ± 0.049	0.156MetTrp: 0.156 ± 0.012	0.962MetTyr: 0.962 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	3.156AsnAla: 3.156 ± 0.061	1.146AsnCys: 1.146 ± 0.04	4.05AsnAsp: 4.05 ± 0.073	5.277AsnGlu: 5.277 ± 0.092	2.686AsnPhe: 2.686 ± 0.063	3.636AsnGly: 3.636 ± 0.08	1.165AsnHis: 1.165 ± 0.034	4.376AsnIle: 4.376 ± 0.071	4.513AsnLys: 4.513 ± 0.087	5.313AsnLeu: 5.313 ± 0.075	1.756AsnMet: 1.756 ± 0.041	3.671AsnAsn: 3.671 ± 0.076	1.451AsnPro: 1.451 ± 0.046	1.427AsnGln: 1.427 ± 0.043	3.094AsnArg: 3.094 ± 0.063	3.921AsnSer: 3.921 ± 0.082	3.69AsnThr: 3.69 ± 0.071	4.501AsnVal: 4.501 ± 0.071	0.305AsnTrp: 0.305 ± 0.016	2.38AsnTyr: 2.38 ± 0.061	0.0AsnXaa: 0.0 ± 0.0
Pro	1.387ProAla: 1.387 ± 0.044	0.662ProCys: 0.662 ± 0.033	1.388ProAsp: 1.388 ± 0.041	1.639ProGlu: 1.639 ± 0.048	1.7ProPhe: 1.7 ± 0.043	1.316ProGly: 1.316 ± 0.055	0.688ProHis: 0.688 ± 0.027	1.802ProIle: 1.802 ± 0.054	1.862ProLys: 1.862 ± 0.053	2.477ProLeu: 2.477 ± 0.053	0.629ProMet: 0.629 ± 0.028	1.404ProAsn: 1.404 ± 0.039	1.143ProPro: 1.143 ± 0.061	0.812ProGln: 0.812 ± 0.04	1.236ProArg: 1.236 ± 0.035	2.44ProSer: 2.44 ± 0.064	1.511ProThr: 1.511 ± 0.044	2.066ProVal: 2.066 ± 0.053	0.158ProTrp: 0.158 ± 0.013	1.142ProTyr: 1.142 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	1.259GlnAla: 1.259 ± 0.047	0.569GlnCys: 0.569 ± 0.027	1.244GlnAsp: 1.244 ± 0.033	1.738GlnGlu: 1.738 ± 0.054	1.256GlnPhe: 1.256 ± 0.039	1.192GlnGly: 1.192 ± 0.039	0.769GlnHis: 0.769 ± 0.028	2.219GlnIle: 2.219 ± 0.052	2.517GlnLys: 2.517 ± 0.057	2.455GlnLeu: 2.455 ± 0.054	0.916GlnMet: 0.916 ± 0.03	2.099GlnAsn: 2.099 ± 0.046	1.053GlnPro: 1.053 ± 0.043	1.179GlnGln: 1.179 ± 0.044	1.743GlnArg: 1.743 ± 0.048	2.074GlnSer: 2.074 ± 0.044	1.421GlnThr: 1.421 ± 0.037	1.491GlnVal: 1.491 ± 0.039	0.137GlnTrp: 0.137 ± 0.011	0.968GlnTyr: 0.968 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	2.584ArgAla: 2.584 ± 0.059	1.277ArgCys: 1.277 ± 0.039	2.92ArgAsp: 2.92 ± 0.068	3.858ArgGlu: 3.858 ± 0.07	2.328ArgPhe: 2.328 ± 0.054	2.44ArgGly: 2.44 ± 0.063	1.051ArgHis: 1.051 ± 0.032	4.345ArgIle: 4.345 ± 0.069	4.97ArgLys: 4.97 ± 0.092	4.213ArgLeu: 4.213 ± 0.073	2.057ArgMet: 2.057 ± 0.046	3.876ArgAsn: 3.876 ± 0.063	1.286ArgPro: 1.286 ± 0.042	1.34ArgGln: 1.34 ± 0.035	3.314ArgArg: 3.314 ± 0.07	3.719ArgSer: 3.719 ± 0.073	3.111ArgThr: 3.111 ± 0.063	3.449ArgVal: 3.449 ± 0.073	0.358ArgTrp: 0.358 ± 0.019	2.235ArgTyr: 2.235 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	3.918SerAla: 3.918 ± 0.073	1.425SerCys: 1.425 ± 0.044	4.183SerAsp: 4.183 ± 0.076	4.361SerGlu: 4.361 ± 0.083	3.837SerPhe: 3.837 ± 0.071	3.893SerGly: 3.893 ± 0.087	1.408SerHis: 1.408 ± 0.034	4.854SerIle: 4.854 ± 0.082	4.94SerLys: 4.94 ± 0.075	6.512SerLeu: 6.512 ± 0.091	1.831SerMet: 1.831 ± 0.051	4.007SerAsn: 4.007 ± 0.083	1.942SerPro: 1.942 ± 0.052	1.724SerGln: 1.724 ± 0.044	3.195SerArg: 3.195 ± 0.059	6.021SerSer: 6.021 ± 0.121	4.552SerThr: 4.552 ± 0.09	4.905SerVal: 4.905 ± 0.071	0.432SerTrp: 0.432 ± 0.019	2.783SerTyr: 2.783 ± 0.061	0.0SerXaa: 0.0 ± 0.0
Thr	2.733ThrAla: 2.733 ± 0.059	1.13ThrCys: 1.13 ± 0.032	3.041ThrAsp: 3.041 ± 0.069	3.371ThrGlu: 3.371 ± 0.064	2.533ThrPhe: 2.533 ± 0.049	3.082ThrGly: 3.082 ± 0.07	1.191ThrHis: 1.191 ± 0.041	3.584ThrIle: 3.584 ± 0.063	3.899ThrLys: 3.899 ± 0.076	4.62ThrLeu: 4.62 ± 0.078	1.169ThrMet: 1.169 ± 0.035	3.27ThrAsn: 3.27 ± 0.069	1.713ThrPro: 1.713 ± 0.059	1.333ThrGln: 1.333 ± 0.04	2.619ThrArg: 2.619 ± 0.056	3.791ThrSer: 3.791 ± 0.065	2.745ThrThr: 2.745 ± 0.07	3.634ThrVal: 3.634 ± 0.07	0.272ThrTrp: 0.272 ± 0.02	2.012ThrTyr: 2.012 ± 0.05	0.0ThrXaa: 0.0 ± 0.0
Val	2.933ValAla: 2.933 ± 0.06	1.675ValCys: 1.675 ± 0.053	3.929ValAsp: 3.929 ± 0.075	4.51ValGlu: 4.51 ± 0.076	3.679ValPhe: 3.679 ± 0.071	3.074ValGly: 3.074 ± 0.069	1.858ValHis: 1.858 ± 0.056	4.374ValIle: 4.374 ± 0.067	5.226ValLys: 5.226 ± 0.083	7.429ValLeu: 7.429 ± 0.103	1.689ValMet: 1.689 ± 0.039	3.858ValAsn: 3.858 ± 0.061	2.184ValPro: 2.184 ± 0.057	2.063ValGln: 2.063 ± 0.046	3.633ValArg: 3.633 ± 0.063	4.516ValSer: 4.516 ± 0.08	2.741ValThr: 2.741 ± 0.056	5.009ValVal: 5.009 ± 0.085	0.401ValTrp: 0.401 ± 0.023	2.927ValTyr: 2.927 ± 0.068	0.0ValXaa: 0.0 ± 0.0
Trp	0.176TrpAla: 0.176 ± 0.015	0.208TrpCys: 0.208 ± 0.014	0.328TrpAsp: 0.328 ± 0.017	0.33TrpGlu: 0.33 ± 0.021	0.294TrpPhe: 0.294 ± 0.02	0.211TrpGly: 0.211 ± 0.018	0.158TrpHis: 0.158 ± 0.015	0.436TrpIle: 0.436 ± 0.021	0.445TrpLys: 0.445 ± 0.025	0.579TrpLeu: 0.579 ± 0.025	0.199TrpMet: 0.199 ± 0.016	0.404TrpAsn: 0.404 ± 0.018	0.169TrpPro: 0.169 ± 0.014	0.199TrpGln: 0.199 ± 0.014	0.347TrpArg: 0.347 ± 0.019	0.442TrpSer: 0.442 ± 0.021	0.295TrpThr: 0.295 ± 0.016	0.293TrpVal: 0.293 ± 0.017	0.06TrpTrp: 0.06 ± 0.009	0.288TrpTyr: 0.288 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.942TyrAla: 1.942 ± 0.047	0.798TyrCys: 0.798 ± 0.03	2.711TyrAsp: 2.711 ± 0.06	2.994TyrGlu: 2.994 ± 0.057	2.614TyrPhe: 2.614 ± 0.062	2.158TyrGly: 2.158 ± 0.053	0.95TyrHis: 0.95 ± 0.034	2.339TyrIle: 2.339 ± 0.043	3.114TyrLys: 3.114 ± 0.063	3.983TyrLeu: 3.983 ± 0.072	0.873TyrMet: 0.873 ± 0.033	2.373TyrAsn: 2.373 ± 0.048	1.002TyrPro: 1.002 ± 0.034	1.053TyrGln: 1.053 ± 0.029	2.18TyrArg: 2.18 ± 0.048	2.49TyrSer: 2.49 ± 0.05	2.041TyrThr: 2.041 ± 0.047	2.889TyrVal: 2.889 ± 0.061	0.2TyrTrp: 0.2 ± 0.016	1.689TyrTyr: 1.689 ± 0.048	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2768 proteins (952872 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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